{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T02:01:02Z","timestamp":1779933662049,"version":"3.53.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00dcB\u0130TAK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.placenta.2024.07.055","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T06:09:06Z","timestamp":1721455746000},"page":"201-206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Unveiling the placental secrets: Exploring histopathological changes and TROP2 expression in intrahepatic cholestasis of pregnancy"],"prefix":"10.1016","volume":"154","author":[{"given":"Cezmi Baran","family":"Ozalp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sozdar","family":"Akdogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilan","family":"Cetinavci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melike Nur","family":"Akin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hulya","family":"Elbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcu","family":"Kasap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.placenta.2024.07.055_bib1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/GRF.0000000000000495","article-title":"Intrahepatic cholestasis of pregnancy","volume":"63","author":"Smith","year":"2020","journal-title":"Clin. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2024.07.055_bib2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.toxlet.2019.09.009","article-title":"Cholestasis-associated reproductive toxicity in male and female rats: the fundamental role of mitochondrial impairment and oxidative stress","volume":"316","author":"Ommati","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.placenta.2024.07.055_bib3","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/S0168-8278(00)80139-7","article-title":"Intrahepatic cholestasis of pregnancy: molecular pathogenesis,diagnosis and management","volume":"33","author":"Lammert","year":"2000","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.placenta.2024.07.055_bib4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1258\/om.2008.080010","article-title":"The molecular genetics of intrahepatic cholestasis of pregnancy","volume":"1","author":"Dixon","year":"2008","journal-title":"Obstet. Med."},{"issue":"3","key":"10.1016\/j.placenta.2024.07.055_bib5","doi-asserted-by":"crossref","first-page":"58.6","DOI":"10.1002\/cld.398","article-title":"Intrahepatic cholestasis of pregnancy: diagnosis and management","volume":"4","author":"Bacq","year":"2014","journal-title":"Clin. Liver Dis."},{"issue":"3","key":"10.1016\/j.placenta.2024.07.055_bib6","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1053\/jhep.2002.36088","article-title":"Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited","volume":"36","author":"Paumgartner","year":"2002","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.placenta.2024.07.055_bib7","article-title":"Interventions for treating cholestasis in pregnancy","author":"Gurung","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"issue":"3","key":"10.1016\/j.placenta.2024.07.055_bib8","article-title":"Stillbirth and associated perinatal outcomes in obstetric cholestasis: a systematic review and meta-analysis of observational studies","volume":"X","author":"Mohan","year":"2019","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"1663","key":"10.1016\/j.placenta.2024.07.055_bib9","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2014.0066","article-title":"The placenta: a multifaceted, transient organ","volume":"370","author":"Burton","year":"2015","journal-title":"Philos Trans R Soc B Biol Sci"},{"issue":"2","key":"10.1016\/j.placenta.2024.07.055_bib10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ogc.2021.02.001","article-title":"Placental function and the development of fetal overgrowth and fetal growth restriction","volume":"48","author":"Dumolt","year":"2021","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"10.1016\/j.placenta.2024.07.055_bib11","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3389\/fendo.2018.00570","article-title":"Regulation of placental development and its impact on fetal growth\u2014new insights from mouse models","volume":"9","author":"Woods","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.placenta.2024.07.055_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-017-3475-2","article-title":"Trop2 enhances invasion of thyroid cancer by inducing MMP2 through ERK and JNK pathways","volume":"17","author":"Guan","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.placenta.2024.07.055_bib13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.4132\/jptm.2017.10.17","article-title":"The significance of TROP2 expression in predicting BRAF mutations in papillary thyroid carcinoma","volume":"52","author":"Kong","year":"2018","journal-title":"J Pathol Transl Med"},{"issue":"8","key":"10.1016\/j.placenta.2024.07.055_bib14","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/sj.bjc.6604677","article-title":"High expression of TROP2 correlates with poor prognosis in pancreatic cancer","volume":"99","author":"Fong","year":"2008","journal-title":"Br. J. Cancer"},{"issue":"9","key":"10.1016\/j.placenta.2024.07.055_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075864","article-title":"Overexpression of TROP2 predicts poor prognosis of patients with cervical cancer and promotes the proliferation and invasion of cervical cancer cells by regulating ERK signaling pathway","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.placenta.2024.07.055_bib16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/dvdy.24242","article-title":"Trop2: from development to disease","volume":"244","author":"McDougall","year":"2015","journal-title":"Dev. Dynam."