{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T09:09:08Z","timestamp":1779008948985,"version":"3.51.4"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007251","name":"National Research University Higher School of Economics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007251","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["24-14-00382"],"award-info":[{"award-number":["24-14-00382"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.placenta.2026.02.005","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:52:01Z","timestamp":1770479521000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["scRNA-seq of preeclamptic trophoblasts identifies EBI3, COL17A1, miR-27a-5p, and miR-193b-5p as hypoxia markers: validation of neuradapt as a superior mimetic to cobalt chloride"],"prefix":"10.1016","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9414-2573","authenticated-orcid":false,"given":"Evgeny","family":"Knyazev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timur","family":"Kulagin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Antipenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Tonevitsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2026.02.005_bib1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41572-023-00417-6","article-title":"Pre-eclampsia","volume":"9","author":"Dimitriadis","year":"2023","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.placenta.2026.02.005_bib2","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.jacc.2020.08.014","article-title":"Preeclampsia\u2014pathophysiology and clinical presentations","volume":"76","author":"Ives","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.placenta.2026.02.005_bib3","doi-asserted-by":"crossref","first-page":"46","DOI":"10.14390\/jsshp.HRP2017-014","article-title":"Hypoxia in the pathogenesis of preeclampsia","volume":"5","author":"Matsubara","year":"2017","journal-title":"Hypertension Research in Pregnancy"},{"key":"10.1016\/j.placenta.2026.02.005_bib4","doi-asserted-by":"crossref","first-page":"5028","DOI":"10.7150\/thno.56141","article-title":"Distinct placental molecular processes associated with early-onset and late-onset preeclampsia","volume":"11","author":"Ren","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.placenta.2026.02.005_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/bcpt.70073","article-title":"Models of endocrine\u2010disrupting effects: human placental steroidogenesis","volume":"137","author":"Mathiesen","year":"2025","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.placenta.2026.02.005_bib6","article-title":"Strategy advancements in placental pharmacokinetics: from in vitro experiments to in silico prediction","volume":"16","author":"Li","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.placenta.2026.02.005_bib7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.actbio.2023.04.033","article-title":"Healthy and diseased placental barrier on-a-chip models suitable for standardized studies","volume":"164","author":"Rabussier","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.placenta.2026.02.005_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202301428","article-title":"Modeling the progression of placental transport from early\u2010 to late\u2010stage pregnancy by tuning trophoblast differentiation and vascularization","volume":"12","author":"Kouthouridis","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.placenta.2026.02.005_bib9","doi-asserted-by":"crossref","first-page":"80","DOI":"10.21519\/0234-2758-2019-35-6-80-86","article-title":"HIF-1\u03b1 activation reduces expression of the microRNA hsa-miR-603 host gene KIAA1217 and increases expression of the target CCND1 gene in BeWo b30 cells","volume":"35","author":"Knyazev","year":"2019","journal-title":"Biotekhnologiya"},{"key":"10.1016\/j.placenta.2026.02.005_bib10","series-title":"Levels of miR-374 Increase in Bewo b30 Cells Exposed to Hypoxia","first-page":"11","author":"Knyazev","year":"2021"},{"key":"10.1016\/j.placenta.2026.02.005_bib11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1134\/S1607672921040104","article-title":"Chemical induction of trophoblast hypoxia by cobalt chloride leads to increased expression of DDIT3","volume":"499","author":"Knyazev","year":"2021","journal-title":"Dokl. Biochem. Biophys."