{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T02:41:29Z","timestamp":1783392089967,"version":"3.54.6"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.placenta.2025.07.001","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T04:38:51Z","timestamp":1751431131000},"page":"200-208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Adaptive changes in placenta of obese pregnant women \u2013 the expression of Bcl-2 and Pim-1"],"prefix":"10.1016","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4953-624X","authenticated-orcid":false,"given":"Magdalena Danuta","family":"Opinc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Golberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zef","family":"Kobos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Brzezi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Karowicz-Bili\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2025.07.001_bib1","doi-asserted-by":"crossref","first-page":"j1","DOI":"10.1136\/bmj.j1","article-title":"Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child","author":"Catalano","year":"2017","journal-title":"Br. Med. J."},{"key":"10.1016\/j.placenta.2025.07.001_bib2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/GRF.0000000000000042","article-title":"The clinical approach to obesity in pregnancy","volume":"57","author":"Overcash","year":"2014","journal-title":"Clin. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2025.07.001_bib3","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/oby.22707","article-title":"Longitudinal study of maternal BMI in successive pregnancies","volume":"28","author":"Reynolds","year":"2020","journal-title":"Obesity"},{"key":"10.1016\/j.placenta.2025.07.001_bib4","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S2213-8587(16)30217-0","article-title":"Preconceptional and maternal obesity: epidemiology and health consequences","volume":"4","author":"Poston","year":"2016","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.placenta.2025.07.001_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2018.e00615","article-title":"Relationship between pre-pregnancy maternal BMI and optimal weight gain in singleton pregnancies","volume":"4","author":"Robillard","year":"2018","journal-title":"Heliyon"},{"key":"10.1016\/j.placenta.2025.07.001_bib6","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1042\/CS20190266","article-title":"Placental function in maternal obesity","volume":"134","author":"Kelly","year":"2020","journal-title":"Clin. Sci."},{"key":"10.1016\/j.placenta.2025.07.001_bib7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2174\/1570161118666200513115316","article-title":"Effects of maternal obesity on placental phenotype","volume":"19","author":"Fowden","year":"2020","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.placenta.2025.07.001_bib8","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.113.116186","article-title":"Increasing maternal body mass index is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory Pathways1","volume":"90","author":"Aye","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.placenta.2025.07.001_bib9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.placenta.2010.12.023","article-title":"Placental structure and inflammation in pregnancies associated with obesity","volume":"32","author":"Roberts","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.07.001_bib10","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.tem.2024.02.002","article-title":"Placental inflammation, oxidative stress, and fetal outcomes in maternal obesity","volume":"35","author":"Zhang","year":"2024","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.placenta.2025.07.001_bib11","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.placenta.2010.02.002","article-title":"Maternal obesity up-regulates inflammatory signaling pathways and enhances cytokine expression in the mid-gestation sheep placenta","volume":"31","author":"Zhu","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.07.001_bib12","doi-asserted-by":"crossref","first-page":"783","DOI":"10.3109\/14767058.2012.760539","article-title":"Maternal obesity and its effect on placental cell turnover","volume":"26","author":"Higgins","year":"2013","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.placenta.2025.07.001_bib13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.placenta.2014.01.003","article-title":"Maternal obesity is associated with a lipotoxic placental environment","volume":"35","author":"Saben","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.07.001_bib14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.placenta.2017.04.010","article-title":"Placental Pim-1 expression is increased in obesity and regulates cytokine- and toll-like receptor-mediated inflammation","volume":"53","author":"Liong","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.07.001_bib15","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.placenta.2014.07.011","article-title":"Cellular inhibitors of apoptosis (cIAP) 1 and 2 are increased in placenta from obese pregnant women","volume":"35","author":"Lappas","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.07.001_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.placenta.2019.12.009","article-title":"Palmitate induces apoptotic cell death and inflammasome activation in human placental macrophages","volume":"90","author":"Rogers","year":"2020","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.07.001_bib17","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3390\/nu12020296","article-title":"Effect of maternal obesity in mice on IL-6 levels and placental endothelial cell