{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:16:54Z","timestamp":1768443414856,"version":"3.49.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"am","delay-in-days":336,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100023986","name":"ICMR National Institute for Research in Environmental Health","doi-asserted-by":"publisher","award":["P30 ES005022"],"award-info":[{"award-number":["P30 ES005022"]}],"id":[{"id":"10.13039\/501100023986","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K99\/R00 HD096112"],"award-info":[{"award-number":["K99\/R00 HD096112"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MWG-146331"],"award-info":[{"award-number":["MWG-146331"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30ES007033"],"award-info":[{"award-number":["P30ES007033"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007812","name":"University of Washington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR002319"],"award-info":[{"award-number":["UL1TR002319"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL132338"],"award-info":[{"award-number":["R01HL132338"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MWG-146331"],"award-info":[{"award-number":["MWG-146331"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UG3OD023271"],"award-info":[{"award-number":["UG3OD023271"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019461","name":"Oregon Institute of Occupational Health Sciences, Oregon Health and Science University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019461","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017476","name":"Urban Child Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017476","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.placenta.2024.12.021","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:08:07Z","timestamp":1735603687000},"page":"29-38","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Associations between maternal plasma concentrations of corticotrophin releasing hormone and the placental transcriptome"],"prefix":"10.1016","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-9398","authenticated-orcid":false,"given":"Alison","family":"Paquette","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Parenti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Lapehn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaini","family":"Konwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leena","family":"Kadam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan J.","family":"Firsick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily S.","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"MacIsaac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo","family":"Bammler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kecia","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Enquobahrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kobor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaja Z.","family":"LeWinn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruby","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Spirzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Myatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole R.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Muglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheela","family":"Sathyanarayana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2024.12.021_bib1","first-page":"1376","article-title":"The human placenta and fetal membranes express the corticotropin-releasing hormone receptor 1alpha (CRH-1alpha) and the CRH-C variant receptor","volume":"83","author":"Karteris","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.placenta.2024.12.021_bib2","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/S0006-291X(87)80261-9","article-title":"The corticotropin releasing hormone gene is expressed in human placenta","volume":"148","author":"Grino","year":"1987","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.placenta.2024.12.021_bib3","first-page":"666","article-title":"Corticotropin-releasing hormone-induced vasodilatation in the human fetal placental circulation","volume":"79","author":"Clifton","year":"1994","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"10.1016\/j.placenta.2024.12.021_bib4","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1210\/en.2011-1673","article-title":"Differential regulation of glucose transporters mediated by CRH receptor type 1 and type 2 in human placental trophoblasts","volume":"153","author":"Gao","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.placenta.2024.12.021_bib5","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1196\/annals.1290.016","article-title":"Maternal and fetal hypothalamic-pituitary-adrenal axes during pregnancy and postpartum","volume":"997","author":"Mastorakos","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.placenta.2024.12.021_bib6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/373427a0","article-title":"Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need","volume":"373","author":"Muglia","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.placenta.2024.12.021_bib7","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1210\/en.2012-1453","article-title":"Regulation of estradiol and progesterone production by CRH-R1 and -R2 is through divergent signaling pathways in cultured human placental