{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:17:42Z","timestamp":1778635062880,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007653","name":"Universit\u00e4tsklinikum Jena","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["01GR2305A"],"award-info":[{"award-number":["01GR2305A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.placenta.2026.01.011","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T23:13:49Z","timestamp":1768691629000},"page":"66-72","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Transplacental passage of ampicillin: Implications for antenatal therapy"],"prefix":"10.1016","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6175-7509","authenticated-orcid":false,"given":"Jana","family":"Pastuschek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Wissenbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udo R.","family":"Markert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine","family":"Zoellkau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekkehard","family":"Schleussner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank T.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Groten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.placenta.2026.01.011_bib1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12916-017-0999-x","article-title":"Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin","volume":"16","author":"Brown","year":"2018","journal-title":"BMC Med."},{"issue":"20","key":"10.1016\/j.placenta.2026.01.011_bib2","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJM200005183422007","article-title":"Intrauterine infection and preterm delivery","volume":"342","author":"Goldenberg","year":"2000","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.placenta.2026.01.011_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122564","article-title":"Preterm prelabor rupture of membranes and outcome of very-low-birth-weight infants in the German neonatal network","volume":"10","author":"Hanke","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.placenta.2026.01.011_bib4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12916-023-02805-x","article-title":"Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis","volume":"21","author":"Dos Anjos Borges","year":"2023","journal-title":"BMC Med."},{"issue":"6","key":"10.1016\/j.placenta.2026.01.011_bib5","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-2013","article-title":"Epidemiology of invasive early-onset neonatal sepsis, 2005 to 2014","volume":"138","author":"Schrag","year":"2016","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.placenta.2026.01.011_bib6","first-page":"373","article-title":"[Prevention and therapy of preterm birth. Guideline of the DGGG, OEGGG and SGGG","volume":"223","author":"Berger","year":"2019","journal-title":"Z. Geburtshilfe Neonatol."},{"issue":"5","key":"10.1016\/j.placenta.2026.01.011_bib7","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1097\/AOG.0000000000004142","article-title":"ACOG practice bulletin no. 217: prelabor rupture of membranes","volume":"136","author":"Siegler","year":"2020","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2026.01.011_bib8","unstructured":"National Institute for Health and Care Excellence (NICE). Preterm labour and birth (NG25). London: NICE; 2015. Available from: https:\/\/www.nice.org.uk\/guidance\/ng25."},{"issue":"1","key":"10.1016\/j.placenta.2026.01.011_bib9","first-page":"e1","article-title":"ACOG practice bulletin no. 188: prelabor rupture of membranes","volume":"131","author":"Committee on Practice","year":"2018","journal-title":"Obstet. Gynecol."},{"issue":"10104","key":"10.1016\/j.placenta.2026.01.011_bib10","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1016\/S0140-6736(17)31002-4","article-title":"Neonatal sepsis","volume":"390","author":"Shane","year":"2017","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.placenta.2026.01.011_bib11","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cmi.2023.07.023","article-title":"Early-versus late-onset sepsis in neonates - time to shift the paradigm?","volume":"30","author":"Russell","year":"2024","journal-title":"Clin. Microbiol. Infect."},{"issue":"2","key":"10.1016\/j.placenta.2026.01.011_bib12","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1476-5381.1962.tb01416.x","article-title":"Pharmacology and chemotherapy of ampicillin--a new broad-spectrum penicillin","volume":"18","author":"Acred","year":"1962","journal-title":"Br. J. Pharmacol. Chemother."},{"issue":"5246","key":"10.1016\/j.placenta.2026.01.011_bib14","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/bmj.2.5246.191","article-title":"Microbiological studies on a new broad-spectrum penicillin","volume":"2","author":"Rolinson","year":"1961","journal-title":"\u201cPenbritin\u201d, Br. Med. J."},{"issue":"1","key":"10.1016\/j.placenta.2026.01.011_bib15","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1067\/mob.2001.113907","article-title":"A population-based case-control teratologic study of ampicillin treatment during pregnancy","volume":"185","author":"Czeizel","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"11","key":"10.1016\/j.placenta.2026.01.011_bib16","doi-asserted-by":"crossref","first-page":"803","DOI":"10.2165\/00128072-200103110-00003","article-title":"Effects of antibacterials on the unborn child: what is known and how should this influence prescribing","volume":"3","author":"Einarson","year":"2001","journal-title":"Paediatr. Drugs"},{"issue":"7","key":"10.1016\/j.placenta.2026.01.011_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajogmf.2023.100978","article-title":"Efficacy of prophylactic antibiotics for preterm premature rupture of membranes: a systematic review and network meta-analysis","volume":"5","author":"Lin","year":"2023","journal-title":"Am. J. Obstet. Gynecol. MFM"},{"issue":"2","key":"10.1016\/j.placenta.2026.01.011_bib18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1055\/a-1674-6394","article-title":"Ampicillin pharmacokinetics in peripartum and laboring women","volume":"41","author":"Judy","year":"2024","journal-title":"Am. J. Perinatol."