{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:30:06Z","timestamp":1791387006406,"version":"4.3.3"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.placenta.2024.01.014","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T11:29:11Z","timestamp":1706527751000},"page":"42-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Nicotine regulates abnormal macrophage polarization and trophoblast invasion associated with preterm labor via the \u03b17nAChR\/SIRT1 axis"],"prefix":"10.1016","volume":"147","author":[{"given":"Aihua","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haozhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2402-5193","authenticated-orcid":false,"given":"Shuiping","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.placenta.2024.01.014_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111846","article-title":"A single-cell atlas of murine reproductive tissues during preterm labor","volume":"42","author":"Garcia-Flores","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.placenta.2024.01.014_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.709229","article-title":"IL-27 mediates pro-inflammatory effects via the ERK signaling pathway during preterm labor","volume":"12","author":"Huang","year":"2021","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.placenta.2024.01.014_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22126260","article-title":"miR-373-3p regulates invasion and migration abilities of trophoblast cells via targeted CD44 and radixin","volume":"22","author":"Lee","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"24","key":"10.1016\/j.placenta.2024.01.014_bib4","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1042\/CS20220149","article-title":"Preeclampsia and syncytiotrophoblast membrane extracellular vesicles (STB-EVs)","volume":"136","author":"Awoyemi","year":"2022","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.placenta.2024.01.014_bib5","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.placenta.2021.04.012","article-title":"Paradigms for investigating invasive trophoblast cell development and contributions to uterine spiral artery remodeling","volume":"113","author":"Varberg","year":"2021","journal-title":"Placenta"},{"issue":"6","key":"10.1016\/j.placenta.2024.01.014_bib6","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/cmi.2014.46","article-title":"Immune cells in term and preterm labor","volume":"11","author":"Gomez-Lopez","year":"2014","journal-title":"Cell. Mol. Immunol."},{"issue":"6","key":"10.1016\/j.placenta.2024.01.014_bib7","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/08830185.2020.1777292","article-title":"Pregnancy immune tolerance at the maternal-fetal interface","volume":"39","author":"Li","year":"2020","journal-title":"Int. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.placenta.2024.01.014_bib8","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.4049\/jimmunol.1502055","article-title":"An M1-like macrophage polarization in decidual tissue during spontaneous preterm labor that is attenuated by rosiglitazone treatment","volume":"196","author":"Xu","year":"2016","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.placenta.2024.01.014_bib9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00005-019-00552-7","article-title":"Role of macrophages in pregnancy and related complications","volume":"67","author":"Jena","year":"2019","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.placenta.2024.01.014_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.642071","article-title":"Stimulation of \u03b17 nicotinic acetylcholine receptor by nicotine suppresses decidual M1 macrophage polarization against inflammation in lipopolysaccharide-induced preeclampsia-like mouse model","volume":"12","author":"Han","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.placenta.2024.01.014_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118314","article-title":"Effect of nicotine on placental inflammation and apoptosis in preeclampsia-like model","volume":"261","author":"Li","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.placenta.2024.01.014_bib12","article-title":"Nicotine in inflammatory diseases: anti-inflammatory and pro-inflammatory effects","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.placenta.2024.01.014_bib13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/1547691X.2017.1394934","article-title":"Effect of nicotine on placental ischemia-induced complement activation and hypertension in the rat","volume":"14","author":"Laule","year":"2017","journal-title":"J. Immunot."