},{"key":"10.1016\/j.placenta.2026.02.005_bib12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10517-019-04342-1","article-title":"Metabolic reprogramming of trophoblast cells in response to hypoxia","volume":"166","author":"Knyazev","year":"2019","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.placenta.2026.02.005_bib13","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10517-019-04352-z","article-title":"Oxyquinoline-dependent changes in claudin-encoding genes contribute to impairment of the barrier function of the trophoblast monolayer","volume":"166","author":"Knyazev","year":"2019","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.placenta.2026.02.005_bib14","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/jat.3749","article-title":"The use of cobalt chloride as a chemical hypoxia model","volume":"39","author":"Mu\u00f1oz-S\u00e1nchez","year":"2019","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.placenta.2026.02.005_bib15","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1093\/toxsci\/kfn251","article-title":"Metal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1\u03b1 protein","volume":"107","author":"Kaczmarek","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.placenta.2026.02.005_bib16","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1186\/s12885-015-1878-5","article-title":"Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells","volume":"15","author":"Miles","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.placenta.2026.02.005_bib17","doi-asserted-by":"crossref","first-page":"15911","DOI":"10.1074\/jbc.M300463200","article-title":"Cobalt Inhibits the Interaction between Hypoxia-inducible Factor-\u03b1 and von Hippel-Lindau Protein by Direct Binding to Hypoxia-inducible Factor-\u03b1","volume":"278","author":"Yuan","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.placenta.2026.02.005_bib18","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1006\/bbrc.2001.5835","article-title":"Hypoxia-inducible factor 2\u03b1 binds to cobalt in vitro","volume":"288","author":"Yuan","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.placenta.2026.02.005_bib19","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1096\/fj.04-3399fje","article-title":"Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway","volume":"19","author":"Hirsil\u00e4","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.placenta.2026.02.005_bib20","doi-asserted-by":"crossref","first-page":"11715","DOI":"10.1073\/pnas.95.20.11715","article-title":"Mitochondrial reactive oxygen species trigger hypoxia-induced transcription","volume":"95","author":"Chandel","year":"1998","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.placenta.2026.02.005_bib21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11010-013-1635-5","article-title":"CoCl2 induces apoptosis through the mitochondria- and death receptor-mediated pathway in the mouse embryonic stem cells","volume":"379","author":"Lee","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.placenta.2026.02.005_bib22","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.biocel.2008.07.012","article-title":"Cobalt induces oxidative stress in isolated liver mitochondria responsible for permeability transition and intrinsic apoptosis in hepatocyte primary cultures","volume":"41","author":"Battaglia","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.placenta.2026.02.005_bib23","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1186\/s40064-016-2405-0","article-title":"Effect of cobalt(II) chloride hexahydrate on some human cancer cell lines","volume":"5","author":"Mahey","year":"2016","journal-title":"SpringerPlus"},{"key":"10.1016\/j.placenta.2026.02.005_bib24","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.scitotenv.2012.06.009","article-title":"Cobalt metabolism and toxicology\u2014A brief update","volume":"432","author":"Simonsen","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.placenta.2026.02.005_bib25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s11010-005-8288-y","article-title":"Soluble nickel interferes with cellular iron homeostasis","volume":"279","author":"Davidson","year":"2005","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.placenta.2026.02.005_bib26","doi-asserted-by":"crossref","first-page":"30485","DOI":"10.1074\/jbc.M112.364208","article-title":"Substrate profile and metal-ion selectivity of human divalent metal-ion Transporter-1","volume":"287","author":"Illing","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.placenta.2026.02.005_bib27","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s11172-019-2433-3","article-title":"Structural optimization of adaptaquin, a HIF prolyl hydroxylase inhibitor","volume":"68","author":"Poloznikov","year":"2019","journal-title":"Russ. Chem. Bull."},{"key":"10.1016\/j.placenta.2026.02.005_bib28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2174\/1872312813666181129100950","article-title":"\u201cBranched Tail\u201d oxyquinoline inhibitors of HIF prolyl hydroxylase: early evaluation of toxicity and metabolism using Liver-on-a-chip","volume":"13","author":"Poloznikov","year":"2019","journal-title":"Drug Metabol. Lett."