{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T02:35:07Z","timestamp":1777775707864,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.placenta.2026.03.004","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:54:12Z","timestamp":1772643252000},"page":"36-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The inverse association between circulatory placental biomarkers in early pregnancy and maternal body mass index"],"prefix":"10.1016","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9101-5093","authenticated-orcid":false,"given":"Nooria","family":"Atta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cleo","family":"Pike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tabitha","family":"Wishlade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla","family":"Sovio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clive J.","family":"Petry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Lockhart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken K.","family":"Ong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ieuan A.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra F.","family":"Goodburn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Aiken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2199-4449","authenticated-orcid":false,"given":"Stephen","family":"O'Rahilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2026.03.004_bib1","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/s13679-024-00580-1","article-title":"Strengths and limitations of BMI in the diagnosis of obesity: what is the path forward?","volume":"13","author":"Sweatt","year":"2024","journal-title":"Curr. Obes. Rep."},{"key":"10.1016\/j.placenta.2026.03.004_bib2","article-title":"Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child","volume":"356","author":"Catalano","year":"2017","journal-title":"Br. Med. J."},{"key":"10.1016\/j.placenta.2026.03.004_bib3","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S2213-8587(16)30217-0","article-title":"Preconceptional and maternal obesity: epidemiology and health consequences","volume":"4","author":"Poston","year":"2016","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.placenta.2026.03.004_bib4","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.2337\/dc24-0725","article-title":"Associations of high BMI and excessive gestational weight gain with pregnancy outcomes in women with type 1 diabetes: a systematic review and meta-analysis","volume":"47","author":"Atta","year":"2024","journal-title":"Diabetes Care"},{"key":"10.1016\/j.placenta.2026.03.004_bib5","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2022.0222","article-title":"Early life impacts of maternal obesity: a window of opportunity to improve the health of two generations","volume":"378","author":"Dearden","year":"2023","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.placenta.2026.03.004_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/nu13041213","article-title":"Maternal obesity and risk of low birth weight, fetal growth restriction, and macrosomia: multiple analyses","volume":"13","author":"Lewandowska","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.placenta.2026.03.004_bib7","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1080\/14767058.2016.1216098","article-title":"The effects of maternal obesity on perinatal outcomes among those born small for gestational age","volume":"30","author":"Yao","year":"2017","journal-title":"J. Matern. Neonatal Med."},{"key":"10.1016\/j.placenta.2026.03.004_bib8","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.placenta.2024.12.015","article-title":"The maternal body mass index and first-trimester placental (vascular) development","volume":"160","author":"Schenkelaars","year":"2025","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.03.004_bib9","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.fertnstert.2012.06.011","article-title":"Maternal body mass index and serum concentrations of human chorionic gonadotropin in very early pregnancy","volume":"98","author":"Eskild","year":"2012","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.placenta.2026.03.004_bib10","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.fertnstert.2018.08.047","article-title":"Effect of body weight on early hormone levels in singleton pregnancies resulting in delivery after in vitro fertilization","volume":"110","author":"Mejia","year":"2018","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.placenta.2026.03.004_bib11","doi-asserted-by":"crossref","DOI":"10.12688\/wellcomeopenres.14818.1","article-title":"Associations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: a nested case-control study","volume":"3","author":"Petry","year":"2018","journal-title":"Wellcome Open Res."},{"key":"10.1016\/j.placenta.2026.03.004_bib12","first-page":"698","article-title":"The inadequacy of the current correction for maternal weight in maternal serum alpha-fetoprotein interpretation","volume":"74","author":"Drugan","year":"1989","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2026.03.004_bib13","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/pd.4090","article-title":"The impact of maternal weight discrepancies on prenatal screening results for Down syndrome","volume":"33","author":"Huang","year":"2013","journal-title":"Prenat. Diagn."