{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:07:24Z","timestamp":1789697244854,"version":"4.0.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Committee","doi-asserted-by":"publisher","award":["JCYJ20180228163459314"],"award-info":[{"award-number":["JCYJ20180228163459314"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Committee","doi-asserted-by":"publisher","award":["JCYJ20190809090803702"],"award-info":[{"award-number":["JCYJ20190809090803702"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2018A0303130277"],"award-info":[{"award-number":["2018A0303130277"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515010515"],"award-info":[{"award-number":["2021A1515010515"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["2021022"],"award-info":[{"award-number":["2021022"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.placenta.2023.10.004","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T11:28:12Z","timestamp":1697196492000},"page":"69-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["MiR-135b-5p targets ADAM12 to suppress invasion and accelerate trophoblast apoptosis in preeclampsia"],"prefix":"10.1016","volume":"143","author":[{"given":"Bo","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taotao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayao","family":"Yong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangkun","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5197-2307","authenticated-orcid":false,"given":"Wen-Lin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.placenta.2023.10.004_bib1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41572-023-00417-6","article-title":"Pre-eclampsia","volume":"9","author":"Dimitriadis","year":"2023","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"5","key":"10.1016\/j.placenta.2023.10.004_bib2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41581-019-0119-6","article-title":"Pre-eclampsia: pathogenesis, novel diagnostics and therapies","volume":"15","author":"Phipps","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"issue":"6","key":"10.1016\/j.placenta.2023.10.004_bib3","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1161\/HYPERTENSIONAHA.117.08821","article-title":"Maternal vascular physiology in preeclampsia","volume":"70","author":"Goulopoulou","year":"2017","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.placenta.2023.10.004_bib4","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cell.2009.01.035","article-title":"Origins and Mechanisms of miRNAs and siRNAs","volume":"136","author":"Carthew","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.placenta.2023.10.004_bib5","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O'Brien","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.placenta.2023.10.004_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.placenta.2020.07.001","article-title":"Placental miRNAs in feto-maternal communication mediated by extracellular vesicles","volume":"102","author":"Morales-Prieto","year":"2020","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2023.10.004_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.995462","article-title":"Role of microRNAs in trophoblast invasion and spiral artery remodeling: implications for preeclampsia","volume":"10","author":"Hayder","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"sup1","key":"10.1016\/j.placenta.2023.10.004_bib8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1080\/15476286.2021.1963105","article-title":"Large-scale transcriptome-wide profiling of microRNAs in human placenta and maternal plasma at early to mid gestation","volume":"18","author":"Smith","year":"2021","journal-title":"RNA Biol."},{"key":"10.1016\/j.placenta.2023.10.004_bib9","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/1471-2148-10-346","article-title":"Origin and evolution of a placental-specific microRNA family in the human genome","volume":"10","author":"Yuan","year":"2010","journal-title":"BMC Evol. Biol."},{"issue":"13","key":"10.1016\/j.placenta.2023.10.004_bib10","doi-asserted-by":"crossref","first-page":"995","DOI":"10.2217\/epi-2021-0055","article-title":"High-throughput miRNA sequencing of the human placenta: expression throughout gestation","volume":"13","author":"Gonzalez","year":"2021","journal-title":"Epigenomics"},{"issue":"9","key":"10.1016\/j.placenta.2023.10.004_bib11","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.placenta.2012.05.009","article-title":"MicroRNA expression profiles of trophoblastic cells","volume":"33","author":"Morales-Prieto","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2023.10.004_bib12","article-title":"Placenta-derived MicroRNAs in the pathophysiology of human pregnancy","volume":"9","author":"Xu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"4 Suppl","key":"10.1016\/j.placenta.2023.10.004_bib13","doi-asserted-by":"crossref","first-page":"S163","DOI":"10.1016\/j.ajog.2015.05.057","article-title":"MicroRNAs in placental