{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:09:41Z","timestamp":1782407381441,"version":"3.54.5"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.placenta.2022.01.004","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T02:42:44Z","timestamp":1641523364000},"page":"38-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Associations between AGT, MTHFR, and VEGF gene polymorphisms and preeclampsia in the Chinese population"],"prefix":"10.1016","volume":"118","author":[{"given":"Guifeng","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianrong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqin","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2022.01.004_bib1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/ki.2009.284","article-title":"The biology of preeclampsia,","volume":"76","author":"Kanasaki","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.placenta.2022.01.004_bib2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1081\/PRG-200030301","article-title":"Maternal deaths associated with hypertensive disorders of pregnancy: a population-based study","volume":"23","author":"Moodley","year":"2004","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.placenta.2022.01.004_bib3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1053\/j.semperi.2011.09.011","article-title":"Maternal mortality from preeclampsia\/eclampsia","volume":"36","author":"Ghulmiyyah","year":"2012","journal-title":"Semin. Perinatol."},{"key":"10.1016\/j.placenta.2022.01.004_bib4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cyto.2017.06.010","article-title":"Vascular endothelial growth factor single nucleotide polymorphisms and haplotypes in pre-eclampsia: a case-control study,","volume":"97","author":"Ben Ali Gannoun","year":"2017","journal-title":"Cytokine"},{"key":"10.1016\/j.placenta.2022.01.004_bib5","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/632732","article-title":"Pathogenesis of preeclampsia: the genetic component","volume":"2012","author":"Valenzuela","year":"2012","journal-title":"J. Pregnancy"},{"key":"10.1016\/j.placenta.2022.01.004_bib6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.mjafi.2016.09.001","article-title":"Pre-eclampsia: molecular events to biomarkers","volume":"73","author":"Sahai","year":"2017","journal-title":"Med. J. Armed Forces India"},{"key":"10.1016\/j.placenta.2022.01.004_bib7","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.tcm.2018.04.009","article-title":"Preeclampsia and the cardiovascular system: an update","volume":"28","author":"Perry","year":"2018","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.placenta.2022.01.004_bib8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/humupd\/dms060","article-title":"Genetic variants in pre-eclampsia: a meta-analysis","volume":"19","author":"Buurma","year":"2013","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.placenta.2022.01.004_bib9","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.mehy.2013.12.024","article-title":"The role of the renin-angiotensin system in the pathogenesis of preeclampsia - new insights into the renin-angiotensin system in preeclampsia,","volume":"82","author":"Seki","year":"2014","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.placenta.2022.01.004_bib10","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.mehy.2015.03.001","article-title":"The potential participation of abdominal pressure in preeclampsia,","volume":"84","author":"Zhang","year":"2015","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.placenta.2022.01.004_bib11","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1172\/JCI119343","article-title":"A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro,","volume":"99","author":"Inoue","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.placenta.2022.01.004_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/ahg.12323","article-title":"Association study of M235T and A-6G polymorphisms in angiotensinogen gene with risk of developing preeclampsia in Iranian population","author":"Alaee","year":"2019","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.placenta.2022.01.004_bib13","doi-asserted-by":"crossref","DOI":"10.1177\/1470320317753924","article-title":"Contribution of angiotensinogen M235T and T174M gene variants and haplotypes to preeclampsia and its severity in (North African) Tunisians","volume":"19","author":"Zitouni","year":"2018","journal-title":"J. Renin Angiotensin Aldosterone Syst"},{"key":"10.1016\/j.placenta.2022.01.004_bib14","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/jn\/129.5.919","article-title":"Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement","volume":"129","author":"Bailey","year":"1999","journal-title":"J. Nutr."},{"key":"10.1016\/j.placenta.2022.01.004_bib15","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/S0002-9378(98)70033-X","article-title":"Plasma homocysteine concentration is increased in preeclampsia and is associated with evidence of endothelial activation","volume":"179","author":"Powers","year":"1998","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2022.01.004_bib16","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0029-7844(97)00223-8","article-title":"Elevated homocyst(e)ine levels with preeclampsia","volume":"90","author":"Rajkovic","year":"1997","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2022.01.004_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s004390050776","article-title":"MTHFR association with arteriosclerotic vascular disease?","volume":"103","author":"Fletcher","year":"1998","journal-title":"Hum. Genet."