},{"issue":"24","key":"10.1016\/j.placenta.2024.01.014_bib14","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1016\/S0024-3205(02)02135-5","article-title":"Nicotine's oxidative and antioxidant properties in CNS","volume":"71","author":"Newman","year":"2002","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.placenta.2024.01.014_bib15","doi-asserted-by":"crossref","first-page":"538.e1","DOI":"10.1016\/j.ajog.2014.04.026","article-title":"Nicotine, an \u03b17 nAChR agonist, reduces lipopolysaccharide-induced inflammatory responses and protects fetuses in pregnant rats","volume":"211","author":"Yang","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.placenta.2024.01.014_bib16","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s11064-021-03480-1","article-title":"The effect of \u03b17nAChR signaling on T cells and macrophages and their clinical implication in the treatment of rheumatic diseases","volume":"47","author":"Pan","year":"2022","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.placenta.2024.01.014_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2022.156054","article-title":"Nicotine ameliorates inflammatory mediators in RU486 induced preterm labor model through activating cholinergic anti-inflammatory pathway","volume":"160","author":"Huang","year":"2022","journal-title":"Cytokine"},{"issue":"3","key":"10.1016\/j.placenta.2024.01.014_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/cells9030728","article-title":"SIRT1 alleviates LPS-induced IL-1\u03b2 production by suppressing NLRP3 inflammasome activation and ROS production in trophoblasts","volume":"9","author":"Park","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.placenta.2024.01.014_bib19","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2147\/DDDT.S348836","article-title":"\u03b1-Mangostin treats early-stage adjuvant-induced arthritis of rat by regulating the CAP-SIRT1 pathway in macrophages","volume":"16","author":"Chen","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"issue":"8","key":"10.1016\/j.placenta.2024.01.014_bib20","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1161\/ATVBAHA.116.307157","article-title":"\u03b17 nicotinic acetylcholine receptor relieves angiotensin II-induced senescence in vascular smooth muscle cells by raising nicotinamide adenine dinucleotide-dependent SIRT1 activity","volume":"36","author":"Li","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.placenta.2024.01.014_bib21","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41564-022-01293-8","article-title":"Preterm birth is associated with xenobiotics and predicted by the vaginal metabolome","volume":"8","author":"Kindschuh","year":"2023","journal-title":"Nat Microbiol"},{"issue":"6","key":"10.1016\/j.placenta.2024.01.014_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13611","article-title":"Macrophage polarization in placenta accreta and macrophage-trophoblast interactions","volume":"88","author":"Che","year":"2022","journal-title":"Am. J. Reprod. Immunol."},{"issue":"7","key":"10.1016\/j.placenta.2024.01.014_bib23","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1007\/s00432-022-04124-9","article-title":"Targeting NAD metabolism regulates extracellular adenosine levels to improve the cytotoxicity of CD8+ effector T cells in the tumor microenvironment of gastric cancer","volume":"149","author":"Liu","year":"2022","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.placenta.2024.01.014_bib24","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.lfs.2018.11.055","article-title":"Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice","volume":"217","author":"Zhang","year":"2019","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.placenta.2024.01.014_bib25","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s43032-022-00917-y","article-title":"Title: \u03b23 adrenergic receptor signaling in the human myometrium","volume":"30","author":"Asif","year":"2023","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.placenta.2024.01.014_bib26","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.intimp.2019.02.050","article-title":"M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds","volume":"70","author":"Wang","year":"2019","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.placenta.2024.01.014_bib27","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.3389\/fimmu.2019.02317","article-title":"Dynamic function and composition changes of immune cells during normal and pathological pregnancy at the maternal-fetal interface","volume":"10","author":"Yang","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.placenta.2024.01.014_bib28","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkac057","article-title":"Epigenetic regulation of macrophage polarization in wound healing","volume":"11","author":"Chen","year":"2023","journal-title":"Burns Trauma"},{"issue":"4","key":"10.1016\/j.placenta.2024.01.014_bib29","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41423-022-00841-w","article-title":"MEF2C promotes M1 macrophage polarization and Th1 responses","volume":"19","author":"Zhao","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.placenta.2024.01.014_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2022.103627","article-title":"Cutting edge: the regulatory mechanisms of macrophage polarization and function during pregnancy","volume":"151","author":"Wang","year":"2022","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.placenta.2024.01.014_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.877314","article-title":"Immune deviation in the decidua during term and preterm labor","volume":"13","author":"Zha","year":"2022","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.placenta.2024.01.014_bib32","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1177\/1933719108329095","article-title":"Inflammation and pregnancy","volume":"16","author":"Challis","year":"2009","journal-title":"Reprod. Sci."