trophoblasts","volume":"153","author":"Gao","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.placenta.2024.12.021_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1476-5381.2011.01631.x","article-title":"Insights into mechanisms of corticotropin-releasing hormone receptor signal transduction","volume":"166","author":"Grammatopoulos","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.placenta.2024.12.021_bib9","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nm0595-460","article-title":"A placental clock controlling the length of human pregnancy","volume":"1","author":"McLean","year":"1995","journal-title":"Nat Med"},{"key":"10.1016\/j.placenta.2024.12.021_bib10","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/0002-9378(94)90457-X","article-title":"Corticotropin-releasing hormone increases prostaglandin F2\u03b1 activity on human myometrium in vitro","volume":"171","author":"Benedetto","year":"1994","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2024.12.021_bib11","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0196-9781(01)00393-X","article-title":"The regulation of human corticotrophin-releasing hormone gene expression in the placenta","volume":"22","author":"King","year":"2001","journal-title":"Peptides"},{"key":"10.1016\/j.placenta.2024.12.021_bib12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.placenta.2024.01.004","article-title":"Human placenta releases extracellular vesicles carrying corticotrophin releasing hormone mRNA into the maternal blood","volume":"146","author":"Paul","year":"2024","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2024.12.021_bib13","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1126\/science.6267699","article-title":"Characterization of a 41-Residue ovine hypothalamic peptide that stimulates secretion of corticotropin and \u03b2-endorphin","volume":"213","author":"Vale","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.placenta.2024.12.021_bib14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1515\/jpme.1996.24.3.243","article-title":"Corticotropin-releasing hormone and related pituitary-adrenal axis hormones in fetal and maternal blood during the second half of pregnancy","volume":"24","author":"Lockwood","year":"1996","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.placenta.2024.12.021_bib15","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1023\/A:1013863205647","article-title":"Regulation of corticotropin-releasing hormone (CRH) transcription and CRH mRNA stability by glucocorticoids","volume":"21","author":"Ma","year":"2001","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.placenta.2024.12.021_bib16","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1210\/jcem-64-5-1054","article-title":"Plasma corticotropin-releasing hormone concentrations during pregnancy and parturition","volume":"64","author":"Campbell","year":"1987","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.placenta.2024.12.021_bib17","first-page":"339","article-title":"Plasma corticotropin-releasing hormone, \u03b2-endorphin and cortisol inter-relationships during human pregnancy","volume":"128","author":"Chan","year":"1993","journal-title":"Acta Endocrinol."},{"key":"10.1016\/j.placenta.2024.12.021_bib18","doi-asserted-by":"crossref","first-page":"912","DOI":"10.2741\/2113","article-title":"Corticotrophin releasing hormone and the timing of birth","volume":"12","author":"Smith","year":"2007","journal-title":"Front. Biosci."},{"key":"10.1016\/j.placenta.2024.12.021_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2023.106697","article-title":"Placental CRH trajectories during gestation and infant outcomes","volume":"160","author":"Aran","year":"2024","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.placenta.2024.12.021_bib20","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.ajog.2004.06.070","article-title":"Placental corticotropin-releasing hormone (CRH), spontaneous preterm birth, and fetal growth restriction: a prospective investigation","volume":"191","author":"Wadhwa","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2024.12.021_bib21","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1210\/jcem.86.12.8080","article-title":"The utility of plasma CRH as a predictor of preterm delivery","volume":"86","author":"Inder","year":"2001","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"10.1016\/j.placenta.2024.12.021_bib22","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.psyneuen.2009.11.007","article-title":"Levels of maternal serum corticotropin-releasing hormone (CRH) at midpregnancy in relation to maternal characteristics","volume":"35","author":"Chen","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.placenta.2024.12.021_bib23","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1471-0528.1995.tb09063.x","article-title":"Corticotrophin-releasing hormone and corticotrophin-releasing hormone binding protein in normal and pre-eclamptic human pregnancies","volume":"102","author":"Perkins","year":"1995","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.placenta.2024.12.021_bib24","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1210\/jc.2010-1740","article-title":"Changes in placental CRH, urocortins, and CRH-receptor mRNA expression associated with preterm delivery and chorioamnionitis","volume":"96","author":"Torricelli","year":"2011","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"10.1016\/j.placenta.2024.12.021_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107078","article-title":"Prenatal phthalate exposure in