},{"key":"10.1016\/j.placenta.2022.01.004_bib18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase,","volume":"10","author":"Frosst","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.placenta.2022.01.004_bib19","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1097\/00004872-200409000-00004","article-title":"Association of C677T polymorphism in the methylenetetrahydrofolate reductase gene with hypertension in pregnancy and pre-eclampsia: a meta-analysis","volume":"22","author":"Kosmas","year":"2004","journal-title":"J. Hypertens."},{"key":"10.1016\/j.placenta.2022.01.004_bib20","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1081\/PRG-100101991","article-title":"Methylenetetrahydrofolate reductase polymorphisms in preeclampsia and the HELLP syndrome","volume":"19","author":"Zusterzeel","year":"2000","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.placenta.2022.01.004_bib21","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ogc.2010.02.013","article-title":"Abnormal placentation, angiogenic factors, and the pathogenesis of preeclampsia","volume":"37","author":"Silasi","year":"2010","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"10.1016\/j.placenta.2022.01.004_bib22","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0002-9440(10)62567-9","article-title":"Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome","volume":"160","author":"Zhou","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.placenta.2022.01.004_bib23","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1053\/beog.2000.0138","article-title":"Angiogenesis and placental growth in normal and compromised pregnancies","volume":"14","author":"Ong","year":"2000","journal-title":"Baillieres Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.placenta.2022.01.004_bib24","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.fertnstert.2008.11.017","article-title":"Association study of vascular endothelial growth factor polymorphisms with the risk of recurrent spontaneous abortion","volume":"93","author":"Lee","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.placenta.2022.01.004_bib25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1042\/CS20040370","article-title":"The vascular endothelial growth factor (VEGF)\/VEGF receptor system and its role under physiological and pathological conditions","volume":"109","author":"Takahashi","year":"2005","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.placenta.2022.01.004_bib26","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3109\/14767058.2012.733760","article-title":"Feto-placental nitric oxide, asymmetric dimethylarginine and vascular endothelial growth factor (VEGF) levels and VEGF gene polymorphisms in severe preeclampsia","volume":"26","author":"Chedraui","year":"2013","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.placenta.2022.01.004_bib27","article-title":"Vascular endothelial growth factor +936C\/T, -634G\/C, -2578C\/A, and -1154G\/A polymorphisms with risk of preeclampsia: a meta-analysis","volume":"8","author":"Cheng","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.placenta.2022.01.004_bib28","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1080\/10641963.2017.1299751","article-title":"The placental vascular endothelial growth factor polymorphisms and preeclampsia\/preeclampsia severity,","volume":"39","author":"Keshavarzi","year":"2017","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.placenta.2022.01.004_bib29","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1080\/10641963.2018.1469644","article-title":"Association of the placental VEGF promoter polymorphisms and VEGF mRNA expression with preeclampsia","volume":"41","author":"Keshavarzi","year":"2019","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.placenta.2022.01.004_bib30","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1111\/jog.12825","article-title":"Vascular endothelial growth factor (VEGF)-634G\/C polymorphism was associated with severe pre-eclampsia and lower serum VEGF level","volume":"41","author":"Salimi","year":"2015","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.placenta.2022.01.004_bib31","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1002\/elps.1150180929","article-title":"Angiotensinogen gene variation in a population case-control study of preeclampsia\/eclampsia in Australians and Chinese","volume":"18","author":"Guo","year":"1997","journal-title":"Electrophoresis"},{"key":"10.1016\/j.placenta.2022.01.004_bib32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1375\/twin.11.1.77","article-title":"No association of the genetic polymorphisms of endothelial nitric oxide synthase, dimethylarginine dimethylaminohydrolase, and vascular endothelial growth factor with preeclampsia in Korean populations","volume":"11","author":"Kim","year":"2008","journal-title":"Twin Res. Hum. Genet."