{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:04:32Z","timestamp":1792681472009,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019230","name":"Wuhan Union Hospital","doi-asserted-by":"publisher","award":["2023XHYN040"],"award-info":[{"award-number":["2023XHYN040"]}],"id":[{"id":"10.13039\/501100019230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Hubei Province Natural Science Foundation","doi-asserted-by":"publisher","award":["JCZRYB202500725"],"award-info":[{"award-number":["JCZRYB202500725"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Hubei Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2022CFB092"],"award-info":[{"award-number":["2022CFB092"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Hubei Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2025AFB732"],"award-info":[{"award-number":["2025AFB732"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401991"],"award-info":[{"award-number":["82401991"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001584"],"award-info":[{"award-number":["82001584"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009076","name":"USTC","doi-asserted-by":"publisher","award":["YD9110002057"],"award-info":[{"award-number":["YD9110002057"]}],"id":[{"id":"10.13039\/501100009076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.placenta.2025.03.020","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T01:46:36Z","timestamp":1743558396000},"page":"50-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Metformin ameliorates trophoblastic immunometabolic disorders via attenuating TLR4\/NF-\u03baB signaling through ATXN7L3-mediated histone H2B monoubiquitination"],"prefix":"10.1016","volume":"165","author":[{"given":"Yang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2025.03.020_bib1","article-title":"Significance of placental mesenchymal stem cell in placenta development and implications for preeclampsia","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.placenta.2025.03.020_bib2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.placenta.2024.03.014","article-title":"Single cell RNA-sequencing reveals the cellular senescence of placental mesenchymal stem\/stromal cell in preeclampsia","volume":"150","author":"Zhang","year":"2024","journal-title":"Placenta"},{"issue":"Suppl A","key":"10.1016\/j.placenta.2025.03.020_bib3","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/j.placenta.2008.11.021","article-title":"Placental stress and pre-eclampsia: a revised view","volume":"30","author":"Redman","year":"2009","journal-title":"Placenta"},{"issue":"2s","key":"10.1016\/j.placenta.2025.03.020_bib4","doi-asserted-by":"crossref","first-page":"S928","DOI":"10.1016\/j.ajog.2020.11.005","article-title":"Placental energy metabolism in health and disease-significance of development and implications for preeclampsia","volume":"226","author":"Aye","year":"2022","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.placenta.2025.03.020_bib5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1161\/CIRCRESAHA.120.318805","article-title":"Immunometabolic endothelial phenotypes: integrating inflammation and glucose metabolism","volume":"129","author":"Xiao","year":"2021","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.placenta.2025.03.020_bib6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-kappaB: a key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J. Clin. Investig."},{"issue":"2","key":"10.1016\/j.placenta.2025.03.020_bib7","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/fsn3.1342","article-title":"Gastrodin improves preeclampsia-induced cell apoptosis by regulation of TLR4\/NF-\u03baB in rats","volume":"8","author":"Mei","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.placenta.2025.03.020_bib8","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.preghy.2020.10.006","article-title":"Apocynin inhibits placental TLR4\/NF-\u03baB signaling pathway and ameliorates preeclampsia-like symptoms in rats","volume":"22","author":"Sha","year":"2020","journal-title":"Pregnancy Hypertens"},{"issue":"4","key":"10.1016\/j.placenta.2025.03.020_bib9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/ni.2833","article-title":"TLR-driven early glycolytic reprogramming via the kinases TBK1-IKK\u025b supports the anabolic demands of dendritic cell activation","volume":"15","author":"Everts","year":"2014","journal-title":"Nat. Immunol."