},{"key":"10.1016\/j.placenta.2026.03.004_bib14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/ije\/dys066","article-title":"Cohort Profile: the Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort","volume":"42","author":"Fraser","year":"2013","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.placenta.2026.03.004_bib15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/ije\/dys064","article-title":"Cohort Profile: the \u2018children of the 90s\u2019\u2014the index offspring of the Avon Longitudinal Study of Parents and children","volume":"42","author":"Boyd","year":"2013","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.placenta.2026.03.004_bib16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/ije\/dyv318","article-title":"Cohort profile: the Cambridge Baby Growth Study (CBGS)","volume":"45","author":"Prentice","year":"2015","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.placenta.2026.03.004_bib17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1471-2393-8-51","article-title":"A prospective cohort study of unselected primiparous women: the pregnancy outcome prediction study","volume":"8","author":"Pasupathy","year":"2008","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.placenta.2026.03.004_bib18","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1016\/S0140-6736(15)00131-2","article-title":"Screening for fetal growth restriction with universal third trimester ultrasonography in nulliparous women in the Pregnancy Outcome Prediction (POP) study: a prospective cohort study","volume":"386","author":"Sovio","year":"2015","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.placenta.2026.03.004_bib19","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.placenta.2016.10.011","article-title":"The pregnancy outcome prediction (POP) study : investigating the relationship between serial prenatal ultrasonography , biomarkers , placental phenotype and adverse pregnancy outcomes","volume":"59","author":"Gaccioli","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.03.004_bib20","doi-asserted-by":"crossref","first-page":"120.e1","DOI":"10.1016\/j.ajog.2023.11.1227","article-title":"Maternal high body mass index, but not gestational diabetes, is associated with poorer educational attainment in mid-childhood","volume":"231","author":"Olga","year":"2024","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2026.03.004_bib21","doi-asserted-by":"crossref","first-page":"100","DOI":"10.12688\/wellcomeopenres.15976.2","article-title":"Gestation at completion of prenatal questionnaires in ALSPAC","volume":"5","author":"Iles-Caven","year":"2020","journal-title":"Wellcome Open Res."},{"key":"10.1016\/j.placenta.2026.03.004_bib22","doi-asserted-by":"crossref","first-page":"408.e1","DOI":"10.1016\/j.ajog.2015.05.021","article-title":"Blood volume determination in obese and normal weight gravidas: the Hydroxyethyl Starch Method","volume":"213","author":"Vricella","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2026.03.004_bib23","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.bja.2022.08.011","article-title":"Maternal body weight and estimated circulating blood volume: a review and practical nonlinear approach","volume":"129","author":"Kennedy","year":"2022","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.placenta.2026.03.004_bib24","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1381\/096089206777346673","article-title":"Estimating blood volume in obese and morbidly obese patients","volume":"16","author":"Lemmens","year":"2006","journal-title":"Obes. Surg."},{"key":"10.1016\/j.placenta.2026.03.004_bib25","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1186\/s12884-019-2619-6","article-title":"Plasma volume expansion across healthy pregnancy: a systematic review and meta-analysis of longitudinal studies","volume":"19","author":"Aguree","year":"2019","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.placenta.2026.03.004_bib26","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1038\/s41591-025-03827-z","article-title":"Polygenic prediction of body mass index and obesity through the life course and across ancestries","volume":"31","author":"Smit","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.placenta.2026.03.004_bib27","unstructured":"PGS catalog - the polygenic Score catalog, (n.d.). https:\/\/www.pgscatalog.org\/(accessed October 23, 2025)."},{"key":"10.1016\/j.placenta.2026.03.004_bib28","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1161\/HYPERTENSIONAHA.124.23400","article-title":"Genetic variants associated with Preeclampsia and maternal serum sFLT 1 levels","volume":"82","author":"MacK","year":"2025","journal-title":"Hypertension"},{"key":"10.1016\/j.placenta.2026.03.004_bib29","unstructured":"Pgsc_calc: a reproducible workflow to calculate polygenic scores \u2014 Polygenic Score (PGS) Catalog Calculator documentation, (n.d.). https:\/\/pgsc-calc.readthedocs.io\/en\/latest\/index.html (accessed October 23, 2025)."