{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T16:48:40Z","timestamp":1747068520296,"version":"3.37.3"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["104-2314-B-006-071-MY2","106-2314-B-006-066-","108-2314-B-006-062-","110-2314-B-006-037-MY3"],"award-info":[{"award-number":["104-2314-B-006-071-MY2","106-2314-B-006-066-","108-2314-B-006-062-","110-2314-B-006-037-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.placenta.2025.01.005","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T07:35:05Z","timestamp":1736494505000},"page":"14-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Association studies of vasoactive genes and preeclampsia in taiwan"],"prefix":"10.1016","volume":"161","author":[{"given":"Mei-Lin","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fong-Ming","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Hsing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Hwan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung-Lin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2025.01.005_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijchy.2021.100084","article-title":"Association of family history with incidence and gestational hypertension outcomes of preeclampsia","volume":"9","author":"Wu","year":"2021","journal-title":"Int J Cardiol Hypertens"},{"issue":"3","key":"10.1016\/j.placenta.2025.01.005_bib2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1471-0528.2004.00042x.x","article-title":"The importance of genetic and environmental effects for pre-eclampsia and gestational hypertension: a family study","volume":"111","author":"Nilsson","year":"2004","journal-title":"BJOG"},{"issue":"5","key":"10.1016\/j.placenta.2025.01.005_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197217","article-title":"The genetic component of preeclampsia: a whole-exome sequencing study","volume":"13","author":"Hansen","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.placenta.2025.01.005_bib4","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1042\/CS20050323","article-title":"Searching for genetic clues to the causes of pre-eclampsia","volume":"110","author":"Chappell","year":"2006","journal-title":"Clin Sci (Lond)."},{"issue":"12","key":"10.1016\/j.placenta.2025.01.005_bib5","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1056\/NEJM200103223441201","article-title":"Paternal and maternal components of the predisposition to preeclampsia","volume":"344","author":"Esplin","year":"2001","journal-title":"N. Engl. J. Med."},{"issue":"1\u20132","key":"10.1016\/j.placenta.2025.01.005_bib6","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.mce.2007.11.022","article-title":"Genetic and epigenetic factors contribute to the onset of preeclampsia","volume":"282","author":"Chelbi","year":"2008","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.placenta.2025.01.005_bib7","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/632732","article-title":"Pathogenesis of preeclampsia: the genetic component","volume":"2012","author":"Valenzuela","year":"2012","journal-title":"J Pregnancy"},{"issue":"7","key":"10.1016\/j.placenta.2025.01.005_bib8","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1001\/jamacardio.2023.1312","article-title":"Genetic risk factors associated with preeclampsia and hypertensive disorders of pregnancy","volume":"8","author":"Tyrmi","year":"2023","journal-title":"JAMA Cardiol"},{"issue":"3","key":"10.1016\/j.placenta.2025.01.005_bib9","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/humupd\/dms060","article-title":"Genetic variants in pre-eclampsia: a meta-analysis","volume":"19","author":"Buurma","year":"2013","journal-title":"Hum. Reprod. Update"},{"issue":"6","key":"10.1016\/j.placenta.2025.01.005_bib10","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1093\/ije\/dys162","article-title":"Genetic association studies in pre-eclampsia: systematic meta-analyses and field synopsis","volume":"41","author":"Staines-Urias","year":"2012","journal-title":"Int. J. Epidemiol."