{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:24:24Z","timestamp":1792211064013,"version":"4.4.0"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2701503"],"award-info":[{"award-number":["2021YFC2701503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.placenta.2023.09.005","type":"journal-article","created":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T09:32:17Z","timestamp":1694338337000},"page":"128-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Role of leptin in the pathophysiology of preeclampsia"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1242-4938","authenticated-orcid":false,"given":"Shuai","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3417-5047","authenticated-orcid":false,"given":"Yijun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-5858","authenticated-orcid":false,"given":"Ping","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7366-0825","authenticated-orcid":false,"given":"Xinghui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10297","key":"10.1016\/j.placenta.2023.09.005_bib1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0140-6736(20)32335-7","article-title":"Pre-eclampsia","volume":"398","author":"Chappell","year":"2021","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.placenta.2023.09.005_bib2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s11906-019-0999-7","article-title":"Hypertensive disorders of pregnancy and future maternal health: how can the evidence guide postpartum management?","volume":"21","author":"Hauspurg","year":"2019","journal-title":"Curr. Hypertens. Rep."},{"issue":"3","key":"10.1016\/j.placenta.2023.09.005_bib3","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.preghy.2014.04.020","article-title":"The six stages of pre-eclampsia","volume":"4","author":"Redman","year":"2014","journal-title":"Pregnancy Hypertens"},{"issue":"2s","key":"10.1016\/j.placenta.2023.09.005_bib4","doi-asserted-by":"crossref","first-page":"S844","DOI":"10.1016\/j.ajog.2021.11.1356","article-title":"The etiology of preeclampsia","volume":"226","author":"Jung","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"12","key":"10.1016\/j.placenta.2023.09.005_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107784","article-title":"CD8(+) T cell functional exhaustion overrides pregnancy-induced fetal antigen alloimmunization","volume":"31","author":"Kinder","year":"2020","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.placenta.2023.09.005_bib6","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1600-0897.2010.00852.x","article-title":"Th1\/Th2\/Th17 and regulatory T-cell paradigm in pregnancy","volume":"63","author":"Saito","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"issue":"8","key":"10.1016\/j.placenta.2023.09.005_bib7","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1210\/en.2005-0406","volume":"146","author":"Lappas","year":"2005","journal-title":"Endocrinology"},{"issue":"2 Pt 1","key":"10.1016\/j.placenta.2023.09.005_bib8","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0002-9378(99)70239-5","article-title":"Preeclampsia: an excessive maternal inflammatory response to pregnancy","volume":"180","author":"Redman","year":"1999","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.placenta.2023.09.005_bib9","doi-asserted-by":"crossref","first-page":"287.e1","DOI":"10.1016\/j.ajog.2016.12.029","article-title":"Failure of physiologic transformation of spiral arteries, endothelial and trophoblast cell activation, and acute atherosis in the basal plate of the placenta","volume":"216","author":"Labarrere","year":"2017","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"10","key":"10.1016\/j.placenta.2023.09.005_bib10","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/sj.ki.5002175","article-title":"Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1","volume":"71","author":"Makris","year":"2007","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.placenta.2023.09.005_bib11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/uog.17494","article-title":"Placental histopathology associated with pre-eclampsia: systematic review and meta-analysis","volume":"50","author":"Falco","year":"2017","journal-title":"Ultrasound Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ajog.2007.07.040","article-title":"Maternal infection and risk of preeclampsia: systematic review and metaanalysis","volume":"198","author":"Conde-Agudelo","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00441-008-0685-6","article-title":"Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity","volume":"335","author":"Bakker","year":"2009","journal-title":"Cell Tissue Res."},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib14","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1152\/ajpregu.00440.2016","article-title":"Metabolic abnormalities and obesity's impact on the risk for developing preeclampsia","volume":"312","author":"Spradley","year":"2017","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"6505","key":"10.1016\/j.placenta.2023.09.005_bib15","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.metabol.2014.09.010","article-title":"Structure, production and signaling of leptin","volume":"64","author":"M\u00fcnzberg","year":"2015","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11154-021-09687-5","article-title":"Leptin as a key regulator of the adipose organ","volume":"23","author":"Pic\u00f3","year":"2022","journal-title":"Rev. Endocr. Metab. Disord."