{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:41:44Z","timestamp":1792593704072,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701530"],"award-info":[{"award-number":["81701530"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2017ZX09304022"],"award-info":[{"award-number":["2017ZX09304022"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.placenta.2025.06.023","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T02:18:13Z","timestamp":1751422693000},"page":"256-267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["METTL3-dependent m6A modification of ERO1A mRNA regulates trophoblast migration and invasion in early-onset severe preeclampsia"],"prefix":"10.1016","volume":"168","author":[{"given":"Lei","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingling","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.placenta.2025.06.023_bib1","doi-asserted-by":"crossref","first-page":"6674","DOI":"10.1038\/s41598-021-86073-w","article-title":"Serum hypoxia-inducible factor-1\u03b1 and uterine artery doppler ultrasound during the first trimester for prediction of preeclampsia","volume":"11","author":"Tianthong","year":"2021","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.placenta.2025.06.023_bib2","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1080\/15476286.2019.1644591","article-title":"CircTRNC18 inhibits trophoblast cell migration and epithelial-mesenchymal transition by regulating miR-762\/Grhl2 pathway in pre-eclampsia","volume":"16","author":"Shen","year":"2019","journal-title":"RNA Biol."},{"key":"10.1016\/j.placenta.2025.06.023_bib3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3389\/fmed.2017.00239","article-title":"Immunological tolerance, pregnancy, and preeclampsia: the roles of semen microbes and the father","volume":"4","author":"Kenny","year":"2017","journal-title":"Front. Med."},{"issue":"4","key":"10.1016\/j.placenta.2025.06.023_bib4","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.semnephrol.2017.05.011","article-title":"Preeclampsia: pathogenesis, prevention, and long-term complications","volume":"37","author":"Jim","year":"2017","journal-title":"Semin. Nephrol."},{"issue":"5","key":"10.1016\/j.placenta.2025.06.023_bib5","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.cellsig.2014.01.013","article-title":"Decreased expression and DNA methylation levels of GATAD1 in preeclamptic placentas","volume":"26","author":"Ma","year":"2014","journal-title":"Cell. Signal."},{"issue":"12","key":"10.1016\/j.placenta.2025.06.023_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166940","article-title":"miR-125b enhances IL-8 production in early-onset severe preeclampsia by targeting Sphingosine-1-Phosphate lyase 1","volume":"11","author":"Yang","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.placenta.2025.06.023_bib7","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/humupd\/dmq052","article-title":"Epigenetics and the placenta","volume":"17","author":"Nelissen","year":"2011","journal-title":"Hum. Reprod. Update"},{"issue":"1","key":"10.1016\/j.placenta.2025.06.023_bib8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2217\/epi.15.101","article-title":"Fetal growth restriction and methylation of growth-related genes in the placenta","volume":"8","author":"Xiao","year":"2016","journal-title":"Epigenomics"},{"issue":"1","key":"10.1016\/j.placenta.2025.06.023_bib9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","article-title":"ALKBH5 is a Mammalian RNA demethylase that impacts RNA metabolism and mouse fertility","volume":"49","author":"Zheng","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.placenta.2025.06.023_bib10","article-title":"Integrated analysis of the transcriptome-wide m6A methylome in preeclampsia and healthy control placentas","volume":"8","author":"Wang","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.placenta.2025.06.023_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.placenta.2020.10.016","article-title":"Upregulation of METTL3 expression and m6A RNA methylation in placental trophoblasts in preeclampsia","volume":"103","author":"Gu","year":"2021","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2025.06.023_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-03662-5","article-title":"circRNA N6-methyladenosine methylation in preeclampsia and the potential role of N6-methyladenosine-modified circPAPPA2 in trophoblast invasion","volume":"11","author":"Zhang","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.placenta.2025.06.023_bib13","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/s41467-021-21594-6","article-title":"METTL3-dependent m(6)A modification programs T follicular helper cell differentiation","volume":"12","author":"Yao","year":"2021","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.placenta.2025.06.023_bib14","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1007\/s12035-018-1138-1","article-title":"mA RNA methylation controls neural development and is involved in human diseases","volume":"56","author":"Du","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.placenta.2025.06.023_bib15","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1053\/j.gastro.2022.06.024","article-title":"METTL3 inhibits antitumor immunity by targeting mA-BHLHE41-CXCL1\/CXCR2 axis to promote colorectal cancer","volume":"163","author":"Chen","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.placenta.2025.06.023_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110440","article-title":"METTL3 promotes the growth and metastasis of pancreatic cancer by regulating the m6A modification and stability of E2F5","volume":"99","author":"Tang","year":"2022","journal-title":"Cell. Signal."