{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:15:57Z","timestamp":1790313357857,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"BBSRC","doi-asserted-by":"publisher","award":["BB\/V016156\/1"],"award-info":[{"award-number":["BB\/V016156\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"MRC","doi-asserted-by":"publisher","award":["MR\/T032863\/1"],"award-info":[{"award-number":["MR\/T032863\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["BFU2017-85571-R"],"award-info":[{"award-number":["BFU2017-85571-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.placenta.2024.04.005","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T15:15:24Z","timestamp":1712675724000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Differential expression of PPP1R12A transcripts, including those harbouring alternatively spliced micro-exons, in placentae from complicated pregnancies"],"prefix":"10.1016","volume":"151","author":[{"given":"Edward","family":"Frew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Sainty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Chappell-Maor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Bone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagne","family":"Daskeviciute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Buhigas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Iglesias-Platas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Lartey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8991-0497","authenticated-orcid":false,"given":"David","family":"Monk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2024.04.005_bib1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1146\/annurev-cellbio-100814-125620","article-title":"Placenta: the forgotten organ","volume":"31","author":"Maltepe","year":"2015","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.placenta.2024.04.005_bib2","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.placenta.2005.12.006","article-title":"The uterine spiral arteries in human pregnancy: facts and controversies","volume":"27","author":"Pijnenborg","year":"2006","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2024.04.005_bib3","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","article-title":"Preeclampsia: pathophysiology, challenges, and perspectives","volume":"124","author":"Rana","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.placenta.2024.04.005_bib4","doi-asserted-by":"crossref","first-page":"S745","DOI":"10.1016\/j.ajog.2017.11.577","article-title":"Pathophysiology of placental-derived fetal growth restriction","volume":"218","author":"Burton","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2024.04.005_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164352","article-title":"Altered expression of human smooth muscle myosin phosphatase targeting (MYPT) isovariants with pregnancy and labour","volume":"11","author":"Lartey","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.placenta.2024.04.005_bib6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1530\/REP-09-0160","article-title":"RHO protein regulation of contraction in the human uterus","volume":"138","author":"Lartey","year":"2009","journal-title":"Reproduction"},{"key":"10.1016\/j.placenta.2024.04.005_bib7","doi-asserted-by":"crossref","first-page":"C432","DOI":"10.1152\/ajpcell.00175.2006","article-title":"MYPT1 mutants demonstrate the importance of aa 888-928 for the interaction with PKGI alpha","volume":"292","author":"Given","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.placenta.2024.04.005_bib8","doi-asserted-by":"crossref","first-page":"C589","DOI":"10.1152\/ajpcell.2000.278.3.C589","article-title":"A myosin phosphatase targeting subunit isoform transition defines a smooth muscle developmental phenotypic switch","volume":"278","author":"Dirksen","year":"2000","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.placenta.2024.04.005_bib9","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1540\/jsmr.52.66","article-title":"MYPT1 isoforms expressed in HEK293T cells are differentially phosphorylated after GTP\u03b3S treatment","volume":"52","author":"Lin","year":"2016","journal-title":"J. Smooth Muscle Res."},{"key":"10.1016\/j.placenta.2024.04.005_bib10","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.3390\/cells11152315","article-title":"Complex transcriptional profiles of the PPP1R12A gene in cells of the circulatory system as revealed by in silico analysis and reverse transcription PCR","volume":"11","author":"Saldanha","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.placenta.2024.04.005_bib11","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.cell.2014.11.035","article-title":"A highly conserved program of neuronal microexons is misregulated in autistic brains","volume":"159","author":"Irimia","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.placenta.2024.04.005_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108560","article-title":"QUAKING regulates microexon alternative splicing of the rho GTPase pathway and controls microglia homeostasis","volume":"33","author":"Lee","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.placenta.2024.04.005_bib13","article-title":"Microexon alternative splicing of small GTPase regulators: implication in central nervous system diseases","volume":"13","author":"Lee","year":"2022","journal-title":"Interdiscip Rev RNA"},{"key":"10.1016\/j.placenta.2024.04.005_bib14","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1101\/gr.133744.111","article-title":"Detecting differential usage of exons from RNA-seq data","volume":"22","author":"Anders","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.placenta.2024.04.005_bib15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3389\/fgene.2016.00062","article-title":"Epigenetic characterisation of CDKN1C in placenta samples from non-syndromic intrauterine growth restriction","volume":"7","author":"Lopez-Abad","year":"2016","journal-title":"Front. Genet."