},{"issue":"2","key":"10.1016\/j.placenta.2025.01.005_bib11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejogrb.2006.10.005","article-title":"Genetic polymorphisms in vasoactive genes and preeclampsia: a meta-analysis","volume":"131","author":"Medica","year":"2007","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"1","key":"10.1016\/j.placenta.2025.01.005_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.21873\/invivo.12236","article-title":"The angiotensin-converting enzyme insertion\/deletion polymorphism as a common risk factor for major pregnancy complications","volume":"35","author":"Gintoni","year":"2021","journal-title":"In Vivo"},{"key":"10.1016\/j.placenta.2025.01.005_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preghy.2019.08.006","article-title":"Renin-angiotensin system gene variants and risk of early- and late-onset preeclampsia: a single center case-control study","volume":"18","author":"Procopciuc","year":"2019","journal-title":"Pregnancy Hypertens"},{"issue":"5","key":"10.1016\/j.placenta.2025.01.005_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0128230","article-title":"Genome-wide transcriptome directed pathway analysis of maternal pre-eclampsia susceptibility genes","volume":"10","author":"Yong","year":"2015","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.placenta.2025.01.005_bib15","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.placenta.2008.06.011","article-title":"The functional role of the renin-angiotensin system in pregnancy and preeclampsia","volume":"29","author":"Irani","year":"2008","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.01.005_bib16","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3389\/fendo.2019.00563","article-title":"Causes and consequences of the dysregulated maternal renin-angiotensin system in preeclampsia","volume":"10","author":"Lumbers","year":"2019","journal-title":"Front. Endocrinol."},{"issue":"8","key":"10.1016\/j.placenta.2025.01.005_bib17","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1042\/CS20130455","article-title":"The renin-angiotensin-aldosterone system in pre-eclampsia: the delicate balance between good and bad","volume":"126","author":"Verdonk","year":"2014","journal-title":"Clin Sci (Lond)."},{"key":"10.1016\/j.placenta.2025.01.005_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.preghy.2022.01.011","article-title":"Renin-angiotensin system in normal pregnancy and in preeclampsia: a comprehensive review","volume":"28","author":"Leal","year":"2022","journal-title":"Pregnancy Hypertens"},{"issue":"2 Pt 2","key":"10.1016\/j.placenta.2025.01.005_bib19","first-page":"R441","article-title":"Nitric oxide and pregnancy","volume":"272","author":"Sladek","year":"1997","journal-title":"Am. J. Physiol."},{"issue":"5","key":"10.1016\/j.placenta.2025.01.005_bib20","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1469-1809.2012.00722.x","article-title":"Angiotensinogen gene M235T and T174M polymorphisms and susceptibility of pre-eclampsia: a meta-analysis","volume":"76","author":"Lin","year":"2012","journal-title":"Ann. Hum. Genet."},{"issue":"1","key":"10.1016\/j.placenta.2025.01.005_bib21","doi-asserted-by":"crossref","DOI":"10.1177\/1470320317753924","article-title":"Contribution of angiotensinogen M235T and T174M gene variants and haplotypes to preeclampsia and its severity in (North African) Tunisians","volume":"19","author":"Zitouni","year":"2018","journal-title":"J Renin Angiotensin Aldosterone Syst."},{"issue":"1","key":"10.1016\/j.placenta.2025.01.005_bib22","doi-asserted-by":"crossref","DOI":"10.1080\/01443615.2023.2171782","article-title":"Pertinence between risk of preeclampsia and the renin-angiotensin-aldosterone system (RAAS) gene polymorphisms: an updated meta-analysis based on 73 studies","volume":"43","author":"Wang","year":"2023","journal-title":"J Obstet Gynaecol"},{"issue":"2","key":"10.1016\/j.placenta.2025.01.005_bib23","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3346\/jkms.2004.19.2.253","article-title":"Association of angiotensin-converting enzyme and angiotensinogen gene polymorphisms with preeclampsia","volume":"19","author":"Choi","year":"2004","journal-title":"J Korean Med Sci."},{"key":"10.1016\/j.placenta.2025.01.005_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/108206","article-title":"Studies on angiotensin-converting enzyme insertion\/deletion polymorphism and genotype distributions in Turkish preeclampsia patients","volume":"2012","author":"Bereketo\u011flu","year":"2012","journal-title":"J Pregnancy"},{"issue":"4","key":"10.1016\/j.placenta.2025.01.005_bib25","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1161\/01.HYP.0000063146.40351.AD","article-title":"Maternal-fetal flow, negative events, and preeclampsia: role of ACE I\/D polymorphism","volume":"41","author":"Mello","year":"2003","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.placenta.2025.01.005_bib26","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.4238\/2012.May.21.1","article-title":"Meta analysis of angiotensin-converting enzyme I\/D polymorphism as a risk factor for preeclampsia in Chinese women","volume":"11","author":"Zhong","year":"2012","journal-title":"Genet. Mol. Res."