},{"issue":"23","key":"10.1016\/j.placenta.2025.03.020_bib10","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1182\/blood-2009-10-249540","article-title":"Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation","volume":"115","author":"Krawczyk","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.placenta.2025.03.020_bib11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cellimm.2018.04.002","article-title":"LPS enhances platelets aggregation via TLR4, which is related to mitochondria damage caused by intracellular ROS, but not extracellular ROS","volume":"328","author":"Feng","year":"2018","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.placenta.2025.03.020_bib12","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/1806344","article-title":"Metformin corrects glucose metabolism reprogramming and NLRP3 inflammasome-induced pyroptosis via inhibiting the TLR4\/NF-\u03baB\/PFKFB3 signaling in trophoblasts: implication for a potential therapy of preeclampsia","volume":"2021","author":"Zhang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.placenta.2025.03.020_bib13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.placenta.2021.02.014","article-title":"PFKFB3 regulates lipopolysaccharide-induced excessive inflammation and cellular dysfunction in HTR-8\/Svneo cells: implications for the role of PFKFB3 in preeclampsia","volume":"106","author":"Zhang","year":"2021","journal-title":"Placenta"},{"issue":"4","key":"10.1016\/j.placenta.2025.03.020_bib14","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.molcel.2016.03.030","article-title":"ATXN7L3 and ENY2 coordinate activity of multiple H2B deubiquitinases important for cellular proliferation and tumor growth","volume":"62","author":"Atanassov","year":"2016","journal-title":"Mol. Cells"},{"issue":"11","key":"10.1016\/j.placenta.2025.03.020_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12113462","article-title":"Histone monoubiquitination in chromatin remodelling: focus on the histone H2B interactome and cancer","volume":"12","author":"Marsh","year":"2020","journal-title":"Cancers"},{"issue":"4","key":"10.1016\/j.placenta.2025.03.020_bib16","article-title":"USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta","volume":"146","author":"Koutelou","year":"2019","journal-title":"Development (Camb., England)"},{"issue":"8","key":"10.1016\/j.placenta.2025.03.020_bib17","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1038\/s41418-021-00759-2","article-title":"Histone H2Bub1 deubiquitylation is essential for mouse development, but does not regulate global RNA polymerase II transcription","volume":"28","author":"Wang","year":"2021","journal-title":"Cell Death Differ."},{"issue":"13","key":"10.1016\/j.placenta.2025.03.020_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23137459","article-title":"SAGA-dependent histone H2Bub1 deubiquitination is essential for cellular ubiquitin balance during embryonic development","volume":"23","author":"El-Saafin","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"23","key":"10.1016\/j.placenta.2025.03.020_bib19","article-title":"The H2Bub1-deposition complex is required for human and mouse cardiogenesis","volume":"150","author":"Barish","year":"2023","journal-title":"Development (Camb., England)"},{"issue":"6","key":"10.1016\/j.placenta.2025.03.020_bib20","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.celrep.2016.01.020","article-title":"RNF20 links histone H2B ubiquitylation with inflammation and inflammation-associated cancer","volume":"14","author":"Tarcic","year":"2016","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.placenta.2025.03.020_bib21","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/ecco-jcc\/jjy165","article-title":"Loss of RNF40 decreases NF-\u03baB activity in colorectal cancer cells and reduces colitis burden in mice","volume":"13","author":"Kosinsky","year":"2019","journal-title":"J. Crohn's & colitis"},{"issue":"5","key":"10.1016\/j.placenta.2025.03.020_bib22","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1038\/s41418-019-0450-2","article-title":"Epigenetic regulation of the Warburg effect by H2B monoubiquitination","volume":"27","author":"Jing","year":"2020","journal-title":"Cell Death Differ."},{"issue":"9","key":"10.1016\/j.placenta.2025.03.020_bib23","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41419-023-06157-5","article-title":"RNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer","volume":"14","author":"Prokakis","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.placenta.2025.03.020_bib24","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3389\/fendo.2020.00191","article-title":"Metformin and its benefits for various diseases","volume":"11","author":"Lv","year":"2020","journal-title":"Front. Endocrinol."},{"issue":"5","key":"10.1016\/j.placenta.2025.03.020_bib25","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1056\/NEJMoa1509819","article-title":"Metformin versus placebo in obese pregnant women without diabetes mellitus","volume":"374","author":"Syngelaki","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.placenta.2025.03.020_bib26","article-title":"Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis","volume":"350","author":"Balsells","year":"2015","journal-title":"BMJ (Clinical research ed.)"