{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:58:55Z","timestamp":1790474335263,"version":"4.1.0"},"reference-count":108,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Ma1550\/12\u20131"],"award-info":[{"award-number":["Ma1550\/12\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["03VP08692"],"award-info":[{"award-number":["03VP08692"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004937","name":"BMBF Berlin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004937","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.placenta.2021.09.011","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T20:43:15Z","timestamp":1632343395000},"page":"70-77","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["The road (not) taken \u2013 Placental transfer and interspecies differences"],"prefix":"10.1016","volume":"115","author":[{"given":"Andr\u00e9","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo R.","family":"Markert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.placenta.2021.09.011_bib1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.14573\/altex.2013.3.275","article-title":"Look back in anger - what clinical studies tell us about preclinical work","volume":"30","author":"Hartung","year":"2013","journal-title":"ALTEX"},{"issue":"3","key":"10.1016\/j.placenta.2021.09.011_bib2","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1476-5381.2010.00922.x","article-title":"Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells","volume":"161","author":"Eastwood","year":"2010","journal-title":"Br. J. Pharmacol."},{"issue":"2\u20133","key":"10.1016\/j.placenta.2021.09.011_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1081\/DMR-120023684","article-title":"New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures","volume":"35","author":"Gebhardt","year":"2003","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.placenta.2021.09.011_bib4","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/0041-008X(65)90095-5","article-title":"Teratogenic effects of thalidomide in rabbits, rats, hamsters, and mice","volume":"7","author":"Fratta","year":"1965","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.placenta.2021.09.011_bib5","series-title":"Revlimid Medication Guide","year":"2013"},{"issue":"3","key":"10.1016\/j.placenta.2021.09.011_bib6","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/bdrb.20115","article-title":"Evaluation of the developmental toxicity of lenalidomide in rabbits","volume":"80","author":"Christian","year":"2007","journal-title":"Birth Defects Res B Dev Reprod Toxicol"},{"key":"10.1016\/j.placenta.2021.09.011_bib7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1289\/ehp.8670113","article-title":"Species differences in pharmacokinetics and drug teratogenesis","volume":"70","author":"Nau","year":"1986","journal-title":"Environ. Health Perspect."},{"issue":"4","key":"10.1016\/j.placenta.2021.09.011_bib8","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1208\/s12248-011-9303-8","article-title":"Factors influencing the use and interpretation of animal models in the development of parenteral drug delivery systems","volume":"13","author":"Martinez","year":"2011","journal-title":"AAPS J."},{"issue":"1","key":"10.1016\/j.placenta.2021.09.011_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.14573\/altex.2012.1.003","article-title":"A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing","volume":"29","author":"Basketter","year":"2012","journal-title":"ALTEX"},{"issue":"1","key":"10.1016\/j.placenta.2021.09.011_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.14573\/altex.2009.1.3","article-title":"Food for thought... on the economics of animal testing","volume":"26","author":"Bottini","year":"2009","journal-title":"ALTEX"},{"issue":"Suppl A","key":"10.1016\/j.placenta.2021.09.011_bib11","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.placenta.2006.11.002","article-title":"Animal models of human placentation--a review","volume":"28","author":"Carter","year":"2007","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2021.09.011_bib12","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.theriogenology.2016.04.041","article-title":"Placentation in mammals: definitive placenta, yolk sac, and paraplacenta","volume":"86","author":"Carter","year":"2016","journal-title":"Theriogenology"},{"issue":"8","key":"10.1016\/j.placenta.2021.09.011_bib13","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nri1897","article-title":"Immunology of placentation in eutherian mammals","volume":"6","author":"Moffett","year":"2006","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.placenta.2021.09.011_bib14","doi-asserted-by":"crossref","first-page":"161098","DOI":"10.1098\/rsos.161098","article-title":"The chinchilla as a novel animal model of pregnancy","volume":"4","author":"Mikkelsen","year":"2017","journal-title":"R Soc Open Sci"},{"issue":"2","key":"10.1016\/j.placenta.2021.09.011_bib15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ando.2016.04.006","article-title":"Placentation in different mammalian species","volume":"77","author":"Chavatte-Palmer","year":"2016","journal-title":"Ann. Endocrinol."