{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:57:34Z","timestamp":1787684254192,"version":"build-2784847793"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.placenta.2023.11.015","type":"journal-article","created":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T17:46:52Z","timestamp":1701539212000},"page":"51-59","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Vascular reactivity is altered in the placentas of fetuses with congenital diaphragmatic hernia"],"prefix":"10.1016","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0582-1129","authenticated-orcid":false,"given":"Emily J.J.","family":"Horn-Oudshoorn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Broekhuizen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhavi S.","family":"Harhangi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinno H.P.","family":"Simons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex J.","family":"Eggink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.H. Jan","family":"Danser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin K.M.","family":"Reiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4457-0940","authenticated-orcid":false,"given":"Philip L.J.","family":"DeKoninck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.placenta.2023.11.015_bib1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.jpedsurg.2016.02.005","article-title":"Congenital diaphragmatic hernia - the past 25 (or so) years","volume":"51","author":"Lally","year":"2016","journal-title":"J. Pediatr. Surg."},{"issue":"9","key":"10.1016\/j.placenta.2023.11.015_bib2","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/jpc.12508","article-title":"Congenital diaphragmatic hernia","volume":"50","author":"Leeuwen","year":"2014","journal-title":"J. Paediatr. Child Health"},{"issue":"6","key":"10.1016\/j.placenta.2023.11.015_bib3","doi-asserted-by":"crossref","first-page":"F617","DOI":"10.1136\/archdischild-2018-316045","article-title":"Neonatal cardiopulmonary transition in an ovine model of congenital diaphragmatic hernia","volume":"104","author":"Kashyap","year":"2019","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"issue":"6","key":"10.1016\/j.placenta.2023.11.015_bib4","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/s41390-019-0345-4","article-title":"Pulmonary hypertension secondary to congenital diaphragmatic hernia: factors and pathways involved in pulmonary vascular remodeling","volume":"85","author":"Montalva","year":"2019","journal-title":"Pediatr. Res."},{"issue":"1","key":"10.1016\/j.placenta.2023.11.015_bib5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s12931-017-0670-2","article-title":"Changes in vasoactive pathways in congenital diaphragmatic hernia associated pulmonary hypertension explain unresponsiveness to pharmacotherapy","volume":"18","author":"Mous","year":"2017","journal-title":"Respir. Res."},{"issue":"Suppl 2","key":"10.1016\/j.placenta.2023.11.015_bib6","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.33549\/physiolres.931922","article-title":"Regulation of fetoplacental vascular bed by hypoxia","volume":"58","author":"Hampl","year":"2009","journal-title":"Physiol. Res."},{"key":"10.1016\/j.placenta.2023.11.015_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/ar.25159","article-title":"Effect of prenatal diaphragmatic hernia on pulmonary arterial morphology","author":"Stainsby","year":"2023","journal-title":"Anat. Rec."},{"issue":"12","key":"10.1016\/j.placenta.2023.11.015_bib8","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1001\/jamapediatrics.2016.2023","article-title":"Evaluation of variability in inhaled nitric oxide use and pulmonary hypertension in patients with congenital diaphragmatic hernia","volume":"170","author":"Putnam","year":"2016","journal-title":"JAMA Pediatr."},{"issue":"1","key":"10.1016\/j.placenta.2023.11.015_bib9","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1159\/000444210","article-title":"Standardized postnatal management of infants with congenital diaphragmatic hernia in europe: the CDH EURO consortium consensus - 2015 update","volume":"110","author":"Snoek","year":"2016","journal-title":"Neonatology"},{"issue":"1","key":"10.1016\/j.placenta.2023.11.015_bib10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jpedsurg.2013.09.024","article-title":"Antenatal maternally-administered phosphodiesterase type 5 inhibitors normalize eNOS expression in the fetal lamb model of congenital diaphragmatic hernia","volume":"49","author":"Shue","year":"2014","journal-title":"J. Pediatr. Surg."