{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:39:49Z","timestamp":1784327989657,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401991"],"award-info":[{"award-number":["82401991"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001584"],"award-info":[{"award-number":["82001584"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Hubei Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2025AFB732"],"award-info":[{"award-number":["2025AFB732"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.placenta.2026.01.017","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:19:52Z","timestamp":1769732392000},"page":"31-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["METTL3-regulated m6A modification modulates autophagy of placental mesenchymal stem\/stromal cell by YTHDF3-mediated degradation of LncRNA GAS5 in preeclampsia"],"prefix":"10.1016","volume":"176","author":[{"given":"Yang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangwei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2026.01.017_bib1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.placenta.2021.02.014","article-title":"PFKFB3 regulates lipopolysaccharide-induced excessive inflammation and cellular dysfunction in HTR-8\/Svneo cells: implications for the role of PFKFB3 in preeclampsia","volume":"106","author":"Zhang","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.01.017_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.596145","article-title":"Current researches, rationale, plausibility, and evidence gaps on metformin for the management of hypertensive disorders of pregnancy","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.placenta.2026.01.017_bib3","article-title":"Significance of placental mesenchymal stem cell in placenta development and implications for Preeclampsia","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.placenta.2026.01.017_bib4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.placenta.2024.03.014","article-title":"Single cell RNA-sequencing reveals the cellular senescence of placental mesenchymal stem\/stromal cell in preeclampsia","volume":"150","author":"Zhang","year":"2024","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.01.017_bib5","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.placenta.2020.07.007","article-title":"Heme oxygenase-1 gene modified human placental mesenchymal stem cells promote placental angiogenesis and spiral artery remodeling by improving the balance of angiogenic factors in vitro","volume":"99","author":"Wu","year":"2020","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.01.017_bib6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev-pharmtox-010716-104936","article-title":"Autophagy: a druggable process","volume":"57","author":"Morel","year":"2017","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"2","key":"10.1016\/j.placenta.2026.01.017_bib7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41419-017-0082-8","article-title":"Autophagy promotes MSC-mediated vascularization in cutaneous wound healing via regulation of VEGF secretion","volume":"9","author":"An","year":"2018","journal-title":"Cell Death Dis."},{"issue":"10","key":"10.1016\/j.placenta.2026.01.017_bib8","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1080\/15548627.2019.1707494","article-title":"Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia","volume":"16","author":"Nakashima","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.placenta.2026.01.017_bib9","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3389\/fgene.2020.00188","article-title":"Long non-coding RNA Gas5 is associated with Preeclampsia and regulates biological behaviors of trophoblast via MicroRNA-21","volume":"11","author":"Zheng","year":"2020","journal-title":"Front. Genet."},{"issue":"5","key":"10.1016\/j.placenta.2026.01.017_bib10","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41419-018-0627-5","article-title":"The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a\/CTGF axis as a ceRNA","volume":"9","author":"Li","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.placenta.2026.01.017_bib11","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.omtn.2019.06.012","article-title":"GAS5\/miR-21 axis as a potential target to rescue ZCL-082-Induced autophagy of female germline stem cells in vitro, molecular therapy","volume":"17","author":"Li","year":"2019","journal-title":"Nucleic acids"},{"issue":"2","key":"10.1016\/j.placenta.2026.01.017_bib12","article-title":"Exploring the role of m6A modification in the great obstetrical syndromes, the journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies","volume":"36","author":"Ning","year":"2023","journal-title":"the International Society of Perinatal Obstet"},{"issue":"11","key":"10.1016\/j.placenta.2026.01.017_bib13","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1007\/s11427-024-2846-4","article-title":"m(6)A deficiency impairs uterine spiral artery remodeling to induce preeclampsia-like symptoms via FGF2, Science China","volume":"68","author":"Liu","year":"2025","journal-title":"Life Sci."},{"issue":"8","key":"10.1016\/j.placenta.2026.01.017_bib14","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1080\/15548627.2019.1586246","article-title":"METTL3 and ALKBH5 oppositely regulate m(6)A modification of TFEB mRNA, which dictates the fate of hypoxia\/reoxygenation-treated cardiomyocytes","volume":"15","author":"Song","year":"2019","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.placenta.2026.01.017_bib15","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.ymthe.2021.09.016","article-title":"METTL3-m(6)A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease","volume":"30","author":"Peng","year":"2022","journal-title":"Mol. Ther. : the journal of the American Society of Gene Therapy"},{"key":"10.1016\/j.placenta.2026.01.017_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2022.09.002","article-title":"The m(6)A methyltransferase METTL3 promotes trophoblast cell invasion by regulating MYLK expression","volume":"129","author":"Zhao","year":"2022","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2026.01.017_bib17","first-page":"e1","article-title":"Gestational hypertension and Preeclampsia","volume":"133","year":"2019","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2026.01.017_bib18","series-title":"The Lancet","article-title":"Pre-eclampsia","author":"Chappell","year":"2021"},{"key":"10.1016\/j.placenta.2026.01.017_bib19","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.placenta.2025.06.009","article-title":"Single cell RNA-sequencing reveals BHLHE40 and NDRG1 as key regulatory molecules modulating the trophoblastic senescence in