},{"issue":"8","key":"10.1016\/j.placenta.2024.01.014_bib33","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1080\/15592294.2017.1347241","article-title":"Maternal inflammatory diet and adverse pregnancy outcomes: circulating cytokines and genomic imprinting as potential regulators?","volume":"12","author":"McCullough","year":"2017","journal-title":"Epigenetics"},{"key":"10.1016\/j.placenta.2024.01.014_bib34","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2147\/JIR.S248382","article-title":"Antibiotics, inflammation, and preterm labor: a missed conclusion","volume":"13","author":"Hantoushzadeh","year":"2020","journal-title":"J. Inflamm. Res."},{"issue":"9","key":"10.1016\/j.placenta.2024.01.014_bib35","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1080\/14767058.2017.1311318","article-title":"Intrauterine infection, immune system and premature birth","volume":"31","author":"Helmo","year":"2018","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"3","key":"10.1016\/j.placenta.2024.01.014_bib36","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00210-022-02346-9","article-title":"Cholinergic dysfunction in COVID-19: frantic search and hoping for the best","volume":"396","author":"Nadwa","year":"2023","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"8","key":"10.1016\/j.placenta.2024.01.014_bib37","first-page":"849","article-title":"Histological villous maturation in placentas of complicated pregnancies","volume":"35","author":"Vangrieken","year":"2020","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.placenta.2024.01.014_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154050","article-title":"Sinomenine inhibits macrophage M1 polarization by downregulating \u03b17nAChR via a feedback pathway of \u03b17nAChR\/ERK\/Egr-1","volume":"100","author":"Zhi","year":"2022","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.placenta.2024.01.014_bib39","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2119\/molmed.2011.00405","article-title":"\u03b17 nicotinic acetylcholine receptor (\u03b17nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex","volume":"18","author":"Olofsson","year":"2012","journal-title":"Mol. Med."},{"key":"10.1016\/j.placenta.2024.01.014_bib40","article-title":"Cholinergic immunomodulation in inflammatory bowel diseases","volume":"19","author":"Serafini","year":"2022","journal-title":"Brain Behav Immun Health"},{"issue":"3","key":"10.1016\/j.placenta.2024.01.014_bib41","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s10753-020-01396-6","article-title":"The role of \u03b17nAChR-mediated cholinergic anti-inflammatory pathway in immune cells","volume":"44","author":"Wu","year":"2021","journal-title":"Inflammation"},{"issue":"7255","key":"10.1016\/j.placenta.2024.01.014_bib42","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nature08197","article-title":"Recent progress in the biology and physiology of sirtuins","volume":"460","author":"Finkel","year":"2009","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.placenta.2024.01.014_bib43","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1095\/biolreprod.116.142372","article-title":"A novel role for SIRT3 in regulating mediators involved in the terminal pathways of human labor and delivery","volume":"95","author":"Lim","year":"2016","journal-title":"Biol. Reprod."},{"issue":"3","key":"10.1016\/j.placenta.2024.01.014_bib44","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.tem.2013.12.001","article-title":"SIRT1 and other sirtuins in metabolism","volume":"25","author":"Chang","year":"2014","journal-title":"Trends Endocrinol. Metabol."},{"issue":"2","key":"10.1016\/j.placenta.2024.01.014_bib45","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41390-019-0528-z","article-title":"The promise and pitfalls of precision medicine to resolve black-white racial disparities in preterm birth","volume":"87","author":"Burris","year":"2020","journal-title":"Pediatr. Res."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400424000304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400424000304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T19:49:33Z","timestamp":1758916173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400424000304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":45,"alternative-id":["S0143400424000304"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2024.01.014","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nicotine regulates abnormal macrophage polarization and trophoblast invasion associated with preterm labor via the \u03b17nAChR\/SIRT1 axis","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2024.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}