{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:36:51Z","timestamp":1790897811413,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.placenta.2024.06.002","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T08:09:42Z","timestamp":1717574982000},"page":"18-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Exploring altered free amino acids and metabolites: Insights into the metabolic landscape of preeclampsia"],"prefix":"10.1016","volume":"154","author":[{"given":"Savas","family":"Karakus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halef Okan","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"19","key":"10.1016\/j.placenta.2024.06.002_bib1","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJMra2109523","article-title":"Preeclampsia","volume":"386","author":"Magee","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.placenta.2024.06.002_bib2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.placenta.2018.04.012","article-title":"Innate immune cells in the placental bed in healthy pregnancy and preeclampsia","volume":"69","author":"Faas","year":"2018","journal-title":"Placenta"},{"issue":"2","key":"10.1016\/j.placenta.2024.06.002_bib3","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/14767058.2018.1489795","article-title":"The significant role of amino acids during pregnancy: nutritional support","volume":"33","author":"Manta-Vogli","year":"2020","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"7","key":"10.1016\/j.placenta.2024.06.002_bib4","doi-asserted-by":"crossref","first-page":"727","DOI":"10.2174\/1389203720666190125110150","article-title":"Epigenetic mechanisms of maternal dietary protein and amino acids affecting growth and development of offspring","volume":"20","author":"Wu","year":"2019","journal-title":"Curr. Protein Pept. Sci."},{"issue":"1","key":"10.1016\/j.placenta.2024.06.002_bib5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/ani9010019","article-title":"Role of maternal dietary protein and amino acids on fetal programming, early neonatal development, and lactation in swine","volume":"9","author":"Zhang","year":"2019","journal-title":"Animals (Basel)"},{"issue":"6","key":"10.1016\/j.placenta.2024.06.002_bib6","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.3390\/nu12061763","article-title":"Amino acids and developmental origins of hypertension","volume":"12","author":"Hsu","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.placenta.2024.06.002_bib7","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1016\/j.placenta.2005.01.003","article-title":"Fetoplacental transport and utilization of amino acids in IUGR--a review","volume":"26","author":"Regnault","year":"2005","journal-title":"Placenta"},{"issue":"4","key":"10.1016\/j.placenta.2024.06.002_bib8","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.preghy.2012.05.001","article-title":"Amino acid profile of plasma and cerebrospinal fluid in preeclampsia","volume":"2","author":"Ter\u00e1n","year":"2012","journal-title":"Pregnancy Hypertens"},{"issue":"5","key":"10.1016\/j.placenta.2024.06.002_bib9","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3390\/nu14051019","article-title":"Maternal amino acid status in severe preeclampsia: a cross-sectional study","volume":"14","author":"Prameswari","year":"2022","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.placenta.2024.06.002_bib10","first-page":"44","article-title":"The definition of severe and early-onset preeclampsia","volume":"3","author":"Tranquilli","year":"2013","journal-title":"Statements from the International Society for the Study of Hypertension in Pregnancy (ISSHP).Pregnancy Hypertens"},{"issue":"1","key":"10.1016\/j.placenta.2024.06.002_bib11","doi-asserted-by":"crossref","first-page":"IX","DOI":"10.3109\/10641950109152635","article-title":"The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP)","volume":"20","author":"Brown","year":"2001","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.placenta.2024.06.002_bib12","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2147\/IJWH.S8550","article-title":"Diagnosis and management of pre-eclampsia: an update","volume":"2","author":"Turner","year":"2010","journal-title":"Int J Womens Health"},{"issue":"1","key":"10.1016\/j.placenta.2024.06.002_bib13","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. Roy. Stat. Soc. B"},{"key":"10.1016\/j.placenta.2024.06.002_bib14","author":"Yerlitas"},{"issue":"3","key":"10.1016\/j.placenta.2024.06.002_bib15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/ATVBAHA.118.311572","article-title":"Amino acids and their metabolism in atherosclerosis","volume":"39","author":"Nitz","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.placenta.2024.06.002_bib16","first-page":"395","article-title":"Increased L-citrulline\/L-arginine plasma ratio in severe preeclampsia","volume":"96","author":"Benedetto","year":"2000","journal-title":"Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.placenta.2024.06.002_bib17","doi-asserted-by":"crossref","first-page":"7517","DOI":"10.1038\/s41598-020-64329-1","article-title":"Sexual dimorphism of metabolomic profile in arterial hypertension","volume":"10","author":"Go\u00efta","year":"2020","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.placenta.2024.06.002_bib18","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ajhg.2018.07.008","article-title":"Argininosuccinate lyase deficiency causes an endothelial-dependent form of hypertension","volume":"103","author":"Kho","year":"2018","journal-title":"Am. J. Hum. Genet."},{"issue":"1\u20131","key":"10.1016\/j.placenta.2024.06.002_bib19","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/pr.2017.143","article-title":"Polymorphisms in urea cycle enzyme genes are associated with persistent pulmonary hypertension of the newborn","volume":"83","author":"Kaluarachchi","year":"2018","journal-title":"Pediatr. Res."