},{"key":"10.1016\/j.placenta.2024.04.005_bib16","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1093\/hmg\/ddu347","article-title":"Altered expression of the imprinted transcription factor PLAGL1 deregulates a network of genes in the human IUGR placenta","volume":"23","author":"Iglesias-Platas","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.placenta.2024.04.005_bib17","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"4","author":"Schmitthen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.placenta.2024.04.005_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13148-019-0630-4","article-title":"Differences in expression rather than methylation at placenta-specific imprinted loci is associated with intrauterine growth restriction","volume":"11","author":"Monteagudo-Sanchez","year":"2019","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.placenta.2024.04.005_bib19","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1080\/15592294.2020.1783168","article-title":"The hypomethylation of imprinted genes in IVF\/ICSI placenta samples is associated with concomitant changes in histone modifications","volume":"15","author":"Choux","year":"2020","journal-title":"Epigenetics"},{"key":"10.1016\/j.placenta.2024.04.005_bib20","doi-asserted-by":"crossref","first-page":"D309","DOI":"10.1093\/nar\/gkaa768","article-title":"DIGGER: exploring the functional role of alternative splicing in protein interactions","volume":"49","author":"Louadi","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.placenta.2024.04.005_bib21","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrm.2017.27","article-title":"Alternative splicing as a regulator of development and tissue identity","volume":"18","author":"Barralle","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.placenta.2024.04.005_bib22","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/ng.841","article-title":"The splicing regulator Rbfox1 (ASBP1) controls neuronal excitation in the mammalian brain","volume":"43","author":"Gehman","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.placenta.2024.04.005_bib23","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.tig.2007.08.001","article-title":"Evolutionary impact of limited splicing fidelity in mammalian genes","volume":"23","author":"Zhang","year":"2007","journal-title":"Trends Genet."},{"key":"10.1016\/j.placenta.2024.04.005_bib24","doi-asserted-by":"crossref","first-page":"37250","DOI":"10.1074\/jbc.M105275200","article-title":"Role of myosin phosphatase isoforms in cGMP-mediated smooth muscle relaxation","volume":"276","author":"Khatri","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.placenta.2024.04.005_bib25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1023\/B:MCBI.0000021373.14288.00","article-title":"Myosin phosphatase: structure, regulation and function","volume":"259","author":"Ito","year":"2004","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.placenta.2024.04.005_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/bs.apha.2016.07.003","article-title":"Smooth muscle phenotypic diversity: effect on vascular function and drug responses","volume":"78","author":"Fisher","year":"2017","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.placenta.2024.04.005_bib27","doi-asserted-by":"crossref","first-page":"R256","DOI":"10.1152\/ajpregu.00145.2014","article-title":"A bioinformatic and computational study of myosin phosphatase subunit diversity","volume":"307","author":"Dippold","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.placenta.2024.04.005_bib28","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/01.RES.0000260189.38975.35","article-title":"Conditioning effect of blood flow on resistance artery smooth muscle myosin phosphatase","volume":"100","author":"Zhang","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.placenta.2024.04.005_bib29","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1161\/01.RES.0000142736.39359.58","article-title":"Vascular reactivity in heart failure: role of myosin light chain phosphatase","volume":"95","author":"Karim","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.placenta.2024.04.005_bib30","doi-asserted-by":"crossref","first-page":"37250","DOI":"10.1074\/jbc.M105275200","article-title":"Role of myosin phosphatase isoforms in cGMP-mediated smooth muscle relaxation","volume":"276","author":"Khatri","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.placenta.2024.04.005_bib31","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S2352-4642(17)30173-6","article-title":"Maternal sildenafil for severe fetal growth restriction (STRIDER): a multicentre, randomised, placebo-controlled, double-blind trial","volume":"2","author":"Sharp","year":"2018","journal-title":"Lancet Child Adolesc Health"},{"key":"10.1016\/j.placenta.2024.04.005_bib32","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.5323","article-title":"Maternal sildenafil vs placebo in pregnant women with severe early-onset fetal growth restriction: a randomized clinical trial","volume":"3","author":"Pels","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.placenta.2024.04.005_bib33","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/uog.20851","article-title":"Effect of sildenafil on maternal hemodynamics in pregnancies complicated by severe early-onset fetal growth restriction: planned subgroup analysis from a multicenter randomized placebo-controlled double-blind trial","volume":"55","author":"Khalil","year":"2020","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2024.04.005_bib34","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.yjmcc.2005.07.009","article-title":"Myosin phosphatase isoform switching in vascular smooth muscle development","volume":"40","author":"Payne","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.placenta.2024.04.005_bib35","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1095\/biolreprod.105.049130","article-title":"Expression of RND proteins in human myometrium","volume":"75","author":"Lartey","year":"2006","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.placenta.2024.04.005_bib36","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1095\/biolreprod.106.058982","article-title":"Up-Regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labour","volume":"76","author":"Lartey","year":"2007","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.placenta.2024.04.005_bib37","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/molehr\/gar078","article-title":"Phasic contractions of isolated human myometrium are associated with Rho-kinase (ROCK)-dependent phosphorylation of myosin phosphatase-targeting subunit (MYPT1)","volume":"18","author":"Hudson","year":"2012","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.placenta.2024.04.005_bib38","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/molehr\/gat045","article-title":"Differential vasodilation of human placental and myometrial arteries related to myofilament Ca(2+)-desensitization and the expression of Hsp20 but not MYPT1","volume":"19","author":"Dordea","year":"2013","journal-title":"Mol. Hum. Reprod."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400424000961?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400424000961?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T04:58:58Z","timestamp":1717217938000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400424000961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":38,"alternative-id":["S0143400424000961"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2024.04.005","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential expression of PPP1R12A transcripts, including those harbouring alternatively spliced micro-exons, in placentae from complicated pregnancies","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2024.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}