homeostasis","volume":"12","author":"Kretschmer","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.placenta.2025.07.001_bib18","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrd.2016.253","article-title":"From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors","volume":"16","author":"Ashkenazi","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.placenta.2025.07.001_bib19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejmech.2019.03.050","article-title":"PIM kinase inhibitors: structural and pharmacological perspectives","volume":"172","author":"Asati","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.placenta.2025.07.001_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5603\/NJO.2016.0001","article-title":"Rodzina onkogennych kinaz PIM-potencjalne cele terapeutyczne w nowotworach UK\u0142adu krwiotw\u00f3rczego i ch\u0142onnego","volume":"66","author":"Szyd\u0142owski","year":"2016","journal-title":"Nowotwory"},{"key":"10.1016\/j.placenta.2025.07.001_bib21","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.biocel.2004.11.005","article-title":"The serine\/threonine kinase Pim-1","volume":"37","author":"Bachmann","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.placenta.2025.07.001_bib22","article-title":"PIM1 signaling in immunoinflammatory diseases: an emerging therapeutic target","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.placenta.2025.07.001_bib23","series-title":"Weight Gain During Pregnancy","author":"Rasmussen","year":"2009"},{"key":"10.1016\/j.placenta.2025.07.001_bib54","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.placenta.2010.12.008","article-title":"A technical note to improve the reporting of studies of the human placenta","volume":"32","author":"Nelson","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.07.001_bib24","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1053\/plac.1999.0486","article-title":"Expression of BCL-2, BAX and BAK in the trophoblast layer of the term human placenta: a unique model of apoptosis within a syncytium","volume":"21","author":"Ratts","year":"2000","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.07.001_bib25","article-title":"The immunolocalization of Bcl-2 in human term placenta","volume":"28","author":"Axt-Fliedner","year":"2001","journal-title":"Clin. Exp. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2025.07.001_bib26","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.placenta.2010.05.006","article-title":"Global gene expression changes induced in the human placenta during labor","volume":"31","author":"Lee","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.07.001_bib27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.placenta.2013.11.005","article-title":"Optimising sample collection for placental research","volume":"35","author":"Burton","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.07.001_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/plac.1999.0450","article-title":"To Be, or not to Be, that is the question. Apoptosis in human trophoblast","volume":"21","author":"Levy","year":"2000","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.07.001_bib29","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.placenta.2008.07.003","article-title":"Live and Let Die \u2013 regulation of Villous Trophoblast Apoptosis in Normal and Abnormal Pregnancies","volume":"29","author":"Heazell","year":"2008","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.07.001_bib30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.diabres.2005.12.014","article-title":"Changes in apoptosis and Bcl-2 expression in human hyperglycemic, term placental trophoblast","volume":"73","author":"Sgarbosa","year":"2006","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.placenta.2025.07.001_bib31","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jdiacomp.2014.03.010","article-title":"Gestational diabetes mellitus alters apoptotic and inflammatory gene expression of trophobasts from human term placenta","volume":"28","author":"Magee","year":"2014","journal-title":"J. Diabet. Complicat."},{"key":"10.1016\/j.placenta.2025.07.001_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0249907","article-title":"Saturated free fatty acids induce placental trophoblast lipoapoptosis","volume":"16","author":"Natarajan","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.placenta.2025.07.001_bib33","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1530\/REP-16-0576","article-title":"Oleate attenuates palmitate-induced endoplasmic reticulum stress and apoptosis in placental trophoblasts","volume":"153","author":"Colvin","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.placenta.2025.07.001_bib34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.placenta.2019.12.003","article-title":"Decreased placental apoptosis and autophagy in pregnancies complicated by gestational diabetes with large-for-gestational age fetuses","volume":"90","author":"Hung","year":"2020","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2025.07.001_bib35","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1078\/0065-1281-00683","article-title":"Expression of proliferation and apoptotic markers in human placenta during pregnancy","volume":"104","author":"Danihel","year":"2002","journal-title":"Acta Histochem."},{"key":"10.1016\/j.placenta.2025.07.001_bib36","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1177\/107155769400100212","article-title":"Differentiation-dependent expression of the BCL-2 proto-oncogene in the human trophoblast lineage","volume":"1","author":"Sakuragi","year":"1994","journal-title":"J. Soc. Gynecol. Invest."