{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:15:11Z","timestamp":1779297311682,"version":"3.51.4"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005412","name":"Shahid Chamran University of Ahvaz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.placenta.2021.02.008","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:36:39Z","timestamp":1614040599000},"page":"49-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Quercetin improved histological structure and upregulated adiponectin and adiponectin receptors in the placenta of rats with gestational diabetes mellitus"],"prefix":"10.1016","volume":"106","author":[{"given":"Mahmood Khaksary","family":"Mahabady","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Mehdi","family":"Shamsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Ranjbar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3258-8550","authenticated-orcid":false,"given":"Mohammad Reza","family":"Tabandeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaveh","family":"Khazaeel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.placenta.2021.02.008_bib1","first-page":"1049","article-title":"Maternal diabetes affects cell proliferation in developing rat placenta","volume":"26","author":"Zorn","year":"2011","journal-title":"Histol. Histopathol."},{"issue":"5","key":"10.1016\/j.placenta.2021.02.008_bib2","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global prevalence of diabetes: estimates for the year 2000 and projections for 2030","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.placenta.2021.02.008_bib3","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/1056-8727(93)90046-2","article-title":"Diabetic embryopathy: a selective review of recent trends","volume":"7","author":"Baker","year":"1993","journal-title":"J. Diabet. Complicat."},{"issue":"2","key":"10.1016\/j.placenta.2021.02.008_bib4","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4239\/wjd.v6.i2.338","article-title":"Effects of maternal diabetes on trophoblast cells","volume":"6","author":"Aires","year":"2015","journal-title":"World J. Diabetes"},{"issue":"9","key":"10.1016\/j.placenta.2021.02.008_bib5","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/nm0997-1029","article-title":"Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans","volume":"3","author":"Masuzaki","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.placenta.2021.02.008_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1293\/tox.2013-0060","article-title":"A comparison of the histological structure of the placenta in experimental animals","volume":"27","author":"Furukawa","year":"2014","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.placenta.2021.02.008_bib7","first-page":"163","article-title":"Trophoblast invasion and placentation: molecular mechanisms and regulation","volume":"88","author":"van den Br\u00fble","year":"2005","journal-title":"Chem. Immunol. Allergy"},{"issue":"1","key":"10.1016\/j.placenta.2021.02.008_bib8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.rbmo.2012.03.018","article-title":"A placenta for life","volume":"25","author":"John","year":"2012","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.placenta.2021.02.008_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1293\/tox.2018-0042","article-title":"Review, Morphology and physiology of rat placenta for toxicological evaluation","volume":"32","author":"Furukawa","year":"2019","journal-title":"J. Toxicol. Pathol."},{"issue":"1","key":"10.1016\/j.placenta.2021.02.008_bib10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2265.2011.04234.x","article-title":"Leptin, adiponectin and other adipokines in gestational diabetes mellitus and pre-eclampsia","volume":"76","author":"Miehle","year":"2012","journal-title":"Clin. Endocrinol."},{"issue":"3","key":"10.1016\/j.placenta.2021.02.008_bib11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/2042018815577039","article-title":"The role of adipokines in gestational diabetes mellitus","volume":"6","author":"Al-Badri","year":"2015","journal-title":"Therapeutic Advances in Endocrinology and Metabolism"},{"issue":"5","key":"10.1016\/j.placenta.2021.02.008_bib12","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1161\/01.HYP.0000095981.92542.F6","article-title":"Paradoxical elevation in adiponectin concentrations in women with preeclampsia","volume":"42","author":"Ramsay","year":"2003","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.placenta.2021.02.008_bib13","first-page":"583","article-title":"Opposing effects of adiponectin receptors 1 and 2 on energy metabolism","volume":"56","author":"Bjursell","year":"2007","journal-title":"American Diabetes Association"},{"key":"10.1016\/j.placenta.2021.02.008_bib14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.placenta.2012.11.024","article-title":"Review: adiponectin \u2013 the missing link between maternal adiposity, placental transport and fetal growth?","volume":"34","author":"Aye","year":"2013","journal-title":"Placenta"},{"issue":"41","key":"10.1016\/j.placenta.2021.02.008_bib15","doi-asserted-by":"crossref","first-page":"12858","DOI":"10.1073\/pnas.1515484112","article-title":"Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth","volume":"112","author":"Aye","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.placenta.2021.02.008_bib16","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/nm788","article-title":"Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase","volume":"8","author":"Yamauchi","year":"2002","journal-title":"Nat. Med."