{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:58:51Z","timestamp":1772121531423,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.placenta.2023.11.009","type":"journal-article","created":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T01:31:00Z","timestamp":1700357460000},"page":"64-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Folate-depletion alters mouse trophoblast stem cell regulation in vitro"],"prefix":"10.1016","volume":"144","author":[{"given":"Joanna","family":"Rakoczy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4496-2271","authenticated-orcid":false,"given":"Erica D.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.placenta.2023.11.009_bib1","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/1471-0528.13202","article-title":"Effectiveness of folic acid supplementation in pregnancy on reducing the risk of small-for-gestational age neonates: a population study, systematic review and meta-analysis","volume":"122","author":"Hodgetts","year":"2015","journal-title":"BJOG"},{"issue":"1","key":"10.1016\/j.placenta.2023.11.009_bib2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41576-019-0169-4","article-title":"Mechanisms of early placental development in mouse and humans","volume":"21","author":"Hemberger","year":"2020","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.placenta.2023.11.009_bib3","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jnutbio.2018.06.003","article-title":"Down-regulation of placental folate transporters in intrauterine growth restriction","volume":"59","author":"Chen","year":"2018","journal-title":"J. Nutr. Biochem."},{"issue":"3","key":"10.1016\/j.placenta.2023.11.009_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2008.06.020","article-title":"One-carbon metabolism enzyme polymorphisms and uteroplacental insufficiency","volume":"199","author":"Furness","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"5","key":"10.1016\/j.placenta.2023.11.009_bib5","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s10815-014-0408-8","article-title":"Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for preeclampsia: a meta-analysis","volume":"32","author":"Wu","year":"2015","journal-title":"J. Assist. Reprod. Genet."},{"issue":"6","key":"10.1016\/j.placenta.2023.11.009_bib6","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1095\/biolreprod.110.088351","article-title":"Possible roles for folic acid in the regulation of trophoblast invasion and placental development in normal early human pregnancy","volume":"84","author":"Williams","year":"2011","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.placenta.2023.11.009_bib7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2016.08.009","article-title":"One-carbon metabolism in health and disease","volume":"25","author":"Ducker","year":"2017","journal-title":"Cell Metabol."},{"issue":"5396","key":"10.1016\/j.placenta.2023.11.009_bib8","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1126\/science.282.5396.2072","article-title":"Promotion of trophoblast stem cell proliferation by FGF4","volume":"282","author":"Tanaka","year":"1998","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.placenta.2023.11.009_bib9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/bdra.23092","article-title":"Moderately high intake of folic acid has a negative impact on mouse embryonic development","volume":"97","author":"Mikael","year":"2013","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"12","key":"10.1016\/j.placenta.2023.11.009_bib10","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1002\/stem.1249","article-title":"DNA methylation profiles define stem cell identity and reveal a tight embryonic-extraembryonic lineage boundary","volume":"30","author":"Senner","year":"2012","journal-title":"Stem Cell."},{"key":"10.1016\/j.placenta.2023.11.009_bib11","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1017\/jns.2016.8","article-title":"Folic acid induces cell type-specific changes in the transcriptome of breast cancer cell lines: a proof-of-concept study","volume":"5","author":"Price","year":"2016","journal-title":"J. Nutr. Sci."},{"issue":"1","key":"10.1016\/j.placenta.2023.11.009_bib12","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ydbio.2009.08.022","article-title":"Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate","volume":"335","author":"Natale","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.placenta.2023.11.009_bib13","series-title":"Cell Doubling Time Calculator","author":"Zulawinska","year":"2023"},{"issue":"4","key":"10.1016\/j.placenta.2023.11.009_bib14","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.placenta.2023.11.009_bib15","doi-asserted-by":"crossref","first-page":"5538","DOI":"10.1038\/ncomms6538","article-title":"Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast","volume":"5","author":"Cambuli","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.placenta.2023.11.009_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/srep25112","article-title":"Plet1 is an epigenetically regulated cell surface protein that provides essential cues to direct trophoblast stem cell differentiation","volume":"6","author":"Murray","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.placenta.2023.11.009_bib17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1530\/REP-19-0293","article-title":"Blastocyst transfer in mice alters the placental transcriptome and growth","volume":"159","author":"Menelaou","year":"2020","journal-title":"Reproduction"},{"issue":"11","key":"10.1016\/j.placenta.2023.11.009_bib18","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1002\/dvdy.22755","article-title":"Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental development","volume":"240","author":"Watson","year":"2011","journal-title":"Dev. Dynam."},{"issue":"9","key":"10.1016\/j.placenta.2023.11.009_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2021.e08071","article-title":"Low folate induces abnormal neuronal maturation and DNA hypomethylation of neuronal differentiation-related genes in cultured mouse neural stem and progenitor cells","volume":"7","author":"Araki","year":"2021","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.placenta.2023.11.009_bib20","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12915-022-01467-0","article-title":"Folate regulates RNA m(5)C modification and translation in neural stem cells","volume":"20","author":"Xu","year":"2022","journal-title":"BMC Biol."},{"issue":"3","key":"10.1016\/j.placenta.2023.11.009_sref21","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202100789","article-title":"Impact of in utero folate exposure on DNA methylation and its potential relevance for later-life health-evidence from mouse models translated to human cohorts","volume":"66","author":"Kok","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"issue":"6 Pt 2","key":"10.1016\/j.placenta.2023.11.009_bib22","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1111\/j.1753-4887.2004.tb00070.x","article-title":"Physiology of folate and vitamin B12 in health and disease","volume":"62","author":"Stover","year":"2004","journal-title":"Nutr. Rev."},{"issue":"2\u20133","key":"10.1016\/j.placenta.2023.11.009_bib23","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1387\/ijdb.082768dh","article-title":"Development and function of trophoblast giant cells in the rodent placenta","volume":"54","author":"Hu","year":"2010","journal-title":"Int. J. Dev. Biol."},{"issue":"2","key":"10.1016\/j.placenta.2023.11.009_bib24","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.cub.2015.11.060","article-title":"Selective amplification of the genome surrounding key placental genes in trophoblast giant cells","volume":"26","author":"Hannibal","year":"2016","journal-title":"Curr. Biol."},{"issue":"21","key":"10.1016\/j.placenta.2023.11.009_bib25","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1101\/gad.1718108","article-title":"Differentiation of trophoblast stem cells into giant cells is triggered by p57\/Kip2 inhibition of CDK1 activity","volume":"22","author":"Ullah","year":"2008","journal-title":"Genes Dev."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400423006057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400423006057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T19:50:15Z","timestamp":1758916215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400423006057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":25,"alternative-id":["S0143400423006057"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2023.11.009","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.09.29.558846","asserted-by":"object"}]},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Folate-depletion alters mouse trophoblast stem cell regulation in vitro","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2023.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}