},{"issue":"4","key":"10.1016\/j.placenta.2021.09.011_bib16","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/bdrc.20027","article-title":"Mechanisms regulating toxicant disposition to the embryo during early pregnancy: an interspecies comparison","volume":"72","author":"Carney","year":"2004","journal-title":"Birth Defects Res C Embryo Today"},{"issue":"6","key":"10.1016\/j.placenta.2021.09.011_bib17","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0002-9378(15)33310-X","article-title":"Transfer of urea, sodium, and chloride across the perfused human placenta","volume":"141","author":"Dancis","year":"1981","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.placenta.2021.09.011_bib18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s004410050623","article-title":"Immunolocalization of GLUT1 and connexin 26 in the rat placenta","volume":"285","author":"Shin","year":"1996","journal-title":"Cell Tissue Res."},{"issue":"6","key":"10.1016\/j.placenta.2021.09.011_bib19","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1083\/jcb.140.6.1453","article-title":"Transplacental uptake of glucose is decreased in embryonic lethal connexin26-deficient mice","volume":"140","author":"Gabriel","year":"1998","journal-title":"J. Cell Biol."},{"issue":"1\u20132","key":"10.1016\/j.placenta.2021.09.011_bib20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.bbamem.2005.09.019","article-title":"Involvement of gap junctions in placental functions and development","volume":"1719","author":"Malassine","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"issue":"6628","key":"10.1016\/j.placenta.2021.09.011_bib21","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/387080a0","article-title":"Connexin 26 mutations in hereditary non-syndromic sensorineural deafness","volume":"387","author":"Kelsell","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.placenta.2021.09.011_bib22","series-title":"Knobil and Neill's Physiology of Reproduction","author":"Plant","year":"2015"},{"issue":"1663","key":"10.1016\/j.placenta.2021.09.011_bib23","doi-asserted-by":"crossref","first-page":"20140066","DOI":"10.1098\/rstb.2014.0066","article-title":"The placenta: a multifaceted, transient organ","volume":"370","author":"Burton","year":"2015","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"issue":"4","key":"10.1016\/j.placenta.2021.09.011_bib24","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1071\/RD9910345","article-title":"Placental transport function","volume":"3","author":"Schneider","year":"1991","journal-title":"Reprod. Fertil. Dev."},{"issue":"2","key":"10.1016\/j.placenta.2021.09.011_bib25","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/icb\/32.2.343","article-title":"Physiology of placental transfer in mammals","volume":"32","author":"Faber","year":"1992","journal-title":"Am. Zool."},{"issue":"3","key":"10.1016\/j.placenta.2021.09.011_bib26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2174\/1567201043334731","article-title":"A review on the molecular mechanisms involved in the placental barrier for drugs","volume":"1","author":"Marin","year":"2004","journal-title":"Curr. Drug Deliv."},{"issue":"8\u20139","key":"10.1016\/j.placenta.2021.09.011_bib27","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1053\/plac.2001.0717","article-title":"Water channel proteins AQP3 and AQP9 are present in syncytiotrophoblast of human term placenta","volume":"22","author":"Damiano","year":"2001","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2021.09.011_bib28","series-title":"Pathology of the Human Placenta","author":"Benirschke","year":"1995"},{"issue":"1","key":"10.1016\/j.placenta.2021.09.011_bib29","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0301-2115(95)02206-M","article-title":"Comparative aspects of placental exchange functions","volume":"63","author":"Schroder","year":"1995","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"Pt 1","key":"10.1016\/j.placenta.2021.09.011_bib30","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1113\/jphysiol.2005.104141","article-title":"Programming placental nutrient transport capacity","volume":"572","author":"Fowden","year":"2006","journal-title":"J. Physiol."},{"issue":"6","key":"10.1016\/j.placenta.2021.09.011_bib31","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1095\/biolreprod.103.024166","article-title":"Developmental dynamics of the definitive mouse placenta assessed by stereology","volume":"70","author":"Coan","year":"2004","journal-title":"Biol. Reprod."},{"issue":"8","key":"10.1016\/j.placenta.2021.09.011_bib32","doi-asserted-by":"crossref","first-page":"894","DOI":"10.2174\/138945007781386901","article-title":"Fetal mechanisms that lead to later hypertension","volume":"8","author":"Gardner","year":"2007","journal-title":"Curr. Drug Targets"},{"issue":"5","key":"10.1016\/j.placenta.2021.09.011_bib33","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1111\/j.1476-5381.2011.01724.x","article-title":"OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies","volume":"165","author":"Roth","year":"2012","journal-title":"Br. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.placenta.2021.09.011_bib34","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1002\/jps.20686","article-title":"Kinetic analyses for species differences in P-glycoprotein-mediated drug transport","volume":"95","author":"Katoh","year":"2006","journal-title":"J Pharm Sci"},{"issue":"6","key":"10.1016\/j.placenta.2021.09.011_bib35","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1002\/jps.20787","article-title":"Species differences of inhibitory effects on P-glycoprotein-mediated drug transport","volume":"96","author":"Suzuyama","year":"2007","journal-title":"J Pharm Sci"},{"issue":"4","key":"10.1016\/j.placenta.2021.09.011_bib36","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1095\/biolreprod.105.042242","article-title":"Multidrug resistance phosphoglycoprotein (ABCB1) in the mouse placenta: fetal protection","volume":"73","author":"Kalabis","year":"2005","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.placenta.2021.09.011_bib37","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuropharm.2006.07.038","article-title":"Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein","volume":"52","author":"Baltes","year":"2007","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.placenta.2021.09.011_bib38","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1124\/dmd.107.019620","article-title":"Species-dependent transport and modulation properties of human and mouse multidrug resistance protein 2 (MRP2\/Mrp2, ABCC2\/Abcc2)","volume":"36","author":"Zimmermann","year":"2008","journal-title":"Drug Metab. Dispos."},{"issue":"3","key":"10.1016\/j.placenta.2021.09.011_bib39","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1476-5381.2009.00336.x","article-title":"Drug transporters in the human blood-placental barrier","volume":"158","author":"Vahakangas","year":"2009","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.placenta.2021.09.011_bib40","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1124\/dmd.109.030791","article-title":"Breast cancer resistance protein (BCRP)-mediated glyburide transport: effect of the C421A\/Q141K BCRP single-nucleotide polymorphism","volume":"38","author":"Pollex","year":"2010","journal-title":"Drug Metab. Dispos."},{"issue":"5","key":"10.1016\/j.placenta.2021.09.011_bib41","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1124\/dmd.117.079228","article-title":"Interindividual regulation of the breast cancer resistance protein\/ABCG2 transporter in term human placentas","volume":"46","author":"Bircsak","year":"2018","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.placenta.2021.09.011_bib42","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2133\/dmpk.DMPK-11-RV-099","article-title":"Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs","volume":"27","author":"Nakanishi","year":"2012","journal-title":"Drug Metabol. Pharmacokinet."},{"issue":"10","key":"10.1016\/j.placenta.2021.09.011_bib43","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.placenta.2015.07.119","article-title":"Organic anion transporter 4 (OAT 4) modifies placental transfer of perfluorinated alkyl acids PFOS and PFOA in human placental ex vivo perfusion system","volume":"36","author":"Kummu","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2021.09.011_bib44","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.yrtph.2019.05.008","article-title":"Interspecies differences in perfluoroalkyl substances (PFAS) toxicokinetics and application to health-based criteria","volume":"106","author":"Pizzurro","year":"2019","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"7","key":"10.1016\/j.placenta.2021.09.011_bib45","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0278-6915(02)00069-8","article-title":"Low-dose in utero effects of xenoestrogens in mice and their relevance to humans: an analytical review of the literature","volume":"40","author":"Witorsch","year":"2002","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.placenta.2021.09.011_bib46","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1055\/s-2004-861549","article-title":"The human fetal adrenal: making adrenal androgens for placental estrogens","volume":"22","author":"Rainey","year":"2004","journal-title":"Semin. Reprod. Med."},{"issue":"8","key":"10.1016\/j.placenta.2021.09.011_bib47","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.bcp.2005.12.035","article-title":"The effect of methadone and buprenorphine on human placental aromatase","volume":"71","author":"Zharikova","year":"2006","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.placenta.2021.09.011_bib48","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/jb\/mvr009","article-title":"Structural basis of species differences between human and experimental animal CYP1A1s in metabolism of 3,3',4,4',5-pentachlorobiphenyl","volume":"149","author":"Yamazaki","year":"2011","journal-title":"J. Biochem."