{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:06:09Z","timestamp":1791846369682,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.placenta.2021.08.053","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T01:15:04Z","timestamp":1629335704000},"page":"39-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["A re-examination of the origins of placental bed giant cells"],"prefix":"10.1016","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0026-9494","authenticated-orcid":false,"given":"Carolyn J.P.","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Aplin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2021.08.053_bib1","series-title":"The Human Placenta","first-page":"182","author":"Boyd","year":"1970"},{"key":"10.1016\/j.placenta.2021.08.053_bib2","series-title":"Entwicklungsgeschichte des Menschen und der h\u04e7heren Thiere","author":"K\u04e7lliker","year":"1861"},{"key":"10.1016\/j.placenta.2021.08.053_bib3","first-page":"451","article-title":"Das menschliche Chorionepithel und dessen Rolle bei der Histogenese der Placenta","author":"Kastschenko","year":"1885","journal-title":"Arch. Anat.Physiol. Lpz."},{"key":"10.1016\/j.placenta.2021.08.053_bib4","first-page":"98","article-title":"Zur Kenntnis der benignen choriopithelialen Zell-invasion in die Wand des Uterus und der Tuben","volume":"58","author":"Meyer","year":"1906","journal-title":"Z. Geburtshilfe Gynakol."},{"key":"10.1016\/j.placenta.2021.08.053_bib5","first-page":"1","article-title":"Sulle modificazioni istologiche dei vasi dell\u2019utero in gravidanza e in puerperio e sul significato anatomico e funzionale delle cellule giganti cosidette sinciziali","volume":"1","author":"Sarteschi","year":"1908","journal-title":"Fogl. Ginec."},{"issue":"1921\/22","key":"10.1016\/j.placenta.2021.08.053_bib6","first-page":"244","article-title":"\u00dcber die choriale Invasion","volume":"56","author":"Schiller","year":"1921","journal-title":"Mschr. Geburtsh."},{"key":"10.1016\/j.placenta.2021.08.053_bib7","first-page":"93","article-title":"Le placenta myom\u00e9trial humain: le m\u00e9chanisme de sa secretion, execr\u00e9tion et absorption","volume":"38","author":"Keiffer","year":"1928","journal-title":"Arch. Biol."},{"key":"10.1016\/j.placenta.2021.08.053_bib8","series-title":"Modern Trends in Pathology","first-page":"180","article-title":"Disorders arising from the human trophoblast","author":"Park","year":"1959"},{"key":"10.1016\/j.placenta.2021.08.053_bib9","first-page":"416","article-title":"The giant cells of the human placental bed","volume":"96","author":"Park","year":"1962","journal-title":"J. Anat., Lond."},{"key":"10.1016\/j.placenta.2021.08.053_bib10","first-page":"423","article-title":"Origine des cellules g\u00e9antes de la caduque humaine","volume":"61","author":"Schramm","year":"1962","journal-title":"Gynecol. Obstet."},{"key":"10.1016\/j.placenta.2021.08.053_bib11","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/0002-9378(67)90619-9","article-title":"Fetomaternal cellular relations in the human basal plate: an ultrastructural study of the placenta","volume":"97","author":"Wynn","year":"1967","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2021.08.053_bib12","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0002-9378(72)90612-6","article-title":"Cytotrophoblast specializations: an ultrastructural study of the human placenta","volume":"114","author":"Wynn","year":"1972","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2021.08.053_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0143-4004(80)80012-9","article-title":"Trophoblast invasion of human decidua from 8 to 18 weeks of pregnancy","volume":"1","author":"Pijnenborg","year":"1980","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2021.08.053_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00006250-195807000-00001","article-title":"Histochemical observations on the human placenta","volume":"12","author":"McKay","year":"1958","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2021.08.053_bib15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1053\/plac.2001.0626","article-title":"Structure of anchoring villi and the trophoblastic shell in the human, Baboon and Macaque","volume":"22","author":"Enders","year":"2001","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2021.08.053_bib16","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/path.1711120403","article-title":"The ultrastructure of the human placental bed","volume":"112","author":"Robertson","year":"1974","journal-title":"J. Pathol."},{"key":"10.1016\/j.placenta.2021.08.053_bib17","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1399-0039.1997.tb02852.x","article-title":"Evaluation of trophoblast HLA-G antigen with a specific monoclonal antibody","volume":"50","author":"Loke","year":"1997","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.placenta.2021.08.053_bib18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF00219017","article-title":"An immunocytochemical study of fetal cells at the maternal-placental interface using monoclonal antibodies to keratins, vimentin and desmin","volume":"246","author":"Khong","year":"1986","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.placenta.2021.08.053_bib19","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000147847","article-title":"Epithelial-mesenchymal transition during trophoblast differentiation","volume":"156","author":"Vi\u0107ovac","year":"1996","journal-title":"Acta Anat."