},{"key":"10.1016\/j.placenta.2022.01.004_bib33","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000352070","article-title":"Association of angiotensinogen gene polymorphisms and angiogenic factors with preeclampsia in Chinese women","volume":"76","author":"Song","year":"2013","journal-title":"Gynecol. Obstet. Invest."},{"key":"10.1016\/j.placenta.2022.01.004_bib34","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1007\/s11033-014-3415-z","article-title":"Methylenetetrahydrofolate reductase gene C677T, A1298C polymorphisms and pre-eclampsia risk: a meta-analysis","volume":"41","author":"Li","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.placenta.2022.01.004_bib35","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s00335-017-9692-9","article-title":"Association of folate metabolism gene polymorphisms and haplotype combination with pulmonary embolism risk in Chinese Han population","volume":"28","author":"Li","year":"2017","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.placenta.2022.01.004_bib36","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s10815-012-9800-4","article-title":"Associations of ACE I\/D, AGT M235T gene polymorphisms with pregnancy induced hypertension in Chinese population: a meta-analysis","volume":"29","author":"Zhu","year":"2012","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.placenta.2022.01.004_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.154995","article-title":"Effects of maternal and fetal vascular endothelial growth factor a single nucleotide polymorphisms on pre-eclampsia: a hybrid design study","volume":"127","author":"Chen","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.placenta.2022.01.004_bib38","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.arcmed.2013.01.011","article-title":"Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and risk of preeclampsia: an updated meta-analysis based on 51 studies","volume":"44","author":"Wang","year":"2013","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.placenta.2022.01.004_bib39","first-page":"67","article-title":"C.o.O. Practice, ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists","volume":"77","author":"A","year":"2002","journal-title":"Int. J. Gynaecol. Obstet."},{"issue":"24","key":"10.1016\/j.placenta.2022.01.004_bib62","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.preghy.2021.02.001","article-title":"Prevalence of hypertensive disorders in pregnancy in China: A systematic review and meta-analysis","author":"Li","year":"2021","journal-title":"Pregnancy Hypertens."},{"key":"10.1016\/j.placenta.2022.01.004_bib40","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/jlb.51.4.421","article-title":"Effector function of hepatocytes and Kupffer cells in the resolution of systemic bacterial infections","volume":"51","author":"Gregory","year":"1992","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.placenta.2022.01.004_bib41","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000146084","article-title":"Genetic analysis of the angiotensinogen gene in pre-eclampsia: study of German women and review of the literature","volume":"66","author":"Knyrim","year":"2008","journal-title":"Gynecol. Obstet. Invest."},{"key":"10.1016\/j.placenta.2022.01.004_bib42","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1469-1809.2012.00722.x","article-title":"Angiotensinogen gene M235T and T174M polymorphisms and susceptibility of pre-eclampsia: a meta-analysis","volume":"76","author":"Lin","year":"2012","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.placenta.2022.01.004_bib43","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.12659\/MSM.896552","article-title":"Association between gene polymorphisms on chromosome 1 and susceptibility to pre-eclampsia: an updated meta-analysis","volume":"22","author":"Zhang","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.placenta.2022.01.004_bib44","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1177\/1470320312440903","article-title":"AGT M235T polymorphism contributes to risk of preeclampsia: evidence from a meta-analysis","volume":"13","author":"Ni","year":"2012","journal-title":"J. Renin-Angiotensin-Aldosterone Syst. JRAAS"},{"key":"10.1016\/j.placenta.2022.01.004_bib45","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1093\/ije\/dys162","article-title":"Genetic association studies in pre-eclampsia: systematic meta-analyses and field synopsis","volume":"41","author":"Staines-Urias","year":"2012","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.placenta.2022.01.004_bib46","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4808046","article-title":"Combination of genetic markers and age effectively facilitates the identification of people with high risk of preeclampsia in the han Chinese population","volume":"2018","author":"Zhou","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.placenta.2022.01.004_bib47","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s10815-014-0408-8","article-title":"Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for preeclampsia: a