},{"key":"10.1016\/j.placenta.2025.06.023_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2022.09.002","article-title":"The mA methyltransferase METTL3 promotes trophoblast cell invasion by regulating MYLK expression","volume":"129","author":"Zhao","year":"2022","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2025.06.023_bib18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41419-020-03309-9","article-title":"ZNF280A promotes lung adenocarcinoma development by regulating the expression of EIF3C","volume":"12","author":"Liu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.placenta.2025.06.023_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9197940","article-title":"Macrophage extracellular traps exacerbate secondary spinal cord injury by modulating macrophage\/microglia polarization via LL37\/P2X7R\/NF-\u03baB signaling pathway","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.placenta.2025.06.023_bib20","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0076-6879(08)02617-7","article-title":"Messenger RNA half-life measurements in Mammalian cells","volume":"448","author":"Chen","year":"2008","journal-title":"Methods Enzymol."},{"issue":"1","key":"10.1016\/j.placenta.2025.06.023_bib21","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","article-title":"The role of m6A modification in the biological functions and diseases","volume":"6","author":"Jiang","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.placenta.2025.06.023_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116171","article-title":"Regulatory role of m6A epitranscriptomic modifications in normal development and congenital malformations during embryogenesis","volume":"173","author":"Yao","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.placenta.2025.06.023_bib23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.placenta.2017.08.070","article-title":"Early- and late-onset preeclampsia and the tissue-specific epigenome of the placenta and newborn","volume":"58","author":"Herzog","year":"2017","journal-title":"Placenta"},{"issue":"5","key":"10.1016\/j.placenta.2025.06.023_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007412","article-title":"Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development","volume":"14","author":"Kasowitz","year":"2018","journal-title":"PLoS Genet."},{"issue":"1","key":"10.1016\/j.placenta.2025.06.023_bib25","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/s12967-022-03496-3","article-title":"The methyltransferase METTL3 promotes tumorigenesis via mediating HHLA2 mRNA m6A modification in human renal cell carcinoma","volume":"20","author":"Zhu","year":"2022","journal-title":"J. Transl. Med."},{"issue":"2","key":"10.1016\/j.placenta.2025.06.023_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2022.113353","article-title":"METTL3 upregulates COPS5 expression in osteosarcoma in an mA-related manner to promote osteosarcoma progression","volume":"420","author":"Zhang","year":"2022","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.placenta.2025.06.023_bib27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.placenta.2025.03.004","article-title":"METTL3 suppressing SLC31A1 m(6)A modification regulates trophoblast migration and invasion","volume":"164","author":"Wang","year":"2025","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.06.023_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.894810","article-title":"METTL3-Mediated m(6)A RNA methylation of ZBTB4 interferes with trophoblast invasion and maybe involved in RSA","volume":"10","author":"Huang","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"22","key":"10.1016\/j.placenta.2025.06.023_bib29","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202401665R","article-title":"METTL3 and IGF2BP2 coordinately regulate FOSL1 mRNA via m6A modification, suppressing trophoblast invasion and contributing to fetal growth restriction","volume":"38","author":"Chen","year":"2024","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.placenta.2025.06.023_bib30","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.4143\/crt.2015.189","article-title":"Overexpression of endoplasmic reticulum oxidoreductin 1-\u03b1 (ERO1L) is associated with poor prognosis of gastric cancer","volume":"48","author":"Seol","year":"2016","journal-title":"Cancer Res. Treat."