relation to placental corticotropin releasing hormone (pCRH) in the CANDLE cohort","volume":"160","author":"Barrett","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.placenta.2024.12.021_bib26","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0002-9378(88)80163-7","article-title":"Corticotropin-releasing hormone in amniotic fluid during gestation and labor and in relation to fetal lung maturation","volume":"159","author":"Laatikainen","year":"1988","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2024.12.021_bib27","doi-asserted-by":"crossref","DOI":"10.1007\/s40572-022-00354-8","article-title":"The placental epigenome as a molecular link between prenatal exposures and fetal health outcomes through the DOHaD hypothesis","author":"Lapehn","year":"2022","journal-title":"Current Environmental Health Reports"},{"key":"10.1016\/j.placenta.2024.12.021_bib28","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-064288","article-title":"Cohort profile: the ECHO prenatal and early childhood pathways to health consortium (ECHO-PATHWAYS)","volume":"12","author":"LeWinn","year":"2022","journal-title":"BMJ Open"},{"key":"10.1016\/j.placenta.2024.12.021_bib29","first-page":"17","volume":"1","author":"Sontag-Padilla","year":"2015","journal-title":"The Urban Child Institute CANDLE Study Methodological Overview and Baseline Sample Description"},{"key":"10.1016\/j.placenta.2024.12.021_bib30","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1093\/hmg\/ddx265","article-title":"Expression quantitative trait loci (eQTLs) in human placentas suggest developmental origins of complex diseases","volume":"26","author":"Peng","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.placenta.2024.12.021_bib31","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1210\/jc.2008-2257","article-title":"Patterns of plasma corticotropin-releasing hormone, progesterone, estradiol, and estriol change and the onset of human labor","volume":"94","author":"Smith","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.placenta.2024.12.021_bib32","doi-asserted-by":"crossref","unstructured":"Paquette Alison G. et al. A comprehensive assessment of associations between prenatal phthalate exposure and the placental transcriptomic landscape. Environmental Health Perspectives 129, 097003.","DOI":"10.1289\/EHP8973"},{"key":"10.1016\/j.placenta.2024.12.021_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107763","article-title":"Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons","volume":"172","author":"Paquette","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.placenta.2024.12.021_bib34","article-title":"Placental transcriptomic signatures of spontaneous preterm birth","author":"Paquette","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2024.12.021_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107310","article-title":"Prenatal exposure to particulate matter and placental gene expression","volume":"165","author":"Enquobahrie","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.placenta.2024.12.021_bib36","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nbt.3519","article-title":"Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat Biotech"},{"key":"10.1016\/j.placenta.2024.12.021_bib37","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.7563.1","article-title":"Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences [version 1; referees: 2 approved]","volume":"4","author":"Soneson","year":"2015","journal-title":"F1000Research"},{"key":"10.1016\/j.placenta.2024.12.021_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"voom: precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.placenta.2024.12.021_bib39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1001\/jamapsychiatry.2021.2877","article-title":"Race as a social construct in psychiatry research and practice","volume":"79","author":"Bryant","year":"2022","journal-title":"JAMA Psychiatr."},{"key":"10.1016\/j.placenta.2024.12.021_bib40","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1056\/NEJMms2029562","article-title":"Race and genetic ancestry in medicine \u2014 a time for reckoning with racism","volume":"384","author":"Borrell","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.placenta.2024.12.021_bib41","article-title":"FRY: a fast approximation to ROAST gene set test with mean aggregated set statistics","volume":"5","author":"Giner","year":"2016","journal-title":"F1000Research"},{"key":"10.1016\/j.placenta.2024.12.021_bib42","doi-asserted-by":"crossref","unstructured":"Paquette, A. et al. A genome scale transcriptional regulatory model of the human placenta. Sci. Adv. 10, eadf3411.","DOI":"10.1126\/sciadv.adf3411"},{"key":"10.1016\/j.placenta.2024.12.021_bib43","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0143-4004(95)90000-4","article-title":"Immunohistochemical localization of endothelial nitric oxide synthase in human villous and extravillous trophoblast populations and expression during syncytiotrophoblast formation in vitro","volume":"16","author":"Eis","year":"1995","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2024.12.021_bib44","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1371\/journal.pgen.0030161","article-title":"Capturing heterogeneity in gene expression studies by surrogate variable