{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:40:15Z","timestamp":1787118015756,"version":"build-2736575974"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.placenta.2024.11.002","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T01:53:57Z","timestamp":1730771637000},"page":"240-252","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["BMP5 promotes trophoblast functions upon N-glycosylation via the BMP5-SMAD1\/5 signaling pathway in preeclampsia"],"prefix":"10.1016","volume":"158","author":[{"given":"Hao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline M.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian V.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1548-6229","authenticated-orcid":false,"given":"Huamin","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.placenta.2024.11.002_bib1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41581-019-0119-6","article-title":"Pre-eclampsia: pathogenesis, novel diagnostics and therapies","volume":"15","author":"Phipps","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"issue":"14","key":"10.1016\/j.placenta.2024.11.002_bib2","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.jacc.2020.08.014","article-title":"PE-pathophysiology and clinical presentations: JACC state-of-the-art review","volume":"76","author":"Ives","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.placenta.2024.11.002_bib3","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1530\/REP-14-0052","article-title":"Role of placenta-specific protein 1 in trophoblast invasion and migration","volume":"148","author":"Chang","year":"2014","journal-title":"Reproduction"},{"issue":"6","key":"10.1016\/j.placenta.2024.11.002_bib4","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.2215\/CJN.12081115","article-title":"PE: updates in pathogenesis, definitions, and guidelines","volume":"11","author":"Phipps","year":"2016","journal-title":"Clin. J. Am. Soc. Nephrol.: CJASN"},{"issue":"2","key":"10.1016\/j.placenta.2024.11.002_bib5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/MNH.0000000000000105","article-title":"Pathogenesis of PE","volume":"24","author":"Sircar","year":"2015","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.placenta.2024.11.002_bib6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jri.2016.08.008","article-title":"Update of syncytiotrophoblast derived extracellular vesicles in normal pregnancy and PE","volume":"119","author":"Tannetta","year":"2017","journal-title":"J. Reprod. Immunol."},{"issue":"Suppl","key":"10.1016\/j.placenta.2024.11.002_bib7","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.placenta.2013.12.008","article-title":"IFPA Senior Award Lecture: making sense of pre-eclampsia - two placental causes of PE?","volume":"35","author":"Redman","year":"2014","journal-title":"Placenta"},{"issue":"2","key":"10.1016\/j.placenta.2024.11.002_bib8","first-page":"529","article-title":"Expression analysis of BMP2, BMP5, BMP10 in human colon tissues from Hirschsprung disease patients","volume":"7","author":"Wu","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"1","key":"10.1016\/j.placenta.2024.11.002_bib9","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12943-018-0925-7","article-title":"Alteration of tumor suppressor BMP5 in sporadic colorectal cancer: a genomic and transcriptomic profiling based study","volume":"17","author":"Chen","year":"2018","journal-title":"Mol. Cancer"},{"issue":"4","key":"10.1016\/j.placenta.2024.11.002_bib10","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/stem.2533","article-title":"Bmp5 regulates neural crest cell survival and proliferation via two different signaling pathways","volume":"35","author":"Shih","year":"2017","journal-title":"Stem Cell."},{"key":"10.1016\/j.placenta.2024.11.002_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.768669","article-title":"Dysregulated BMP2 in the placenta may contribute to early-onset PE by regulating human trophoblast expression of extracellular matrix and adhesion molecules","volume":"9","author":"Yi","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"19","key":"10.1016\/j.placenta.2024.11.002_bib12","doi-asserted-by":"crossref","first-page":"7362","DOI":"10.1073\/pnas.1201595109","article-title":"Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment","volume":"109","author":"Home","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"4","key":"10.1016\/j.placenta.2024.11.002_bib13","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1210\/en.2016-1629","article-title":"BMP7 induces uterine receptivity and blastocyst attachment","volume":"158","author":"Monsivais","year":"2017","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/j.placenta.2024.11.002_bib14","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1242\/dev.126.8.1753","article-title":"Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup","volume":"126","author":"Solloway","year":"1999","journal-title":"Development"},{"issue":"7","key":"10.1016\/j.placenta.2024.11.002_bib15","doi-asserted-by":"crossref","first-page":"9646","DOI":"10.18632\/aging.202708","article-title":"BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice","volume":"13","author":"Shao","year":"2021","journal-title":"Aging"},{"issue":"15","key":"10.1016\/j.placenta.2024.11.002_bib16","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1016\/j.yexcr.2011.06.001","article-title":"Bone morphogenetic protein -4 and -5 in pancreatic cancer--novel bidirectional players","volume":"317","author":"Virtanen","year":"2011","journal-title":"Exp. Cell Res."