},{"issue":"6","key":"10.1016\/j.placenta.2021.09.011_bib49","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1124\/mol.109.054825","article-title":"Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice","volume":"75","author":"Flaveny","year":"2009","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.placenta.2021.09.011_bib50","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S1028-4559(09)60032-2","article-title":"Syncytial knots, sprouts, apoptosis, and trophoblast deportation from the human placenta","volume":"48","author":"Burton","year":"2009","journal-title":"Taiwan. J. Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.placenta.2021.09.011_bib51","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.placenta.2003.10.017","article-title":"Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies","volume":"25","author":"Bottalico","year":"2004","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2021.09.011_bib52","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ebiom.2019.06.007","article-title":"Placental effects and transfer of sildenafil in healthy and preeclamptic conditions","volume":"45","author":"Hitzerd","year":"2019","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.placenta.2021.09.011_bib53","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0041-008X(77)90054-0","article-title":"Comparative distribution and embryotoxicity of acetylsalicylic acid in pregnant rats and rhesus monkeys","volume":"41","author":"Wilson","year":"1977","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"5","key":"10.1016\/j.placenta.2021.09.011_bib54","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s40262-019-00836-3","article-title":"Fetal physiologically based pharmacokinetic models: systems information on fetal blood components and binding proteins","volume":"59","author":"Abduljalil","year":"2020","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.placenta.2021.09.011_bib55","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.envres.2014.04.030","article-title":"Effect of hemoglobin adjustment on the precision of mercury concentrations in maternal and cord blood","volume":"132","author":"Kim","year":"2014","journal-title":"Environ. Res."},{"issue":"12","key":"10.1016\/j.placenta.2021.09.011_bib56","doi-asserted-by":"crossref","first-page":"a011627","DOI":"10.1101\/cshperspect.a011627","article-title":"Evolution of hemoglobin and its genes","volume":"2","author":"Hardison","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"6","key":"10.1016\/j.placenta.2021.09.011_bib57","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/bdrb.20178","article-title":"Species-specificity of ethylene glycol-induced developmental toxicity: toxicokinetic and whole embryo culture studies in the rabbit","volume":"83","author":"Carney","year":"2008","journal-title":"Birth Defects Res B Dev Reprod Toxicol"},{"issue":"3","key":"10.1016\/j.placenta.2021.09.011_bib58","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0163-7258(81)90034-6","article-title":"Transfer of drugs across the placenta","volume":"14","author":"Waddell","year":"1981","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.placenta.2021.09.011_bib59","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/00000542-199609000-00021","article-title":"Effects of fetal pH on local anesthetic transfer across the human placenta","volume":"85","author":"Johnson","year":"1996","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.placenta.2021.09.011_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1051\/rnd:2003002","article-title":"Materno-foetal exchanges and utilisation of nutrients by the foetus: comparison between species","volume":"43","author":"Pere","year":"2003","journal-title":"Reprod. Nutr. Dev."},{"issue":"1","key":"10.1016\/j.placenta.2021.09.011_bib61","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/eesa.1993.1040","article-title":"The relevance of fat content in toxicity of lipophilic chemicals to terrestrial animals with special reference to dieldrin and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)","volume":"26","author":"Geyer","year":"1993","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"10","key":"10.1016\/j.placenta.2021.09.011_bib62","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1439-0442.1998.tb00862.x","article-title":"Transplacental transfer of radionuclides. A review","volume":"45","author":"von Zallinger","year":"1998","journal-title":"Zentralblatt f\u00fcr Veterinarmed. A"},{"issue":"6","key":"10.1016\/j.placenta.2021.09.011_bib63","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1080\/09553009114551251","article-title":"The incorporation of plutonium by the embryo and fetus of rats and Guinea-pigs","volume":"59","author":"Morgan","year":"1991","journal-title":"Int. J. Radiat. Biol."