analysis","volume":"3","author":"Leek","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.placenta.2024.12.021_bib45","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/35001608","article-title":"Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis","volume":"403","author":"Mi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.placenta.2024.12.021_bib46","article-title":"The multifaceted role of GCM1 during trophoblast differentiation in the human placenta","volume":"vol. 119","author":"Jeyarajah","year":"2022"},{"key":"10.1016\/j.placenta.2024.12.021_bib47","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1210\/en.2002-220922","article-title":"The central role of human chorionic gonadotropin in the formation of human placental syncytium","volume":"144","author":"Yang","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.placenta.2024.12.021_bib48","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1210\/jc.2003-031299","article-title":"Corticotropin-releasing hormone system in human adipose tissue","volume":"89","author":"Seres","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.placenta.2024.12.021_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22083940","article-title":"Effect of central corticotropin-releasing factor on hepatic lipid metabolism and inflammation-related gene expression in rats","volume":"22","author":"Nakade","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2024.12.021_bib50","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/0026-0495(76)90119-0","article-title":"Carbohydrate and lipid metabolism during human labor: free fatty acids, glucose, insulin, and lactic acid metabolism during normal and oxytocin-induced labor for postmaturity","volume":"25","author":"Kashyap","year":"1976","journal-title":"Metabolism"},{"key":"10.1016\/j.placenta.2024.12.021_bib51","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1210\/jc.2004-1513","article-title":"Polyol concentrations in the fluid compartments of the human conceptus during the first trimester of pregnancy: maintenance of redox potential in a low oxygen environment","volume":"90","author":"Jauniaux","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.placenta.2024.12.021_bib52","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1203\/01.PDR.0000180549.86614.73","article-title":"Fetal and maternal non-glucose carbohydrates and polyols concentrations in normal human pregnancies at term","volume":"58","author":"Brusati","year":"2005","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.placenta.2024.12.021_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114093","article-title":"Aryl hydrocarbon receptor (AHR) functions: balancing opposing processes including inflammatory reactions","volume":"178","author":"Bock","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.placenta.2024.12.021_bib54","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.3390\/ijms19123762","article-title":"Expression, localization, and activity of the aryl hydrocarbon receptor in the human placenta","volume":"19","author":"Wakx","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2024.12.021_bib55","article-title":"ITE and TCDD differentially regulate the vascular remodeling of rat placenta via the activation of AhR","volume":"9","author":"Wu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.placenta.2024.12.021_bib56","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/his.12681","article-title":"GATA3 expression in gestational trophoblastic tissues and tumours","volume":"67","author":"Mirkovic","year":"2015","journal-title":"Histopathology"},{"key":"10.1016\/j.placenta.2024.12.021_bib57","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1093\/humupd\/dmac027","article-title":"BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis","volume":"28","author":"Louwen","year":"2022","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.placenta.2024.12.021_bib58","doi-asserted-by":"crossref","first-page":"9744","DOI":"10.1128\/MCB.24.22.9744-9751.2004","article-title":"Essential requirement of CCAAT\/enhancer binding proteins in embryogenesis","volume":"24","author":"B\u00e9gay","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.placenta.2024.12.021_bib59","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1080\/14767058.2017.1397119","article-title":"Fatty acid transporter expression and regulation is impaired in placental macrovascular endothelial cells in obese women","volume":"32","author":"Yang","year":"2019","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.placenta.2024.12.021_bib60","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.plipres.2008.11.001","article-title":"Transport of fatty acids across the human placenta: a review","volume":"48","author":"Duttaroy","year":"2009","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.placenta.2024.12.021_bib61","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.biocel.2011.01.017","article-title":"C-terminal binding protein: a metabolic sensor implicated in regulating adipogenesis","volume":"43","author":"Jack","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.placenta.2024.12.021_bib62","doi-asserted-by":"crossref","first-page":"6315","DOI":"10.1038\/s41467-021-26638-5","article-title":"The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis","volume":"12","author":"Sekiya","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.placenta.2024.12.021_bib63","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1113\/JP278553","article-title":"What's so special about lipid transport in the human placenta?","volume":"597","author":"Thornburg","year":"2019","journal-title":"J