},{"issue":"8","key":"10.1016\/j.placenta.2021.02.008_bib17","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/90992","article-title":"The adipocyte-secreted protein Acrp30 enhances hepatic insulin action","volume":"7","author":"Berg","year":"2001","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.placenta.2021.02.008_bib18","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1172\/JCI14120","article-title":"Endogenous glucose production is inhibited by the adipose-derived protein Acrp30","volume":"108","author":"Combs","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.placenta.2021.02.008_bib19","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.3390\/ijms20051190","article-title":"Beneficial effects of adiponectin on glucose and lipid metabolism and atherosclerotic progression: mechanisms and perspectives","volume":"20","author":"Yanai","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"32","key":"10.1016\/j.placenta.2021.02.008_bib20","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.2174\/092986712803833227","article-title":"Adiponectin in pregnancy: implications for health and disease","volume":"19","author":"Retnakaran","year":"2012","journal-title":"Curr. Med. Chem."},{"issue":"6941","key":"10.1016\/j.placenta.2021.02.008_bib21","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nature01705","article-title":"Cloning of adiponectin receptors that mediate antidiabetic metabolic effects","volume":"423","author":"Yamauchi","year":"2003","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.placenta.2021.02.008_bib22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S2213-8587(13)70120-7","article-title":"Adiponectin and its receptors: implications for obesity-associated diseases and longevity","volume":"2","author":"Kadowaki","year":"2014","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"9326","key":"10.1016\/j.placenta.2021.02.008_bib23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0140-6736(02)09335-2","article-title":"Adiponectin and development of type 2 diabetes in the Pima Indian population","volume":"360","author":"Lindsay","year":"2002","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.placenta.2021.02.008_bib24","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.1210\/jc.2004-0930","article-title":"Expression and regulation of adiponectin and receptor in human and rat placenta","volume":"90","author":"Caminos","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.placenta.2021.02.008_bib25","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1210\/en.2009-0058","article-title":"Adiponectin attenuation of endocrine function within human term trophoblast cells","volume":"150","author":"McDonald","year":"2009","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.placenta.2021.02.008_bib26","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.pharmthera.2009.11.001","article-title":"Glycaemic control in type 2 diabetes: targets and new therapies","volume":"125","author":"Tahrani","year":"2010","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.placenta.2021.02.008_bib27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00041433-200102000-00008","article-title":"Flavonoids protect LDL from oxidation and attenuate atherosclerosis","volume":"12","author":"Fuhrman","year":"2001","journal-title":"Curr. Opin. Lipidol."},{"issue":"5","key":"10.1016\/j.placenta.2021.02.008_bib28","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3390\/nu8050310","article-title":"The possible role of flavonoids in the prevention of diabetic complications","volume":"8","author":"Testa","year":"2016","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.placenta.2021.02.008_bib29","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/0006-2952(91)90501-U","article-title":"Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives. Relationship to antioxidant activity and to iron ion-reducing ability","volume":"42","author":"Laughton","year":"1991","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.placenta.2021.02.008_bib30","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0076-6879(90)86128-I","article-title":"Flavonoids as antioxidants: determination of radical-scavenging efficiencies","volume":"186","author":"Bors","year":"1990","journal-title":"Methods Enzymol."