},{"key":"10.1016\/j.placenta.2026.02.005_bib29","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.biochi.2016.12.004","article-title":"Structure-activity relationship for branched oxyquinoline HIF activators: effect of modifications to phenylacetamide \u201ctail,\u201d","volume":"133","author":"Poloznikov","year":"2017","journal-title":"Biochimie"},{"key":"10.1016\/j.placenta.2026.02.005_bib30","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3390\/antiox11020220","article-title":"Structure\u2013activity relationships and transcriptomic analysis of hypoxia-inducible factor prolyl hydroxylase inhibitors","volume":"11","author":"Poloznikov","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.placenta.2026.02.005_bib31","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.2174\/1566524023666230913111300","article-title":"CoCl2-mimicked hypoxia induces the assembly of stress granules in trophoblast cells via eIF2\u03b1 phosphorylation-dependent and -Independent pathways","volume":"24","author":"Ma","year":"2024","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.placenta.2026.02.005_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.114189","article-title":"Microcystin-LR prenatal exposure drives preeclampsia-like changes in mice by inhibiting the expression of TGF-\u03b2 and VEGFA","volume":"182","author":"Guo","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.placenta.2026.02.005_bib33","doi-asserted-by":"crossref","DOI":"10.5812\/tms-122263","article-title":"Effect of eicosapentaenoic acid on sFlt-1 and HIF-1\u03b1 expression under induced hypoxia conditions in trophoblast tumor cell line (JEG-3)","volume":"1","author":"Moradian","year":"2022","journal-title":"Trends in Medical Sciences"},{"key":"10.1016\/j.placenta.2026.02.005_bib34","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2198923","article-title":"Trophoblast exosomal UCA1 induces endothelial injury through the PFN1\u2010RhoA\/ROCK pathway in preeclampsia: a human\u2010specific adaptive pathogenic mechanism","volume":"2022","author":"Wu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.placenta.2026.02.005_bib35","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s42003-023-04623-6","article-title":"Placental cell type deconvolution reveals that cell proportions drive preeclampsia gene expression differences","volume":"6","author":"Campbell","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.placenta.2026.02.005_bib36","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/humupd\/dmae006","article-title":"Revealing the molecular landscape of human placenta: a systematic review and meta-analysis of single-cell RNA sequencing studies","volume":"30","author":"Derisoud","year":"2024","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.placenta.2026.02.005_bib37","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.medj.2023.07.005","article-title":"Two distinct molecular faces of preeclampsia revealed by single-cell transcriptomics","volume":"4","author":"Admati","year":"2023","journal-title":"Med"},{"key":"10.1016\/j.placenta.2026.02.005_bib38","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/1471-2105-15-293","article-title":"Jvenn: an interactive venn diagram viewer","volume":"15","author":"Bardou","year":"2014","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.placenta.2026.02.005_bib39","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41467-017-02391-6","article-title":"Perturbation-response genes reveal signaling footprints in cancer gene expression","volume":"9","author":"Schubert","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.placenta.2026.02.005_bib40","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.placenta.2010.08.011","article-title":"Trophoblast invasion: assessment of cellular models using gene expression signatures","volume":"31","author":"Bilban","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.02.005_bib41","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1134\/S0026893319030130","article-title":"Impedance spectroscopy and transcriptome analysis of choriocarcinoma BeWo b30 as a model of human placenta","volume":"53","author":"Nikulin","year":"2019","journal-title":"Mol Biol"},{"key":"10.1016\/j.placenta.2026.02.005_bib42","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.placenta.2026.02.005_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1291642","article-title":"A cross-sectional analysis of syncytiotrophoblast membrane extracellular vesicles\u2013derived transcriptomic biomarkers in early-onset preeclampsia","volume":"10","author":"Awoyemi","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.placenta.2026.02.005_bib44","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3390\/biomedicines12040721","article-title":"miRNAs: from master regulators of gene expression to biomarkers involved in intercellular communication","volume":"12","author":"Levantini","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.placenta.2026.02.005_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2024.1371168","article-title":"MicroRNA analysis of medium\/large placenta extracellular vesicles in normal and preeclampsia pregnancies","volume":"11","author":"Awoyemi","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.placenta.2026.02.005_bib46","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1093\/biolre\/ioaf108","article-title":"Evaluation of optimal trophoblastic models to mimic uterine vessel remodeling in human pregnancy","volume":"113","author":"Li","year":"2025","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.placenta.2026.02.005_bib47","first-page":"1231","article-title":"The establishment of a cell line of human hormone-synthesizing trophoblastic cells in vitro","volume":"28","author":"Pattillo","year":"1968","journal-title":"Cancer Res."