},{"issue":"5","key":"10.1016\/j.placenta.2025.03.020_bib27","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1210\/jc.2014-4403","article-title":"Comparative efficacy and safety of OADs in management of GDM: network meta-analysis of randomized controlled trials","volume":"100","author":"Jiang","year":"2015","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"3","key":"10.1016\/j.placenta.2025.03.020_bib28","doi-asserted-by":"crossref","first-page":"356.e1","DOI":"10.1016\/j.ajog.2015.12.019","article-title":"Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction","volume":"214","author":"Brownfoot","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.placenta.2025.03.020_bib29","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.fertnstert.2018.11.032","article-title":"Direct toxicity of insulin on the human placenta and protection by metformin","volume":"111","author":"Vega","year":"2019","journal-title":"Fertil. Steril."},{"issue":"1","key":"10.1016\/j.placenta.2025.03.020_bib30","doi-asserted-by":"crossref","first-page":"9240","DOI":"10.1038\/s41598-021-88650-5","article-title":"Impact of metformin treatment during pregnancy on maternal outcomes: a systematic review\/meta-analysis","volume":"11","author":"Tarry-Adkins","year":"2021","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.placenta.2025.03.020_bib31","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.cell.2011.03.043","article-title":"Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis","volume":"145","author":"Mihaylova","year":"2011","journal-title":"Cell"},{"issue":"18","key":"10.1016\/j.placenta.2025.03.020_bib32","doi-asserted-by":"crossref","first-page":"16426","DOI":"10.1074\/jbc.M110.199372","article-title":"AMP-activated protein kinase regulates beta-catenin transcription via histone deacetylase 5","volume":"286","author":"Zhao","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.placenta.2025.03.020_bib33","doi-asserted-by":"crossref","first-page":"809","DOI":"10.3892\/ol.2014.2158","article-title":"Metformin inhibits histone H2B monoubiquitination and downstream gene transcription in human breast cancer cells","volume":"8","author":"Du","year":"2014","journal-title":"Oncol. Lett."},{"issue":"7","key":"10.1016\/j.placenta.2025.03.020_bib34","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1111\/dom.13262","article-title":"Epigenetic effects of metformin: from molecular mechanisms to clinical implications","volume":"20","author":"Bridgeman","year":"2018","journal-title":"Diabetes Obes. Metabol."},{"issue":"2","key":"10.1016\/j.placenta.2025.03.020_bib35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jphs.2017.09.032","article-title":"Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1\u03b2 secretion in human trophoblasts","volume":"135","author":"Tamura","year":"2017","journal-title":"J. Pharmacol. Sci."},{"issue":"3","key":"10.1016\/j.placenta.2025.03.020_bib36","first-page":"728","article-title":"SIRT1 alleviates LPS-induced IL-1\u03b2 production by suppressing NLRP3 inflammasome activation and ROS production in trophoblasts","volume":"9","author":"Park","year":"2020"},{"issue":"2","key":"10.1016\/j.placenta.2025.03.020_bib37","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1189\/jlb.1112603","article-title":"A leading role for the immune system in the pathophysiology of preeclampsia","volume":"94","author":"Laresgoiti-Servitje","year":"2013","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.placenta.2025.03.020_bib38","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/0002-9378(94)90463-4","article-title":"A new animal model for human preeclampsia: ultra-low-dose endotoxin infusion in pregnant rats","volume":"171","author":"Faas","year":"1994","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.placenta.2025.03.020_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124001","article-title":"Single administration of ultra-low-dose lipopolysaccharide in rat early pregnancy induces TLR4 activation in the placenta contributing to preeclampsia","volume":"10","author":"Xue","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.placenta.2025.03.020_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.103108","article-title":"ATXN7L3 positively regulates SMAD7 transcription in hepatocellular carcinoma with growth inhibitory function","volume":"62","author":"Sun","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.placenta.2025.03.020_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101437","article-title":"Comparative analysis of the mitochondrial morphology, energy metabolism, and gene expression signatures in three types of blastocyst-derived stem cells","volume":"30","author":"Choi","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.placenta.2025.03.020_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.891748","article-title":"SEC5 is involved in M2 polarization of macrophages via the STAT6 pathway, and its dysfunction in decidual macrophages is associated with recurrent spontaneous