{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:00:06Z","timestamp":1774584006905,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"India Ministry of Science & Technology Department of Biotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.placenta.2026.03.010","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:43:40Z","timestamp":1773215020000},"page":"44-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Disrupted placental circadian clock networks drive preeclampsia pathogenesis: An integrative bioinformatic analysis of key hub genes and regulatory pathways"],"prefix":"10.1016","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0636-3098","authenticated-orcid":false,"given":"Ramesh","family":"Muruganantham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paranitharan","family":"Nagarajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thirunavukkarasu","family":"Velusamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8302-2472","authenticated-orcid":false,"given":"Hsi-Lung","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saradhadevi","family":"Muthukrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3700-1907","authenticated-orcid":false,"given":"Velayuthaprabhu","family":"Shanmugam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.placenta.2026.03.010_bib1","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1161\/HYP.0000000000000208","article-title":"Hypertension in pregnancy: diagnosis, blood pressure goals, and pharmacotherapy: a scientific statement from the American heart association","volume":"79","author":"Garovic","year":"2022","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.placenta.2026.03.010_bib2","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1097\/AOG.0000000000003891","article-title":"Gestational hypertension and preeclampsia: ACOG practice bulletin, number 222","volume":"135","year":"2020","journal-title":"Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.placenta.2026.03.010_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2013.05.005","article-title":"Global and regional estimates of preeclampsia and eclampsia: a systematic review","volume":"170","author":"Abalos","year":"2013","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.placenta.2026.03.010_bib4","article-title":"Inflammation in preeclampsia: genetic biomarkers, mechanisms, and therapeutic strategies","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"issue":"18","key":"10.1016\/j.placenta.2026.03.010_bib5","doi-asserted-by":"crossref","first-page":"e902","DOI":"10.1161\/CIR.0000000000000961","article-title":"Adverse pregnancy outcomes and cardiovascular disease risk: unique opportunities for cardiovascular disease prevention in women: a scientific statement from the American Heart Association","volume":"143","author":"Parikh","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.placenta.2026.03.010_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2019.07.004","article-title":"The two-stage placental model of preeclampsia: an update","volume":"134","author":"Staff","year":"2019","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.placenta.2026.03.010_bib7","article-title":"Pre-eclampsia: pathophysiology and clinical implications","volume":"366","author":"Burton","year":"2019","journal-title":"Bmj"},{"issue":"3","key":"10.1016\/j.placenta.2026.03.010_bib8","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nrg.2016.150","article-title":"Transcriptional architecture of the mammalian circadian clock","volume":"18","author":"Takahashi","year":"2017","journal-title":"Nat. Rev. Genet."},{"issue":"7","key":"10.1016\/j.placenta.2026.03.010_bib9","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.placenta.2012.03.008","article-title":"A rhythmic placenta? Circadian variation, clock genes and placental function","volume":"33","author":"Waddell","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.03.010_bib10","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3389\/fendo.2013.00092","article-title":"Shift work and circadian dysregulation of reproduction","volume":"4","author":"Gamble","year":"2013","journal-title":"Front. Endocrinol."},{"issue":"12","key":"10.1016\/j.placenta.2026.03.010_bib11","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1111\/j.1471-0528.2011.03066.x","article-title":"Shift work and pregnancy outcomes: a systematic review with meta\u2010analysis of currently available epidemiological studies","volume":"118","author":"Bonzini","year":"2011","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"issue":"1","key":"10.1016\/j.placenta.2026.03.010_bib12","article-title":"Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia","volume":"12","author":"Zhou","year":"2022","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.placenta.2026.03.010_bib13","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.3390\/ijms24032363","article-title":"Disruption of the expression of the placental clock and melatonin genes in preeclampsia","volume":"24","author":"Diallo","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2026.03.010_bib14","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3389\/fphar.2018.00697","article-title":"Master regulators connectivity map: a transcription factors-centered approach to drug repositioning","volume":"9","author":"De Bastiani","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.placenta.2026.03.010_bib15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12920-019-0548-x","article-title":"Placental microRNAs in pregnancies with early onset intrauterine growth restriction and preeclampsia: potential impact on gene expression and pathophysiology","volume":"12","author":"Awamleh","year":"2019","journal-title":"BMC Med. Genom."