},{"key":"10.1016\/j.placenta.2025.06.023_bib31","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.freeradbiomed.2015.01.011","article-title":"ERO1: a protein disulfide oxidase and H2O2 producer","volume":"83","author":"Zito","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.placenta.2025.06.023_bib32","first-page":"103","article-title":"The role of ERO1alpha in modulating cancer progression and immune escape","volume":"2","author":"Johnson","year":"2020","journal-title":"J Cancer Immunol (Wilmington)"},{"issue":"1","key":"10.1016\/j.placenta.2025.06.023_bib33","doi-asserted-by":"crossref","first-page":"9389","DOI":"10.1038\/s41598-017-09976-7","article-title":"Hypoxia-inducible ERO1\u03b1 promotes cancer progression through modulation of integrin-\u03b21 modification and signalling in HCT116 colorectal cancer cells","volume":"7","author":"Takei","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.placenta.2025.06.023_bib34","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ebiom.2019.02.041","article-title":"Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1\u03b1 and protein disulfide isomerase suppresses the progression of cervical cancer","volume":"41","author":"Zhang","year":"2019","journal-title":"EBioMedicine"},{"issue":"8","key":"10.1016\/j.placenta.2025.06.023_bib35","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1080\/15548627.2016.1183844","article-title":"Cocaine induces astrocytosis through ER stress-mediated activation of autophagy","volume":"12","author":"Periyasamy","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.placenta.2025.06.023_bib36","doi-asserted-by":"crossref","first-page":"6727","DOI":"10.2147\/CMAR.S188746","article-title":"Expression of endoplasmic reticulum oxidoreductase 1-\u03b1 in cholangiocarcinoma tissues and its effects on the proliferation and migration of cholangiocarcinoma cells","volume":"11","author":"Yan","year":"2019","journal-title":"Cancer Manag. Res."},{"issue":"6","key":"10.1016\/j.placenta.2025.06.023_bib37","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1177\/1933719113512530","article-title":"Expression of notch family proteins in placentas from patients with early-onset severe preeclampsia","volume":"21","author":"Zhao","year":"2014","journal-title":"Reprod. Sci."},{"issue":"2","key":"10.1016\/j.placenta.2025.06.023_bib38","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3109\/10641955.2013.853777","article-title":"Expression levels of seven candidate genes in human peripheral blood mononuclear cells and their association with preeclampsia","volume":"33","author":"Martinez-Fierro","year":"2014","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.placenta.2025.06.023_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2023.11.011","article-title":"Identification of gene signature markers in gestational hypertension and early-onset pre-eclampsia","volume":"145","author":"Soobryan","year":"2024","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2025.06.023_bib40","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12915-024-01959-1","article-title":"Hierarchical lncRNA regulatory network in early-onset severe preeclampsia","volume":"22","author":"Liu","year":"2024","journal-title":"BMC Biol."},{"issue":"18","key":"10.1016\/j.placenta.2025.06.023_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/nu15183877","article-title":"Decreased fatty acid oxidation gene expression in pre-eclampsia according to the onset and presence of intrauterine growth restriction","volume":"15","author":"Abascal-Saiz","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.placenta.2025.06.023_bib42","series-title":"Preeclampsia. StatPearls","author":"Karrar","year":"2025"},{"key":"10.1016\/j.placenta.2025.06.023_bib43","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.placenta.2019.12.013","article-title":"HTR-8\/SVneo: a model for epithelial to mesenchymal transition in the human placenta","volume":"90","author":"Msheik","year":"2020","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2025.06.023_bib44","doi-asserted-by":"crossref","first-page":"83","DOI":"10.5115\/acb.20.234","article-title":"JEG-3 placental cells in toxicology studies: a promising tool to reveal pregnancy disorders","volume":"54","author":"Olivier","year":"2021","journal-title":"Anat. Cell Biol."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400425002309?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400425002309?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T08:19:58Z","timestamp":1777105198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400425002309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":44,"alternative-id":["S0143400425002309"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2025.06.023","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"METTL3-dependent m6A modification of ERO1A mRNA regulates trophoblast migration and invasion in early-onset severe preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2025.06.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}