},{"issue":"7","key":"10.1016\/j.placenta.2026.01.011_bib20","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/0002-9378(66)90439-X","article-title":"Placental transfer of ampicillin","volume":"96","author":"MacAulay","year":"1966","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"5480","key":"10.1016\/j.placenta.2026.01.011_bib21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/bmj.1.5480.137","article-title":"Transplacental passage of ampicillin","volume":"1","author":"Blecher","year":"1966","journal-title":"Br. Med. J."},{"issue":"7","key":"10.1016\/j.placenta.2026.01.011_bib22","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/0002-9378(66)90438-8","article-title":"Transfer of ampicillin into fetus and amniotic fluid from maternal plasma in late pregnancy","volume":"96","author":"Bray","year":"1966","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.placenta.2026.01.011_bib23","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1471-0528.1966.tb15547.x","article-title":"The passage of ampicillin into the liquor amnii and the foetal circulation","volume":"73","author":"Williams","year":"1966","journal-title":"J. Obstet. Gynaecol. Br. Commonw."},{"issue":"1","key":"10.1016\/j.placenta.2026.01.011_bib24","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/BF00679716","article-title":"[Placental transfer of ampicillin into the fetus for the management of listeria infections in pregnancy]","volume":"206","author":"M\u00fcller","year":"1968","journal-title":"Arch Gynakol."},{"issue":"4","key":"10.1016\/j.placenta.2026.01.011_bib25","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3109\/00016348009154086","article-title":"Study of ampicillin levels in maternal serum, umbilical cord serum and amniotic fluid following administration of pivampicillin","volume":"59","author":"Jordheim","year":"1980","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"7 Pt 1","key":"10.1016\/j.placenta.2026.01.011_bib26","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0002-9378(16)32738-7","article-title":"Transplacental ampicillin: inhibitory concentrations in neonatal serum","volume":"138","author":"Kraybill","year":"1980","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.placenta.2026.01.011_bib27","first-page":"124","article-title":"Antibiotic concentration in maternal blood, cord blood, and placental membranes in chorioamnionitis","volume":"72","author":"Gilstrap","year":"1988","journal-title":"Obstet. Gynecol."},{"issue":"4 Pt 1","key":"10.1016\/j.placenta.2026.01.011_bib28","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/S0002-9378(96)80035-4","article-title":"Ampicillin for neonatal group B streptococcal prophylaxis: how rapidly can bactericidal concentrations be achieved?","volume":"175","author":"Bloom","year":"1996","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.placenta.2026.01.011_bib29","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.ajog.2005.07.098","article-title":"Optimal timing of ampicillin administration to pregnant women for establishing bactericidal levels in the prophylaxis of group B streptococcus","volume":"194","author":"Colombo","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.placenta.2026.01.011_bib30","doi-asserted-by":"crossref","first-page":"F152","DOI":"10.1136\/archdischild-2016-312546","article-title":"Are postnatal ampicillin levels actually related to the duration of intrapartum antibiotic prophylaxis prior to delivery? A pharmacokinetic study in 120 neonates","volume":"103","author":"Berardi","year":"2018","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"issue":"2","key":"10.1016\/j.placenta.2026.01.011_bib31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.5414\/CPP44057","article-title":"Placental transfer of antibiotics administered to the mother: a review","volume":"44","author":"Pacifici","year":"2006","journal-title":"Int. J. Clin. Pharm. Ther."},{"key":"10.1016\/j.placenta.2026.01.011_bib32","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.earlhumdev.2019.05.020","article-title":"The transplacental passage of commonly used intrapartum antibiotics and its impact on the newborn management: a narrative review","volume":"135","author":"Viel-Theriault","year":"2019","journal-title":"Early Hum. Dev."},{"issue":"6","key":"10.1016\/j.placenta.2026.01.011_bib33","doi-asserted-by":"crossref","first-page":"670 e1","DOI":"10.1016\/j.ajog.2021.05.032","article-title":"Therapeutic concentration of ciprofloxacin and transfer across the human term placenta","volume":"225","author":"Noergaard","year":"2021","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2026.01.011_bib34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.placenta.2022.05.003","article-title":"Ex vivo dual perfusion of an isolated human placenta cotyledon: towards protocol standardization and improved inter-centre comparability","volume":"126","author":"Schneider","year":"2022","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.01.011_bib35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.placenta.2021.02.017","article-title":"Ex vivo dual perfusion of an isolated cotyledon of human placenta: history and future challenges","volume":"107","author":"Schneider","year":"2021","journal-title":"Placenta"},{"issue":"6","key":"10.1016\/j.placenta.2026.01.011_bib36","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/0002-9378(72)90909-X","article-title":"Transfer across the perfused human placenta of antipyrine, sodium and leucine","volume":"114","author":"Schneider","year":"1972","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2026.01.011_bib37","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.placenta.2021.05.010","article-title":"Ex vivo human placental transfer study on recombinant Von Willebrand factor (rVWF)","volume":"111","author":"Pastuschek","year":"2021","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.placenta.2026.01.011_bib38","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/infdis\/136.3.370","article-title":"Pharmacokinetics of ampicillin during pregnancy","volume":"136","author":"Philipson","year":"1977","journal-title":"J. Infect. Dis."