preeclampsia","volume":"168","author":"Zhang","year":"2025","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2026.01.017_bib20","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1186\/s13287-022-03089-3","article-title":"PFKFB3-mediated glycometabolism reprogramming modulates endothelial differentiation and angiogenic capacity of placenta-derived mesenchymal stem cells","volume":"13","author":"Zhang","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.placenta.2026.01.017_bib21","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.omtn.2021.01.005","article-title":"MALAT1 sponges miR-26a and miR-26b to regulate endothelial cell angiogenesis via PFKFB3-driven glycolysis in early-onset preeclampsia, molecular therapy","volume":"23","author":"Li","year":"2021","journal-title":"Nucleic acids"},{"key":"10.1016\/j.placenta.2026.01.017_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/1806344","article-title":"Metformin corrects glucose metabolism reprogramming and NLRP3 inflammasome-induced pyroptosis via inhibiting the TLR4\/NF-\u03baB\/PFKFB3 signaling in trophoblasts: implication for a potential therapy of Preeclampsia","volume":"2021","author":"Zhang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.placenta.2026.01.017_bib23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.placenta.2026.01.017_bib24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/978-1-4939-2742-5_9","article-title":"The Western blot","volume":"1318","author":"Hnasko","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.placenta.2026.01.017_bib25","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.3389\/fimmu.2018.03142","article-title":"Galectin-9 alleviates LPS-Induced Preeclampsia-Like impairment in rats via switching decidual macrophage polarization to M2 subtype","volume":"9","author":"Li","year":"2018","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.placenta.2026.01.017_bib26","doi-asserted-by":"crossref","first-page":"7337","DOI":"10.1007\/s11033-022-07524-9","article-title":"Umbilical cord-derived mesenchymal stem cell conditioned medium reverses neuronal oxidative injury by inhibition of TRPM2 activation and the JNK signaling pathway","volume":"49","author":"Wang","year":"2022","journal-title":"Mol. Biol. Rep."},{"issue":"5","key":"10.1016\/j.placenta.2026.01.017_bib27","doi-asserted-by":"crossref","first-page":"11933","DOI":"10.1080\/21655979.2022.2067286","article-title":"Bone mesenchymal stem cells (BMSCs)-derived exosomal microRNA-21-5p regulates Kruppel-like factor 3 (KLF3) to promote osteoblast proliferation in vitro","volume":"13","author":"You","year":"2022","journal-title":"Bioengineered"},{"issue":"4","key":"10.1016\/j.placenta.2026.01.017_bib28","doi-asserted-by":"crossref","first-page":"9060","DOI":"10.1080\/21655979.2022.2052652","article-title":"Mesenchymal stem cells inhibited the apoptosis of alveolar epithelial cells caused by ARDS through CXCL12\/CXCR4 axis","volume":"13","author":"He","year":"2022","journal-title":"Bioengineered"},{"issue":"9","key":"10.1016\/j.placenta.2026.01.017_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9091178","article-title":"Autophagy, mesenchymal stem cell differentiation, and secretion","volume":"9","author":"Menshikov","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.placenta.2026.01.017_bib30","article-title":"Efficient promotion of autophagy and angiogenesis using mesenchymal stem cell therapy enhanced by the low-energy shock waves in the treatment of erectile dysfunction","volume":"2018","author":"Zhu","year":"2018","journal-title":"Stem Cell. Int."},{"issue":"6","key":"10.1016\/j.placenta.2026.01.017_bib31","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s10815-024-03093-x","article-title":"Expression of long non-coding RNA GAS5 by first trimester screening predicts the occurrence of gestational hypertension and pre-eclampsia","volume":"41","author":"Wang","year":"2024","journal-title":"J. Assist. Reprod. Genet."},{"issue":"4","key":"10.1016\/j.placenta.2026.01.017_bib32","first-page":"475","article-title":"Expression of long-chain noncoding RNA GAS5 in osteoarthritis and its effect on apoptosis and autophagy of osteoarthritis chondrocytes","volume":"36","author":"Ji","year":"2021","journal-title":"Histol. Histopathol."},{"issue":"11","key":"10.1016\/j.placenta.2026.01.017_bib33","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1007\/s43032-023-01250-8","article-title":"N6-methyladenosine (m6A) modification in Preeclampsia","volume":"30","author":"Zhang","year":"2023","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.placenta.2026.01.017_bib34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.placenta.2020.10.016","article-title":"Upregulation of METTL3 expression and m6A RNA methylation in placental trophoblasts in preeclampsia","volume":"103","author":"Gu","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.01.017_bib35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.placenta.2025.03.004","article-title":"METTL3 suppressing SLC31A1 m(6)A modification regulates trophoblast migration and invasion","volume":"164","author":"Wang","year":"2025","journal-title":"Placenta"},{"issue":"11","key":"10.1016\/j.placenta.2026.01.017_bib36","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/s41419-020-03148-8","article-title":"The mechanism of m(6)A methyltransferase METTL3-mediated autophagy in reversing gefitinib resistance in NSCLC cells by \u03b2-elemene","volume":"11","author":"Liu","year":"2020","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.placenta.2026.01.017_bib37","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/cr.2017.15","article-title":"YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA","volume":"27","author":"Shi","year":"2017","journal-title":"Cell Res."},{"issue":"1","key":"10.1016\/j.placenta.2026.01.017_bib38","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1038\/s41467-022-32963-0","article-title":"Autophagy induction promoted by m(6)A reader YTHDF3 through translation upregulation of FOXO3 mRNA","volume":"13","author":"Hao","year":"2022","journal-title":"Nat. Commun."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426000299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426000299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T08:29:31Z","timestamp":1779006571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400426000299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":38,"alternative-id":["S0143400426000299"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2026.01.017","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"METTL3-regulated m6A modification modulates autophagy of placental mesenchymal stem\/stromal cell by YTHDF3-mediated degradation of LncRNA GAS5 in preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2026.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}