},{"issue":"6","key":"10.1016\/j.placenta.2025.01.005_bib27","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1097\/00004872-199917060-00007","article-title":"Angiotensin-converting enzyme insertion-deletion polymorphism in normotensive and pre-eclamptic pregnancies","volume":"17","author":"Morgan","year":"1999","journal-title":"J. Hypertens."},{"issue":"3","key":"10.1016\/j.placenta.2025.01.005_bib28","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1067\/mob.2001.116722","article-title":"Insertion-deletion polymorphism in the gene for angiotensin-converting enzyme is associated with obstetric cholestasis but not with preeclampsia","volume":"185","author":"Heiskanen","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.placenta.2025.01.005_bib29","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejogrb.2004.01.035","article-title":"Associations of polymorphisms of the angiotensinogen M235 polymorphism and angiotensin-converting-enzyme intron 16 insertion\/deletion polymorphism with preeclampsia in Korean women","volume":"116","author":"Kim","year":"2004","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"3","key":"10.1016\/j.placenta.2025.01.005_bib30","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/10641955.2020.1769644","article-title":"An insertion-deletion polymorphism in angiotensin-converting enzyme is associated with a reduced risk of preeclampsia: an evidence-based meta-analysis from 44 studies","volume":"39","author":"Huang","year":"2020","journal-title":"Hypertens. Pregnancy"},{"issue":"26","key":"10.1016\/j.placenta.2025.01.005_bib31","article-title":"eNOS genetic polymorphisms and cancer risk: a meta-analysis and a case-control study of breast cancer","volume":"94","author":"Gao","year":"2015","journal-title":"Medicine (Baltim.)"},{"issue":"10","key":"10.1016\/j.placenta.2025.01.005_bib32","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1097\/00004872-200210000-00022","article-title":"The Glu298Asp polymorphism of the NOS 3 gene as a determinant of the baseline production of nitric oxide","volume":"20","author":"Veldman","year":"2002","journal-title":"J. Hypertens."},{"key":"10.1016\/j.placenta.2025.01.005_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/793040","article-title":"Endothelial nitric oxide synthase gene polymorphisms and the risk of hypertension in an Indian population","volume":"2014","author":"Shankarishan","year":"2014","journal-title":"BioMed Res. Int."},{"issue":"5","key":"10.1016\/j.placenta.2025.01.005_bib34","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/01.fpc.0000199499.08725.d5","article-title":"A -786T>C polymorphism in the endothelial nitric oxide synthase gene reduces serum nitrite\/nitrate levels from the heart due to an intracoronary injection of acetylcholine","volume":"16","author":"Nakayama","year":"2006","journal-title":"Pharmacogenetics Genom."},{"issue":"1","key":"10.1016\/j.placenta.2025.01.005_bib35","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/bbrc.1998.8267","article-title":"Evidence of association of the ecNOS gene polymorphism with plasma NO metabolite levels in humans","volume":"245","author":"Tsukada","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.placenta.2025.01.005_bib36","article-title":"Associations between nitric oxide synthase 3 gene polymorphisms and preeclampsia risk: a meta-analysis","volume":"6","author":"Zeng","year":"2016","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.placenta.2025.01.005_bib37","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/hr.2016.95","article-title":"Endothelial nitric oxide synthase gene G894T polymorphism and risk assessment for pregnancy-induced hypertension: evidence from 11 700 subjects","volume":"39","author":"Ma","year":"2016","journal-title":"Hypertens. Res."},{"issue":"12","key":"10.1016\/j.placenta.2025.01.005_bib38","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1007\/s43032-021-00632-0","article-title":"Association between endothelial nitric oxide synthase (eNOS) -786 T\/C and 27-bp VNTR 4b\/a polymorphisms and preeclampsia development","volume":"28","author":"Sljivancanin","year":"2021","journal-title":"Reprod. Sci."},{"issue":"24","key":"10.1016\/j.placenta.2025.01.005_bib39","first-page":"5321","article-title":"Population structure of Han Chinese in the modern Taiwanese population based on 10,000 participants in the Taiwan Biobank project","volume":"25","author":"Chen","year":"2016","journal-title":"Hum. Mol. Genet."