{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T23:29:02Z","timestamp":1792970942609,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471720"],"award-info":[{"award-number":["82471720"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2704703"],"award-info":[{"award-number":["2022YFC2704703"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.placenta.2025.03.014","type":"journal-article","created":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T04:14:22Z","timestamp":1742616862000},"page":"4-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Indole-3-lactic acid derived from tryptophan metabolism promotes trophoblast migration and invasion by activating the AhR\/VCAN pathway"],"prefix":"10.1016","volume":"165","author":[{"given":"Yingying","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengtian","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1745-3183","authenticated-orcid":false,"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.placenta.2025.03.014_bib1","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1097\/AOG.0000000000003891","article-title":"Gestational hypertension and preeclampsia: ACOG practice bulletin, number 222","volume":"135","year":"2020","journal-title":"Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.placenta.2025.03.014_bib2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41572-023-00417-6","article-title":"Pre-eclampsia","volume":"9","author":"Dimitriadis","year":"2023","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"10297","key":"10.1016\/j.placenta.2025.03.014_bib3","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0140-6736(20)32335-7","article-title":"Pre-eclampsia","volume":"398","author":"Chappell","year":"2021","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.placenta.2025.03.014_bib4","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","article-title":"Preeclampsia: pathophysiology, challenges, and perspectives","volume":"124","author":"Rana","year":"2019","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.placenta.2025.03.014_bib5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41581-019-0119-6","article-title":"Pre-eclampsia: pathogenesis, novel diagnostics and therapies","volume":"15","author":"Phipps","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.placenta.2025.03.014_bib6","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1038\/s41467-018-05470-4","article-title":"Microbial tryptophan catabolites in health and disease","volume":"9","author":"Roager","year":"2018","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.placenta.2025.03.014_bib7","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","article-title":"Gut microbiota regulation of tryptophan metabolism in health and disease","volume":"23","author":"Agus","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"8","key":"10.1016\/j.placenta.2025.03.014_bib8","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.cmet.2023.06.004","article-title":"Tryptophan metabolism in health and disease","volume":"35","author":"Xue","year":"2023","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.placenta.2025.03.014_bib9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.5468\/ogs.2014.57.4.249","article-title":"The tryptophan utilization concept in pregnancy","volume":"57","author":"Badawy","year":"2014","journal-title":"Obstet. Gynecol. Sci."},{"issue":"1","key":"10.1016\/j.placenta.2025.03.014_bib10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0029-7844(96)00084-1","article-title":"Decreased plasma tryptophan in pregnancy","volume":"88","author":"Schrocksnadel","year":"1996","journal-title":"Obstet. Gynecol."},{"issue":"5","key":"10.1016\/j.placenta.2025.03.014_bib11","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20150197","article-title":"Tryptophan metabolism, disposition and utilization in pregnancy","volume":"35","author":"Badawy","year":"2015","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.placenta.2025.03.014_bib12","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3389\/fimmu.2014.00230","article-title":"The role of placental tryptophan catabolism","volume":"5","author":"Sedlmayr","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.placenta.2025.03.014_bib13","doi-asserted-by":"crossref","DOI":"10.1177\/1178646919840321","article-title":"Altered tryptophan catabolism in placentas from women with pre-eclampsia","volume":"12","author":"Keaton","year":"2019","journal-title":"Int. J. Tryptophan Res."},{"issue":"3","key":"10.1016\/j.placenta.2025.03.014_bib14","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1067\/mob.2003.156","article-title":"Decreased tryptophan catabolism by placental indoleamine 2,3-dioxygenase in preeclampsia","volume":"188","author":"Kudo","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.placenta.2025.03.014_bib15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/HYPERTENSIONAHA.120.14970","article-title":"l-Tryptophan-Induced vasodilation is enhanced in preeclampsia: studies on its uptake and metabolism in the human placenta","volume":"76","author":"Broekhuizen","year":"2020","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.placenta.2025.03.014_bib16","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1007\/s43032-021-00759-0","article-title":"Differential distribution of tryptophan-metabolites in fetal and maternal circulations during normotensive and preeclamptic pregnancies","volume":"29","author":"Zhao","year":"2022","journal-title":"Reprod. Sci."