},{"issue":"1 Pt 2","key":"10.1016\/j.placenta.2023.09.005_bib18","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1161\/01.HYP.31.1.409","article-title":"Chronic leptin infusion increases arterial pressure","volume":"31","author":"Shek","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.placenta.2023.09.005_bib19","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3389\/fphys.2018.00640","article-title":"Obesity, fat mass and immune system: role for leptin","volume":"9","author":"Francisco","year":"2018","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.placenta.2023.09.005_bib20","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaa204","article-title":"The importance of leptin to reproduction","volume":"162","author":"Childs","year":"2021","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1515\/cclm-2014-0387","article-title":"Role of leptin in female reproduction","volume":"53","author":"P\u00e9rez-P\u00e9rez","year":"2015","journal-title":"Clin. Chem. Lab. Med."},{"issue":"7","key":"10.1016\/j.placenta.2023.09.005_bib22","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.tips.2015.04.014","article-title":"Adipokines in health and disease","volume":"36","author":"Fasshauer","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib23","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1530\/ror.0.0050018","article-title":"Placental leptin","volume":"5","author":"Ashworth","year":"2000","journal-title":"Rev. Reprod."},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib24","doi-asserted-by":"crossref","first-page":"T83","DOI":"10.1530\/JOE-14-0358","article-title":"20 years of leptin: role of leptin in energy homeostasis in humans","volume":"223","author":"Rosenbaum","year":"2014","journal-title":"J. Endocrinol."},{"issue":"5","key":"10.1016\/j.placenta.2023.09.005_bib25","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2174\/1566524020666201015144702","article-title":"JAK2-mediated intracellular signaling","volume":"21","author":"Sopjani","year":"2021","journal-title":"Curr. Mol. Med."},{"issue":"3","key":"10.1016\/j.placenta.2023.09.005_bib26","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cellbi.2003.12.003","article-title":"Leptin-induced signal transduction pathways","volume":"28","author":"Hegyi","year":"2004","journal-title":"Cell Biol. Int."},{"issue":"2","key":"10.1016\/j.placenta.2023.09.005_bib27","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/jcmm.13369","article-title":"Leptin action in normal and pathological pregnancies","volume":"22","author":"P\u00e9rez-P\u00e9rez","year":"2018","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/biof.201","article-title":"Adipokines, an adipose tissue and placental product with biological functions during pregnancy","volume":"38","author":"D'Ippolito","year":"2012","journal-title":"Biofactors"},{"key":"10.1016\/j.placenta.2023.09.005_bib29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cca.2016.04.036","article-title":"Serum levels of leptin, adiponectin and resistin in relation to clinical characteristics in normal pregnancy and preeclampsia","volume":"458","author":"Song","year":"2016","journal-title":"Clin. Chim. Acta"},{"issue":"3","key":"10.1016\/j.placenta.2023.09.005_bib30","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s10875-010-9507-1","article-title":"Leptin activates human B cells to secrete TNF-\u03b1, IL-6, and IL-10 via JAK2\/STAT3 and p38MAPK\/ERK1\/2 signaling pathway","volume":"31","author":"Agrawal","year":"2011","journal-title":"J. Clin. Immunol."},{"issue":"5","key":"10.1016\/j.placenta.2023.09.005_bib31","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1161\/HYPERTENSIONAHA.120.16425","article-title":"Maternal angiotensin increases placental leptin in early gestation via an alternative renin-angiotensin system pathway: suggesting a link to preeclampsia","volume":"77","author":"Nonn","year":"2021","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.placenta.2023.09.005_bib32","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1161\/01.HYP.0000198555.51645.f1","article-title":"Leptin regulates cardiomyocyte contractile function through endothelin-1 receptor-NADPH oxidase pathway","volume":"47","author":"Dong","year":"2006","journal-title":"Hypertension"},{"issue":"37","key":"10.1016\/j.placenta.2023.09.005_bib33","doi-asserted-by":"crossref","first-page":"15512","DOI":"10.1074\/jbc.M117.802249","article-title":"NMDA receptors mediate leptin signaling and regulate potassium channel trafficking in pancreatic \u03b2-cells","volume":"292","author":"Wu","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.placenta.2023.09.005_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2020.110933","article-title":"Pregnancy-induced adaptation of central sensitivity to leptin and insulin","volume":"516","author":"Khant Aung","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"issue":"9","key":"10.1016\/j.placenta.2023.09.005_bib35","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1093\/humrep\/15.9.2033","article-title":"Longitudinal analysis of maternal plasma leptin concentrations during normal pregnancy and pre-eclampsia","volume":"15","author":"Anim-Nyame","year":"2000","journal-title":"Hum. Reprod."