{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:14:46Z","timestamp":1782958486934,"version":"3.54.5"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007824","name":"Soochow University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471158"],"award-info":[{"award-number":["32471158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171112"],"award-info":[{"award-number":["32171112"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271713"],"award-info":[{"award-number":["82271713"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20405"],"award-info":[{"award-number":["U23A20405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970859"],"award-info":[{"award-number":["31970859"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.placenta.2025.05.006","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T02:29:47Z","timestamp":1746844187000},"page":"12-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Molecular insights into the corin function at the uteroplacental interface"],"prefix":"10.1016","volume":"180","author":[{"given":"Ningzheng","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0561-9315","authenticated-orcid":false,"given":"Qingyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2025.05.006_bib1","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1152\/physrev.00031.2019","article-title":"Physiology of the endometrium and regulation of menstruation","volume":"100","author":"Critchley","year":"2020","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.placenta.2025.05.006_bib2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1055\/s-2007-991042","article-title":"Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives","volume":"25","author":"Gellersen","year":"2007","journal-title":"Semin. Reprod. Med."},{"key":"10.1016\/j.placenta.2025.05.006_bib3","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.163422","article-title":"Vascular changes in the cycling and early pregnant uterus","volume":"8","author":"Massri","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.placenta.2025.05.006_bib4","doi-asserted-by":"crossref","first-page":"14926","DOI":"10.1074\/jbc.274.21.14926","article-title":"Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart","volume":"274","author":"Yan","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.placenta.2025.05.006_bib5","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1126\/science.abj8754","article-title":"Accurate prediction of protein structures and interactions using a three-track neural network","volume":"373","author":"Baek","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.placenta.2025.05.006_bib6","doi-asserted-by":"crossref","first-page":"20963","DOI":"10.1074\/jbc.M110.217570","article-title":"Human corin isoforms with different cytoplasmic tails that alter cell surface targeting","volume":"286","author":"Qi","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.placenta.2025.05.006_bib7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s42003-025-07545-7","article-title":"Positively charged cytoplasmic residues in corin prevent signal peptidase cleavage and endoplasmic reticulum retention","volume":"8","author":"Li","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.placenta.2025.05.006_bib8","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.35672","article-title":"N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding","volume":"7","author":"Wang","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.placenta.2025.05.006_bib9","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.56059","article-title":"A conserved LDL-receptor motif regulates corin and CD320 membrane targeting in polarized renal epithelial cells","volume":"9","author":"Zhang","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.placenta.2025.05.006_bib10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ajpath.2023.09.008","article-title":"Overexpression of corin ameliorates kidney fibrosis through inhibition of wnt\/\u03b2-catenin signaling in mice","volume":"194","author":"Su","year":"2024","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.placenta.2025.05.006_bib11","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/nm.3920","article-title":"PCSK6-mediated corin activation is essential for normal blood pressure","volume":"21","author":"Chen","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.placenta.2025.05.006_bib12","article-title":"Proprotein convertase subtilisin\/kexin 6 in cardiovascular biology and disease","volume":"23","author":"Wu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2025.05.006_bib13","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1042\/BST20190760","article-title":"Function and regulation of corin in physiology and disease","volume":"48","author":"Dong","year":"2020","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.placenta.2025.05.006_bib14","doi-asserted-by":"crossref","first-page":"10066","DOI":"10.1074\/jbc.M110.185082","article-title":"Ectodomain shedding and autocleavage of the cardiac membrane protease corin","volume":"286","author":"Jiang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.placenta.2025.05.006_bib15","doi-asserted-by":"crossref","first-page":"6931","DOI":"10.1046\/j.1432-1033.2000.01806.x","article-title":"Localization of the mosaic transmembrane serine protease corin to heart myocytes","volume":"267","author":"Hooper","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.placenta.2025.05.006_bib16","doi-asserted-by":"crossref","first-page":"8525","DOI":"10.1073\/pnas.150149097","article-title":"Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme","volume":"97","author":"Yan","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.placenta.2025.05.006_bib17","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMoa2301908","article-title":"Corin and left atrial cardiomyopathy, hypertension, arrhythmia, and fibrosis","volume":"389","author":"Baris Feldman","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.placenta.2025.05.006_bib18","first-page":"1","article-title":"BNP molecular forms and processing by the cardiac serine protease corin","volume":"61","author":"Ichiki","year":"2013","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.placenta.2025.05.006_bib19","doi-asserted-by":"crossref","first-page":"R639","DOI":"10.1152\/ajpregu.00074.2015","article-title":"Pro-B-type