health and disease","volume":"213","author":"Mouillet","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2023.10.004_bib14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.placenta.2017.11.005","article-title":"Dysregulated placental microRNAs in early and late onset preeclampsia","volume":"61","author":"Lykoudi","year":"2018","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2023.10.004_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.782845","article-title":"Preeclamptic women have disrupted placental microRNA expression at the time of preeclampsia diagnosis: meta-analysis","volume":"9","author":"Cirkovic","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"1","key":"10.1016\/j.placenta.2023.10.004_bib16","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12958-021-00783-4","article-title":"Roles of noncoding RNAs in preeclampsia","volume":"19","author":"Sun","year":"2021","journal-title":"Reprod. Biol. Endocrinol. : RB Elektron."},{"issue":"3","key":"10.1016\/j.placenta.2023.10.004_bib17","article-title":"Detection and characterization of placental microRNAs in maternal plasma","volume":"54","author":"C.S","year":"2008","journal-title":"Clin. Chem."},{"key":"10.1016\/j.placenta.2023.10.004_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.973585","article-title":"A review on the importance of miRNA-135 in human diseases","volume":"13","author":"Kadkhoda","year":"2022","journal-title":"Front. Genet."},{"issue":"5","key":"10.1016\/j.placenta.2023.10.004_bib19","first-page":"1122","article-title":"Hypertension in pregnancy. Report of the American College of Obstetricians and gynecologists' task force on hypertension in pregnancy","volume":"122","year":"2013","journal-title":"Obstet. Gynecol."},{"issue":"5","key":"10.1016\/j.placenta.2023.10.004_bib20","first-page":"1122","article-title":"Hypertension in pregnancy. Report of the American College of Obstetricians and gynecologists' task force on hypertension in pregnancy","volume":"122","year":"2013","journal-title":"Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.placenta.2023.10.004_bib21","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1530\/REP-14-0052","article-title":"Role of placenta-specific protein 1 in trophoblast invasion and migration","volume":"148","author":"Chang","year":"2014","journal-title":"Reproduction"},{"issue":"2","key":"10.1016\/j.placenta.2023.10.004_bib22","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1006\/excr.1993.1139","article-title":"Establishment and characterization of first trimester human trophoblast cells with extended lifespan","volume":"206","author":"Graham","year":"1993","journal-title":"Exp. Cell Res."},{"issue":"15","key":"10.1016\/j.placenta.2023.10.004_bib23","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1091\/mbc.E17-07-0471","article-title":"Knockdown of a disintegrin A metalloprotease 12 (ADAM12) during adipogenesis reduces cell numbers, delays differentiation, and increases lipid accumulation in 3T3-L1 cells","volume":"29","author":"C.C","year":"2018","journal-title":"Mol. Biol. Cell"},{"issue":"2","key":"10.1016\/j.placenta.2023.10.004_bib24","article-title":"The human protein atlas-Integrated omics for single cell mapping of the human proteome","volume":"32","author":"D.A.L","year":"2023","journal-title":"Protein Sci."},{"key":"10.1016\/j.placenta.2023.10.004_bib25","series-title":"Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids, Current Protocols in Cell Biology Chapter 3","author":"Thery","year":"2006"},{"issue":"6","key":"10.1016\/j.placenta.2023.10.004_bib26","first-page":"817","article-title":"miRNA expression for early diagnosis of preeclampsia onset: hope or hype?, the journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies","volume":"31","author":"Lagana","year":"2018","journal-title":"the International Society of Perinatal Obstet"},{"issue":"3","key":"10.1016\/j.placenta.2023.10.004_bib27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12291-019-00844-x","article-title":"MicroRNAs and diseases: promising biomarkers for diagnosis and therapeutics","volume":"34","author":"Dwivedi","year":"2019","journal-title":"Indian J. Clin. Biochem. : Indian J. Clin. Biochem."},{"issue":"13","key":"10.1016\/j.placenta.2023.10.004_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23137167","article-title":"MicroRNA-based diagnosis and therapy","volume":"23","author":"Ho","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"D1","key":"10.1016\/j.placenta.2023.10.004_bib29","doi-asserted-by":"crossref","first-page":"D211","DOI":"10.1093\/nar\/gkab808","article-title":"miRNATissueAtlas2: an update to the human miRNA tissue atlas","volume":"50","author":"Keller","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.placenta.2023.10.004_bib30","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.tjog.2014.03.001","article-title":"Potential role of circulating microRNAs as early markers of