},{"issue":"1","key":"10.1016\/j.placenta.2021.02.008_bib31","doi-asserted-by":"crossref","DOI":"10.5812\/zjrms.88636","article-title":"Protective effect of quercetin on morphological and histometrical changes of placenta in streptozotocin-induced diabetic rat","volume":"22","author":"Shamsi","year":"2019","journal-title":"Zahedan j res med sci"},{"key":"10.1016\/j.placenta.2021.02.008_bib32","first-page":"212","article-title":"Plasma metabolites of quercetin and their antioxidant properties","volume":"275","author":"Morand","year":"1998","journal-title":"Am. J. Physiol."},{"issue":"5","key":"10.1016\/j.placenta.2021.02.008_bib33","doi-asserted-by":"crossref","first-page":"450","DOI":"10.4103\/0019-5154.159626","article-title":"Comparing the efficacy of hematoxylin and eosin, periodic acid Schiff and fluorescent periodic acid schiff-acriflavine techniques for demonstration of basement membrane in oral lichen planus: a histochemical study","volume":"60","author":"Pujar","year":"2015","journal-title":"Indian J. Dermatol."},{"issue":"7","key":"10.1016\/j.placenta.2021.02.008_bib34","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1590\/S0100-736X2016000700018","article-title":"Histological features of the placenta and their relation to the gross and data from Thoroughbred mares","volume":"36","author":"Pazinato","year":"2016","journal-title":"Pesqui. Vet. Bras."},{"issue":"4","key":"10.1016\/j.placenta.2021.02.008_bib35","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: M inimum information for publication of quantitative real-time PCR Experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"issue":"9","key":"10.1016\/j.placenta.2021.02.008_bib36","first-page":"555","article-title":"Effect of enrofloxacin on histochemistry, immunohistochemistry and molecular changes in lamb articular cartilage","volume":"53","author":"Khazaeel","year":"2015","journal-title":"Acta Med. Iran."},{"issue":"1","key":"10.1016\/j.placenta.2021.02.008_bib37","article-title":"In vivo and in vitro evidence for placental DNA damage in preeclampsia","volume":"9","author":"Tadesse","year":"2014","journal-title":"Public Library of Science one"},{"issue":"6","key":"10.1016\/j.placenta.2021.02.008_bib38","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.103.024166","article-title":"Developmental dynamics of the definitive mouse placenta assessed by stereology","volume":"70","author":"Coan","year":"2004","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.placenta.2021.02.008_bib39","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.placenta.2014.11.021","article-title":"A systematic review of placental pathology in maternal diabetes mellitus","volume":"36","author":"Huynh","year":"2015","journal-title":"Placenta"},{"issue":"11","key":"10.1016\/j.placenta.2021.02.008_bib40","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.2337\/diab.35.11.1254","article-title":"Fine structural abnormalities of the placenta in diabetic rats","volume":"35","author":"Gewolb","year":"1986","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.placenta.2021.02.008_bib41","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0012-1606(03)00210-0","article-title":"Gestation stage-dependent intrauterine trophoblast cell invasion in the rat and mouse: novel endocrine phenotype and regulation","volume":"260","author":"Ain","year":"2003","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.placenta.2021.02.008_bib42","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1385\/ENDO:19:1:13","article-title":"Placental glucose transfer and fetal growth","volume":"19","author":"Baumann","year":"2002","journal-title":"Endocrine"},{"issue":"1","key":"10.1016\/j.placenta.2021.02.008_bib43","first-page":"31","article-title":"Maternal diabetes affects specific extracellular matrix components during placentation","volume":"212","author":"Giachini","year":"2008","journal-title":"Journal compilation Anatomical Society of Great Britain and Ireland"},{"issue":"1","key":"10.1016\/j.placenta.2021.02.008_bib44","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1053\/plac.2001.0738","article-title":"Comparative developmental anatomy of the murine and human placenta","volume":"23","author":"Georgiades","year":"2002","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.placenta.2021.02.008_bib45","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1055\/s-0029-1211275","article-title":"Placental structure: in a comparative aspect","volume":"102","author":"Leiser","year":"1994","journal-title":"Exp. Clin. Endocrinol."