},{"issue":"8","key":"10.1016\/j.placenta.2021.09.011_bib64","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.1210\/en.2004-1619","article-title":"Transcriptional regulation of dehydroepiandrosterone sulfotransferase (SULT2A1) by estrogen-related receptor alpha","volume":"146","author":"Seely","year":"2005","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.placenta.2021.09.011_bib65","first-page":"449","article-title":"A brief account of the discovery of the fetal\/placental unit for estrogen production in equine and human pregnancies: relation to human medicine","volume":"90","author":"Raeside","year":"2017","journal-title":"Yale J. Biol. Med."},{"issue":"1\u20132","key":"10.1016\/j.placenta.2021.09.011_bib66","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1515\/jpme.1995.23.1-2.61","article-title":"Erythropoietin transplacental passage--review of animal studies","volume":"23","author":"Widness","year":"1995","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.placenta.2021.09.011_bib67","series-title":"Endocrine and Biochemical Development of the Fetus and Neonate","first-page":"213","article-title":"Lipid metabolic interactions in the mother during pregnancy and their fetal repercussions","author":"Herrera","year":"1990"},{"key":"10.1016\/j.placenta.2021.09.011_bib68","first-page":"223","article-title":"The role of the visceral yolk sac in mediating protein utilization by rat embryos cultured in vitro","volume":"66","author":"Freeman","year":"1981","journal-title":"J. Embryol. Exp. Morphol."},{"issue":"3","key":"10.1016\/j.placenta.2021.09.011_bib69","doi-asserted-by":"crossref","first-page":"R87","DOI":"10.1530\/JOE-14-0025","article-title":"Thyroid hormones in fetal growth and prepartum maturation","volume":"221","author":"Forhead","year":"2014","journal-title":"J. Endocrinol."},{"issue":"6","key":"10.1016\/j.placenta.2021.09.011_bib70","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/bdrb.21089","article-title":"Placental transfer of Fc-containing biopharmaceuticals across species, an industry survey analysis","volume":"98","author":"Bowman","year":"2013","journal-title":"Birth Defects Res B Dev Reprod Toxicol"},{"issue":"2","key":"10.1016\/j.placenta.2021.09.011_bib71","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1269\/jrr.22.242","article-title":"Cross placental transfer of 198Au-colloid in near term rats","volume":"22","author":"Takahashi","year":"1981","journal-title":"J. Radiat. Res."},{"issue":"2","key":"10.1016\/j.placenta.2021.09.011_bib72","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/bdrb.21105","article-title":"Placental transfer of a fully human IgG2 monoclonal antibody in the cynomolgus monkey, rat, and rabbit: a comparative assessment from during organogenesis to late gestation","volume":"101","author":"Moffat","year":"2014","journal-title":"Birth Defects Res B Dev Reprod Toxicol"},{"issue":"5","key":"10.1016\/j.placenta.2021.09.011_bib73","doi-asserted-by":"crossref","first-page":"S183","DOI":"10.1067\/mjd.2001.113720","article-title":"Teratogenicity of isotretinoin revisited: species variation and the role of all-trans-retinoic acid","volume":"45","author":"Nau","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"issue":"1","key":"10.1016\/j.placenta.2021.09.011_bib74","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/biolre\/ioaa048","article-title":"Barusiban, a selective oxytocin receptor antagonist: placental transfer in rabbit, monkey, and humandagger","volume":"103","author":"Helmer","year":"2020","journal-title":"Biol. Reprod."},{"issue":"3","key":"10.1016\/j.placenta.2021.09.011_bib75","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/tera.1420090311","article-title":"Placental transfer of diphenylhydantoin: effects of species, gestational age, and route of administration","volume":"9","author":"Stevens","year":"1974","journal-title":"Teratology"},{"issue":"2","key":"10.1016\/j.placenta.2021.09.011_bib76","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1203\/00006450-197502000-00009","article-title":"Placental transfer and fetal urinary excretion of gentamicin during constant rate maternal infusion","volume":"9","author":"Kauffman","year":"1975","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.placenta.2021.09.011_bib77","series-title":"N.I.o.H. Office of AIDS Research","article-title":"Recommendations for the use of antiretroviral drugs in pregnant women with HIV infection and interventions to reduce perinatal HIV transmission in the United States","author":"gov","year":"2018"},{"issue":"1","key":"10.1016\/j.placenta.2021.09.011_bib78","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000457072","article-title":"Maternal-fetal distribution of morphine and alfentanil in near-term sheep and rhesus monkeys","volume":"9","author":"Golub","year":"1986","journal-title":"Dev. Pharmacol. Ther."},{"key":"10.1016\/j.placenta.2021.09.011_bib79","series-title":"N.I.o.H. Office of AIDS Research","article-title":"Recommendations for the use of antiretroviral drugs in pregnant women with HIV infection and interventions to reduce perinatal HIV transmission in the United States","author":"gov","year":"2020"},{"issue":"2","key":"10.1016\/j.placenta.2021.09.011_bib80","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1584\/jpestics.D17-079","article-title":"Species differences in the developmental toxicity of procymidone-Placental transfer of procymidone in pregnant rats, rabbits, and monkeys","volume":"43","author":"Tarui","year":"2018","journal-title":"J. Pestic. Sci."