},{"issue":"5","key":"10.1016\/j.placenta.2023.11.015_bib11","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/jpsu.2003.50172","article-title":"Expression of heme oxygenase-1 and endothelial nitric oxide synthase in the lung of newborns with congenital diaphragmatic hernia and persistent pulmonary hypertension","volume":"38","author":"Solari","year":"2003","journal-title":"J. Pediatr. Surg."},{"issue":"4","key":"10.1016\/j.placenta.2023.11.015_bib12","doi-asserted-by":"crossref","first-page":"L734","DOI":"10.1152\/ajplung.00180.2016","article-title":"Clinically relevant timing of antenatal sildenafil treatment reduces pulmonary vascular remodeling in congenital diaphragmatic hernia","volume":"311","author":"Mous","year":"2016","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"8","key":"10.1016\/j.placenta.2023.11.015_bib13","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.jpedsurg.2010.12.015","article-title":"Nitric oxide activity through guanylate cyclase and phosphodiesterase modulation is impaired in fetal lambs with congenital diaphragmatic hernia","volume":"46","author":"de Buys Roessingh","year":"2011","journal-title":"J. Pediatr. Surg."},{"issue":"1","key":"10.1016\/j.placenta.2023.11.015_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3109\/01902149509031743","article-title":"Angiotensin-converting enzyme activity is increased in lungs of rats with pulmonary hypoplasia and congenital diaphragmatic hernia","volume":"21","author":"Bos","year":"1995","journal-title":"Exp. Lung Res."},{"issue":"9","key":"10.1016\/j.placenta.2023.11.015_bib15","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1136\/adc.65.9.994","article-title":"Congenital diaphragmatic hernia: impact of prostanoids in the perioperative period","volume":"65","author":"Bos","year":"1990","journal-title":"Arch. Dis. Child."},{"issue":"2","key":"10.1016\/j.placenta.2023.11.015_bib16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/adc.59.2.143","article-title":"Congenital diaphragmatic hernia: association between pulmonary vascular resistance and plasma thromboxane concentrations","volume":"59","author":"Ford","year":"1984","journal-title":"Arch. Dis. Child."},{"issue":"3","key":"10.1016\/j.placenta.2023.11.015_bib17","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.mehy.2015.06.001","article-title":"A \"cure\" for preeclampsia: improving neonatal outcomes by overcoming excess fetal placental vascular resistance","volume":"85","author":"Byrne","year":"2015","journal-title":"Med. Hypotheses"},{"issue":"3","key":"10.1016\/j.placenta.2023.11.015_bib18","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/1097-4644(20000901)78:3<458::AID-JCB10>3.0.CO;2-F","article-title":"Human umbilical vein endothelial cells (HUVECs) show Ca(2+) mobilization as well as Ca(2+) influx upon hypoxia","volume":"78","author":"Aono","year":"2000","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.placenta.2023.11.015_bib19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/jcp.1041520127","article-title":"Effect of hypoxia upon intracellular calcium concentration of human endothelial cells","volume":"152","author":"Arnould","year":"1992","journal-title":"J. Cell. Physiol."},{"issue":"Pt 5","key":"10.1016\/j.placenta.2023.11.015_bib20","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1042\/BST0350890","article-title":"Ion channel switching and activation in smooth-muscle cells of occlusive vascular diseases","volume":"35","author":"Beech","year":"2007","journal-title":"Biochem. Soc. Trans."},{"issue":"5","key":"10.1016\/j.placenta.2023.11.015_bib21","doi-asserted-by":"crossref","first-page":"C951","DOI":"10.1152\/ajpcell.00512.2010","article-title":"Hypoxia. 4. Hypoxia and ion channel function","volume":"300","author":"Shimoda","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"Pt 3","key":"10.1016\/j.placenta.2023.11.015_bib22","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1113\/jphysiol.2001.013003","article-title":"Electrophysiologically distinct smooth muscle cell subtypes in rat conduit and resistance pulmonary arteries","volume":"538","author":"Smirnov","year":"2002","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.placenta.2023.11.015_bib23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.chest.2016.09.001","article-title":"Hypoxic pulmonary vasoconstriction: from molecular mechanisms to medicine","volume":"151","author":"Dunham-Snary","year":"2017","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.placenta.2023.11.015_bib24","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1183\/13993003.00798-2015","article-title":"Potassium channels in pulmonary arterial hypertension","volume":"46","author":"Boucherat","year":"2015","journal-title":"Eur. Respir. J."