natriuretic peptide is cleaved intracellularly: impact of distance between O-glycosylation and cleavage sites","volume":"309","author":"Nishikimi","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.placenta.2025.05.006_bib20","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1152\/physrev.00022.2015","article-title":"Molecular physiology of membrane guanylyl cyclase receptors","volume":"96","author":"Kuhn","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.placenta.2025.05.006_bib21","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1161\/CIRCRESAHA.116.306082","article-title":"Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of \u03b2-adrenoceptor-stimulated contractility in early cardiac hypertrophy","volume":"116","author":"Perera","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.placenta.2025.05.006_bib22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/s12933-024-02475-w","article-title":"Cardiac corin and atrial natriuretic peptide regulate liver glycogen metabolism and glucose homeostasis","volume":"23","author":"Li","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.placenta.2025.05.006_bib23","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.3390\/biology11081101","article-title":"Corin deficiency alters adipose tissue phenotype and impairs thermogenesis in mice","volume":"11","author":"Zhang","year":"2022","journal-title":"Biology"},{"key":"10.1016\/j.placenta.2025.05.006_bib24","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1172\/JCI59701","article-title":"Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes","volume":"122","author":"Bordicchia","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.placenta.2025.05.006_bib25","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.biochi.2015.05.017","article-title":"Natriuretic peptide control of energy balance and glucose homeostasis","volume":"124","author":"Cou\u00e9","year":"2016","journal-title":"Biochimie"},{"key":"10.1016\/j.placenta.2025.05.006_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108075","article-title":"Atrial natriuretic peptide orchestrates a coordinated physiological response to fuel non-shivering thermogenesis","volume":"32","author":"Carper","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.placenta.2025.05.006_bib27","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1172\/JCI64526","article-title":"Natriuretic peptides enhance the oxidative capacity of human skeletal muscle","volume":"122","author":"Engeli","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.placenta.2025.05.006_bib28","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.2337\/db09-0393","article-title":"Natriuretic peptides\/cGMP\/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity","volume":"58","author":"Miyashita","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.placenta.2025.05.006_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adl4374","article-title":"Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity","volume":"10","author":"Carper","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.placenta.2025.05.006_bib30","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/s42003-024-07077-6","article-title":"Deficiencies in corin and atrial natriuretic peptide-mediated signaling impair endochondral ossification in bone development","volume":"7","author":"Zhou","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.placenta.2025.05.006_bib31","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1002\/mc.23739","article-title":"The serine protease CORIN promotes progression of gastric cancer by mediating the ERK1\/2 MAPK pathway","volume":"63","author":"Hong","year":"2024","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.placenta.2025.05.006_bib32","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1161\/CIRCULATIONAHA.105.568881","article-title":"Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension","volume":"112","author":"Dries","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.placenta.2025.05.006_bib33","doi-asserted-by":"crossref","first-page":"7867","DOI":"10.1074\/jbc.M112.411512","article-title":"Corin mutation R539C from hypertensive patients impairs zymogen activation and generates an inactive alternative ectodomain fragment","volume":"288","author":"Dong","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.placenta.2025.05.006_bib34","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1002\/humu.23318","article-title":"Identification and functional analysis of CORIN variants in hypertensive patients","volume":"38","author":"Zhang","year":"2017","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.placenta.2025.05.006_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.625072","article-title":"Single-nucleotide polymorphisms in the 3' untranslated region of corin associated with cardiovascular diseases in a Chinese han population: a case-control study","volume":"8","author":"Zhao","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.placenta.2025.05.006_bib36","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1111\/jch.14401","article-title":"Associations of corin genetic polymorphisms with salt sensitivity, blood pressure changes, and hypertension incidence in Chinese adults","volume":"23","author":"Zou","year":"2021","journal-title":"J. Clin. Hypertens."},{"key":"10.1016\/j.placenta.2025.05.006_bib37","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1056\/NEJMc2313870","article-title":"Corin and left atrial cardiomyopathy, hypertension, arrhythmia, and fibrosis","volume":"390","author":"Dominy","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.placenta.2025.05.006_bib38","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.gene.2018.01.080","article-title":"Association of rs2271037 and rs3749585 polymorphisms in CORIN with susceptibility to hypertension in a Chinese Han population: a case-control study","volume":"651","author":"Chen","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.placenta.2025.05.006_bib39","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1161\/01.HYP.0000258566.95867.9e","article-title":"Corin I555(P568) allele is associated with enhanced cardiac hypertrophic response to increased systemic