},{"issue":"1","key":"10.1016\/j.placenta.2021.09.011_bib81","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0014-5793(96)00812-5","article-title":"Novel harmful effects of [60]fullerene on mouse embryos in vitro and in vivo","volume":"393","author":"Tsuchiya","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.placenta.2021.09.011_bib82","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3109\/17435390.2011.626539","article-title":"Distribution of silver nanoparticles in pregnant mice and developing embryos","volume":"6","author":"Austin","year":"2012","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.placenta.2021.09.011_bib83","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1743-8977-10-21","article-title":"Biodistribution and toxicity of pegylated single wall carbon nanotubes in pregnant mice","volume":"10","author":"Campagnolo","year":"2013","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.placenta.2021.09.011_bib84","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.placenta.2021.02.017","article-title":"Ex vivo dual perfusion of an isolated cotyledon of human placenta: history and future challenges","volume":"107","author":"Schneider","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2021.09.011_bib85","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.placenta.2020.12.014","article-title":"Research on nanoparticles in human perfused placenta: state of the art and perspectives","volume":"104","author":"Aengenheister","year":"2021","journal-title":"Placenta"},{"issue":"6","key":"10.1016\/j.placenta.2021.09.011_bib86","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/0002-9378(72)90909-X","article-title":"Transfer across the perfused human placenta of antipyrine, sodium and leucine","volume":"114","author":"Schneider","year":"1972","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"8","key":"10.1016\/j.placenta.2021.09.011_bib87","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.3109\/10428194.2012.758844","article-title":"Establishment of a one-sided ex vivo human placenta perfusion model to assess adhesion and invasion behavior of T cell leukemia cell lines","volume":"54","author":"Schamberger","year":"2013","journal-title":"Leuk. Lymphoma"},{"issue":"6","key":"10.1016\/j.placenta.2021.09.011_bib88","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.placenta.2004.10.002","article-title":"Human placental explants in culture: approaches and assessments","volume":"26","author":"Miller","year":"2005","journal-title":"Placenta"},{"issue":"2\u20133","key":"10.1016\/j.placenta.2021.09.011_bib89","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0143-4004(97)90079-5","article-title":"Culture of syncytiotrophoblast for the study of human placental transfer. Part I: isolation and purification of cytotrophoblast","volume":"18","author":"Bloxam","year":"1997","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.placenta.2021.09.011_bib90","doi-asserted-by":"crossref","first-page":"1800112","DOI":"10.1002\/gch2.201800112","article-title":"Placenta-on-a-Chip: in vitro study of caffeine transport across placental barrier using liquid chromatography mass spectrometry","volume":"3","author":"Pemathilaka","year":"2019","journal-title":"Glob Chall"},{"issue":"2","key":"10.1016\/j.placenta.2021.09.011_bib91","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0014-4827(90)90310-7","article-title":"Modulators of cyclic AMP metabolism induce syncytiotrophoblast formation in vitro","volume":"186","author":"Wice","year":"1990","journal-title":"Exp. Cell Res."},{"issue":"9","key":"10.1016\/j.placenta.2021.09.011_bib92","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.placenta.2010.06.016","article-title":"Stimulation of syncytium formation in vitro in human trophoblast cells by galectin-1","volume":"31","author":"Fischer","year":"2010","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2021.09.011_bib93","doi-asserted-by":"crossref","first-page":"15606","DOI":"10.1038\/s41598-020-72559-6","article-title":"Inspired by the human placenta: a novel 3D bioprinted membrane system to create barrier models","volume":"10","author":"Kreuder","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.placenta.2021.09.011_bib94","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.placenta.2020.02.015","article-title":"Placental perfusion and mathematical modelling","volume":"93","author":"Lewis","year":"2020","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2021.09.011_bib95","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.addr.2016.08.002","article-title":"Placental control of drug delivery","volume":"116","author":"Al-Enazy","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"8\u20139","key":"10.1016\/j.placenta.2021.09.011_bib96","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1080\/10408440591007412","article-title":"Mode of action: yolk sac poisoning and impeded histiotrophic nutrition--HBOC-related congenital malformations","volume":"35","author":"Holson","year":"2005","journal-title":"Crit. Rev. Toxicol."