},{"issue":"Suppl 5","key":"10.1016\/j.placenta.2026.01.011_bib39","doi-asserted-by":"crossref","first-page":"S503","DOI":"10.1093\/clinids\/8.Supplement_5.503","article-title":"Pharmacokinetics of sulbactam\/ampicillin in humans: a review","volume":"8","author":"Foulds","year":"1986","journal-title":"Rev. Infect. Dis."},{"issue":"1","key":"10.1016\/j.placenta.2026.01.011_bib40","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2165\/00003088-199427010-00005","article-title":"Review of beta-lactam antibiotics in pregnancy. The need for adjustment of dosage schedules","volume":"27","author":"Heikkila","year":"1994","journal-title":"Clin. Pharmacokinet."},{"issue":"2","key":"10.1016\/j.placenta.2026.01.011_bib42","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1472-8206.2008.00572.x","article-title":"Oral absorption of ampicillin: role of paracellular route vs. PepT1 transporter","volume":"22","author":"Lafforgue","year":"2008","journal-title":"Fundam. Clin. Pharmacol."},{"issue":"11","key":"10.1016\/j.placenta.2026.01.011_bib43","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1440-1681.1997.tb02707.x","article-title":"Drug disposition in mother and foetus","volume":"24","author":"Morgan","year":"1997","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"2\u20133","key":"10.1016\/j.placenta.2026.01.011_bib44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF00614007","article-title":"On the absorption and metabolism of 35S-ampicillin","volume":"9","author":"Swahn","year":"1975","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"4","key":"10.1016\/j.placenta.2026.01.011_bib45","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0143-4004(85)80043-6","article-title":"Maternal to fetal movement of creatinine as a measure of perfusion efficiency and diffusional transfer in the isolated human placental lobule","volume":"6","author":"Eaton","year":"1985","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2026.01.011_bib46","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.reprotox.2010.01.006","article-title":"Quality assessment of a placental perfusion protocol","volume":"30","author":"Mathiesen","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.placenta.2026.01.011_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116177","article-title":"Safety assessment of the SGLT2 inhibitors empagliflozin, dapagliflozin and canagliflozin during pregnancy: an ex vivo human placenta perfusion and in vitro study","volume":"171","author":"Kuoni","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.placenta.2026.01.011_bib48","doi-asserted-by":"crossref","first-page":"R1495","DOI":"10.1152\/ajpregu.2000.279.4.R1495","article-title":"Expression of members of the multidrug resistance protein family in human term placenta","volume":"279","author":"St-Pierre","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"Suppl A","key":"10.1016\/j.placenta.2026.01.011_bib49","doi-asserted-by":"crossref","first-page":"S159","DOI":"10.1053\/plac.2002.0821","article-title":"Mechanisms of drug transfer across the human placenta-a workshop report","volume":"23","author":"St-Pierre","year":"2002","journal-title":"Placenta"},{"issue":"8","key":"10.1016\/j.placenta.2026.01.011_bib50","doi-asserted-by":"crossref","first-page":"487","DOI":"10.2165\/00003088-200443080-00001","article-title":"Drug transfer and metabolism by the human placenta","volume":"43","author":"Syme","year":"2004","journal-title":"Clin. Pharmacokinet."},{"issue":"6","key":"10.1016\/j.placenta.2026.01.011_bib51","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s00134-020-06050-1","article-title":"Antimicrobial therapeutic drug monitoring in critically ill adult patients: a position paper","volume":"46","author":"Abdul-Aziz","year":"2020","journal-title":"Intensive Care Med."},{"issue":"1","key":"10.1016\/j.placenta.2026.01.011_bib52","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ijantimicag.2007.02.002","article-title":"Continuous infusion of beta-lactam antibiotics in severe infections: a review of its role","volume":"30","author":"Roberts","year":"2007","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"6","key":"10.1016\/j.placenta.2026.01.011_bib53","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1128\/AAC.01429-08","article-title":"Evaluation of cefotaxime and desacetylcefotaxime concentrations in cord blood after intrapartum prophylaxis with cefotaxime","volume":"53","author":"Lepercq","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"issue":"4","key":"10.1016\/j.placenta.2026.01.011_bib54","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1128\/AAC.3.4.463","article-title":"Metabolism of penicillins to penicilloic acids and 6-aminopenicillanic acid in man and its significance in assessing penicillin absorption","volume":"3","author":"Cole","year":"1973","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426000238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426000238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:05:45Z","timestamp":1778634345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400426000238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":51,"alternative-id":["S0143400426000238"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2026.01.011","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transplacental passage of ampicillin: Implications for antenatal therapy","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2026.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}