},{"issue":"8","key":"10.1016\/j.placenta.2024.11.002_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101371","article-title":"C-mannosylation enhances the structural stability of human RNase 2","volume":"23","author":"Frank","year":"2020","journal-title":"iScience"},{"issue":"41","key":"10.1016\/j.placenta.2024.11.002_bib18","doi-asserted-by":"crossref","first-page":"31164","DOI":"10.1074\/jbc.M110.149195","article-title":"N-glycosylation gene DPAGT1 is a target of the Wnt\/beta-catenin signaling pathway","volume":"285","author":"Sengupta","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.placenta.2024.11.002_bib19","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.4251\/wjgo.v15.i7.1119","article-title":"Core fucosylation and its roles in gastrointestinal glycoimmunology","volume":"15","author":"Zhang","year":"2023","journal-title":"World J. Gastrointest. Oncol."},{"issue":"18","key":"10.1016\/j.placenta.2024.11.002_bib20","doi-asserted-by":"crossref","first-page":"12229","DOI":"10.1021\/acsomega.1c01111","article-title":"Combinatorial design of a sialic acid-imprinted binding site","volume":"6","author":"Mavliutova","year":"2021","journal-title":"ACS Omega"},{"issue":"2","key":"10.1016\/j.placenta.2024.11.002_bib21","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1042\/BST20221406","article-title":"Roles of N-linked glycosylation and glycan-binding proteins in placentation: trophoblast infiltration, immunomodulation, angiogenesis, and pathophysiology","volume":"51","author":"Huang","year":"2023","journal-title":"Biochem. Soc. Trans."},{"issue":"2","key":"10.1016\/j.placenta.2024.11.002_bib22","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/jcp.29022","article-title":"N-glycosylation of uterine endometrium determines its receptivity","volume":"235","author":"Yu","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"1\u20132","key":"10.1016\/j.placenta.2024.11.002_bib23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1080\/19336918.2015.1120397","article-title":"Intrauterine trophoblast migration: a comparative view of humans and rodents","volume":"10","author":"Silva","year":"2016","journal-title":"Cell Adhes. Migrat."},{"issue":"1","key":"10.1016\/j.placenta.2024.11.002_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.105911","article-title":"Perturbation of placental protein glycosylation by endoplasmic reticulum stress promotes maladaptation of maternal hepatic glucose metabolism","volume":"26","author":"Yung","year":"2022","journal-title":"iScience"},{"issue":"10","key":"10.1016\/j.placenta.2024.11.002_bib25","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1177\/1933719118765967","article-title":"Expression of N-acetylglucosaminyltransferase III promotes trophoblast invasion and migration in early human placenta","volume":"26","author":"Deng","year":"2019","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.placenta.2024.11.002_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.placenta.2018.11.005","article-title":"FUT8 drives the proliferation and invasion of trophoblastic cells via IGF-1\/IGF-1R signaling pathway","volume":"75","author":"Yu","year":"2019","journal-title":"Placenta"},{"issue":"10","key":"10.1016\/j.placenta.2024.11.002_bib27","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41419-023-06166-4","article-title":"\u03b11,3-fucosylation of MEST promotes invasion potential of cytotrophoblast cells by activating translation initiation","volume":"14","author":"Wang","year":"2023","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.placenta.2024.11.002_bib28","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/humrep\/der362","article-title":"Lipopolysaccharide induces cytokine production and decreases extravillous trophoblast invasion through a mitogen-activated protein kinase-mediated pathway: possible mechanisms of first trimester placental dysfunction","volume":"27","author":"Anton","year":"2012","journal-title":"Hum. Reprod."},{"issue":"10","key":"10.1016\/j.placenta.2024.11.002_bib29","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.placenta.2007.01.011","article-title":"Hyperglycosylated hCG","volume":"28","author":"Cole","year":"2007","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.placenta.2024.11.002_bib30","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4161\/auto.22927","article-title":"Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in PE","volume":"9","author":"Nakashima","year":"2013","journal-title":"Autophagy"},{"issue":"8","key":"10.1016\/j.placenta.2024.11.002_bib31","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1002\/jcb.26648","article-title":"AP1 mediates uPA\/uPAR induced FUT4 expression and trophoblast invasion","volume":"119","author":"Zheng","year":"2018","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.placenta.2024.11.002_bib32","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0014-4827(03)00089-2","article-title":"Noncatalytic domain of uPA stimulates human extravillous trophoblast migration by using phospholipase C, phosphatidylinositol 3-kinase and mitogen-activated protein kinase","volume":"286","author":"Liu","year":"2003","journal-title":"Exp. Cell Res."