},{"issue":"8","key":"10.1016\/j.placenta.2021.09.011_bib97","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1080\/17425255.2018.1499726","article-title":"An update on expression and function of P-gp\/ABCB1 and BCRP\/ABCG2 in the placenta and fetus","volume":"14","author":"Han","year":"2018","journal-title":"Expet Opin. Drug Metabol. Toxicol."},{"issue":"8","key":"10.1016\/j.placenta.2021.09.011_bib98","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1093\/infdis\/jix552","article-title":"Zika virus replicates in proliferating cells in explants from first-trimester human placentas, potential sites for dissemination of infection","volume":"217","author":"Tabata","year":"2018","journal-title":"J. Infect. Dis."},{"issue":"3","key":"10.1016\/j.placenta.2021.09.011_bib99","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3201\/eid2303.161499","article-title":"Zika virus RNA replication and persistence in brain and placental tissue","volume":"23","author":"Bhatnagar","year":"2017","journal-title":"Emerg. Infect. Dis."},{"issue":"1","key":"10.1016\/j.placenta.2021.09.011_bib100","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41426-018-0199-6","article-title":"Zika virus infection in human placental tissue explants is enhanced in the presence of dengue virus antibodies in-vitro","volume":"7","author":"Hermanns","year":"2018","journal-title":"Emerg. Microb. Infect."},{"issue":"6","key":"10.1016\/j.placenta.2021.09.011_bib101","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1007\/s00404-017-4361-5","article-title":"Viral infection, proliferation, and hyperplasia of Hofbauer cells and absence of inflammation characterize the placental pathology of fetuses with congenital Zika virus infection","volume":"295","author":"Schwartz","year":"2017","journal-title":"Arch. Gynecol. Obstet."},{"issue":"1","key":"10.1016\/j.placenta.2021.09.011_bib102","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/jlb.50.1.57","article-title":"Development, differentiation, and maturation of macrophages in the chorionic villi of mouse placenta with special reference to the origin of Hofbauer cells","volume":"50","author":"Takahashi","year":"1991","journal-title":"J. Leukoc. Biol."},{"issue":"7","key":"10.1016\/j.placenta.2021.09.011_bib103","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008413","article-title":"Role of microglia in the dissemination of Zika virus from mother to fetal brain","volume":"14","author":"Xu","year":"2020","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"4","key":"10.1016\/j.placenta.2021.09.011_bib104","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1152\/physrev.00040.2011","article-title":"Evolution of placental function in mammals: the molecular basis of gas and nutrient transfer, hormone secretion, and immune responses","volume":"92","author":"Carter","year":"2012","journal-title":"Physiol. Rev."},{"issue":"15","key":"10.1016\/j.placenta.2021.09.011_bib105","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/bdr2.1350","article-title":"Bone development in laboratory mammals used in developmental toxicity studies","volume":"110","author":"DeSesso","year":"2018","journal-title":"Birth Defects Res"},{"key":"10.1016\/j.placenta.2021.09.011_bib106","series-title":"E.C. Agency","author":"European Chemicals Agency","year":"2014"},{"issue":"2","key":"10.1016\/j.placenta.2021.09.011_bib107","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1177\/0192623313482206","article-title":"The placenta in toxicology. Part IV: battery of toxicological test systems based on human placenta","volume":"42","author":"Gohner","year":"2014","journal-title":"Toxicol. Pathol."},{"issue":"1","key":"10.1016\/j.placenta.2021.09.011_bib108","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.yexcr.2018.02.017","article-title":"Human serum alters cell culture behavior and improves spheroid formation in comparison to fetal bovine serum","volume":"365","author":"Heger","year":"2018","journal-title":"Exp. Cell Res."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400421005907?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400421005907?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T18:04:53Z","timestamp":1758909893000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400421005907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":108,"alternative-id":["S0143400421005907"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2021.09.011","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The road (not) taken \u2013 Placental transfer and interspecies differences","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2021.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}