afterload","volume":"49","author":"Rame","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.placenta.2025.05.006_bib40","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1161\/CIRCHEARTFAILURE.109.866822","article-title":"Dysfunctional corin i555(p568) allele is associated with impaired brain natriuretic peptide processing and adverse outcomes in blacks with systolic heart failure: results from the Genetic Risk Assessment in Heart Failure substudy","volume":"2","author":"Rame","year":"2009","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.placenta.2025.05.006_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1164524","article-title":"Corin deficiency impairs cardiac function in mouse models of heart failure","volume":"10","author":"Niu","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.placenta.2025.05.006_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1120487","article-title":"Falling corin and ANP activity levels accelerate development of heart failure and cardiac fibrosis","volume":"10","author":"Gladysheva","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.placenta.2025.05.006_bib43","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/HYPERTENSIONAHA.112.193631","article-title":"Corin overexpression improves cardiac function, heart failure, and survival in mice with dilated cardiomyopathy","volume":"61","author":"Gladysheva","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.placenta.2025.05.006_bib44","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.3390\/ijms21103456","article-title":"Corin overexpression reduces myocardial infarct size and modulates cardiomyocyte apoptotic cell death","volume":"21","author":"Sullivan","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2025.05.006_bib45","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3390\/ijms21010203","article-title":"Cardiac-specific overexpression of catalytically inactive corin reduces edema, contractile dysfunction, and death in mice with dilated cardiomyopathy","volume":"21","author":"Tripathi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2025.05.006_bib46","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.019961","article-title":"Recombinant soluble corin improves cardiac function in mouse models of heart failure","volume":"10","author":"Niu","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.placenta.2025.05.006_bib47","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.035858","article-title":"Association between genetically determined serum corin and the risk of stroke in Chinese adults: a mendelian randomization study","volume":"13","author":"Liu","year":"2024","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.placenta.2025.05.006_bib48","article-title":"Association between CORIN promoter methylation and stroke: results from two independent samples of Chinese adults","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Neurol."},{"key":"10.1016\/j.placenta.2025.05.006_bib49","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1161\/STROKEAHA.114.008368","article-title":"Serum soluble corin is decreased in stroke","volume":"46","author":"Peng","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.placenta.2025.05.006_bib50","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.035075","article-title":"Serum soluble corin and long-term clinical outcomes after acute ischemic stroke","volume":"13","author":"Wang","year":"2024","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.placenta.2025.05.006_bib51","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/humrep\/det028","article-title":"Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first trimester decidua","volume":"28","author":"Kaitu'u-Lino","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.placenta.2025.05.006_bib52","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nature10897","article-title":"Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy","volume":"484","author":"Cui","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.placenta.2025.05.006_bib53","doi-asserted-by":"crossref","first-page":"19425","DOI":"10.1073\/pnas.2003913117","article-title":"Kr\u00fcppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy","volume":"117","author":"Wang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.placenta.2025.05.006_bib54","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.placenta.2012.11.016","article-title":"Role of corin and atrial natriuretic peptide in preeclampsia","volume":"34","author":"Zhou","year":"2013","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.05.006_bib55","doi-asserted-by":"crossref","first-page":"38390","DOI":"10.1074\/jbc.M205686200","article-title":"Genomic structures of the human and murine corin genes and functional GATA elements in their promoters","volume":"277","author":"Pan","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.placenta.2025.05.006_bib56","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/cvr\/cvab102","article-title":"Isolation and characterization of human embryonic stem cell-derived heart field-specific cardiomyocytes unravels new insights into their transcriptional and electrophysiological profiles","volume":"118","author":"Pezhouman","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.placenta.2025.05.006_bib57","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s13287-024-03741-0","article-title":"Retinoic acid modulation guides human-induced pluripotent stem cell differentiation towards left or right ventricle-like cardiomyocytes","volume":"15","author":"Zhang","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.placenta.2025.05.006_bib58","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.69584","article-title":"Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomes","volume":"10","author":"Mika","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.placenta.2025.05.006_bib59","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1172\/JCI65710","article-title":"BMPR2 is required for postimplantation uterine function and pregnancy maintenance","volume":"123","author":"Nagashima","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.placenta.2025.05.006_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2024.102408","article-title":"Axl deficiency promotes preeclampsia and vascular malformations in mice","volume":"36","author":"Zhou","year":"2025","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.placenta.2025.05.006_bib61","doi-asserted-by":"crossref","DOI":"10.1172\/JCI151053","article-title":"Atrial