},{"issue":"10","key":"10.1016\/j.placenta.2024.11.002_bib33","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1093\/humrep\/der239","article-title":"Impact of CCN3 (NOV) glycosylation on migration\/invasion properties and cell growth of the choriocarcinoma cell line Jeg3","volume":"26","author":"Yang","year":"2011","journal-title":"Hum. Reprod."},{"issue":"5","key":"10.1016\/j.placenta.2024.11.002_bib34","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/uog.6366","article-title":"Role of uterine artery Doppler in interpreting low PAPP-A values in first-trimester screening for Down syndrome in pregnancies at high risk of impaired placentation","volume":"33","author":"Herraiz","year":"2009","journal-title":"Ultrasound Obstet. Gynecol. : off. J. Int. Soc. Ultrasound. Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.placenta.2024.11.002_bib35","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cytogfr.2005.01.009","article-title":"BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk","volume":"16","author":"Miyazono","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"issue":"1","key":"10.1016\/j.placenta.2024.11.002_bib36","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1038\/s41467-021-23571-5","article-title":"Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1\/SMAD5 axis","volume":"12","author":"Monsivais","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.placenta.2024.11.002_bib37","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jconrel.2011.12.041","article-title":"Non-glycosylated BMP-2 can induce ectopic bone formation at lower concentrations compared to glycosylated BMP-2","volume":"159","author":"van de Watering","year":"2012","journal-title":"J. Contr. Release : off. J. Control. Release Soc."},{"issue":"3","key":"10.1016\/j.placenta.2024.11.002_bib38","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/glycob\/cwt110","article-title":"Asparagine-linked glycosylation of bone morphogenetic protein-2 is required for secretion and osteoblast differentiation","volume":"24","author":"Hang","year":"2014","journal-title":"Glycobiology"},{"issue":"1","key":"10.1016\/j.placenta.2024.11.002_bib39","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1742-4658.2007.06187.x","article-title":"Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand","volume":"275","author":"Saremba","year":"2008","journal-title":"FEBS J."},{"issue":"16","key":"10.1016\/j.placenta.2024.11.002_bib40","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1002\/pros.24241","article-title":"Upregulated bone morphogenetic protein 5 enhances proliferation and epithelial-mesenchymal transition process in benign prostatic hyperplasia via BMP\/Smad signaling pathway","volume":"81","author":"Liu","year":"2021","journal-title":"Prostate"},{"issue":"16","key":"10.1016\/j.placenta.2024.11.002_bib41","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1002\/pros.24241","article-title":"Upregulated bone morphogenetic protein 5 enhances proliferation and epithelial-mesenchymal transition process in benign prostatic hyperplasia via BMP\/Smad signaling pathway","volume":"81","author":"Liu","year":"2021","journal-title":"Prostate"},{"key":"10.1016\/j.placenta.2024.11.002_bib42","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54542","article-title":"Regulation of stem\/progenitor cell maintenance by BMP5 in prostate homeostasis and cancer initiation","volume":"9","author":"Tremblay","year":"2020","journal-title":"Elife"},{"issue":"14","key":"10.1016\/j.placenta.2024.11.002_bib43","doi-asserted-by":"crossref","first-page":"5784","DOI":"10.1158\/0008-5472.CAN-08-4428","article-title":"Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis","volume":"69","author":"Johnsen","year":"2009","journal-title":"Cancer Res."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400424007434?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400424007434?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T08:25:06Z","timestamp":1733991906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400424007434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":43,"alternative-id":["S0143400424007434"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2024.11.002","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BMP5 promotes trophoblast functions upon N-glycosylation via the BMP5-SMAD1\/5 signaling pathway in preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2024.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}