{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:00:05Z","timestamp":1787580005225,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571465"],"award-info":[{"award-number":["81571465"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871175"],"award-info":[{"award-number":["81871175"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2021YFS0208"],"award-info":[{"award-number":["2021YFS0208"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.placenta.2022.01.014","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T11:45:27Z","timestamp":1643024727000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["SIRT3 deficiency affects the migration, invasion, tube formation and necroptosis of trophoblast and is implicated in the pathogenesis of preeclampsia"],"prefix":"10.1016","volume":"120","author":[{"given":"Hongbiao","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4540-7336","authenticated-orcid":false,"given":"Rong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2022.01.014_bib1","first-page":"2048","article-title":"Evaluation of coagulation factors and serum ferritin in preeclamptic Pakistani women","volume":"70","author":"Shaheen","year":"2020","journal-title":"J. Pakistan Med. Assoc."},{"key":"10.1016\/j.placenta.2022.01.014_bib2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/ajh\/hpab003","article-title":"The role of mitochondrial dysfunction in preeclampsia: causative factor or collateral damage?","volume":"34","author":"Smith","year":"2021","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.placenta.2022.01.014_bib3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.placenta.2020.10.004","article-title":"Macrophage-stimulating protein is decreased in severe preeclampsia and regulates the biological behavior of HTR-8\/SVneo trophoblast cells","volume":"103","author":"Chen","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2022.01.014_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101402","article-title":"miR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia","volume":"29","author":"Zhang","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.placenta.2022.01.014_bib5","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1164\/rccm.201510-2106CI","article-title":"Necroptosis: a novel cell death modality and its potential relevance for critical care medicine","volume":"194","author":"Moreno-Gonzalez","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.placenta.2022.01.014_bib6","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2021.4922","article-title":"The potential role of necroptosis in clinical diseases (Review)","volume":"47","author":"Dai","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.placenta.2022.01.014_bib7","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.placenta.2022.01.014_bib8","first-page":"624","article-title":"Necroptosis: a novel manner of cell death, associated with stroke (Review)","volume":"41","author":"Liu","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.placenta.2022.01.014_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2017.01.002","article-title":"Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction","volume":"51","author":"Hannan","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2022.01.014_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.483","article-title":"Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis","volume":"8","author":"Bailey","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.placenta.2022.01.014_bib11","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/s41419-019-2162-4","article-title":"Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors","volume":"10","author":"Cheng","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.placenta.2022.01.014_bib12","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1038\/cdd.2012.62","article-title":"SIRT3 protects from hypoxia and staurosporine-mediated cell death by maintaining mitochondrial membrane potential and intracellular pH","volume":"19","author":"Pellegrini","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.placenta.2022.01.014_bib13","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.1111\/jcmm.15100","article-title":"SIRT3 deficiency delays diabetic skin wound healing via oxidative stress and necroptosis enhancement","volume":"24","author":"Yang","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.placenta.2022.01.014_bib14","first-page":"591","article-title":"Sirtuin 3 induces apoptosis and necroptosis by regulating mutant p53 expression in small-cell lung cancer","volume":"43","author":"Tang","year":"2020","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.placenta.2022.01.014_bib15","doi-asserted-by":"crossref","first-page":"8820355","DOI":"10.1155\/2020\/8820355","article-title":"The SIRT3 and SIRT6 promote prostate cancer progression by inhibiting necroptosis-mediated innate immune response","volume":"2020","author":"Fu","year":"2020","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.placenta.2022.01.014_bib16","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.placenta.2016.12.018","article-title":"Protective proteins and telomere length in placentas from patients with pre-eclampsia in the last trimester of gestation","volume":"50","author":"Broady","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2022.01.014_bib17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5830\/CVJA-2016-009","article-title":"Pre-eclampsia: its pathogenesis and pathophysiolgy","volume":"27","author":"Gathiram","year":"2016","journal-title":"Cardiovasc. J. Afr."},{"key":"10.1016\/j.placenta.2022.01.014_bib18","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.2215\/CJN.12081115","article-title":"Preeclampsia: updates in pathogenesis, definitions, and guidelines","volume":"11","author":"Phipps","year":"2016","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"Suppl A","key":"10.1016\/j.placenta.2022.01.014_bib19","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.placenta.2008.11.009","article-title":"The two stage model of preeclampsia: variations on the theme","volume":"30","author":"Roberts","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2022.01.014_bib20","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41401-020-0490-7","article-title":"Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation","volume":"42","author":"Song","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.placenta.2022.01.014_bib21","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.mam.2012.12.008","article-title":"Placental trophoblast cell differentiation: physiological regulation and pathological relevance to preeclampsia","volume":"34","author":"Ji","year":"2013","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.placenta.2022.01.014_bib22","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S1995-7645(13)60112-1","article-title":"SIRT3 expression in hepatocellular carcinoma and its impact on proliferation and invasion of hepatoma cells","volume":"6","author":"Zhang","year":"2013","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.placenta.2022.01.014_bib23","first-page":"978","article-title":"The expression of SIRT3 in primary hepatocellular carcinoma and the mechanism of its tumor suppressing effects","volume":"21","author":"Liu","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.placenta.2022.01.014_bib24","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317691178","article-title":"SIRT3 functions as a tumor suppressor in hepatocellular carcinoma","volume":"39","author":"Zeng","year":"2017","journal-title":"Tumour Biol"},{"key":"10.1016\/j.placenta.2022.01.014_bib25","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbrc.2016.05.098","article-title":"Down-regulation of SIRT3 promotes ovarian carcinoma metastasis","volume":"475","author":"Dong","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.placenta.2022.01.014_bib26","doi-asserted-by":"crossref","first-page":"10151","DOI":"10.7314\/APJCP.2014.15.23.10151","article-title":"4-Hydroxynonenal promotes growth and angiogenesis of breast cancer cells through HIF-1\u03b1 stabilization","volume":"15","author":"Li","year":"2014","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.placenta.2022.01.014_bib27","article-title":"Myocardial injection of apelin-overexpressing bone marrow cells improves cardiac repair via upregulation of Sirt3 after myocardial infarction","volume":"8","author":"Li","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.placenta.2022.01.014_bib28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/micc.12093","article-title":"Regulation of placental angiogenesis","volume":"21","author":"Chen","year":"2014","journal-title":"Microcirculation"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400422000248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400422000248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T18:04:47Z","timestamp":1758909887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400422000248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":28,"alternative-id":["S0143400422000248"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2022.01.014","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SIRT3 deficiency affects the migration, invasion, tube formation and necroptosis of trophoblast and is implicated in the pathogenesis of preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2022.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}