},{"issue":"6","key":"10.1016\/j.placenta.2023.09.005_bib36","doi-asserted-by":"crossref","first-page":"E1051","DOI":"10.1152\/ajpendo.00094.2005","article-title":"Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling","volume":"289","author":"Morrison","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"6836","key":"10.1016\/j.placenta.2023.09.005_bib37","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/35078085","article-title":"Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus","volume":"411","author":"Cowley","year":"2001","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib38","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1210\/jc.2012-2309","article-title":"Cerebrospinal fluid levels of leptin, proopiomelanocortin, and agouti-related protein in human pregnancy: evidence for leptin resistance","volume":"98","author":"Page-Wilson","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.placenta.2023.09.005_bib39","first-page":"4298","article-title":"Leptin production and release in the dually in vitro perfused human placenta","volume":"85","author":"Linnemann","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib40","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1053\/plac.2002.0805","article-title":"Placental leptin receptor isoforms in normal and pathological pregnancies","volume":"24","author":"Challier","year":"2003","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib41","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/REP-17-0512","article-title":"Involvement of leptin in the molecular physiology of the placenta","volume":"155","author":"Schanton","year":"2018","journal-title":"Reproduction"},{"issue":"9","key":"10.1016\/j.placenta.2023.09.005_bib42","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/molehr\/gal064","article-title":"Relationships between maternal plasma leptin, placental leptin mRNA and protein in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsia","volume":"12","author":"Laivuori","year":"2006","journal-title":"Mol. Hum. Reprod."},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib43","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1080\/10641955.2022.2033763","article-title":"Preconceptual leptin levels in gestational diabetes and hypertensive pregnancy","volume":"41","author":"Peltokorpi","year":"2022","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.placenta.2023.09.005_bib44","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cca.2016.10.013","article-title":"Serum inhibin and leptin: risk factors for pre-eclampsia?","volume":"463","author":"Chrelias","year":"2016","journal-title":"Clin. Chim. Acta"},{"issue":"1\u20132","key":"10.1016\/j.placenta.2023.09.005_bib45","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.mce.2012.12.018","article-title":"Hypomethylation of the LEP gene in placenta and elevated maternal leptin concentration in early onset pre-eclampsia","volume":"367","author":"Hogg","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"issue":"7","key":"10.1016\/j.placenta.2023.09.005_bib46","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1055\/s-2002-33466","article-title":"A polymorphism in the leptin promoter region (-2548 G\/A) influences gene expression and adipose tissue secretion of leptin","volume":"34","author":"Hoffstedt","year":"2002","journal-title":"Horm. Metab. Res."},{"issue":"5","key":"10.1016\/j.placenta.2023.09.005_bib47","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1002\/ijc.24372","article-title":"Functional analysis of the -2548G\/A leptin gene polymorphism in breast cancer cells","volume":"125","author":"Terrasi","year":"2009","journal-title":"Int. J. Cancer"},{"issue":"Web Server issue","key":"10.1016\/j.placenta.2023.09.005_bib48","doi-asserted-by":"crossref","first-page":"W306","DOI":"10.1093\/nar\/gki375","article-title":"I-Mutant2.0: predicting stability changes upon mutation from the protein sequence or structure","volume":"33","author":"Capriotti","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.placenta.2023.09.005_bib49","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5412084","article-title":"Variations in the obesity gene \"LEPR\" contribute to risk of type 2 diabetes mellitus: evidence from a meta-analysis","volume":"2016","author":"Yang","year":"2016","journal-title":"J. Diabetes Res."},{"issue":"3","key":"10.1016\/j.placenta.2023.09.005_bib50","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s004390100468","article-title":"A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women","volume":"108","author":"Quinton","year":"2001","journal-title":"Hum. Genet."},{"issue":"3","key":"10.1016\/j.placenta.2023.09.005_bib51","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.4238\/2013.January.4.14","article-title":"High leptin level and leptin receptor Lys656Asn variant are risk factors for preeclampsia","volume":"12","author":"Wang","year":"2013","journal-title":"Genet. Mol. Res."