},{"key":"10.1016\/j.placenta.2021.08.053_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007698","article-title":"Genome amplification and cellular senescence are hallmarks of human placenta development","volume":"14","author":"Velicky","year":"2018","journal-title":"PLoS Genet."},{"key":"10.1016\/j.placenta.2021.08.053_bib21","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/humrep\/14.2.496","article-title":"Are human placeal bed giant cells merely aggregates of small mononuclear trophoblast cells? An ultrastructural and immunocytochemical study","volume":"14","author":"Al-Lamki","year":"1999","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.placenta.2021.08.053_bib22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.placenta.2020.10.017","article-title":"J-L Mege, Placental macrophages: origin, heterogeneity, function and role in pregnancy-associated infections","volume":"103","author":"Mezouar","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2021.08.053_bib23","series-title":"Cell Fusion in Health and Disease. 1: Cell Fusion in Health","first-page":"97","article-title":"Macrophage fusion and multinucleated giant cells of inflammation","author":"McNally","year":"2011"},{"key":"10.1016\/j.placenta.2021.08.053_bib24","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.ajpath.2019.02.006","article-title":"An overview of the derivation and function of multinucleated giant cells and their role in pathologic processes","volume":"189","author":"Brooks","year":"2019","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.placenta.2021.08.053_bib25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/humrep\/det353","article-title":"Distribution of decidual natural killer cells and macrophages in the neighbourhood of the trophoblast invasion front: a quantitative evaluation","volume":"29","author":"Helige","year":"2014","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.placenta.2021.08.053_bib26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.placenta.2008.10.004","article-title":"Localization of angiogenic growth factors and their receptors in the human placental bed throughout normal human pregnancy","volume":"30","author":"Schiessl","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2021.08.053_bib27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cyto.2019.01.013","article-title":"The senescence-associated secretory phenotype and its regulation","volume":"117","author":"Lopes-Paciencia","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.placenta.2021.08.053_bib28","doi-asserted-by":"crossref","DOI":"10.1093\/humupd\/dmab015","article-title":"Cell dynamics in human villous trophoblast","author":"Aplin","year":"2021","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.placenta.2021.08.053_bib29","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/s41422-018-0066-y","article-title":"Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta","volume":"28","author":"Liu","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.placenta.2021.08.053_bib30","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","article-title":"Single-cell reconstruction of the early maternal-fetal interface in humans","volume":"563","author":"Vento-Tormo","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.placenta.2021.08.053_bib31","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1084\/jem.158.4.1211","article-title":"Elevated serum levels in human pregnancy of a molecule immunochemically similar to eosinophil granule major basic protein","volume":"158","author":"Maddox","year":"1983","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.placenta.2021.08.053_bib32","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1083\/jcb.201210152","article-title":"Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force","volume":"201","author":"Wolf","year":"2013","journal-title":"J. Cell Biol."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400421005609?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400421005609?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T18:04:28Z","timestamp":1758909868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400421005609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":32,"alternative-id":["S0143400421005609"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2021.08.053","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A re-examination of the origins of placental bed giant cells","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2021.08.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}