natriuretic peptide promotes uterine decidualization and a TRAIL-dependent mechanism in spiral artery remodeling","volume":"131","author":"Zhang","year":"2021","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.placenta.2025.05.006_bib62","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0143-4004(98)90055-8","article-title":"Decidual spiral artery remodelling begins before cellular interaction with cytotrophoblasts","volume":"19","author":"Craven","year":"1998","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.05.006_bib63","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.3390\/ijms24076182","article-title":"Investigating the effects of atrial natriuretic peptide on the maternal endothelium to determine potential implications for preeclampsia","volume":"24","author":"Binder","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2025.05.006_bib64","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200833RRR","article-title":"ANP promotes HTR-8\/SVneo cell invasion by upregulating protein kinase N 3 via autophagy inhibition","volume":"37","author":"Chu","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.placenta.2025.05.006_bib65","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.12659\/MSM.915449","article-title":"Is atrial natriuretic peptide (ANP) and natriuretic peptide receptor-A (NPR-A) expression in human placenta and decidua normal?","volume":"25","author":"Tan","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.placenta.2025.05.006_bib66","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1161\/CIRCULATIONAHA.123.064391","article-title":"A galectin-9-driven CD11c(high) decidual macrophage subset suppresses uterine vascular remodeling in preeclampsia","volume":"149","author":"Li","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.placenta.2025.05.006_bib67","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","article-title":"Single-cell reconstruction of the early maternal-fetal interface in humans","volume":"563","author":"Vento-Tormo","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.placenta.2025.05.006_bib68","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1161\/CIRCRESAHA.122.320771","article-title":"Gut dysbiosis promotes preeclampsia by regulating macrophages and trophoblasts","volume":"131","author":"Jin","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.placenta.2025.05.006_bib69","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.immuni.2021.03.021","article-title":"The CD94\/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice","volume":"54","author":"Shreeve","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.placenta.2025.05.006_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114881","article-title":"CD36-mediated arachidonic acid influx from decidual stromal cells increases inflammatory macrophages in miscarriage","volume":"43","author":"Chen","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.placenta.2025.05.006_bib71","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0140-6736(20)32335-7","article-title":"Pre-eclampsia","volume":"398","author":"Chappell","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.placenta.2025.05.006_bib72","article-title":"Natriuretic peptide signaling in uterine biology and preeclampsia","volume":"24","author":"Wu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2025.05.006_bib73","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1001\/jamacardio.2023.1312","article-title":"Genetic risk factors associated with preeclampsia and hypertensive disorders of pregnancy","volume":"8","author":"Tyrmi","year":"2023","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.placenta.2025.05.006_bib74","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/s41591-023-02374-9","article-title":"Polygenic prediction of preeclampsia and gestational hypertension","volume":"29","author":"Honigberg","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.placenta.2025.05.006_bib75","doi-asserted-by":"crossref","first-page":"17909","DOI":"10.1074\/jbc.M114.551424","article-title":"Corin mutations K317E and S472G from preeclamptic patients alter zymogen activation and cell surface targeting","volume":"289","author":"Dong","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.placenta.2025.05.006_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113176","article-title":"Highly significant association between two common single nucleotide polymorphisms in CORIN gene and preeclampsia in Caucasian women","volume":"9","author":"Stepanian","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.placenta.2025.05.006_bib77","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.tig.2021.06.014","article-title":"Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation","volume":"38","author":"Kan","year":"2022","journal-title":"Trends Genet."},{"key":"10.1016\/j.placenta.2025.05.006_bib78","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1136\/pmj-2022-141802","article-title":"Association between CORIN methylation and hypertension in Chinese adults","volume":"99","author":"Shi","year":"2023","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.placenta.2025.05.006_bib79","doi-asserted-by":"crossref","DOI":"10.1212\/NXG.0000000000000679","article-title":"DNA methylation of the natriuretic peptide system genes and ischemic stroke: gene-based and gene set analyses","volume":"8","author":"Peng","year":"2022","journal-title":"Neurol. Genet."},{"key":"10.1016\/j.placenta.2025.05.006_bib80","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.placenta.2024.02.005","article-title":"Association between CORIN promoter methylation and hypertensive disorders of pregnancy - a nested case-control study","volume":"148","author":"Fan","year":"2024","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.05.006_bib81","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","article-title":"The role of m6A modification in the biological functions and diseases","volume":"6","author":"Jiang","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.placenta.2025.05.006_bib82","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.gendis.2022.05.032","article-title":"Decreased expression of m6A demethylase ALKBH5 in decidua contributes to preeclampsia via m6A-CORIN-HuR pathway","volume":"10","author":"Yang","year":"2023","journal-title":"Genes Dis."