},{"year":"2018","series-title":"Risk Factors for Preeclampsia","author":"Shiozaki","key":"10.1016\/j.placenta.2025.01.005_bib40"},{"issue":"5 Pt 1","key":"10.1016\/j.placenta.2025.01.005_bib41","first-page":"1691","article-title":"National high blood pressure education program working group report on high blood pressure in pregnancy","volume":"163","year":"1990","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.placenta.2025.01.005_bib42","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1067\/mob.2000.107928","article-title":"Report of the national high blood pressure education program working group on high blood pressure in pregnancy","volume":"183","year":"2000","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"9461","key":"10.1016\/j.placenta.2025.01.005_bib43","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet."},{"issue":"2","key":"10.1016\/j.placenta.2025.01.005_bib44","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.tjog.2012.04.014","article-title":"Interleukin-1\u03b2 gene is not associated with preeclampsia in Taiwanese","volume":"51","author":"Kang","year":"2012","journal-title":"Taiwan. J. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.placenta.2025.01.005_bib45","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.tjog.2014.04.017","article-title":"An association study of interleukin-4 gene and preeclampsia in Taiwan","volume":"53","author":"Kang","year":"2014","journal-title":"Taiwan. J. Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.placenta.2025.01.005_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11030862","article-title":"Polymorphisms within the tumor necrosis factor-alpha gene is associated with preeclampsia in Taiwanese Han populations","volume":"11","author":"Lin","year":"2023","journal-title":"Biomedicines"},{"issue":"5","key":"10.1016\/j.placenta.2025.01.005_bib47","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/S0002-9378(16)32981-7","article-title":"Angiotensin-converting enzyme: serum levels during normal pregnancy","volume":"135","author":"Parente","year":"1979","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.placenta.2025.01.005_bib48","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0092-8674(92)90275-H","article-title":"Molecular basis of human hypertension: role of angiotensinogen","volume":"71","author":"Jeunemaitre","year":"1992","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.placenta.2025.01.005_bib49","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1056\/NEJM199503163321103","article-title":"A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease","volume":"332","author":"Lindpaintner","year":"1995","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.placenta.2025.01.005_bib50","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s004390000454","article-title":"The missense Glu298Asp variant of the endothelial nitric oxide synthase gene is strongly associated with placental abruption","volume":"108","author":"Yoshimura","year":"2001","journal-title":"Hum. Genet."},{"issue":"2","key":"10.1016\/j.placenta.2025.01.005_bib51","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1101\/gr.2.2.112","article-title":"Modeling of heteroduplex formation during PCR from mixtures of DNA templates","volume":"2","author":"Ruano","year":"1992","journal-title":"PCR Methods Appl."},{"issue":"1","key":"10.1016\/j.placenta.2025.01.005_bib52","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/(SICI)1096-8628(19970221)74:1<91::AID-AJMG18>3.0.CO;2-M","article-title":"Rapid molecular haplotyping of the first exon of the human dopamine D4 receptor gene by heteroduplex analysis","volume":"74","author":"Chang","year":"1997","journal-title":"Am. J. Med. Genet."},{"issue":"1","key":"10.1016\/j.placenta.2025.01.005_bib53","first-page":"181","article-title":"Diagnosis and management of gestational hypertension and preeclampsia","volume":"102","author":"Sibai","year":"2003","journal-title":"Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.placenta.2025.01.005_bib54","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/GCO.0b013e3282f73380","article-title":"Hypertensive disorders of pregnancy: the United States perspective","volume":"20","author":"Sibai","year":"2008","journal-title":"Curr. Opin. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.placenta.2025.01.005_bib56","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1161\/01.HYP.0000104525.76016.77","article-title":"Implication of an AGT haplotype in a multigene association study with pregnancy hypertension","volume":"43","author":"L\u00e9vesque","year":"2004","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.placenta.2025.01.005_bib77","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1038\/s41598-017-05411-z","article-title":"The gene variants of maternal\/fetal renin-angiotensin system in preeclampsia: a hybrid case-parent\/mother-control study","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.placenta.2025.01.005_bib78","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1080\/01443615.2020.1837757","article-title":"A