},{"issue":"1","key":"10.1016\/j.placenta.2025.03.014_bib17","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2347728","article-title":"Human gut-associated Bifidobacterium species salvage exogenous indole, a uremic toxin precursor, to synthesize indole-3-lactic acid via tryptophan","volume":"16","author":"Yong","year":"2024","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.placenta.2025.03.014_bib18","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s40168-022-01408-7","article-title":"Lactobacillus reuteri tryptophan metabolism promotes host susceptibility to CNS autoimmunity","volume":"10","author":"Montgomery","year":"2022","journal-title":"Microbiome"},{"issue":"6353","key":"10.1016\/j.placenta.2025.03.014_bib19","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1126\/science.aah5825","article-title":"Lactobacillus reuteri induces gut intraepithelial CD4(+)CD8alphaalpha(+) T cells","volume":"357","author":"Cervantes-Barragan","year":"2017","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.placenta.2025.03.014_bib20","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12967-023-04109-3","article-title":"Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia\/reperfusion injury via positive regulation of YAP and Nrf2","volume":"21","author":"Zhang","year":"2023","journal-title":"J. Transl. Med."},{"issue":"6","key":"10.1016\/j.placenta.2025.03.014_bib21","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.cmet.2023.04.015","article-title":"Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8(+) T cell immunity","volume":"35","author":"Zhang","year":"2023","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.placenta.2025.03.014_bib22","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/s41564-023-01363-5","article-title":"Microbiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer","volume":"8","author":"Han","year":"2023","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.placenta.2025.03.014_bib23","article-title":"Indole-3-lactic acid derived from tryptophan metabolism alleviates the sFlt-1-induced preeclampsia-like phenotype via the activation of aryl hydrocarbon receptor","author":"Wei","year":"2024","journal-title":"Life Sci."},{"issue":"10","key":"10.1016\/j.placenta.2025.03.014_bib24","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1124\/dmd.115.064246","article-title":"Indole and tryptophan metabolism: endogenous and dietary routes to ah receptor activation","volume":"43","author":"Hubbard","year":"2015","journal-title":"Drug Metab. Dispos."},{"issue":"8","key":"10.1016\/j.placenta.2025.03.014_bib25","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1369\/jhc.2010.955955","article-title":"Expression of aryl hydrocarbon receptor in human placentas and fetal tissues","volume":"58","author":"Jiang","year":"2010","journal-title":"J. Histochem. Cytochem."},{"issue":"12","key":"10.1016\/j.placenta.2025.03.014_bib26","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nrc3846","article-title":"Aryl hydrocarbon receptor ligands in cancer: friend and foe","volume":"14","author":"Murray","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.placenta.2025.03.014_bib27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev.pharmtox.43.100901.135828","article-title":"Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals","volume":"43","author":"Denison","year":"2003","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"3","key":"10.1016\/j.placenta.2025.03.014_bib28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1124\/mol.116.107367","article-title":"Buprenorphine, norbuprenorphine, R-methadone, and S-methadone upregulate BCRP\/ABCG2 expression by activating aryl hydrocarbon receptor in human placental trophoblasts","volume":"91","author":"Neradugomma","year":"2017","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.placenta.2025.03.014_bib29","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.reprotox.2020.08.008","article-title":"Aryl hydrocarbon receptor (AhR) agonist beta-naphthoflavone regulated gene networks in human primary trophoblasts","volume":"96","author":"El-Dairi","year":"2020","journal-title":"Reprod. Toxicol."},{"issue":"2","key":"10.1016\/j.placenta.2025.03.014_bib30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.toxlet.2013.09.014","article-title":"Dexamethasone accelerates degradation of aryl hydrocarbon receptor (AHR) and suppresses CYP1A1 induction in placental JEG-3 cell line","volume":"223","author":"Stejskalova","year":"2013","journal-title":"Toxicol. Lett."},{"issue":"3","key":"10.1016\/j.placenta.2025.03.014_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms8030398","article-title":"Potential effects of indole-3-lactic acid, a metabolite of human bifidobacteria, on NGF-induced neurite outgrowth in PC12 cells","volume":"8","author":"Wong","year":"2020","journal-title":"Microorganisms"},{"issue":"48","key":"10.1016\/j.placenta.2025.03.014_bib32","doi-asserted-by":"crossref","first-page":"18792","DOI":"10.1021\/acs.jafc.3c06183","article-title":"Indole-3-Lactic acid, a tryptophan metabolite of lactiplantibacillus plantarum DPUL-S164, improved intestinal barrier damage by activating AhR and Nrf2 signaling pathways","volume":"71","author":"Wang","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.placenta.2025.03.014_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2021.101611","article-title":"Overexpressed versican promoted cell multiplication, migration and invasion in gastric cancer","volume":"73","author":"Zhai","year":"2021","journal-title":"Tissue Cell"},{"issue":"1","key":"10.1016\/j.placenta.2025.03.014_bib34","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1530\/REP-18-0333","article-title":"Versican V1 in human endometrial epithelial cells promotes BeWo spheroid adhesion in vitro","volume":"157","author":"Miyazaki","year":"2019","journal-title":"Reproduction"},{"issue":"4","key":"10.1016\/j.placenta.2025.03.014_bib35","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/humupd\/dmaa017","article-title":"Investigation of human trophoblast invasion in vitro","volume":"26","author":"Abbas","year":"2020","journal-title":"Hum. Reprod. Update"},{"issue":"1","key":"10.1016\/j.placenta.2025.03.014_bib36","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1186\/s12916-022-02657-x","article-title":"Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study","volume":"20","author":"Li","year":"2022","journal-title":"BMC Med."