{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:55:23Z","timestamp":1792097723411,"version":"4.4.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["24ZR1459500"],"award-info":[{"award-number":["24ZR1459500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471726"],"award-info":[{"award-number":["82471726"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.placenta.2025.04.011","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:05:05Z","timestamp":1746183905000},"page":"140-151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Single-cell RNA sequencing reveals altered placental microenvironment due to maternal high-fat diet"],"prefix":"10.1016","volume":"167","author":[{"given":"Xing-yu","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-dan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-ren","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-nan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-nan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-hong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7472-4402","authenticated-orcid":false,"given":"Yan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2025.04.011_bib1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S2352-4642(21)00374-6","article-title":"Global, regional, and country estimates of metabolic syndrome burden in children and adolescents in 2020: a systematic review and modelling analysis","volume":"6","author":"Noubiap","year":"2022","journal-title":"Lancet Child Adolesc. Health"},{"key":"10.1016\/j.placenta.2025.04.011_bib2","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/nutrit\/nux053","article-title":"Developmental origins of health and disease: current knowledge and potential mechanisms","volume":"75","author":"Hoffman","year":"2017","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.placenta.2025.04.011_bib3","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00002.2020","article-title":"Developmental origins of metabolic diseases","volume":"101","author":"Hoffman","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.placenta.2025.04.011_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2020.581723","article-title":"Maternal high-fat diet leads to non-alcoholic fatty liver disease through upregulating hepatic SCD1 expression in Neonate rats","volume":"7","author":"Cao","year":"2020","journal-title":"Front. Nutr."},{"key":"10.1016\/j.placenta.2025.04.011_bib5","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/cells9010184","article-title":"A review of FoxO1-regulated metabolic diseases and related drug discoveries","volume":"9","author":"Peng","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.placenta.2025.04.011_bib6","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1146\/annurev-cellbio-100814-125620","article-title":"Placenta: the forgotten organ","volume":"31","author":"Maltepe","year":"2015","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.placenta.2025.04.011_bib7","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1152\/physrev.00029.2015","article-title":"Placental origins of chronic disease","volume":"96","author":"Burton","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.placenta.2025.04.011_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.108977","article-title":"Obesity phenotype induced by high-fat diet leads to maternal-fetal constraint, placental inefficiency, and fetal growth restriction in mice","volume":"104","author":"Sanches","year":"2022","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.placenta.2025.04.011_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aat6114","article-title":"Immune responses at the maternal-fetal interface","volume":"4","author":"Ander","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.placenta.2025.04.011_bib10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jri.2017.10.045","article-title":"The role of decidual immune cells on human pregnancy","volume":"124","author":"Liu","year":"2017","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.placenta.2025.04.011_bib11","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.52004","article-title":"Single cell transcriptional signatures of the human placenta in term and preterm parturition","volume":"8","author":"Pique-Regi","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.placenta.2025.04.011_bib12","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","article-title":"Single-cell reconstruction of the early maternal\u2013fetal interface in humans","volume":"563","author":"Vento-Tormo","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.placenta.2025.04.011_bib13","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.cell.2018.02.001","article-title":"Mapping the mouse cell atlas by microwell-seq","volume":"172","author":"Han","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.placenta.2025.04.011_bib14","article-title":"Single-cell RNA sequencing reveals the heterogeneity of tumor-associated macrophage in non-small cell lung cancer and differences between sexes","volume":"12","author":"Yang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.placenta.2025.04.011_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2021.112715","article-title":"Single-cell RNA-seq revealed diverse cell types in the mouse placenta at mid-gestation","volume":"405","author":"Zhou","year":"2021","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.placenta.2025.04.011_bib16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41576-019-0169-4","article-title":"Mechanisms of early placental development in mouse and humans","volume":"21","author":"Hemberger","year":"2020","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.placenta.2025.04.011_bib17","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41421-022-00513-z","article-title":"A differentiation roadmap of murine placentation at single-cell resolution","volume":"9","author":"Jiang","year":"2023","journal-title":"Cell Discov"},{"key":"10.1016\/j.placenta.2025.04.011_bib18","doi-asserted-by":"crossref","first-page":"E1164","DOI":"10.1073\/pnas.1112304108","article-title":"A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast","volume":"108","author":"Dupressoir","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.placenta.2025.04.011_bib19","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.devcel.2021.06.005","article-title":"De novo generation of macrophage from placenta-derived hemogenic endothelium","volume":"56","author":"Liang","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.placenta.2025.04.011_bib20","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.3390\/nu15143263","article-title":"Dietary folic acid supplementation attenuates maternal high-fat diet-induced fetal intrauterine growth retarded via ameliorating placental inflammation and oxidative stress in rats","volume":"15","author":"Zhang","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.placenta.2025.04.011_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2016.00028","article-title":"Placental adaptation: what can we learn from birthweight:placental weight ratio?","volume":"7","author":"Hayward","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.placenta.2025.04.011_bib22","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/nm1452","article-title":"Decidual NK cells regulate key developmental processes at the human fetal-maternal interface","volume":"12","author":"Hanna","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.placenta.2025.04.011_bib23","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200891","article-title":"Phenotypic and functional characterization of first-trimester human placental macrophages, Hofbauer cells","volume":"218","author":"Thomas","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.placenta.2025.04.011_bib24","doi-asserted-by":"crossref","first-page":"R213","DOI":"10.1530\/REP-20-0007","article-title":"Placental glycogen stores and fetal growth: insights from genetic mouse models","volume":"159","author":"Tunster","year":"2020","journal-title":"Reprod. Camb. Engl."