study of the association between angiotensinogen (AGT) gene polymorphism (M235T) and preeclampsia in Thai pregnant women","volume":"41","author":"Jansaka","year":"2021","journal-title":"J Obstet Gynaecol"},{"key":"10.1016\/j.placenta.2025.01.005_bib79","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.placenta.2022.01.004","article-title":"Associations between AGT, MTHFR, and VEGF gene polymorphisms and preeclampsia in the Chinese population","volume":"118","author":"Ding","year":"2022","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.01.005_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2023.103924","article-title":"Preeclampsia is associated with reduced renin, aldosterone, and PlGF levels, and increased sFlt-1\/PlGF ratio, and specific angiotensin-converting enzyme Ins-Del gene variants","volume":"157","author":"Zitouni","year":"2023","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.placenta.2025.01.005_bib80","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8875230","article-title":"I\/D polymorphism gene ACE and risk of preeclampsia in women with gestational diabetes mellitus","volume":"2020","author":"Dmitrenko","year":"2020","journal-title":"Dis. Markers"},{"issue":"12","key":"10.1016\/j.placenta.2025.01.005_bib81","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/s41371-018-0096-4","article-title":"ACE gene rs4343 polymorphism elevates the risk of preeclampsia in pregnant women","volume":"32","author":"Abedin Do","year":"2018","journal-title":"J. Hum. Hypertens."},{"issue":"12","key":"10.1016\/j.placenta.2025.01.005_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e22223","article-title":"The gene polymorphisms of eNOS and MTHFR modulates the development of preeclampsia in Han population","volume":"9","author":"Rao","year":"2023","journal-title":"Heliyon"},{"issue":"2","key":"10.1016\/j.placenta.2025.01.005_bib66","doi-asserted-by":"crossref","DOI":"10.1080\/14767058.2023.2290918","article-title":"Association of endothelial nitric oxide synthase gene variants in pre-eclampsia: an updated systematic review and meta-analysis","volume":"36","author":"Tesfa","year":"2023","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"3","key":"10.1016\/j.placenta.2025.01.005_bib65","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000358831","article-title":"Polymorphisms of the endothelial nitric oxide synthase gene in preeclampsia in a Han Chinese population","volume":"77","author":"Chen","year":"2014","journal-title":"Gynecol. Obstet. Invest."},{"issue":"3","key":"10.1016\/j.placenta.2025.01.005_bib82","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.tjog.2018.11.035","article-title":"The VNTR polymorphism of the endothelial nitric oxide synthase gene and blood pressure in women at the end of pregnancy","volume":"58","author":"Reshetnikov","year":"2019","journal-title":"Taiwan. J. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.placenta.2025.01.005_bib55","first-page":"145","article-title":"Implications of the angiotensin converting enzyme gene insertion\/deletion polymorphism in health and disease: a snapshot review","volume":"1","author":"Gard","year":"2010","journal-title":"Int J Mol Epidemiol Genet"},{"issue":"6","key":"10.1016\/j.placenta.2025.01.005_bib57","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/ahg.12323","article-title":"Association study of M235T and A-6G polymorphisms in angiotensinogen gene with risk of developing preeclampsia in Iranian population","volume":"83","author":"Alaee","year":"2019","journal-title":"Ann. Hum. Genet."},{"issue":"1\u20132","key":"10.1016\/j.placenta.2025.01.005_bib58","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cccn.2003.11.010","article-title":"The association between preeclampsia and angiotensin-converting enzyme insertion\/deletion polymorphism","volume":"341","author":"G\u00fcrd\u00f6l","year":"2004","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.placenta.2025.01.005_bib59","doi-asserted-by":"crossref","DOI":"10.1007\/s10528-023-10620-5","article-title":"Association of ACE\u2217(Insertion\/Deletion) variant with the elevated risk of preeclampsia among gestational women","author":"El Azab","year":"2024","journal-title":"Biochem. Genet."