},{"key":"10.1016\/j.placenta.2025.05.006_bib83","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adi0077","article-title":"Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human","volume":"16","author":"Roh","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.placenta.2025.05.006_bib84","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1053\/j.semperi.2009.02.008","article-title":"Cardiopulmonary complications of pre-eclampsia","volume":"33","author":"Bauer","year":"2009","journal-title":"Semin. Perinatol."},{"key":"10.1016\/j.placenta.2025.05.006_bib85","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1161\/HYPERTENSIONAHA.110.162321","article-title":"Maternal cardiac dysfunction and remodeling in women with preeclampsia at term","volume":"57","author":"Melchiorre","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.placenta.2025.05.006_bib86","first-page":"68","article-title":"Pregnancy-associated cardiac hypertrophy in corin-deficient mice: observations in a transgenic model of preeclampsia","volume":"35","author":"Baird","year":"2019","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.placenta.2025.05.006_bib87","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1095\/biolreprod.115.132696","article-title":"Onset and regression of pregnancy-induced cardiac alterations in gestationally hypertensive mice: the role of the natriuretic peptide system","volume":"93","author":"Ventura","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.placenta.2025.05.006_bib88","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/S0140-6736(14)60685-1","article-title":"Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1\u00b725 million people","volume":"383","author":"Rapsomaniki","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.placenta.2025.05.006_bib89","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/uog.14685","article-title":"Longitudinal changes in maternal corin and mid-regional proatrial natriuretic peptide in women at risk of pre-eclampsia","volume":"45","author":"Khalil","year":"2015","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2025.05.006_bib90","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.placenta.2016.10.002","article-title":"Increased levels of soluble corin in pre-eclampsia and fetal growth restriction","volume":"48","author":"Miyazaki","year":"2016","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.05.006_bib91","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.preghy.2011.10.001","article-title":"Plasma soluble corin and N-terminal pro-atrial natriuretic peptide levels in pregnancy induced hypertension","volume":"2","author":"Zaki","year":"2012","journal-title":"Pregnancy Hypert."},{"key":"10.1016\/j.placenta.2025.05.006_bib92","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1089\/jwh.2015.5199","article-title":"Increased serum soluble corin in mid pregnancy is associated with hypertensive disorders of pregnancy","volume":"24","author":"Liu","year":"2015","journal-title":"J. Womens Health (Larchmt)"},{"key":"10.1016\/j.placenta.2025.05.006_bib93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preghy.2017.12.001","article-title":"Aberrant pro-atrial natriuretic peptide\/corin\/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia","volume":"11","author":"Gu","year":"2018","journal-title":"Pregnancy Hypert."},{"key":"10.1016\/j.placenta.2025.05.006_bib94","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1161\/HYPERTENSIONAHA.118.12137","article-title":"Role of corin in blood pressure regulation in Normotensive and hypertensive pregnancy","volume":"73","author":"Badrov","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.placenta.2025.05.006_bib95","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.ajpath.2019.12.012","article-title":"Placental overexpression of soluble CORIN in preeclampsia","volume":"190","author":"Degrelle","year":"2020","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.placenta.2025.05.006_bib96","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.2147\/IJGM.S297344","article-title":"Nested case-control study of corin combined with sFlt-1\/PLGF in predicting the risk of preeclampsia","volume":"14","author":"Liu","year":"2021","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/j.placenta.2025.05.006_bib97","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.preghy.2020.11.007","article-title":"Correlation between corin, N-terminal pro-atrial natriuretic peptide and neonatal adverse prognostic in hypertensive disorders of pregnancy","volume":"23","author":"Lin","year":"2021","journal-title":"Pregnancy Hypert."},{"key":"10.1016\/j.placenta.2025.05.006_bib98","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1080\/14767058.2019.1615433","article-title":"The role of G protein-associated estrogen receptor (GPER) 1, corin, raftlin, and estrogen in etiopathogenesis of intrauterine growth retardation","volume":"34","author":"Ozer","year":"2021","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.placenta.2025.05.006_bib99","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3390\/jcm12010061","article-title":"Corin-the early marker of preeclampsia in pregestational diabetes mellitus","volume":"12","author":"Boro\u0144","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.placenta.2025.05.006_bib100","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/jch.14450","article-title":"Correlation between N-terminal pro-atrial natriuretic peptide, corin, and target organ damage in hypertensive disorders of pregnancy","volume":"24","author":"Zhang","year":"2022","journal-title":"J. Clin. Hypertens."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400425001596?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400425001596?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T19:55:04Z","timestamp":1780862104000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400425001596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":100,"alternative-id":["S0143400425001596"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2025.05.006","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular insights into the corin function at the uteroplacental interface","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2025.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}