abortion","volume":"10","author":"Yang","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.placenta.2025.03.020_bib43","article-title":"Maternal siRNA silencing of placental SAA2 mitigates preterm birth following intrauterine inflammation","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"issue":"39","key":"10.1016\/j.placenta.2025.03.020_bib44","doi-asserted-by":"crossref","first-page":"27891","DOI":"10.1074\/jbc.274.39.27891","article-title":"Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB","volume":"274","author":"Hirota","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.placenta.2025.03.020_bib45","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.placenta.2008.01.006","article-title":"Hypoxia inducible factor 1 alpha regulates matrigel-induced endovascular differentiation under normoxia in a human extravillous trophoblast cell line","volume":"29","author":"Fukushima","year":"2008","journal-title":"Placenta"},{"issue":"5","key":"10.1016\/j.placenta.2025.03.020_bib46","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1530\/REP-18-0339","article-title":"H19 regulates trophoblastic spheroid adhesion by competitively binding to let-7","volume":"157","author":"He","year":"2019","journal-title":"Reproduction (Camb., England)"},{"issue":"10","key":"10.1016\/j.placenta.2025.03.020_bib47","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1080\/15548627.2022.2039000","article-title":"A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence","volume":"18","author":"Yang","year":"2022","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.placenta.2025.03.020_bib48","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.ajpath.2011.10.023","article-title":"Placental syndecan expression is altered in human idiopathic fetal growth restriction","volume":"180","author":"Chui","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.placenta.2025.03.020_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1002616","article-title":"African swine fever virus infection activates inflammatory responses through downregulation of the anti-inflammatory molecule C1QTNF3","volume":"13","author":"Lv","year":"2022","journal-title":"Front. Immunol."},{"issue":"18","key":"10.1016\/j.placenta.2025.03.020_bib50","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1101\/gad.250225.114","article-title":"The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription","volume":"28","author":"Bonnet","year":"2014","journal-title":"Gene Dev."},{"issue":"42","key":"10.1016\/j.placenta.2025.03.020_bib51","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.1038\/onc.2017.187","article-title":"let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery","volume":"36","author":"Spolverini","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.placenta.2025.03.020_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.103179","article-title":"Hepatocellular carcinoma reduces ATXN7L3 to evade estrogen-dependent growth suppression","volume":"63","author":"Bean","year":"2021","journal-title":"EBioMedicine"},{"issue":"4","key":"10.1016\/j.placenta.2025.03.020_bib53","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.2353\/ajpath.2007.061273","article-title":"Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension","volume":"171","author":"Socha","year":"2007","journal-title":"Am. J. Pathol."},{"issue":"8","key":"10.1016\/j.placenta.2025.03.020_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13081817","article-title":"USP22 suppresses SPARC expression in acute colitis and inflammation-associated colorectal cancer","volume":"13","author":"Kosinsky","year":"2021","journal-title":"Cancers"},{"issue":"4","key":"10.1016\/j.placenta.2025.03.020_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13040739","article-title":"Metformin reduces histone H3K4me3 at the promoter regions of positive cell cycle regulatory genes in lung cancer cells","volume":"13","author":"Kim","year":"2021","journal-title":"Cancers"},{"issue":"6","key":"10.1016\/j.placenta.2025.03.020_bib56","first-page":"1899","article-title":"Metformin inhibits ovarian cancer via decreasing H3K27 trimethylation","volume":"52","author":"Tang","year":"2018","journal-title":"Int. J. Oncol."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400425000918?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400425000918?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T07:57:27Z","timestamp":1762243047000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400425000918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":56,"alternative-id":["S0143400425000918"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2025.03.020","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metformin ameliorates trophoblastic immunometabolic disorders via attenuating TLR4\/NF-\u03baB signaling through ATXN7L3-mediated histone H2B monoubiquitination","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2025.03.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}