},{"key":"10.1016\/j.placenta.2025.04.011_bib25","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1159\/000355222","article-title":"The placental exposome: placental determinants of fetal adiposity and postnatal body composition","volume":"63","author":"Lewis","year":"2013","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.placenta.2025.04.011_bib26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fphys.2016.00012","article-title":"Placental responses to changes in the maternal environment determine fetal growth","volume":"7","author":"Dimasuay","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.placenta.2025.04.011_bib27","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.60266","article-title":"Single nuclei RNA-seq of mouse placental labyrinth development","volume":"9","author":"Marsh","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.placenta.2025.04.011_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11414","article-title":"Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal-foetal interface during pregnancy","volume":"7","author":"Nelson","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.placenta.2025.04.011_bib29","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1146\/annurev.immunol.21.120601.141152","article-title":"BAFF and april: a tutorial on B cell survival","volume":"21","author":"Mackay","year":"2003","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.placenta.2025.04.011_bib30","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev-pathmechdis-111523-023459","article-title":"Cell responses to the placenta and fetus","volume":"20","author":"Rizzuto","year":"2025","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"10.1016\/j.placenta.2025.04.011_bib31","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4103\/2096-2924.268161","article-title":"Role of decidual natural killer cells at the maternal\u2013fetal interface during pregnancy","volume":"3","author":"Yang","year":"2019","journal-title":"Reprod. Dev. Med."},{"key":"10.1016\/j.placenta.2025.04.011_bib32","doi-asserted-by":"crossref","first-page":"L360","DOI":"10.1152\/ajplung.00105.2015","article-title":"Maternal high-fat diet is associated with impaired fetal lung development","volume":"309","author":"Mayor","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.placenta.2025.04.011_bib33","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.placenta.2007.12.010","article-title":"Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta","volume":"29","author":"Challier","year":"2008","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.04.011_bib34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.placenta.2014.01.003","article-title":"Maternal obesity is associated with a lipotoxic placental environment","volume":"35","author":"Saben","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.04.011_bib35","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3390\/ijms26010395","article-title":"Mechanism of THBS1 regulation of MDCK cell proliferation and apoptosis through TGF-\u03b2\/smad signalling","volume":"26","author":"Li","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2025.04.011_bib36","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/biolre\/ioaa166","article-title":"Maternal high fat diet-induced obesity affects trophoblast differentiation and placental function in mice","volume":"103","author":"Kretschmer","year":"2020","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.placenta.2025.04.011_bib37","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1161\/CIRCULATIONAHA.122.061934","article-title":"Placental inflammation leads to abnormal embryonic heart development","volume":"147","author":"Ward","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.placenta.2025.04.011_bib38","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3390\/nu12020296","article-title":"Effect of maternal obesity in mice on IL-6 levels and placental endothelial cell homeostasis","volume":"12","author":"Kretschmer","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.placenta.2025.04.011_bib39","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1002\/dvdy.20981","article-title":"Origin and characteristics of glycogen cells in the developing murine placenta","volume":"235","author":"Coan","year":"2006","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.placenta.2025.04.011_bib40","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.placenta.2017.01.114","article-title":"Review: alterations in placental glycogen deposition in complicated pregnancies: current preclinical and clinical evidence","volume":"54","author":"Akison","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.04.011_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01414","article-title":"What defines NK cell functional fate: phenotype or metabolism?","volume":"10","author":"Poznanski","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.placenta.2025.04.011_bib42","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1002\/JLB.MR0718-260R","article-title":"NK cell metabolism","volume":"105","author":"Gardiner","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.placenta.2025.04.011_bib43","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cmet.2019.06.001","article-title":"Macrophages and metabolism in the tumor microenvironment","volume":"30","author":"Vitale","year":"2019","journal-title":"Cell Metab."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400425001134?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400425001134?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T07:56:11Z","timestamp":1762242971000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400425001134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":43,"alternative-id":["S0143400425001134"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2025.04.011","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-cell RNA sequencing reveals altered placental microenvironment due to maternal high-fat diet","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2025.04.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}