},{"key":"10.1016\/j.placenta.2026.02.005_bib48","article-title":"Metabolism and homeostasis of energy in trophoblast cells of the placenta: from development to disease","author":"Sah","year":"2025","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.placenta.2026.02.005_bib49","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.placenta.2024.12.011","article-title":"Single-nuclei RNA-sequencing fails to detect molecular dysregulation in the preeclamptic placenta","volume":"159","author":"Admati","year":"2025","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.02.005_bib50","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.101170","article-title":"Comparative analysis of the syncytiotrophoblast in placenta tissue and trophoblast organoids using snRNA sequencing","volume":"13","author":"Keenen","year":"2025","journal-title":"eLife"},{"key":"10.1016\/j.placenta.2026.02.005_bib51","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13059-020-1949-z","article-title":"Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data","volume":"21","author":"Holland","year":"2020","journal-title":"Genome Biol."},{"key":"10.1016\/j.placenta.2026.02.005_bib52","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1038\/s41598-019-39426-5","article-title":"Trophoblast-specific expression of Hif-1\u03b1 results in preeclampsia-like symptoms and fetal growth restriction","volume":"9","author":"Albers","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.placenta.2026.02.005_bib53","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.placenta.2021.04.012","article-title":"Paradigms for investigating invasive trophoblast cell development and contributions to uterine spiral artery remodeling","volume":"113","author":"Varberg","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.02.005_bib54","doi-asserted-by":"crossref","first-page":"704","DOI":"10.3390\/ijms22020704","article-title":"The role of NF-\u03baB in uterine spiral arteries remodeling, insight into the cornerstone of preeclampsia","volume":"22","author":"Socha","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2026.02.005_bib55","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.freeradbiomed.2023.09.030","article-title":"Apelin\/APJ system protects placental trophoblasts from hypoxia-induced oxidative stress through activating PI3K\/Akt signaling pathway in preeclampsia","volume":"208","author":"Ye","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.placenta.2026.02.005_bib56","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/humupd\/dmae007","article-title":"TGF\u03b2 signalling: a nexus between inflammation, placental health and preeclampsia throughout pregnancy","volume":"30","author":"Horvat Mercnik","year":"2024","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.placenta.2026.02.005_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.708824","article-title":"Assessment of placental extracellular vesicles-associated fas ligand and TNF-related apoptosis-inducing ligand in pregnancies complicated by early and late onset preeclampsia","volume":"12","author":"Ayala-Ram\u00edrez","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.placenta.2026.02.005_bib58","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s10517-018-4074-1","article-title":"TNF\u03b1-Induced expression of transport protein genes in HUVEC cells is associated with enhanced expression of transcription factor genes RELB and NFKB2 of the non-canonical NF-\u03baB pathway","volume":"164","author":"Knyazev","year":"2018","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.placenta.2026.02.005_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1134\/S160767291701001X","article-title":"Transcriptomic changes in human umbilical cord blood endothelial cells under simulated microgravity","volume":"472","author":"Rudimov","year":"2017","journal-title":"Dokl. Biochem. Biophys."},{"key":"10.1016\/j.placenta.2026.02.005_bib60","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.placenta.2007.06.004","article-title":"Expression of Interleukin-27 by human trophoblast cells","volume":"28","author":"Coulomb-L\u2019Hermin\u00e9","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.02.005_bib61","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1038\/s41467-019-12484-z","article-title":"Human placental trophoblast cells contribute to maternal\u2013fetal tolerance through expressing IL-35 and mediating iTR35 conversion","volume":"10","author":"Liu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.placenta.2026.02.005_bib62","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.humimm.2015.10.004","article-title":"Higher decidual EBI3 and HLA-G mRNA expression in preeclampsia: cause or consequence of preeclampsia","volume":"77","author":"Prins","year":"2016","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.placenta.2026.02.005_bib63","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12968","article-title":"Systemic transcriptome comparison between early\u2010 and late\u2010onset pre\u2010eclampsia shows distinct pathology and novel biomarkers","volume":"54","author":"Guo","year":"2021","journal-title":"Cell Prolif."