},{"issue":"4","key":"10.1016\/j.placenta.2023.11.015_bib25","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1095\/biolreprod.106.051607","article-title":"Reactivity of human placental chorionic plate vessels from pregnancies complicated by intrauterine growth restriction (IUGR)","volume":"75","author":"Wareing","year":"2006","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.placenta.2023.11.015_bib26","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1213\/01.ane.0000222468.76942.d8","article-title":"Hypoxemic fetoplacental vasoconstriction: a graduated response to reduced oxygen conditions in the human placenta","volume":"103","author":"Ramasubramanian","year":"2006","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.placenta.2023.11.015_bib27","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.placenta.2020.09.016","article-title":"Correlation between chorionic plate vascularization and risk of bronchopulmonary dysplasia in extremely preterm infants","volume":"101","author":"Shapiro","year":"2020","journal-title":"Placenta"},{"issue":"4","key":"10.1016\/j.placenta.2023.11.015_bib28","doi-asserted-by":"crossref","first-page":"H1638","DOI":"10.1152\/ajpheart.01120.2007","article-title":"Chronic hypoxia increases fetoplacental vascular resistance and vasoconstrictor reactivity in the rat","volume":"294","author":"Jakoubek","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.placenta.2023.11.015_bib29","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/uog.22134","article-title":"ISUOG Practice Guidelines: diagnosis and management of small-for-gestational-age fetus and fetal growth restriction","volume":"56","author":"Lees","year":"2020","journal-title":"Ultrasound Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.placenta.2023.11.015_bib30","first-page":"H2204","article-title":"Hemodynamic model for analysis of Doppler ultrasound indexes of umbilical blood flow","volume":"276","author":"Kleiner-Assaf","year":"1999","journal-title":"Am. J. Physiol."},{"issue":"1","key":"10.1016\/j.placenta.2023.11.015_bib31","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.placenta.2004.11.008","article-title":"Reactivity of human placental chorionic plate vessels is modified by level of oxygenation: differences between arteries and veins","volume":"27","author":"Wareing","year":"2006","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.placenta.2023.11.015_bib32","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0002-9378(94)70311-6","article-title":"Functional characteristics of small placental arteries","volume":"170","author":"McCarthy","year":"1994","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.placenta.2023.11.015_bib33","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/HYPERTENSIONAHA.120.14970","article-title":"L-Tryptophan-Induced vasodilation is enhanced in preeclampsia: studies on its uptake and metabolism in the human placenta","volume":"76","author":"Broekhuizen","year":"2020","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.placenta.2023.11.015_bib49","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s12033-012-9539-2","article-title":"Quantitative PCR pitfalls: the case of the human placenta","volume":"52","author":"Lanoix","year":"2012","journal-title":"Mol. Biotechnol."},{"issue":"34","key":"10.1016\/j.placenta.2023.11.015_bib50","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.10969","article-title":"Thromboxane A2 receptor (TBXA2R) is a potent survival factor for triple negative breast cancers (TNBCs)","volume":"7","author":"Orr","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.placenta.2023.11.015_bib34","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ebiom.2019.06.007","article-title":"Placental effects and transfer of sildenafil in healthy and preeclamptic conditions","volume":"45","author":"Hitzerd","year":"2019","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.placenta.2023.11.015_bib35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12890-020-1113-2","article-title":"NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension","volume":"20","author":"Mulvaney","year":"2020","journal-title":"BMC Pulm. Med."},{"issue":"3","key":"10.1016\/j.placenta.2023.11.015_bib36","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1053\/j.semperi.2015.12.004","article-title":"Pharmacologic strategies in neonatal pulmonary hypertension other than nitric oxide","volume":"40","author":"Lakshminrusimha","year":"2016","journal-title":"Semin. Perinatol."