meta-analysis","volume":"32","author":"Wu","year":"2015","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.placenta.2022.01.004_bib48","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.clinbiochem.2012.12.016","article-title":"Analysis of polymorphisms and haplotypes in genes associated with vascular tone, hypertension and oxidative stress in Mexican-Mestizo women with severe preeclampsia","volume":"46","author":"Coral-Vazquez","year":"2013","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.placenta.2022.01.004_bib49","first-page":"1085","article-title":"The methylenetetrahydrofolate reductase 677 C-->T polymorphism and preeclampsia in two populations,","volume":"99","author":"Prasmusinto","year":"2002","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2022.01.004_bib50","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s00011-016-0953-y","article-title":"Association of gene polymorphisms of FV, FII, MTHFR, SERPINE1, CTLA4, IL10, and TNFalpha with pre-eclampsia in Chinese women","volume":"65","author":"Zhou","year":"2016","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.placenta.2022.01.004_bib51","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1111\/j.1447-0756.2012.01846.x","article-title":"Candidate gene study of genetic thrombophilic polymorphisms in pre-eclampsia and recurrent pregnancy loss in Sinhalese women","volume":"38","author":"Dissanayake","year":"2012","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.placenta.2022.01.004_bib52","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.tjog.2015.08.005","article-title":"Methylenetetrahydrofolate reductase gene polymorphism in endometrial cancer: a systematic review and meta-analysis,","volume":"54","author":"Wang","year":"2015","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2022.01.004_bib53","doi-asserted-by":"crossref","first-page":"8931","DOI":"10.3390\/ijms15058931","article-title":"Tagging SNPs in the MTHFR gene and risk of ischemic stroke in a Chinese population","volume":"15","author":"Zhou","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2022.01.004_bib54","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/bdra.23199","article-title":"MTHFR rs2274976 polymorphism is a risk marker for nonsyndromic cleft lip with or without cleft palate in the Brazilian population","volume":"100","author":"de Aquino","year":"2014","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.placenta.2022.01.004_bib55","article-title":"Association study between genetic polymorphisms in folate metabolism and gastric cancer susceptibility in Chinese Han population: a case-control study,","volume":"7","author":"Wei","year":"2019","journal-title":"Mol. Genet. Genom. Med."},{"key":"10.1016\/j.placenta.2022.01.004_bib56","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.8627","article-title":"Single nucleotide polymorphism of MTHFR rs1801133 associated with elevated Hcy levels affects susceptibility to cerebral small vessel disease","volume":"8","author":"Yuan","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.placenta.2022.01.004_bib57","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1186\/s12872-020-01618-7","article-title":"Association of ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with Coronary Artery Disease (CAD)","volume":"20","author":"Raina","year":"2020","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.placenta.2022.01.004_bib58","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3345\/kjp.2011.54.8.335","article-title":"Polymorphisms of methylenetetrahydrofolate reductase are not a risk factor for Kawasaki disease in the Korean population","volume":"54","author":"Yoon","year":"2011","journal-title":"Kor. J. Pediatr."},{"issue":"11","key":"10.1016\/j.placenta.2022.01.004_bib59","article-title":"No association between polymorphisms\/haplotypes of the vascular endothelial growth factor gene and preeclampsia","volume":"35","author":"Garza-Veloz","year":"2011","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.placenta.2022.01.004_bib60","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/molehr\/gah048","article-title":"Vascular endothelial growth factor gene polymorphisms and pre-eclampsia","volume":"10","author":"Papazoglou","year":"2004","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.placenta.2022.01.004_bib61","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00404-014-3503-2","article-title":"Investigation of polymorphisms in pre-eclampsia related genes VEGF and IL1A","volume":"291","author":"Silva","year":"2015","journal-title":"Arch. Gynecol. Obstet."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014340042200011X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014340042200011X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T18:05:47Z","timestamp":1758909947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014340042200011X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":62,"alternative-id":["S014340042200011X"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2022.01.004","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations between AGT, MTHFR, and VEGF gene polymorphisms and preeclampsia in the Chinese population","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2022.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}