},{"issue":"2","key":"10.1016\/j.placenta.2025.03.014_bib37","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1042\/CS20191253","article-title":"Short-chain fatty acids accompanying changes in the gut microbiome contribute to the development of hypertension in patients with preeclampsia","volume":"134","author":"Chang","year":"2020","journal-title":"Clin. Sci. (Lond.)"},{"issue":"1","key":"10.1016\/j.placenta.2025.03.014_bib38","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s12866-021-02327-7","article-title":"Gut microbiota changes in preeclampsia, abnormal placental growth and healthy pregnant women","volume":"21","author":"Huang","year":"2021","journal-title":"BMC Microbiol."},{"issue":"9","key":"10.1016\/j.placenta.2025.03.014_bib39","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1097\/CM9.0000000000000734","article-title":"Gut microbiota dysbiosis in preeclampsia patients in the second and third trimesters","volume":"133","author":"Wang","year":"2020","journal-title":"Chin Med J (Engl)."},{"issue":"11","key":"10.1016\/j.placenta.2025.03.014_bib40","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1161\/CIRCRESAHA.120.317612","article-title":"Kynurenine relaxes arteries of normotensive women and those with preeclampsia","volume":"128","author":"Worton","year":"2021","journal-title":"Circ. Res."},{"issue":"20","key":"10.1016\/j.placenta.2025.03.014_bib41","doi-asserted-by":"crossref","DOI":"10.1172\/JCI158346","article-title":"Impaired renal reserve contributes to preeclampsia via the kynurenine and soluble fms-like tyrosine kinase 1 pathway","volume":"132","author":"Dupont","year":"2022","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.placenta.2025.03.014_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114429","article-title":"Limosilactobacillus reuteri ameliorates preeclampsia in mice via improving gut dysbiosis and endothelial dysfunction","volume":"161","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"45","key":"10.1016\/j.placenta.2025.03.014_bib43","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2309032120","article-title":"Bacterial indole-3-lactic acid affects epithelium-macrophage crosstalk to regulate intestinal homeostasis","volume":"120","author":"Yu","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"1","key":"10.1016\/j.placenta.2025.03.014_bib44","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s40168-024-01896-9","article-title":"Bacteroides uniformis degrades beta-glucan to promote Lactobacillus johnsonii improving indole-3-lactic acid levels in alleviating colitis","volume":"12","author":"Zhang","year":"2024","journal-title":"Microbiome"},{"key":"10.1016\/j.placenta.2025.03.014_bib45","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.reprotox.2015.11.005","article-title":"Potential involvement of placental AhR in unexplained recurrent spontaneous abortion","volume":"59","author":"Wu","year":"2016","journal-title":"Reprod. Toxicol."},{"issue":"47","key":"10.1016\/j.placenta.2025.03.014_bib46","doi-asserted-by":"crossref","first-page":"16677","DOI":"10.1073\/pnas.0404379101","article-title":"Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development","volume":"101","author":"Walisser","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.placenta.2025.03.014_bib47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.placenta.2024.05.134","article-title":"The role of aryl hydrocarbon receptors in nutrient metabolism and immune regulation at the maternal-fetal interface","volume":"154","author":"Li","year":"2024","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2025.03.014_bib48","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/bbrc.1997.6053","article-title":"Benzo(a)pyrene, but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, alters cell proliferation and c-myc and growth factor expression in human placental choriocarcinoma JEG-3 cells","volume":"231","author":"Zhang","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"13","key":"10.1016\/j.placenta.2025.03.014_bib49","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1161\/CIRCULATIONAHA.123.066298","article-title":"Versican promotes cardiomyocyte proliferation and cardiac repair","volume":"149","author":"Feng","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.placenta.2025.03.014_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215779","article-title":"Versican secreted by the ovary links ovulation and migration in fallopian tube derived serous cancer","volume":"543","author":"Russo","year":"2022","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.placenta.2025.03.014_bib51","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1186\/s40001-024-02223-6","article-title":"Distinct phenotypes in the preeclamptic-like mouse model induced by adenovirus carrying sFlt1 and recombinant sFlt1 protein","volume":"29","author":"Wei","year":"2024","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.placenta.2025.03.014_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2023.156190","article-title":"sFlt-1-enriched exosomes induced endothelial cell dysfunction and a preeclampsia-like phenotype in mice","volume":"166","author":"Huang","year":"2023","journal-title":"Cytokine"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400425000852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400425000852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T23:50:00Z","timestamp":1746834600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400425000852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":52,"alternative-id":["S0143400425000852"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2025.03.014","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Indole-3-lactic acid derived from tryptophan metabolism promotes trophoblast migration and invasion by activating the AhR\/VCAN pathway","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2025.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}