},{"issue":"11","key":"10.1016\/j.placenta.2023.11.015_bib37","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1161\/hc3601.096826","article-title":"Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension","volume":"104","author":"Wilkens","year":"2001","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.placenta.2023.11.015_bib38","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/PCC.0b013e3181936aee","article-title":"Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn","volume":"10","author":"Lakshminrusimha","year":"2009","journal-title":"Pediatr. Crit. Care Med."},{"key":"10.1016\/j.placenta.2023.11.015_bib39","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40748-017-0066-9","article-title":"Milrinone in congenital diaphragmatic hernia - a randomized pilot trial: study protocol, review of literature and survey of current practices","volume":"3","author":"Lakshminrusimha","year":"2017","journal-title":"Matern Health Neonatol Perinatol"},{"issue":"6","key":"10.1016\/j.placenta.2023.11.015_bib40","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1001\/jamapediatrics.2023.0405","article-title":"Association between early prostacyclin therapy and extracorporeal life support use in patients with congenital diaphragmatic hernia","volume":"177","author":"Ramaraj","year":"2023","journal-title":"JAMA Pediatr."},{"issue":"5","key":"10.1016\/j.placenta.2023.11.015_bib41","doi-asserted-by":"crossref","first-page":"H1474","DOI":"10.1152\/ajpheart.1992.262.5.H1474","article-title":"Effects of birth-related stimuli on L-arginine-dependent pulmonary vasodilation in ovine fetus","volume":"262","author":"Cornfield","year":"1992","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"4","key":"10.1016\/j.placenta.2023.11.015_bib42","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1006\/bbrc.2001.4869","article-title":"Developmental changes of nitric oxide-sensitive guanylyl cyclase expression in pulmonary arteries","volume":"283","author":"Behrends","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.placenta.2023.11.015_bib43","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/ppul.20696","article-title":"Alterations in cGMP, soluble guanylate cyclase, phosphodiesterase 5, and B-type natriuretic peptide induced by chronic increased pulmonary blood flow in lambs","volume":"42","author":"Oishi","year":"2007","journal-title":"Pediatr. Pulmonol."},{"issue":"2","key":"10.1016\/j.placenta.2023.11.015_bib44","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000097125","article-title":"Cardiovascular effects of sildenafil in neonates and infants with congenital diaphragmatic hernia and pulmonary hypertension","volume":"91","author":"Noori","year":"2007","journal-title":"Neonatology"},{"issue":"11","key":"10.1016\/j.placenta.2023.11.015_bib45","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-032122","article-title":"The CoDiNOS trial protocol: an international randomised controlled trial of intravenous sildenafil versus inhaled nitric oxide for the treatment of pulmonary hypertension in neonates with congenital diaphragmatic hernia","volume":"9","author":"Cochius-den Otter","year":"2019","journal-title":"BMJ Open"},{"issue":"4","key":"10.1016\/j.placenta.2023.11.015_bib46","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/ppul.21181","article-title":"Expression and function of phosphodiesterases in nitrofen-induced congenital diaphragmatic hernia in rats","volume":"45","author":"van der Horst","year":"2010","journal-title":"Pediatr. Pulmonol."},{"issue":"3","key":"10.1016\/j.placenta.2023.11.015_bib47","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41390-020-01299-0","article-title":"Lung function between 8 and 15 years of age in very preterm infants with fetal growth restriction","volume":"90","author":"Arigliani","year":"2021","journal-title":"Pediatr. Res."},{"issue":"3","key":"10.1016\/j.placenta.2023.11.015_bib48","doi-asserted-by":"crossref","first-page":"e450","DOI":"10.1542\/peds.2008-3249","article-title":"I. Extremely Low Gestational Age Newborn Study, Fetal growth restriction and chronic lung disease among infants born before the 28th week of gestation","volume":"124","author":"Bose","year":"2009","journal-title":"Pediatrics"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400423006112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400423006112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T07:19:45Z","timestamp":1715325585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400423006112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":50,"alternative-id":["S0143400423006112"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2023.11.015","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vascular reactivity is altered in the placentas of fetuses with congenital diaphragmatic hernia","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2023.11.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}