{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:44:21Z","timestamp":1791945861781,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["1435\/20"],"award-info":[{"award-number":["1435\/20"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.placenta.2026.03.009","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:51:50Z","timestamp":1773906710000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Cortisol in early pregnancy: Impact on pregnancy outcomes"],"prefix":"10.1016","volume":"178","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7605-0599","authenticated-orcid":false,"given":"Noam","family":"Tomasis Damri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maayan","family":"Hagbi Bal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Sheiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Shoham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimrit Yaniv","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Yoles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa Dina","family":"Israel-Tov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifat","family":"Baram Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Bergman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Rosenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayal","family":"Haimov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilana","family":"Shoham-Vardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Wainstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2026.03.009_bib1","unstructured":"Disorders of the adrenal cortex | Harrison's principles of internal medicine, 20e | AccessMedicine | McGraw hill medical [internet]. [cited 2021 December 31]. Available from: https:\/\/accessmedicine-mhmedical-com.ezproxy.bgu.ac.il\/content.aspx?sectionid=192287137&bookid=2129#1165971816."},{"issue":"2","key":"10.1016\/j.placenta.2026.03.009_bib2","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1960","article-title":"Molecular links between endocrine, nervous and immune system during chronic stress","volume":"11","author":"Zefferino","year":"2021","journal-title":"Brain. Behav."},{"key":"10.1016\/j.placenta.2026.03.009_bib3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.yhbeh.2017.12.014","article-title":"Early life stress and cortisol: a meta-analysis","volume":"98","author":"Fogelman","year":"2018","journal-title":"Horm. Behav."},{"key":"10.1016\/j.placenta.2026.03.009_bib4","first-page":"126","volume":"117","author":"Cwikel","year":"2004"},{"issue":"1","key":"10.1016\/j.placenta.2026.03.009_bib5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.biopsycho.2014.04.003","article-title":"Pregnancy anxiety and prenatal cortisol trajectories","volume":"100","author":"Kane","year":"2014","journal-title":"Biol. Psychol."},{"issue":"2","key":"10.1016\/j.placenta.2026.03.009_bib6","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.physbeh.2011.02.041","article-title":"Hair cortisol levels as a retrospective marker of hypothalamic-pituitary axis activity throughout pregnancy: comparison to salivary cortisol","volume":"104","author":"D'Anna-Hernandez","year":"2011","journal-title":"Physiol. Behav."},{"issue":"4","key":"10.1016\/j.placenta.2026.03.009_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2019.06.045","article-title":"Physiological and psychological stress responses to labor and delivery as expressed by salivary cortisol: a prospective study","volume":"221","author":"Miller","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.placenta.2026.03.009_bib8","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.pedneo.2019.03.003","article-title":"Basal serum cortisol concentration in very low birth weight infants","volume":"60","author":"Hwang","year":"2019","journal-title":"Pediatr. Neonatol."},{"issue":"1","key":"10.1016\/j.placenta.2026.03.009_bib9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s12020-018-1586-4","article-title":"Increased cortisol metabolism in women with pregnancy-related hypertension","volume":"61","author":"Kosicka","year":"2018","journal-title":"Endocrine"},{"issue":"6","key":"10.1016\/j.placenta.2026.03.009_bib10","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1210\/jc.2018-02312","article-title":"A lower maternal cortisol-to-cortisone ratio precedes clinical diagnosis of preterm and term preeclampsia by many weeks","volume":"104","author":"Jayasuriya","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.placenta.2026.03.009_bib11","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1177\/1099800418758952","article-title":"Comparison of hair cortisol levels and perceived stress in mothers who deliver at preterm and term","volume":"20","author":"Duffy","year":"2018","journal-title":"Biol. Res. Nurs."},{"key":"10.1016\/j.placenta.2026.03.009_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.psyneuen.2017.05.021","article-title":"Can stress biomarkers predict preterm birth in women with threatened preterm labor?","volume":"83","author":"Garc\u00eda-Blanco","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.placenta.2026.03.009_bib14","first-page":"1","article-title":"Is the risk of low birth weight or preterm labor greater when maternal stress is experienced during pregnancy","author":"Rodrigues","year":"2018","journal-title":"Systemat. Rev. Meta-Anal. Cohort Stud."},{"issue":"2","key":"10.1016\/j.placenta.2026.03.009_bib15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.neubiorev.2004.10.007","article-title":"Antenatal maternal anxiety and stress and the neurobehavioural development of the fetus and child: links and possible mechanisms. A review","volume":"29","author":"Van Den Bergh","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"5","key":"10.1016\/j.placenta.2026.03.009_bib16","doi-asserted-by":"crossref","first-page":"E150","DOI":"10.1097\/AOG.0000000000002046","article-title":"Methods for estimating the due date","volume":"129","author":"Pettker","year":"2017","journal-title":"Obstetr. Gynecol. [Internet]"},{"key":"10.1016\/j.placenta.2026.03.009_bib17","unstructured":"Cortisol Saliva ELISA \u2013 Instructions for Use (IBL International Tecan).Pdf."