},{"issue":"12","key":"10.1016\/j.placenta.2025.01.005_bib61","doi-asserted-by":"crossref","first-page":"7984","DOI":"10.1002\/jcp.30470","article-title":"Novel insights for the role of nitric oxide in placental vascular function during and beyond pregnancy","volume":"236","author":"Krause","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"9","key":"10.1016\/j.placenta.2025.01.005_bib62","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1007\/s00726-015-2014-1","article-title":"The role of arginine, homoarginine and nitric oxide in pregnancy","volume":"47","author":"Khalil","year":"2015","journal-title":"Amino Acids"},{"issue":"6 Pt 1","key":"10.1016\/j.placenta.2025.01.005_bib63","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1373\/49.6.847","article-title":"Genotype-specific influence on nitric oxide synthase gene expression, protein concentrations, and enzyme activity in cultured human endothelial cells","volume":"49","author":"Song","year":"2003","journal-title":"Clin. Chem."},{"issue":"6","key":"10.1016\/j.placenta.2025.01.005_bib64","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1161\/hy1201.097305","article-title":"Endothelial nitric oxide synthase gene polymorphism and maternal vascular adaptation to pregnancy","volume":"38","author":"Savvidou","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.placenta.2025.01.005_bib68","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1471-2393-11-89","article-title":"Polymorphisms of the endothelial nitric oxide synthase (NOS3) gene in preeclampsia: a candidate-gene association study","volume":"11","author":"Zdoukopoulos","year":"2011","journal-title":"BMC Pregnancy Childbirth"},{"issue":"4","key":"10.1016\/j.placenta.2025.01.005_bib69","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jsgi.2003.12.002","article-title":"Polymorphisms of thrombophilic and vasoactive genes and severe preeclampsia: a pilot study","volume":"11","author":"Tempfer","year":"2004","journal-title":"J. Soc. Gynecol. Invest."},{"issue":"1","key":"10.1016\/j.placenta.2025.01.005_bib70","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000072324","article-title":"Genetic and environmental contributions to severe preeclampsia: lack of association with the endothelial nitric oxide synthase Glu298Asp variant in a developing country","volume":"56","author":"Yoshimura","year":"2003","journal-title":"Gynecol. Obstet. Invest."},{"issue":"5 Pt 1","key":"10.1016\/j.placenta.2025.01.005_bib71","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.amjhyper.2004.01.006","article-title":"No association of the Asp298 variant of the endothelial nitric oxide synthase gene with preeclampsia","volume":"17","author":"Landau","year":"2004","journal-title":"Am. J. Hypertens."},{"issue":"3","key":"10.1016\/j.placenta.2025.01.005_bib72","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00109-004-0618-0","article-title":"Association of angiotensinogen haplotypes with angiotensinogen levels but not with blood pressure or coronary artery disease: the Ludwigshafen Risk and Cardiovascular Health Study","volume":"83","author":"Renner","year":"2005","journal-title":"J Mol Med (Berl)."},{"issue":"3","key":"10.1016\/j.placenta.2025.01.005_bib73","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/physiolgenomics.00076.2002","article-title":"Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse","volume":"11","author":"Cvetkovic","year":"2002","journal-title":"Physiol. Genom."},{"issue":"1","key":"10.1016\/j.placenta.2025.01.005_bib74","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1399-0004.1997.tb02411.x","article-title":"Genetic variation of the angiotensin-converting enzyme gene: increased frequency of the insertion allele in Koreans","volume":"51","author":"Hong","year":"1997","journal-title":"Clin. Genet."},{"issue":"2","key":"10.1016\/j.placenta.2025.01.005_bib75","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0928-4680(01)00068-2","article-title":"Polymorphisms in angiotensinogen gene (M235T and G(-6)A) in multifactorial diseases","volume":"8","author":"Vask","year":"2001","journal-title":"Pathophysiology"},{"issue":"4","key":"10.1016\/j.placenta.2025.01.005_bib76","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI114844","article-title":"An insertion\/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels","volume":"86","author":"Rigat","year":"1990","journal-title":"J. Clin. Invest."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400425000153?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400425000153?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T07:26:25Z","timestamp":1740468385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400425000153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":82,"alternative-id":["S0143400425000153"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2025.01.005","relation":{},"ISSN":["0143-4004"],"issn-type":[{"type":"print","value":"0143-4004"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association studies of vasoactive genes and preeclampsia in taiwan","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2025.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}