},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib52","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12881-020-01104-z","article-title":"Leptin receptor gene polymorphisms c.668A>G and c.1968G>C in Sudanese women with preeclampsia: a case-control study","volume":"21","author":"Saad","year":"2020","journal-title":"BMC Med. Genet."},{"issue":"5","key":"10.1016\/j.placenta.2023.09.005_bib53","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/0951359042000196277","article-title":"Augmentation of leptin and hypoxia-inducible factor 1alpha mRNAs in the pre-eclamptic placenta","volume":"18","author":"Iwagaki","year":"2004","journal-title":"Gynecol. Endocrinol."},{"issue":"8\u20139","key":"10.1016\/j.placenta.2023.09.005_bib54","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0143-4004(03)00139-5","article-title":"Reduced placental perfusion causes an increase in maternal serum leptin","volume":"24","author":"Moore","year":"2003","journal-title":"Placenta"},{"issue":"9","key":"10.1016\/j.placenta.2023.09.005_bib55","first-page":"3225","article-title":"Augmented placental production of leptin in preeclampsia: possible involvement of placental hypoxia","volume":"83","author":"Mise","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.placenta.2023.09.005_bib56","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.preghy.2013.04.064","article-title":"PP037. Relationship of serum leptin levels to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in women with preeclampsia","volume":"3","author":"Rig\u00f3","year":"2013","journal-title":"Pregnancy Hypertens"},{"key":"10.1016\/j.placenta.2023.09.005_bib57","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/298401","article-title":"Leptin increases blood pressure and markers of endothelial activation during pregnancy in rats","volume":"2013","author":"Ibrahim","year":"2013","journal-title":"BioMed Res. Int."},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib58","doi-asserted-by":"crossref","DOI":"10.1080\/14767058.2023.2183472","article-title":"Evaluation of maternal serum SERPINC1, E-selectin, P-selectin, RBP4 and PP13 levels in pregnancies complicated with preeclampsia","volume":"36","author":"Palalioglu","year":"2023","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"10","key":"10.1016\/j.placenta.2023.09.005_bib59","doi-asserted-by":"crossref","first-page":"R855","DOI":"10.1152\/ajpregu.00286.2014","article-title":"Chronic hyperleptinemia results in the development of hypertension in pregnant rats","volume":"308","author":"Palei","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"48","key":"10.1016\/j.placenta.2023.09.005_bib60","doi-asserted-by":"crossref","first-page":"19006","DOI":"10.1073\/pnas.0809743105","article-title":"Leptin-enhanced neointimal hyperplasia is reduced by mTOR and PI3K inhibitors","volume":"105","author":"Shan","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.placenta.2023.09.005_bib61","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1080\/14767058.2018.1514597","article-title":"LAMA5 promotes human umbilical vein endothelial cells migration, proliferation, and angiogenesis and is decreased in preeclampsia","volume":"33","author":"Zhang","year":"2020","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"4","key":"10.1016\/j.placenta.2023.09.005_bib62","doi-asserted-by":"crossref","first-page":"C481","DOI":"10.1152\/ajpcell.00404.2018","article-title":"ANXA4 promotes trophoblast invasion via the PI3K\/Akt\/eNOS pathway in preeclampsia","volume":"316","author":"Xu","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib63","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/cvr\/cvr275","article-title":"Leptin promotes the mobilization of vascular progenitor cells and neovascularization by NOX2-mediated activation of MMP9","volume":"93","author":"Schroeter","year":"2012","journal-title":"Cardiovasc. Res."},{"issue":"7","key":"10.1016\/j.placenta.2023.09.005_bib64","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.2337\/diabetes.54.7.2227","article-title":"Signaling pathways involved in human vascular smooth muscle cell proliferation and matrix metalloproteinase-2 expression induced by leptin: inhibitory effect of metformin","volume":"54","author":"Li","year":"2005","journal-title":"Diabetes"},{"issue":"8","key":"10.1016\/j.placenta.2023.09.005_bib65","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/gaab045","article-title":"Acetylcholine ameliorated hypoxia-induced oxidative stress and apoptosis in trophoblast cells via p38 MAPK\/NF-\u03baB pathway","volume":"27","author":"Wang","year":"2021","journal-title":"Mol. Hum. Reprod."},{"issue":"9","key":"10.1016\/j.placenta.2023.09.005_bib66","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.cellsig.2010.05.003","article-title":"Leptin upregulates VEGF in breast cancer via canonic and non-canonical signalling pathways and NFkappaB\/HIF-1alpha activation","volume":"22","author":"Gonzalez-Perez","year":"2010","journal-title":"Cell. Signal."