Physiol"},{"key":"10.1016\/j.placenta.2024.12.021_bib64","article-title":"The expression and localization of N-myc downstream-regulated gene 1 in human trophoblasts","volume":"8","author":"Shi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.placenta.2024.12.021_bib65","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mce.2012.05.007","article-title":"Corticotropin-releasing hormone regulates common target genes with divergent functions in corticotrope and neuronal cells","volume":"362","author":"Graf","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.placenta.2024.12.021_bib66","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1021\/pr0605421","article-title":"Identification of novel protein biomarkers of preterm birth in human Cervical\u2212Vaginal fluid","volume":"6","author":"Pereira","year":"2007","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.placenta.2024.12.021_bib67","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1210\/jc.2016-3831","article-title":"Cord blood adipocyte fatty acid\u2013binding protein levels correlate with gestational age and birth weight in neonates","volume":"102","author":"Joung","year":"2017","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"10.1016\/j.placenta.2024.12.021_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155413","article-title":"Transcription analysis of the myometrium of labouring and non-labouring women","volume":"11","author":"Sharp","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.placenta.2024.12.021_bib69","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.placenta.2024.11.007","article-title":"A transcriptomic comparison of in vitro models of the human placenta","volume":"159","author":"Lapehn","year":"2024","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2024.12.021_bib70","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1477-7827-11-30","article-title":"Effects of corticotrophin releasing hormone (CRH) on cell viability and differentiation in the human BeWo choriocarcinoma cell line: a potential syncytialisation inducer distinct from cyclic adenosine monophosphate (cAMP)","volume":"11","author":"Chen","year":"2013","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.placenta.2024.12.021_bib71","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1006\/viro.2002.1428","article-title":"Developmental expression of HERV-R (ERV3) and HERV-K in human tissue","volume":"297","author":"Andersson","year":"2002","journal-title":"Virology"},{"key":"10.1016\/j.placenta.2024.12.021_bib72","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.placenta.2021.01.006","article-title":"Syncytins expressed in human placental trophoblast","volume":"113","author":"Roberts","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2024.12.021_bib73","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-023-02403-6","article-title":"Placental transcriptomic signatures of prenatal and preconceptional maternal stress","author":"Baker","year":"2024","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.placenta.2024.12.021_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.socscimed.2020.113461","article-title":"Maternal exposure to childhood traumatic events, but not multi-domain psychosocial stressors, predict placental corticotrophin releasing hormone across pregnancy","volume":"266","author":"Steine","year":"2020","journal-title":"Soc. Sci. Med."},{"key":"10.1016\/j.placenta.2024.12.021_bib75","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1001\/jamapediatrics.2020.2904","article-title":"Identification of modifiable social and behavioral factors associated with childhood cognitive performance","volume":"174","author":"LeWinn","year":"2020","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.placenta.2024.12.021_bib76","article-title":"Preterm birth and corticotrophin-releasing hormone as a placental clock","volume":"164","author":"Herrera","year":"2023","journal-title":"Endocrinology"},{"key":"10.1016\/j.placenta.2024.12.021_bib77","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1289\/EHP595","article-title":"Small-magnitude effect sizes in epigenetic end points are important in children's environmental health studies: the children's environmental health and Disease prevention research center's epigenetics working group","volume":"125","author":"Breton","year":"2017","journal-title":"Environmental Health Perspectives"},{"key":"10.1016\/j.placenta.2024.12.021_bib78","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1011689","article-title":"Prenatal polycyclic aromatic hydrocarbon (PAH) exposure in relation to placental corticotropin releasing hormone (pCRH) in the CANDLE pregnancy cohort","volume":"13","author":"Barrett","year":"2022","journal-title":"Front. Endocrinol."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400424008129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400424008129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T19:31:01Z","timestamp":1750102261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400424008129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":78,"alternative-id":["S0143400424008129"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2024.12.021","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations between maternal plasma concentrations of corticotrophin releasing hormone and the placental transcriptome","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2024.12.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}