preeclampsia","volume":"53","author":"Ura","year":"2014","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2023.10.004_bib31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.placenta.2017.11.011","article-title":"Identification of potential early biomarkers of preeclampsia","volume":"61","author":"Timofeeva","year":"2018","journal-title":"Placenta"},{"issue":"9","key":"10.1016\/j.placenta.2023.10.004_bib32","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-011920","article-title":"Predictive value of miR-210 as a novel biomarker for pre-eclampsia: a systematic review protocol","volume":"6","author":"Nikuei","year":"2016","journal-title":"BMJ Open"},{"issue":"28","key":"10.1016\/j.placenta.2023.10.004_bib33","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000007515","article-title":"MiR-210 and miR-155 as potential diagnostic markers for pre-eclampsia pregnancies","volume":"96","author":"Gan","year":"2017","journal-title":"Medicine"},{"issue":"12","key":"10.1016\/j.placenta.2023.10.004_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21124264","article-title":"Exosomes as messengers between mother and fetus in pregnancy","volume":"21","author":"Czernek","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2023.10.004_bib35","article-title":"Downregulation of miR-135b-5p suppresses progression of esophageal cancer and contributes to the effect of cisplatin","volume":"11","author":"Di","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.placenta.2023.10.004_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.110029","article-title":"Cancer-associated fibroblasts-derived exosomes upregulate microRNA-135b-5p to promote colorectal cancer cell growth and angiogenesis by inhibiting thioredoxin-interacting protein","volume":"84","author":"Yin","year":"2021","journal-title":"Cell. Signal."},{"issue":"1","key":"10.1016\/j.placenta.2023.10.004_bib37","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41420-022-00814-y","article-title":"MiR-135b-5p is an oncogene in pancreatic cancer to regulate GPRC5A expression by targeting transcription factor KLF4","volume":"8","author":"Liu","year":"2022","journal-title":"Cell death discovery"},{"issue":"1","key":"10.1016\/j.placenta.2023.10.004_bib38","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1080\/15384047.2021.2017222","article-title":"Cancer-associated fibroblasts derived extracellular vesicles promote angiogenesis of colorectal adenocarcinoma cells through miR-135b-5p\/FOXO1 axis","volume":"23","author":"Dai","year":"2022","journal-title":"Cancer Biol. Ther."},{"issue":"9","key":"10.1016\/j.placenta.2023.10.004_bib39","first-page":"1296","article-title":"Repression of miR-135b-5p promotes metastasis of early-stage breast cancer by regulating downstream target SDCBP, Laboratory investigation","volume":"99","author":"Pu","year":"2019","journal-title":"a journal of technical methods and pathology"},{"issue":"5","key":"10.1016\/j.placenta.2023.10.004_bib40","doi-asserted-by":"crossref","first-page":"12338","DOI":"10.1080\/21655979.2022.2073655","article-title":"MicroRNA-135b-5p regulates trophoblast cell function by targeting phosphoinositide-3-kinase regulatory subunit 2 in preeclampsia","volume":"13","author":"Zhang","year":"2022","journal-title":"Bioengineered"},{"issue":"12","key":"10.1016\/j.placenta.2023.10.004_bib41","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/jhh.2017.65","article-title":"Elevated microRNA-34a contributes to trophoblast cell apoptosis in preeclampsia by targeting BCL-2","volume":"31","author":"Guo","year":"2017","journal-title":"J. Hum. Hypertens."},{"issue":"2","key":"10.1016\/j.placenta.2023.10.004_bib42","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.bbrc.2015.04.055","article-title":"MicroRNA-135b suppresses extravillous trophoblast-derived HTR-8\/SVneo cell invasion by directly down regulating CXCL12 under low oxygen conditions","volume":"461","author":"Tamaru","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.placenta.2023.10.004_bib43","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.biopha.2017.11.074","article-title":"miR-135b-5p Promotes migration, invasion and EMT of pancreatic cancer cells by targeting NR3C2, Biomedicine & pharmacotherapy","volume":"96","author":"Zhang","year":"2017","journal-title":"Biomedecine & pharmacotherapie"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400423005775?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400423005775?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T19:50:14Z","timestamp":1758916214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400423005775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":43,"alternative-id":["S0143400423005775"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2023.10.004","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MiR-135b-5p targets ADAM12 to suppress invasion and accelerate trophoblast apoptosis in preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2023.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}