},{"issue":"6","key":"10.1016\/j.placenta.2023.09.005_bib67","first-page":"2484","article-title":"HIF-1\u03b1 affects trophoblastic apoptosis involved in the onset of preeclampsia by regulating FOXO3a under hypoxic conditions","volume":"21","author":"Zhang","year":"2020","journal-title":"Mol. Med. Rep."},{"issue":"7","key":"10.1016\/j.placenta.2023.09.005_bib68","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/molehr\/gag053","article-title":"Modulation of placental vascular endothelial growth factor by leptin and hCG","volume":"9","author":"Islami","year":"2003","journal-title":"Mol. Hum. Reprod."},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib69","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.vph.2006.06.014","article-title":"Leptin inhibits cell growth of human vascular smooth muscle cells","volume":"46","author":"Bohlen","year":"2007","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.placenta.2023.09.005_bib70","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/105489","article-title":"Leptin inhibits the proliferation of vascular smooth muscle cells induced by angiotensin II through nitric oxide-dependent mechanisms","volume":"2010","author":"Rodr\u00edguez","year":"2010","journal-title":"Mediat. Inflamm."},{"issue":"3","key":"10.1016\/j.placenta.2023.09.005_bib71","doi-asserted-by":"crossref","first-page":"H661","DOI":"10.1152\/ajpheart.00202.2020","article-title":"Vascular mechanisms and molecular targets in hypertensive pregnancy and preeclampsia","volume":"319","author":"Qu","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"7","key":"10.1016\/j.placenta.2023.09.005_bib72","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1161\/HYPERTENSIONAHA.121.18832","article-title":"Midgestation leptin infusion induces characteristics of clinical preeclampsia in mice, which is ablated by endothelial mineralocorticoid receptor deletion","volume":"79","author":"Faulkner","year":"2022","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.placenta.2023.09.005_bib73","doi-asserted-by":"crossref","first-page":"E481","DOI":"10.1152\/ajpendo.00103.2007","article-title":"Leptin increases endothelin type A receptor levels in vascular smooth muscle cells","volume":"294","author":"Juan","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"1\u20133","key":"10.1016\/j.placenta.2023.09.005_bib74","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejphar.2007.06.051","article-title":"Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells","volume":"573","author":"Chao","year":"2007","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.placenta.2023.09.005_bib75","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/jhh.2011.29","article-title":"The relationship between circulating endothelin-1, soluble fms-like tyrosine kinase-1 and soluble endoglin in preeclampsia","volume":"26","author":"Aggarwal","year":"2012","journal-title":"J. Hum. Hypertens."},{"issue":"4","key":"10.1016\/j.placenta.2023.09.005_bib76","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s11906-018-0828-4","article-title":"The endothelin system: a critical player in the pathophysiology of preeclampsia","volume":"20","author":"Granger","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"issue":"5","key":"10.1016\/j.placenta.2023.09.005_bib77","doi-asserted-by":"crossref","first-page":"H1949","DOI":"10.1152\/ajpheart.00724.2019","article-title":"Impact of hyperleptinemia during placental ischemia-induced hypertension in pregnant rats","volume":"320","author":"Palei","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"10","key":"10.1016\/j.placenta.2023.09.005_bib78","doi-asserted-by":"crossref","first-page":"R855","DOI":"10.1152\/ajpregu.00286.2014","article-title":"Chronic hyperleptinemia results in the development of hypertension in pregnant rats","volume":"308","author":"Palei","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib79","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/cimm.1999.1594","article-title":"Human leptin enhances activation and proliferation of human circulating T lymphocytes","volume":"199","author":"Mart\u00edn-Romero","year":"2000","journal-title":"Cell. Immunol."},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib80","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1600-0897.2007.00486.x","article-title":"IL-10 and inflammatory markers (TNF-alpha, IL-6 and IL-8) in pre-eclamptic, normotensive pregnant and healthy non-pregnant women","volume":"58","author":"Sharma","year":"2007","journal-title":"Am. J. Reprod. Immunol."},{"issue":"8","key":"10.1016\/j.placenta.2023.09.005_bib81","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/molehr\/6.8.763","article-title":"Placental leptin in normal, diabetic and fetal growth-retarded pregnancies","volume":"6","author":"Lea","year":"2000","journal-title":"Mol. Hum. Reprod."},{"issue":"5","key":"10.1016\/j.placenta.2023.09.005_bib82","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s11596-009-0519-0","article-title":"Effect of leptin on cytotrophoblast proliferation and invasion","volume":"29","author":"Liu","year":"2009","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."