},{"issue":"3\u20134","key":"10.1016\/j.placenta.2024.07.055_bib17","first-page":"84","article-title":"Trop2 and its overexpression in cancers: regulation and clinical\/therapeuticimplications","volume":"6","author":"Shvartsur","year":"2015","journal-title":"Genes Cancer"},{"issue":"2","key":"10.1016\/j.placenta.2024.07.055_bib18","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/hep.510260216","article-title":"Intrahepatic cholestasis of pregnancy: a French prospective study","volume":"26","author":"Bacq","year":"1997","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.placenta.2024.07.055_bib19","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/0016-5085(91)90292-S","article-title":"Intrahepatic cholestasis of pregnancy and acute fatty liver of pregnancy. An unusual but favorable association?","volume":"100","author":"Vanjak","year":"1991","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.placenta.2024.07.055_bib20","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ogc.2010.02.011","article-title":"Cholestasis of pregnancy","volume":"37","author":"Pathak","year":"2010","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"issue":"1","key":"10.1016\/j.placenta.2024.07.055_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.aohep.2022.100879","article-title":"Body mass index implications in intrahepatic cholestasis of pregnancy and placental histopathological alterations","volume":"28","author":"Valdovinos-Bello","year":"2023","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.placenta.2024.07.055_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.733225","article-title":"Studies on novel diagnostic and predictive biomarkers of intrahepatic cholestasis of pregnancy through metabolomics and proteomics","volume":"12","author":"Dong","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.placenta.2024.07.055_bib23","article-title":"Intrahepatic cholestasis of pregnancy is associated with reduced nitric oxide synthase (iNOS) in plasma and placentas: a pilot study","volume":"27","author":"Wang","year":"2021","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"issue":"8","key":"10.1016\/j.placenta.2024.07.055_bib24","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1177\/0963689718786882","article-title":"Trop2 guarantees cardioprotective effects of cortical bone-derived stem cells on myocardial ischemia\/reperfusion injury","volume":"27","author":"Li","year":"2018","journal-title":"Cell Transplant."},{"issue":"1","key":"10.1016\/j.placenta.2024.07.055_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1755-8794-7-42","article-title":"Placental gene-expression profiles of intrahepatic cholestasis of pregnancy reveal involvement of multiple molecular pathways in blood vessel formation and inflammation","volume":"7","author":"Du","year":"2014","journal-title":"BMC Med. Genom."},{"issue":"8","key":"10.1016\/j.placenta.2024.07.055_bib26","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1073\/pnas.78.8.5147","article-title":"Human trophoblast cell-surface antigens defined by monoclonal antibodies","volume":"78","author":"Lipinski","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.placenta.2024.07.055_bib27","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/onc.2012.36","article-title":"Upregulation of Trop-2 quantitatively stimulates human cancer growth","volume":"32","author":"Trerotola","year":"2013","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.placenta.2024.07.055_bib28","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1369\/0022155411410430","article-title":"Expression of Trop2 cell surface glycoprotein in normal and tumor tissues: potential implications as a cancer therapeutic target","volume":"59","author":"Stepan","year":"2011","journal-title":"J. Histochem. Cytochem."},{"issue":"12","key":"10.1016\/j.placenta.2024.07.055_bib29","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1038\/onc.2012.151","article-title":"The Trop-2 signalling network in cancer growth","volume":"32","author":"Guerra","year":"2013","journal-title":"Oncogene"},{"issue":"10","key":"10.1016\/j.placenta.2024.07.055_bib30","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s10072-013-1326-8","article-title":"TROP2 expression and its correlation with tumor proliferation and angiogenesis in human gliomas","volume":"34","author":"Ning","year":"2013","journal-title":"Neurol. Sci."},{"issue":"24","key":"10.1016\/j.placenta.2024.07.055_bib31","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.21037\/atm-22-5976","article-title":"A literature review of the promising future of TROP2: a potential drug therapy target","volume":"10","author":"Wen","year":"2022","journal-title":"Ann. Transl. Med."},{"issue":"1","key":"10.1016\/j.placenta.2024.07.055_bib32","first-page":"112","article-title":"miR125b1 and TROP2 in preeclampsiacomplicated by foetal growth restriction: a morphological and biomolecular study","volume":"119","author":"Licini","year":"2015","journal-title":"Ital. J. Anat Embryol."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400424003503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400424003503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T22:03:38Z","timestamp":1725141818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400424003503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":32,"alternative-id":["S0143400424003503"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2024.07.055","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling the placental secrets: Exploring histopathological changes and TROP2 expression in intrahepatic cholestasis of pregnancy","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2024.07.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}