},{"key":"10.1016\/j.placenta.2026.03.009_bib18","volume":"vol. 2","year":"2020"},{"issue":"1","key":"10.1016\/j.placenta.2026.03.009_bib19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1471-244X-10-111","article-title":"Validation of the Arabic version of the cohen perceived stress scale (PSS-10) among pregnant and postpartum women","volume":"10","author":"Chaaya","year":"2010","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.placenta.2026.03.009_bib20","article-title":"Comparison of salivary cortisol, amylase, and chromogranin A diurnal profiles in healthy volunteers","volume":"142","author":"Jantaratnotai","year":"2022","journal-title":"Arch. Oral. Biol. [Internet]"},{"key":"10.1016\/j.placenta.2026.03.009_bib21","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.clinbiochem.2018.02.012","article-title":"Establishment of reference intervals for the salivary cortisol circadian cycle, by electrochemiluminescence (ECLIA), in healthy adults","volume":"54","author":"Gagnon","year":"2018","journal-title":"Clin Biochem. [Internet]"},{"issue":"6","key":"10.1016\/j.placenta.2026.03.009_bib22","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s00404-021-06251-z","article-title":"Cumulative life stressors and stress response to threatened preterm labour as birth date predictors","volume":"305","author":"Campos-Berga","year":"2022","journal-title":"Arch. Gynecol. Obstet."},{"issue":"5","key":"10.1016\/j.placenta.2026.03.009_bib23","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1210\/jcem.83.5.4804","article-title":"Maternal corticotropin-releasing hormone is increased with impending preterm birth","volume":"83","author":"Korebrits","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.placenta.2026.03.009_bib24","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.infbeh.2005.12.010","article-title":"Prenatal cortisol, prematurity and low birthweight","volume":"29","author":"Field","year":"2006","journal-title":"Infant Behav. Dev."},{"issue":"6","key":"10.1016\/j.placenta.2026.03.009_bib25","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.peptides.2005.10.002","article-title":"Elevated maternal cortisol early in pregnancy predicts third trimester levels of placental corticotropin releasing hormone (CRH): priming the placental clock","volume":"27","author":"Sandman","year":"2006","journal-title":"Peptides (NY)"},{"issue":"4","key":"10.1016\/j.placenta.2026.03.009_bib26","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/schbul\/sbaa171","article-title":"Black American maternal prenatal choline, offspring gestational age at birth, and developmental predisposition to mental illness","volume":"47","author":"Hunter","year":"2021","journal-title":"Schizophr. Bull."},{"issue":"1","key":"10.1016\/j.placenta.2026.03.009_bib27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2147\/IJWH.S42268","article-title":"Family cohesion, acculturation, maternal cortisol, and preterm birth in Mexican-American women","volume":"5","author":"Ruiz","year":"2013","journal-title":"Int. J. Womens Health"},{"issue":"4","key":"10.1016\/j.placenta.2026.03.009_bib28","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.repbio.2018.09.004","article-title":"Can hair steroids predict pregnancy longevity?","volume":"18","author":"Schonblum","year":"2018","journal-title":"Reprod. Biol."},{"issue":"11","key":"10.1016\/j.placenta.2026.03.009_bib29","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/aje\/kwp061","article-title":"Stress pathways to spontaneous preterm birth: the role of stressors, psychological distress, and stress hormones","volume":"169","author":"Kramer","year":"2009","journal-title":"Am. J. Epidemiol."},{"issue":"3","key":"10.1016\/j.placenta.2026.03.009_bib30","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ajog.2004.04.018","article-title":"Racial and ethnic disparities in preterm birth: the role of stressful life events","volume":"191","author":"Lu","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"9129","key":"10.1016\/j.placenta.2026.03.009_bib31","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0140-6736(05)60824-0","article-title":"Fetal exposure to maternal cortisol","volume":"352","author":"Gitau","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.placenta.2026.03.009_bib32","article-title":"11\u03b2-Hydroxysteroid dehydrogenase 2 in preeclampsia","volume":"2016","author":"Kosicka","year":"2016","journal-title":"Internet J. Endocrinol."},{"issue":"1","key":"10.1016\/j.placenta.2026.03.009_bib33","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1210\/jc.2002-021378","article-title":"Placental 11\u03b2-Hydroxysteroid Dehydrogenase-2 and fetal cortisol\/cortisone shuttle in small preterm infants","volume":"88","author":"Kajantie","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.placenta.2026.03.009_bib34","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.psyneuen.2017.05.026","article-title":"Determinants of cortisol during pregnancy \u2013 the ABCD cohort","volume":"83","author":"Bleker","year":"2017","journal-title":"Psychoneuroendocrinology"},{"issue":"10","key":"10.1016\/j.placenta.2026.03.009_bib36","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.psyneuen.2009.06.011","article-title":"Assessing salivary cortisol in large-scale, epidemiological research","volume":"34","author":"Adam","year":"2009","journal-title":"Psychoneuroendocrinology [Internet]"},{"issue":"3","key":"10.1016\/j.placenta.2026.03.009_bib37","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/jog.12555","article-title":"Analysis of gene expression and preliminary study of methylation about 11\u03b2-HSD2 gene in placentas of Chinese pre-eclampsia patients of Han ethnicity","volume":"41","author":"Hu","year":"2015","journal-title":"J. Obstet. Gynaecol. Res."},{"issue":"3","key":"10.1016\/j.placenta.2026.03.009_bib38","first-page":"1313","article-title":"Decreased gene expression of 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase in human placenta of patients with preeclampsia","volume":"86","author":"Schoof","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.placenta.2026.03.009_bib39","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.placenta.2011.06.014","article-title":"Elevated glucocorticoid metabolism in placental tissue from first trimester pregnancies at increased risk of pre-eclampsia","volume":"32","author":"Mukherjee","year":"2011","journal-title":"Placenta"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426000871?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426000871?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T17:04:43Z","timestamp":1776877483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400426000871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":37,"alternative-id":["S0143400426000871"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2026.03.009","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cortisol in early pregnancy: Impact on pregnancy outcomes","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2026.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}