{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:35:26Z","timestamp":1771299326870,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007028","name":"Leona M and Harry B Helmsley Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.placenta.2024.10.008","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:50:27Z","timestamp":1729039827000},"page":"126-135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Gene expression profiles in placenta and their association with anesthesia, delivery mode and maternal diabetes"],"prefix":"10.1016","volume":"158","author":[{"given":"Bassam","family":"Aljani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette I.","family":"Garbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva-Maria","family":"Sedlmeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramona","family":"Lickert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Rost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anette-Gabriele","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezio","family":"Bonifacio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8009-5959","authenticated-orcid":false,"given":"Anne","family":"Eugster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2024.10.008_bib1","doi-asserted-by":"crossref","DOI":"10.1146\/annurev-cellbio-100814-125620","article-title":"Placenta: the forgotten organ","volume":"31","author":"Maltepe","year":"2015","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.placenta.2024.10.008_bib2","doi-asserted-by":"crossref","DOI":"10.1242\/dev.202088","article-title":"Maternal-fetal cross-talk via the placenta: influence on offspring development and metabolism","volume":"150","author":"Kramer","year":"2023","journal-title":"Development"},{"key":"10.1016\/j.placenta.2024.10.008_bib3","article-title":"Placental structure, function and drug transfer","volume":"15","author":"Griffiths","year":"2015","journal-title":"Cont. Educ. Anaesth. Crit. Care Pain"},{"key":"10.1016\/j.placenta.2024.10.008_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.placenta.2006.11.002","article-title":"Animal models of human placentation - a review","volume":"28","author":"Carter","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2024.10.008_bib5","doi-asserted-by":"crossref","DOI":"10.1042\/CS20060339","article-title":"Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches","volume":"113","author":"Jansson","year":"2007","journal-title":"Clin. Sci."},{"key":"10.1016\/j.placenta.2024.10.008_bib6","doi-asserted-by":"crossref","DOI":"10.1097\/GRF.0b013e3182993a2e","article-title":"Role of placental nutrient sensing in developmental programming","volume":"56","author":"Jansson","year":"2013","journal-title":"Clin. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2024.10.008_bib7","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2014.0066","article-title":"The placenta: a multifaceted, transient organ","volume":"370","author":"Burton","year":"2015","journal-title":"Phil. Trans. Biol. Sci."},{"key":"10.1016\/j.placenta.2024.10.008_bib8","doi-asserted-by":"crossref","DOI":"10.1007\/s43032-022-00983-2","article-title":"Maternal underweight and obesity are associated with placental pathologies in human pregnancy","volume":"29","author":"Scott","year":"2022","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.placenta.2024.10.008_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/nu14102025","article-title":"Fetomaternal expression of glucose transporters (GLUTs)\u2014biochemical, cellular and clinical aspects","volume":"14","author":"Sibiak","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.placenta.2024.10.008_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2014.08.009","article-title":"Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers","volume":"212","author":"Acosta","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2024.10.008_bib11","doi-asserted-by":"crossref","DOI":"10.3109\/14767050009020519","article-title":"Effect of diabetes in pregnancy on offspring: follow-up research in the Pima Indians","volume":"9","author":"Dabelea","year":"2000","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.placenta.2024.10.008_bib12","doi-asserted-by":"crossref","DOI":"10.1210\/jc.2006-0624","article-title":"Review: consequences of fetal exposure to maternal diabetes in offspring","volume":"91","author":"Fetita","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.placenta.2024.10.008_bib13","doi-asserted-by":"crossref","DOI":"10.2337\/diabetes.49.12.2201","article-title":"Parental transmission of type 2 diabetes: the framingham offspring study","volume":"49","author":"Meigs","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.placenta.2024.10.008_bib14","doi-asserted-by":"crossref","DOI":"10.1097\/00006254-198503000-00011","article-title":"Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers","volume":"40","author":"Warram","year":"1985","journal-title":"Obstet. Gynecol. Surv."},{"key":"10.1016\/j.placenta.2024.10.008_bib15","doi-asserted-by":"crossref","DOI":"10.1007\/s00125-008-1022-z","article-title":"Maternal type 1 diabetes reduces the risk of islet autoantibodies: relationships with birthweight and maternal HbA1c","volume":"51","author":"Bonifacio","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.placenta.2024.10.008_bib16","article-title":"Thymus growth and fetal immune responses in diabetic pregnancies","volume":"49","author":"Warncke","year":"2017","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.placenta.2024.10.008_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/S2213-8587(23)00190-0","article-title":"Maternal type 1 diabetes and relative protection against offspring transmission","volume":"11","author":"Allen","year":"2023","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.placenta.2024.10.008_bib18","doi-asserted-by":"crossref","DOI":"10.1007\/s00125-024-06176-7","article-title":"Caesarean section and risk of type 1 diabetes","author":"Singh","year":"2024","journal-title":"Diabetologia"},{"key":"10.1016\/j.placenta.2024.10.008_bib19","doi-asserted-by":"crossref","DOI":"10.1007\/s11892-015-0579-4","article-title":"Preeclampsia and diabetes","volume":"15","author":"Weissgerber","year":"2015","journal-title":"Curr. Diabetes Rep."