},{"key":"10.1016\/j.placenta.2026.02.005_bib64","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3892\/mmr.2022.12905","article-title":"Significance of placental CD200 expression in patients with preeclampsia: comparison between early- and late-onset patients","volume":"27","author":"Tsubokura","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.placenta.2026.02.005_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003905","article-title":"STOX1 overexpression in choriocarcinoma cells mimics transcriptional alterations observed in preeclamptic placentas","volume":"3","author":"Rigourd","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.placenta.2026.02.005_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105693","article-title":"Metformin exhibits its therapeutic effect in the treatment of pre-eclampsia via modulating the Met\/H19\/miR-148a-5p\/P28 and Met\/H19\/miR-216-3p\/EBI3 signaling pathways","volume":"74","author":"Shu","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.placenta.2026.02.005_bib67","series-title":"Biochemistry of Collagens, Laminins and Elastin","first-page":"153","article-title":"Type XVII collagen","author":"Crespo-Bravo","year":"2024"},{"key":"10.1016\/j.placenta.2026.02.005_bib68","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000038638","article-title":"Detection and assessment of immune and stromal related risk genes to predict preeclampsia: a bioinformatics analysis with dataset","volume":"103","author":"Qin","year":"2024","journal-title":"Medicine"},{"key":"10.1016\/j.placenta.2026.02.005_bib69","first-page":"1","article-title":"Integrated analysis identifies four genes as novel diagnostic biomarkers which correlate with immune infiltration in preeclampsia","volume":"2022","author":"Yang","year":"2022","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.placenta.2026.02.005_bib70","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.17305\/bb.2024.10532","article-title":"The landscape of N1-methyladenosine (m1A) modification in mRNA of the decidua in severe preeclampsia","volume":"24","author":"Tong","year":"2024","journal-title":"Biomolecules and Biomedicine"},{"key":"10.1016\/j.placenta.2026.02.005_bib71","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1635878","article-title":"Molecular signatures of preeclampsia subtypes determined through integrated weighted gene co-expression network analysis and differential gene expression analysis of placental transcriptomics","volume":"13","author":"Han","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.placenta.2026.02.005_bib72","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1177\/1933719115570898","article-title":"Identification of early-onset preeclampsia-related genes and MicroRNAs by bioinformatics approaches","volume":"22","author":"Song","year":"2015","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.placenta.2026.02.005_bib73","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10517-015-3011-9","article-title":"Suppression of ITGB4 gene expression in PC-3 cells with short interfering RNA induces changes in the expression of \u03b2-Integrins associated with RGD-receptors","volume":"159","author":"Knyazev","year":"2015","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.placenta.2026.02.005_bib74","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/gaab030","article-title":"Excess fibronectin 1 participates in pathogenesis of pre-eclampsia by promoting apoptosis and autophagy in vascular endothelial cells","volume":"27","author":"Wu","year":"2021","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.placenta.2026.02.005_bib75","doi-asserted-by":"crossref","first-page":"8738","DOI":"10.3390\/ijms25168738","article-title":"Different proteomic profiles regarding antihypertensive therapy in preeclampsia pregnant","volume":"25","author":"Pinto-Souza","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2026.02.005_bib76","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1080\/10641955.2017.1385795","article-title":"FN1, FOS, and ITGA5 induce preeclampsia: abnormal expression and methylation","volume":"36","author":"Zhao","year":"2017","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.placenta.2026.02.005_bib77","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1097\/HJH.0000000000003129","article-title":"Hypoxia regulates fibrosis-related genes via histone lactylation in the placentas of patients with preeclampsia","volume":"40","author":"Li","year":"2022","journal-title":"J. Hypertens."