},{"key":"10.1016\/j.placenta.2021.02.008_bib46","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1152\/physrev.00029.2015","article-title":"Placental origins of chronic disease","volume":"96","author":"Burton","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.placenta.2021.02.008_bib47","series-title":"Pathology of the Human Placenta","first-page":"394","author":"Benirschke","year":"2006"},{"issue":"3","key":"10.1016\/j.placenta.2021.02.008_bib48","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2337\/diab.24.3.257","article-title":"Cell membrane changes in chronically diabetic rats","volume":"24","author":"Chandramouli","year":"1975","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.placenta.2021.02.008_bib49","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/01.EHX.0000414585.81633.b3","article-title":"Histological and immunohistochemical changes in placental chorionic villi of patients with poorly controlled gestational diabetes","volume":"35","author":"T Abou-Elghait","year":"2012","journal-title":"Egyptian Journal of Histology"},{"issue":"11","key":"10.1016\/j.placenta.2021.02.008_bib50","first-page":"2952","article-title":"Histological changes of the human placenta in pregnancies complicated with diabetes","volume":"10","author":"Treesh","year":"2015","journal-title":"J. Cytol. Histol."},{"issue":"9","key":"10.1016\/j.placenta.2021.02.008_bib51","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.2337\/diabetes.54.9.2712","article-title":"Changes of adiponectin oligomer composition by moderate weight reduction","volume":"54","author":"Bobbert","year":"2005","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.placenta.2021.02.008_bib52","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2337\/dc07-s203","article-title":"The human placenta in gestational diabetes mellitus","volume":"30","author":"Desoye","year":"2007","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.placenta.2021.02.008_bib53","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1210\/en.2003-1068","article-title":"A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity","volume":"145","author":"Combs","year":"2004","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.placenta.2021.02.008_bib54","doi-asserted-by":"crossref","first-page":"123","DOI":"10.33549\/physiolres.930479","article-title":"Review, adiponectin and its role in the obesity-induced insulin resistance and related complications","volume":"53","author":"Haluz\u00edk","year":"2004","journal-title":"Physiol. Res."},{"key":"10.1016\/j.placenta.2021.02.008_bib55","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5463762","article-title":"Adiponectin and leptin at early pregnancy: association to actual glucose disposal and risk for GDM\u2014a prospective cohort study","author":"Bozkurt","year":"2018","journal-title":"Internet J. Endocrinol."},{"issue":"10","key":"10.1016\/j.placenta.2021.02.008_bib56","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1210\/jc.2006-0980","article-title":"Modulation of adipokines and cytokines in gestational diabetes and macrosomia","volume":"91","author":"At\u00e8gbo","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.placenta.2021.02.008_bib57","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.diabres.2007.12.012","article-title":"Adipokines and insulin resistance during pregnancy","volume":"80","author":"Zavalza-Gomez","year":"2008","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"1","key":"10.1016\/j.placenta.2021.02.008_bib58","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4239\/wjd.v6.i1.151","article-title":"Adiponectin: probe of the molecular paradigm associating diabetes and obesity","volume":"6","author":"Ghoshal","year":"2015","journal-title":"World J. Diabetes"},{"issue":"4","key":"10.1016\/j.placenta.2021.02.008_bib59","doi-asserted-by":"crossref","first-page":"267","DOI":"10.7762\/cnr.2017.6.4.267","article-title":"Adiponectin concentration in gestational diabetic women: a case-control study","volume":"6","author":"Mohammadi","year":"2017","journal-title":"Clinical Nutrition Research"},{"issue":"10","key":"10.1016\/j.placenta.2021.02.008_bib60","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s00592-019-01355-0","article-title":"Placental expressions and serum levels of adiponectin, visfatin, and omentin in GDM","volume":"56","author":"Vilivong","year":"2019","journal-title":"Acta Diabetol."},{"issue":"3","key":"10.1016\/j.placenta.2021.02.008_bib61","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nm1557","article-title":"Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions","volume":"13","author":"Yamauchi","year":"2007","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.placenta.2021.02.008_bib62","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.beem.2013.09.003","article-title":"Adiponectin receptors: a review of their structure, function and how they work","volume":"28","author":"Yamauchi","year":"2014","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"issue":"3","key":"10.1016\/j.placenta.2021.02.008_bib63","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s00239-004-0375-2","article-title":"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif","volume":"61","author":"Tom Tang","year":"2005","journal-title":"J. Mol. Evol."