},{"issue":"6","key":"10.1016\/j.placenta.2024.06.002_bib20","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.tips.2015.03.006","article-title":"Arginase: an old enzyme with new tricks","volume":"36","author":"Caldwell","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.placenta.2024.06.002_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115325","article-title":"Nitric oxide deficiency is a primary driver of hypertension","volume":"206","author":"Bryan","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"7","key":"10.1016\/j.placenta.2024.06.002_bib22","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1089\/ars.2007.1959","article-title":"Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective","volume":"10","author":"Chen","year":"2008","journal-title":"Antioxidants Redox Signal."},{"issue":"7","key":"10.1016\/j.placenta.2024.06.002_bib23","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1097\/00004872-200207000-00008","article-title":"Collagen and hypertension","volume":"20","author":"Deinum","year":"2002","journal-title":"J. Hypertens."},{"issue":"11","key":"10.1016\/j.placenta.2024.06.002_bib24","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1097\/HJH.0000000000001793","article-title":"Collagen biomarkers predict new onset of hypertension in normotensive participants: the Multi-Ethnic Study of Atherosclerosis","volume":"36","author":"Duprez","year":"2018","journal-title":"J. Hypertens."},{"issue":"8","key":"10.1016\/j.placenta.2024.06.002_bib25","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1097\/01.hjh.0000173780.67308.f1","article-title":"The use of collagen-derived serum peptides for the clinical assessment of hypertensive heart disease","volume":"23","author":"L\u00f3pez","year":"2005","journal-title":"J. Hypertens."},{"key":"10.1016\/j.placenta.2024.06.002_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6691734","article-title":"Identification of potential metabolic markers of hypertension in Chinese children","volume":"2021","author":"Sun","year":"2021","journal-title":"Int. J. Hypertens."},{"issue":"6","key":"10.1016\/j.placenta.2024.06.002_bib27","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.3390\/ijms25063545","article-title":"Metabolomics of plasma in XLH patients with arterial hypertension: new insights into the underlying mechanisms","volume":"25","author":"L\u00f3pez-Romero","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.placenta.2024.06.002_bib28","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.jhep.2019.11.007","article-title":"The phosphatidylethanolamine biosynthesis pathway provides a new target for cancer chemotherapy","volume":"72","author":"Guan","year":"2020","journal-title":"J. Hepatol."},{"issue":"38","key":"10.1016\/j.placenta.2024.06.002_bib29","doi-asserted-by":"crossref","first-page":"28438","DOI":"10.1074\/jbc.M605861200","article-title":"Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2","volume":"281","author":"Tian","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.placenta.2024.06.002_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2021.100118","article-title":"The maternal blood lipidome is indicative of the pathogenesis of severe preeclampsia","volume":"62","author":"He","year":"2021","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.placenta.2024.06.002_bib31","first-page":"2020","article-title":"Maternal blood lipidomics analyses link critical metabolic pathways associated with severe preeclampsia","author":"Liu","year":"2020","journal-title":"medRxiv"},{"issue":"7","key":"10.1016\/j.placenta.2024.06.002_bib32","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","article-title":"Preeclampsia: pathophysiology, challenges, and perspectives","volume":"124","author":"Rana","year":"2019","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.placenta.2024.06.002_bib33","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/jamacardio.2017.1276","article-title":"Early identification of pregnant women at risk for preeclampsia: USPSTF recommendations on screening for preeclampsia","volume":"2","author":"Gulati","year":"2017","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.placenta.2024.06.002_bib34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.placenta.2017.11.011","article-title":"Identification of potential early biomarkers of preeclampsia","volume":"61","author":"Timofeeva","year":"2018","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2024.06.002_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119134","article-title":"Protective effect of oral histidine on hypertension in Dahl salt-sensitive rats induced by high-salt diet","volume":"270","author":"Yang","year":"2021","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.placenta.2024.06.002_bib36","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/BF00170838","article-title":"Alpha-fluoromethylhistidine, an inhibitor of histamine biosynthesis, causes arterial hypertension","volume":"354","author":"Campos","year":"1996","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"1","key":"10.1016\/j.placenta.2024.06.002_bib37","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1440-1681.2009.05227.x","article-title":"Oral L-histidine exerts antihypertensive effects via central histamine H3 receptors and decreases nitric oxide content in the rostral ventrolateral medulla in spontaneously hypertensive rats","volume":"37","author":"Toba","year":"2010","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"4","key":"10.1016\/j.placenta.2024.06.002_bib38","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/01.shk.0000081665.84347.a3","article-title":"Endogenous central histamine-induced reversal of critical hemorrhagic hypotension in rats: studies with L-histidine","volume":"20","author":"Jochem","year":"2003","journal-title":"Shock"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400424002601?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400424002601?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T22:02:19Z","timestamp":1725141739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400424002601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":38,"alternative-id":["S0143400424002601"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2024.06.002","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring altered free amino acids and metabolites: Insights into the metabolic landscape of preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2024.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}