{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:29:40Z","timestamp":1791386980395,"version":"4.3.3"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P-37161-B"],"award-info":[{"award-number":["P-37161-B"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["101036702"],"award-info":[{"award-number":["101036702"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.placenta.2026.01.018","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T07:49:39Z","timestamp":1769586579000},"page":"73-77","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Characterization, organoid formation and differentiation potential of the novel term trophoblast cell line TB\/SVTERT350"],"prefix":"10.1016","volume":"175","author":[{"given":"Gudrun","family":"Meinhardt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Waldh\u00e4usl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Haider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Pollheimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Fiala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Bettelheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Gamauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Postl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Wieser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Grillari-Voglauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6625-8950","authenticated-orcid":false,"given":"Martin","family":"Kn\u00f6fler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2026.01.018_bib1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/1471-213X-7-137","article-title":"The first trimester human trophoblast cell line ACH-3P: a novel tool to study autocrine\/paracrine regulatory loops of human trophoblast subpopulations--TNF-alpha stimulates MMP15 expression","volume":"7","author":"Hiden","year":"2007","journal-title":"BMC Dev. Biol."},{"issue":"5","key":"10.1016\/j.placenta.2026.01.018_bib2","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1210\/jcem-32-5-683","article-title":"Isolation of hormone-producing clonal lines of human choriocarcinoma","volume":"32","author":"Kohler","year":"1971","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.placenta.2026.01.018_bib3","first-page":"124","article-title":"Efficient, rapid and reliable establishment of human trophoblast cell lines using poly-L-ornithine","volume":"4","author":"Choy","year":"2000","journal-title":"Early Pregnancy"},{"issue":"2","key":"10.1016\/j.placenta.2026.01.018_bib4","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1006\/excr.1993.1139","article-title":"Establishment and characterization of first trimester human trophoblast cells with extended lifespan","volume":"206","author":"Graham","year":"1993","journal-title":"Exp. Cell Res."},{"issue":"11","key":"10.1016\/j.placenta.2026.01.018_bib5","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.placenta.2009.08.007","article-title":"The isolation and characterization of a novel telomerase immortalized first trimester trophoblast cell line, Swan 71","volume":"30","author":"Straszewski-Chavez","year":"2009","journal-title":"Placenta"},{"issue":"11","key":"10.1016\/j.placenta.2026.01.018_bib6","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.placenta.2010.08.011","article-title":"Trophoblast invasion: assessment of cellular models using gene expression signatures","volume":"31","author":"Bilban","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.01.018_bib7","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.placenta.2020.10.011","article-title":"Cytogenomics of six human trophoblastic cell lines","volume":"103","author":"Weber","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.01.018_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2016.12.007","article-title":"HTR-8\/SVneo cell line contains a mixed population of cells","volume":"50","author":"Abou-Kheir","year":"2017","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2026.01.018_bib9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1365-2567.2008.03019.x","article-title":"Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies","volume":"127","author":"Apps","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.placenta.2026.01.018_bib10","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.placenta.2021.02.022","article-title":"Molecular characteristics of established trophoblast-derived cell lines","volume":"108","author":"Pastuschek","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.01.018_bib11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.placenta.2020.12.013","article-title":"3-Dimensional JEG-3 choriocarcinoma cell organoids as a model for trophoblast expansion and differentiation","volume":"104","author":"Dietrich","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.01.018_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.placenta.2023.01.005","article-title":"3D organoid formation and EVT differentiation of various trophoblastic cell lines","volume":"133","author":"Dietrich","year":"2023","journal-title":"Placenta"},{"issue":"16","key":"10.1016\/j.placenta.2026.01.018_bib13","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2426385122","article-title":"The multifaceted roles of the transcriptional coactivator TAZ in extravillous trophoblast development of the human placenta","volume":"122","author":"Meinhardt","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"22","key":"10.1016\/j.placenta.2026.01.018_bib14","doi-asserted-by":"crossref","first-page":"dev202152","DOI":"10.1242\/dev.202152","article-title":"NOTCH3 signalling controls human trophoblast stem cell expansion and differentiation","volume":"150","author":"Dietrich","year":"2023","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.placenta.2026.01.018_bib15","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.stemcr.2016.01.006","article-title":"What is trophoblast? A combination of criteria define human first-trimester trophoblast","volume":"6","author":"Lee","year":"2016","journal-title":"Stem Cell Rep."},{"issue":"4","key":"10.1016\/j.placenta.2026.01.018_bib16","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1210\/en.2010-0936","article-title":"Transcription factor AP-2alpha promotes EGF-dependent invasion of human trophoblast","volume":"152","author":"Biadasiewicz","year":"2011","journal-title":"Endocrinology"},{"issue":"24","key":"10.1016\/j.placenta.2026.01.018_bib17","doi-asserted-by":"crossref","first-page":"13562","DOI":"10.1073\/pnas.2002630117","article-title":"Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta","volume":"117","author":"Meinhardt","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"30","key":"10.1016\/j.placenta.2026.01.018_bib18","doi-asserted-by":"crossref","first-page":"17864","DOI":"10.1073\/pnas.2002449117","article-title":"TEAD4 ensures postimplantation development by promoting trophoblast self-renewal: an implication in early human pregnancy loss","volume":"117","author":"Saha","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"48","key":"10.1016\/j.placenta.2026.01.018_bib19","doi-asserted-by":"crossref","first-page":"E7710","DOI":"10.1073\/pnas.1612335113","article-title":"Notch1 controls development of the extravillous trophoblast lineage in the human placenta","volume":"113","author":"Haider","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.placenta.2026.01.018_bib20","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.stemcr.2018.07.004","article-title":"Self-Renewing trophoblast Organoids Recapitulate the Developmental Program of the early human placenta","volume":"11","author":"Haider","year":"2018","journal-title":"Stem Cell Rep."},{"issue":"1","key":"10.1016\/j.placenta.2026.01.018_bib21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.stem.2017.11.004","article-title":"Derivation of human trophoblast stem cells","volume":"22","author":"Okae","year":"2018","journal-title":"Cell Stem Cell"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426000305?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426000305?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T14:07:47Z","timestamp":1774015667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400426000305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":21,"alternative-id":["S0143400426000305"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2026.01.018","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization, organoid formation and differentiation potential of the novel term trophoblast cell line TB\/SVTERT350","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2026.01.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}