},{"key":"10.1016\/j.placenta.2026.03.004_bib30","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41586-018-0753-3","article-title":"Trophoblast organoids as a model for maternal-fetal interactions during human placentation","volume":"564","author":"Turco","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.placenta.2026.03.004_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031380","article-title":"Human chorionic gonadotropin and early embryogenesis: review","volume":"23","author":"D\u2019hauterive","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2026.03.004_bib32","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.3109\/00016349.2010.505639","article-title":"Biology of pregnancy-associated plasma protein-A in relation to prenatal diagnostics: an overview","volume":"89","author":"Kirkegaard","year":"2010","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.placenta.2026.03.004_bib33","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1053\/plac.2002.0816","article-title":"Alpha-fetoprotein gene expression in early and full-term human trophoblast","volume":"23","author":"Lafuste","year":"2002","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.03.004_bib34","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1097\/01.OGX.0000099770.97668.18","article-title":"Levels of alpha-fetoprotein during pregnancy and early infancy in normal and disease states","volume":"58","author":"Mizejewski","year":"2003","journal-title":"Obstet. Gynecol. Surv."},{"key":"10.1016\/j.placenta.2026.03.004_bib35","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1210\/clinem\/dgaa660","article-title":"Maternal obesity influences placental nutrient transport, inflammatory status, and morphology in human term placenta","volume":"106","author":"Nogues","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.placenta.2026.03.004_bib36","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1053\/plac.2002.0881","article-title":"Macrophage inhibitory Cytokine-1 in gestational tissues and maternal serum in normal and pre-eclamptic pregnancy","volume":"24","author":"Marjono","year":"2003","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.03.004_bib37","article-title":"The human placenta: new perspectives on its formation and function during early pregnancy","volume":"290","author":"Burton","year":"2023","journal-title":"Proceedings. Biol. Sci."},{"key":"10.1016\/j.placenta.2026.03.004_bib38","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/00125480-200201000-00003","article-title":"The Arias-Stella reaction: facts and fancies four decades after","volume":"9","author":"Arias-Stella","year":"2002","journal-title":"Adv. Anat. Pathol."},{"key":"10.1016\/j.placenta.2026.03.004_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-24779-1","article-title":"Climatic windows for human migration out of Africa in the past 300,000 years","volume":"12","author":"Beyer","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.placenta.2026.03.004_bib40","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.physbeh.2004.02.007","article-title":"Energy balance and reproduction","volume":"81","author":"Schneider","year":"2004","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.placenta.2026.03.004_bib41","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0015-0282(01)03010-2","article-title":"Leptin and reproduction: a review","volume":"77","author":"Moschos","year":"2002","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.placenta.2026.03.004_bib42","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0143-4004(98)90105-9","article-title":"Compensatory placental growth after restricted maternal nutrition in early pregnancy","volume":"19","author":"Lumey","year":"1998","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.03.004_bib43","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/640291","article-title":"Maternal obesity and occurrence of fetal macrosomia: a systematic review and meta-analysis","volume":"2014","author":"Gaudet","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.placenta.2026.03.004_bib44","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1053\/j.semperi.2003.10.012","article-title":"First trimester origins of fetal growth impairment","volume":"28","author":"Smith","year":"2004","journal-title":"Semin. Perinatol."},{"key":"10.1016\/j.placenta.2026.03.004_bib45","first-page":"1736","article-title":"Evidence for involvement of GIP and GLP-1 receptors and the gut-gonadal axis in regulating female reproductive function in mice","volume":"12","author":"Khan","year":"2022","journal-title":"Biomol"},{"key":"10.1016\/j.placenta.2026.03.004_bib46","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/aogs.15010","article-title":"The hidden impact of GLP-1 receptor agonists on endometrial receptivity and implantation","volume":"104","author":"Sola-Leyva","year":"2025","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"16","key":"10.1016\/j.placenta.2026.03.004_bib47","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s12884-016-0983-z","article-title":"Concordance between self-reported pre-pregnancy body mass index (BMI) and BMI measured at the first prenatal study contact","volume":"161","author":"Natamba","year":"2016","journal-title":"BMC Pregnancy Childbirth"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426000755?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426000755?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:12:54Z","timestamp":1777486374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400426000755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":47,"alternative-id":["S0143400426000755"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2026.03.004","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The inverse association between circulatory placental biomarkers in early pregnancy and maternal body mass index","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2026.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}