},{"key":"10.1016\/j.placenta.2026.02.005_bib78","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.791640","article-title":"HIF-dependent NFATC1 activation upregulates ITGA5 and PLAUR in intestinal epithelium in inflammatory bowel disease","volume":"12","author":"Knyazev","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.placenta.2026.02.005_bib79","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-96823-9","article-title":"Cystatin 6 (CST6) and legumain (LGMN) are potential mediators in the pathogenesis of preeclampsia","volume":"15","author":"Botha","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.placenta.2026.02.005_bib80","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.placenta.2009.01.012","article-title":"Differential placental gene expression in severe preeclampsia","volume":"30","author":"Sitras","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.02.005_bib81","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1080\/07853890.2022.2071459","article-title":"The role of miRNA-210 in pre-eclampsia development","volume":"54","author":"Jaszczuk","year":"2022","journal-title":"Ann. Med."},{"key":"10.1016\/j.placenta.2026.02.005_bib82","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.placenta.2023.12.003","article-title":"MicroRNA miR-27a as a possible regulator of anti-inflammatory macrophage phenotype in preeclamptic placenta","volume":"145","author":"Vishnyakova","year":"2024","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.02.005_bib83","doi-asserted-by":"crossref","first-page":"612","DOI":"10.2174\/1871530321666211208152709","article-title":"miR-27b-3p is highly expressed in serum of patients with preeclampsia and has clinical significance","volume":"22","author":"Yang","year":"2022","journal-title":"Endocr., Metab. Immune Disord.: Drug Targets"},{"key":"10.1016\/j.placenta.2026.02.005_bib84","first-page":"2262","article-title":"MicroRNA-27a inhibits trophoblast cell migration and invasion by targeting SMAD2: potential role in preeclampsia","volume":"20","author":"Zheng","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.placenta.2026.02.005_bib85","doi-asserted-by":"crossref","first-page":"6531","DOI":"10.1007\/s11033-020-05705-y","article-title":"Potential pathophysiological role of microRNA 193b-5p in human placentae from pregnancies complicated by preeclampsia and intrauterine growth restriction","volume":"47","author":"Awamleh","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.placenta.2026.02.005_bib86","doi-asserted-by":"crossref","first-page":"110","DOI":"10.17816\/JOWD663110-115","article-title":"Peculiarities of placental microRNA expression in pregnancies complicated by gestational diabetes mellitus and preeclampsia","volume":"66","author":"Pakin","year":"2017","journal-title":"Journal of Obstetrics and Women\u2019s Diseases"},{"key":"10.1016\/j.placenta.2026.02.005_bib87","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1210\/clinem\/dgad751","article-title":"Early-pregnancy serum maternal and placenta-derived exosomes miRNAs vary based on pancreatic \u03b2-Cell function in GDM","volume":"109","author":"Razo-Azamar","year":"2024","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.placenta.2026.02.005_bib88","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4161\/rna.8.1.14300","article-title":"Deep-sequencing of human Argonaute-associated small RNAs provides insight into miRNA sorting and reveals argonaute association with RNA fragments of diverse origin","volume":"8","author":"Burroughs","year":"2011","journal-title":"RNA Biol."},{"key":"10.1016\/j.placenta.2026.02.005_bib89","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-15388-4","article-title":"Deep sequencing and analyses of miRNAs, isomiRs and miRNA induced silencing complex (miRISC)-associated miRNome in primary human chondrocytes","volume":"7","author":"Haseeb","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.placenta.2026.02.005_bib90","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.celrep.2014.08.027","article-title":"Nontemplated nucleotide additions distinguish the small RNA composition in cells from exosomes","volume":"8","author":"Koppers-Lalic","year":"2014","journal-title":"Cell Rep."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426000524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426000524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T08:29:07Z","timestamp":1779006547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400426000524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":90,"alternative-id":["S0143400426000524"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2026.02.005","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"scRNA-seq of preeclamptic trophoblasts identifies EBI3, COL17A1, miR-27a-5p, and miR-193b-5p as hypoxia markers: validation of neuradapt as a superior mimetic to cobalt chloride","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2026.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}