},{"issue":"7547","key":"10.1016\/j.placenta.2021.02.008_bib64","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nature14301","article-title":"Crystal structures of the human adiponectin receptors","volume":"520","author":"Tanabe","year":"2015","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.placenta.2021.02.008_bib65","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1074\/jbc.M209033200","article-title":"Globular adiponectin protected ob\/ob mice from diabetes and ApoE-deficient mice from atherosclerosis","volume":"278","author":"Yamauchi","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.placenta.2021.02.008_bib66","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1210\/en.2005-0406","article-title":"Leptin and adiponectin stimulate the release of proinflammatory cytokines and prostaglandins from human placenta and maternal adipose tissue via nuclear factor kappaB, peroxisomal proliferator-activate receptor-gamma and extracellularly regulated kinase \u00bd","volume":"146","author":"Lappas","year":"2005","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.placenta.2021.02.008_bib67","doi-asserted-by":"crossref","first-page":"501","DOI":"10.33549\/physiolres.930830","article-title":"Changes in placental adipocytokine gene expression associated with gestational diabetes mellitus","volume":"55","author":"Meller","year":"2006","journal-title":"Physiol. Res."},{"issue":"2","key":"10.1016\/j.placenta.2021.02.008_bib68","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3844\/ajbbsp.2010.136.140","article-title":"Expression of adiponectin receptors in human placenta and its possible implication in gestational diabetes","volume":"6","author":"Al Husseini","year":"2010","journal-title":"Am. J. Biochem. Biotechnol."},{"issue":"6","key":"10.1016\/j.placenta.2021.02.008_bib69","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1210\/jc.2004-1980","article-title":"Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics","volume":"90","author":"Chen","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.placenta.2021.02.008_bib70","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1007\/s00125-006-0194-7","article-title":"Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines","volume":"49","author":"Chen","year":"2006","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.placenta.2021.02.008_bib71","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.mce.2009.08.002","article-title":"Expression of adipokines and estrogen receptors in adipose tissue and placenta of patients with gestational diabetes mellitus","volume":"314","author":"Kleiblova","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"issue":"29","key":"10.1016\/j.placenta.2021.02.008_bib72","article-title":"Insulin\/Foxo1\u2002pathway\u2002regulates\u2002expression\u2002levels\u2002of adiponectin receptors\u2002and\u2002adiponectin\u2002sensitivity","volume":"279","author":"Tsuchida","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.placenta.2021.02.008_bib73","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1210\/er.2005-0005","article-title":"Adiponectin and adiponectin receptors","volume":"26","author":"Kadowaki","year":"2005","journal-title":"Endocr. Rev."},{"issue":"5","key":"10.1016\/j.placenta.2021.02.008_bib74","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2337\/db09-0824","article-title":"Full-length adiponectin attenuates insulin signaling and inhibits insulin-stimulated amino Acid transport in human primary trophoblast cells","volume":"59","author":"Jones","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.placenta.2021.02.008_bib75","doi-asserted-by":"crossref","first-page":"21491","DOI":"10.1038\/srep21491","article-title":"Amelioration of intracellular stress and reduction of neural tube defects in embryos of diabetic mice by phytochemical quercetin","volume":"6","author":"Cao","year":"2016","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.placenta.2021.02.008_bib76","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/jbt.11","article-title":"Effects of quercetin on antioxidant defense in streptozotocin-induced diabetic rats","volume":"15","author":"Sanders","year":"2001","journal-title":"J. Biochem. Mol. Toxicol."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400421000515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400421000515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T18:02:46Z","timestamp":1758909766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400421000515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":76,"alternative-id":["S0143400421000515"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2021.02.008","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quercetin improved histological structure and upregulated adiponectin and adiponectin receptors in the placenta of rats with gestational diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2021.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}