},{"issue":"4","key":"10.1016\/j.placenta.2023.09.005_bib83","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1203\/01.pdr.0000304935.19183.07","article-title":"Regulation of placental growth hormone secretion in a human trophoblast model--the effects of hormones and adipokines","volume":"63","author":"Zeck","year":"2008","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.placenta.2023.09.005_bib84","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7052176","article-title":"Leptin promotes HTR-8\/SVneo cell invasion via the crosstalk between MTA1\/WNT and PI3K\/AKT pathways","volume":"2022","author":"Fan","year":"2022","journal-title":"Dis. Markers"},{"issue":"4","key":"10.1016\/j.placenta.2023.09.005_bib85","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1095\/biolreprod.113.114876","article-title":"Leptin-promoted human extravillous trophoblast invasion is MMP14 dependent and requires the cross talk between Notch1 and PI3K\/Akt signaling","volume":"90","author":"Wang","year":"2014","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.placenta.2023.09.005_bib86","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ajpath.2018.10.015","article-title":"Role of endoplasmic reticulum stress in proinflammatory cytokine-mediated inhibition of trophoblast invasion in placenta-related complications of pregnancy","volume":"189","author":"Lee","year":"2019","journal-title":"Am. J. Pathol."},{"issue":"4","key":"10.1016\/j.placenta.2023.09.005_bib87","doi-asserted-by":"crossref","first-page":"E404","DOI":"10.1152\/ajpendo.00426.2013","article-title":"Placental mitochondrial content and function in intrauterine growth restriction and preeclampsia","volume":"306","author":"Mand\u00f2","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.placenta.2023.09.005_bib88","doi-asserted-by":"crossref","first-page":"884","DOI":"10.3109\/14767058.2011.601367","article-title":"Analysis of the original causes of placental oxidative stress in normal pregnancy and pre-eclampsia: a hypothesis","volume":"25","author":"Yang","year":"2012","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.placenta.2023.09.005_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108255","article-title":"Oxidative stress in pregnancy complicated by preeclampsia","volume":"681","author":"San Juan-Reyes","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.placenta.2023.09.005_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101861","article-title":"Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia","volume":"40","author":"Guerby","year":"2021","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.placenta.2023.09.005_bib91","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cardiores.2006.05.001","article-title":"Redox signaling in hypertension","volume":"71","author":"Paravicini","year":"2006","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.placenta.2023.09.005_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2018.12.005","article-title":"Oxidative stress: normal pregnancy versus preeclampsia","volume":"1866","author":"Chiarello","year":"2020","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.placenta.2023.09.005_bib93","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2265.2011.04234.x","article-title":"Leptin, adiponectin and other adipokines in gestational diabetes mellitus and pre-eclampsia","volume":"76","author":"Miehle","year":"2012","journal-title":"Clin. Endocrinol."},{"issue":"2","key":"10.1016\/j.placenta.2023.09.005_bib94","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ejogrb.2004.02.046","article-title":"Serum leptin levels in hypertensive disorder of pregnancy","volume":"120","author":"Ozkan","year":"2005","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"7","key":"10.1016\/j.placenta.2023.09.005_bib95","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s00109-021-02068-0","article-title":"Insulin-mediated immune dysfunction in the development of preeclampsia","volume":"99","author":"van Niekerk","year":"2021","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.placenta.2023.09.005_bib96","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.preghy.2020.09.005","article-title":"First trimester elevations of hematocrit, lipid peroxidation and nitrates in women with twin pregnancies who develop preeclampsia","volume":"22","author":"Ramiro-Cortijo","year":"2020","journal-title":"Pregnancy Hypertens"},{"issue":"3","key":"10.1016\/j.placenta.2023.09.005_bib97","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1620\/tjem.206.233","article-title":"Exogenous leptin increases lipid peroxidation in the mouse brain","volume":"206","author":"Kutlu","year":"2005","journal-title":"Tohoku J. Exp. Med."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014340042300557X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014340042300557X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T18:11:25Z","timestamp":1758910285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014340042300557X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":97,"alternative-id":["S014340042300557X"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2023.09.005","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of leptin in the pathophysiology of preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2023.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}