},{"key":"10.1016\/j.placenta.2024.10.008_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.placenta.2010.12.008","article-title":"A technical note to improve the reporting of studies of the human placenta","volume":"32","author":"Nelson","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2024.10.008_bib21","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-15-941","article-title":"Human placental transcriptome shows sexually dimorphic gene expression and responsiveness to maternal dietary n-3 long-chain polyunsaturated fatty acid intervention during pregnancy","volume":"15","author":"Sedlmeier","year":"2014","journal-title":"BMC Genom."},{"key":"10.1016\/j.placenta.2024.10.008_bib22","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btw354","article-title":"MultiQC: summarize analysis results for multiple tools and samples in a single report","volume":"32","author":"Ewels","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.placenta.2024.10.008_bib23","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.placenta.2024.10.008_bib24","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btt656","article-title":"FeatureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.placenta.2024.10.008_bib25","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.placenta.2024.10.008_bib26","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1186\/s12859-016-1323-z","article-title":"variancePartition: interpreting drivers of variation in complex gene expression studies","volume":"17","author":"Hoffman","year":"2016","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.placenta.2024.10.008_bib27","author":"Kolde"},{"key":"10.1016\/j.placenta.2024.10.008_bib28","volume":"vol. 16","author":"Yu","year":"2012"},{"key":"10.1016\/j.placenta.2024.10.008_bib29","doi-asserted-by":"crossref","DOI":"10.1186\/s13293-022-00459-7","article-title":"Sex at the interface: the origin and impact of sex differences in the developing human placenta","volume":"13","author":"Braun","year":"2022","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.placenta.2024.10.008_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10133000","article-title":"Sex differences are here to stay: relevance to prenatal care","volume":"10","author":"Inkster","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.placenta.2024.10.008_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.placenta.2014.03.014","article-title":"Fetal sex specific differences in human placentation: a prospective cohort study","volume":"35","author":"Brown","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2024.10.008_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2019.00022","article-title":"Sex differences in nutrition, growth, and metabolism in preterm infants","volume":"7","author":"Alur","year":"2019","journal-title":"Front Pediatr"},{"key":"10.1016\/j.placenta.2024.10.008_bib33","doi-asserted-by":"crossref","DOI":"10.1186\/s13293-020-00299-3","article-title":"Fetal sex and maternal pregnancy outcomes: a systematic review and meta-analysis","volume":"11","author":"Broere-Brown","year":"2020","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.placenta.2024.10.008_bib34","doi-asserted-by":"crossref","DOI":"10.1515\/jpm-2011-0137","article-title":"Fetal sex and perinatal outcomes","volume":"40","author":"Aibar","year":"2012","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.placenta.2024.10.008_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2017.00144","article-title":"Effect of fetal sex on maternal and obstetric outcomes","volume":"5","author":"Al-Qaraghouli","year":"2017","journal-title":"Front Pediatr"},{"key":"10.1016\/j.placenta.2024.10.008_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2016.03.023","article-title":"Single-cell RNA-seq reveals lineage and X chromosome dynamics in human preimplantation embryos","volume":"165","author":"Petropoulos","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.placenta.2024.10.008_bib37","article-title":"The PI3K-AKT-mTOR pathway activates recovery from general anesthesia","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.placenta.2024.10.008_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2011.00051","article-title":"PI3K\/AKT\/mTOR pathway in angiogenesis","volume":"4","author":"Karar","year":"2011","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.placenta.2024.10.008_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2022.06.026","article-title":"Epidural-related maternal fever: incidence, pathophysiology, outcomes, and management","volume":"228","author":"Patel","year":"2023","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2024.10.008_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/srep29715","article-title":"Gene expression in term placentas is regulated more by spinal or epidural anesthesia than by late-onset preeclampsia or gestational diabetes mellitus","volume":"6","author":"Lekva","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.placenta.2024.10.008_bib41","doi-asserted-by":"crossref","DOI":"10.1111\/imr.13077","article-title":"Mechanisms of immune regulation by the placenta: role of type I interferon and interferon-stimulated genes signaling during pregnancy","volume":"308","author":"Ding","year":"2022","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.placenta.2024.10.008_bib42","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2021-067946","article-title":"Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis","author":"Ye","year":"2022","journal-title":"The BMJ"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400424006787?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400424006787?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T08:24:21Z","timestamp":1733991861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400424006787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":42,"alternative-id":["S0143400424006787"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2024.10.008","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene expression profiles in placenta and their association with anesthesia, delivery mode and maternal diabetes","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2024.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}