},{"key":"10.1016\/j.placenta.2025.07.001_bib37","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1600-0897.2008.00609.x","article-title":"Bcl-2 and Bax expressions in pre-term, term and post-term placentas","volume":"60","author":"Daher","year":"2008","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.placenta.2025.07.001_bib38","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1507\/endocrj.47.317","article-title":"Changes in proliferative potential, apoptosis and Bcl-2 protein expression in cytotrophoblasts and syncytiotrophoblast in human placenta over the course of pregnancy","volume":"47","author":"Ishihara","year":"2000","journal-title":"Endocr. J."},{"key":"10.1016\/j.placenta.2025.07.001_bib39","doi-asserted-by":"crossref","DOI":"10.1111\/j.1439-0264.2010.01012.x","article-title":"Apoptosis and Bcl-2 protein expression in human placenta over the course of normal pregnancy","author":"Soni","year":"2010","journal-title":"Anat. Histol. Embryol."},{"key":"10.1016\/j.placenta.2025.07.001_bib40","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1093\/humrep\/13.6.1717","article-title":"BCL-2 expression in the human placenta and its correlation with fibrin deposits","volume":"13","author":"Marzioni","year":"1998","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.placenta.2025.07.001_bib41","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.yexcr.2017.07.019","article-title":"PIM kinases 1, 2 and 3 in intracellular LIF signaling, proliferation and apoptosis in trophoblastic cells","volume":"359","author":"Mary Photini","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.placenta.2025.07.001_bib42","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1038\/sj.onc.1202741","article-title":"The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway","volume":"18","author":"Lilly","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.placenta.2025.07.001_bib43","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.febslet.2004.06.050","article-title":"Pim\u20101 kinase promotes inactivation of the pro\u2010apoptotic bad protein by phosphorylating it on the Ser 112 gatekeeper site","volume":"571","author":"Aho","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.placenta.2025.07.001_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2121-7-1","article-title":"Pim kinases phosphorylate multiple sites on bad and promote 14-3-3 binding and dissociation from Bcl-XL","volume":"7","author":"Macdonald","year":"2006","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.placenta.2025.07.001_bib45","first-page":"428","article-title":"Inhibition of PIM1 kinase attenuates inflammation-induced pro-labour mediators in human foetal membranes in vitro","volume":"23","author":"Lim","year":"2017","journal-title":"MHR: Basic Science of Reproductive Medicine"},{"key":"10.1016\/j.placenta.2025.07.001_bib46","doi-asserted-by":"crossref","first-page":"5478","DOI":"10.1073\/pnas.0508035103","article-title":"Gene expression patterns in human placenta","volume":"103","author":"Sood","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.placenta.2025.07.001_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-53199-x","article-title":"Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats","volume":"9","author":"Napso","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.placenta.2025.07.001_bib48","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/aji.12303","article-title":"Fetal sex\u2010based differences in maternal hormones, angiogenic factors, and immune mediators during pregnancy and the postpartum period","volume":"73","author":"Enninga","year":"2015","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.placenta.2025.07.001_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1479960","article-title":"Placental trophoblast aging in advanced maternal age is related to increased oxidative damage and decreased YAP","volume":"13","author":"Guo","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.placenta.2025.07.001_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.837694","article-title":"Gestational age variation in human placental drug transporters","volume":"13","author":"Goetzl","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.placenta.2025.07.001_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.807750","article-title":"Placental inflammasome mRNA levels differ by mode of delivery and fetal sex","volume":"13","author":"Arthurs","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.placenta.2025.07.001_bib52","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.2353\/ajpath.2007.070528","article-title":"Oxidative stress, gene expression, and protein changes induced in the human placenta during labor","volume":"171","author":"Cindrova-Davies","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.placenta.2025.07.001_bib53","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/molehr\/gam083","article-title":"Gene expression profile in labouring and non-labouring human placenta near term","volume":"14","author":"Sitras","year":"2008","journal-title":"Mol. Hum. Reprod."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400425002334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400425002334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T08:18:06Z","timestamp":1777105086000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400425002334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":54,"alternative-id":["S0143400425002334"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2025.07.001","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adaptive changes in placenta of obese pregnant women \u2013 the expression of Bcl-2 and Pim-1","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2025.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}