},{"issue":"7","key":"10.1016\/j.placenta.2026.03.010_bib16","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.placenta.2026.03.010_bib17","author":"Hayles"},{"issue":"D1","key":"10.1016\/j.placenta.2026.03.010_bib18","doi-asserted-by":"crossref","first-page":"D545","DOI":"10.1093\/nar\/gkaa970","article-title":"KEGG: integrating viruses and cellular organisms","volume":"49","author":"Kanehisa","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.placenta.2026.03.010_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.xinn.2021.100141","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"The innovation"},{"issue":"D1","key":"10.1016\/j.placenta.2026.03.010_bib20","doi-asserted-by":"crossref","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: customizable protein\u2013protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.placenta.2026.03.010_bib21","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"issue":"Suppl 4","key":"10.1016\/j.placenta.2026.03.010_bib22","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst. Biol."},{"issue":"D1","key":"10.1016\/j.placenta.2026.03.010_bib23","first-page":"D87","article-title":"Jaspar 2020: update of the open-access database of transcription factor binding profiles","volume":"48","author":"Fornes","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.placenta.2026.03.010_bib24","doi-asserted-by":"crossref","first-page":"D239","DOI":"10.1093\/nar\/gkx1141","article-title":"DIANA-TarBase v8: a decade-long collection of experimentally supported miRNA\u2013gene interactions","volume":"46","author":"Karagkouni","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"10.1016\/j.placenta.2026.03.010_bib25","doi-asserted-by":"crossref","first-page":"W234","DOI":"10.1093\/nar\/gkz240","article-title":"NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis","volume":"47","author":"Zhou","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.placenta.2026.03.010_bib26","doi-asserted-by":"crossref","first-page":"D1068","DOI":"10.1093\/nar\/gkx1143","article-title":"DGIdb 3.0: a redesign and expansion of the drug\u2013gene interaction database","volume":"46","author":"Cotto","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.placenta.2026.03.010_bib27","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev.pharmtox.48.113006.094626","article-title":"Circadian timing in cancer treatments","volume":"50","author":"L\u00e9vi","year":"2010","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"4","key":"10.1016\/j.placenta.2026.03.010_bib28","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/humupd\/dmae007","article-title":"TGF\u03b2 signalling: a nexus between inflammation, placental health and preeclampsia throughout pregnancy","volume":"30","author":"Horvat Mercnik","year":"2024","journal-title":"Hum. Reprod. Update"},{"issue":"3","key":"10.1016\/j.placenta.2026.03.010_bib29","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3390\/biom10030453","article-title":"The TGF\u03b2 family in human placental development at the fetal-maternal interface","volume":"10","author":"Chuva de Sousa Lopes","year":"2020","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.placenta.2026.03.010_bib30","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1210\/en.2015-1696","article-title":"Aberrant TGF\u03b2 signaling contributes to altered trophoblast differentiation in preeclampsia","volume":"157","author":"Xu","year":"2016","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.placenta.2026.03.010_bib31","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s11010-021-04294-z","article-title":"The role of endoglin and its soluble form in pathogenesis of preeclampsia","volume":"477","author":"Margioula-Siarkou","year":"2022","journal-title":"Mol. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.placenta.2026.03.010_bib32","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1161\/HYPERTENSIONAHA.119.13348","article-title":"Soluble endoglin as a marker for preeclampsia, its severity, and the occurrence of adverse outcomes","volume":"74","author":"Lea\u00f1os-Miranda","year":"2019","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.placenta.2026.03.010_bib33","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1159\/000443076","article-title":"Rac1\/\u03b2-catenin signalling pathway contributes to trophoblast cell invasion by targeting snail and MMP9","volume":"38","author":"Fan","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"issue":"9","key":"10.1016\/j.placenta.2026.03.010_bib34","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2174\/15680096113136660102","article-title":"The role of snail in EMT and tumorigenesis","volume":"13","author":"Wang","year":"2013","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.placenta.2026.03.010_bib35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.20517\/2394-4722.2023.34","article-title":"Role of epithelial-mesenchymal transition factor SNAI1 and its targets in ovarian cancer aggressiveness","volume":"9","author":"Suzuki","year":"2023","journal-title":"Journal of cancer metastasis and treatment"},{"issue":"8","key":"10.1016\/j.placenta.2026.03.010_bib36","doi-asserted-by":"crossref","first-page":"370","DOI":"10.5483\/BMBRep.2022.55.8.174","article-title":"Epithelial to mesenchymal transition (EMT) of feto-maternal reproductive tissues generates inflammation: a detrimental factor for preterm birth","volume":"55","author":"Menon","year":"2022","journal-title":"BMB Rep."},{"issue":"1","key":"10.1016\/j.placenta.2026.03.010_bib37","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/hr.2016.97","article-title":"Mesenchymal-to-epithelial transition in the placental tissues of patients with preeclampsia","volume":"40","author":"Du","year":"2017","journal-title":"Hypertens. Res."},{"issue":"1","key":"10.1016\/j.placenta.2026.03.010_bib50","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cmet.2016.09.010","article-title":"Circadian clock interaction with HIF1\u03b1 mediates oxygenic metabolism and anaerobic glycolysis in skeletal muscle","volume":"25","author":"Peek","year":"2017","journal-title":"Cell Metab."},{"issue":"17","key":"10.1016\/j.placenta.2026.03.010_bib51","doi-asserted-by":"crossref","first-page":"12115","DOI":"10.1074\/jbc.274.17.12115","article-title":"Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. Demonstration of competition and compensation","volume":"274","author":"Chan","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.placenta.2026.03.010_bib38","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1016\/j.placenta.2017.05.005","article-title":"GATA factors: master regulators of gene expression in trophoblast progenitors","volume":"60","author":"Paul","year":"2017","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2026.03.010_bib39","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1080\/21655979.2021.2018094","article-title":"Retracted ARTICLE: Forkhead-box C1 attenuates high glucose-induced trophoblast cell injury during gestational diabetes mellitus via activating adenosine monophosphate-activated protein kinase through regulating fibroblast growth factor 19","volume":"13","author":"Cao","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.placenta.2026.03.010_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2021.611112","article-title":"miR-16-5p, miR-103-3p, and miR-27b-3p as early peripheral biomarkers of fetal growth restriction","volume":"9","author":"Tagliaferri","year":"2021","journal-title":"Front. Pediatr."},{"issue":"1","key":"10.1016\/j.placenta.2026.03.010_bib41","doi-asserted-by":"crossref","DOI":"10.1080\/10641955.2025.2470626","article-title":"Preeclampsia pathogenesis and prediction-where are we now: the focus on the role of galectins and miRNAs","volume":"44","author":"Karadzov Orlic","year":"2025","journal-title":"Hypertens. Pregnancy"},{"issue":"20","key":"10.1016\/j.placenta.2026.03.010_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252011062","article-title":"Impacts of maternal preeclampsia exposure on offspring neuronal development: recent insights and interventional approaches","volume":"25","author":"Zhang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"24","key":"10.1016\/j.placenta.2026.03.010_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252413508","article-title":"Circadian effects of melatonin receptor-targeting molecules in vitro","volume":"25","author":"Chhe","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.placenta.2026.03.010_bib44","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.3109\/0886022X.2014.926216","article-title":"Melatonin secretion is impaired in women with preeclampsia and an abnormal circadian blood pressure rhythm","volume":"36","author":"Bouchlariotou","year":"2014","journal-title":"Ren. Fail."},{"issue":"13","key":"10.1016\/j.placenta.2026.03.010_bib45","doi-asserted-by":"crossref","first-page":"6985","DOI":"10.3390\/ijms22136985","article-title":"The road to low-dose aspirin therapy for the prevention of preeclampsia began with the placenta","volume":"22","author":"Walsh","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.placenta.2026.03.010_bib46","doi-asserted-by":"crossref","first-page":"819","DOI":"10.7326\/M14-1884","article-title":"Low-dose aspirin use for the prevention of morbidity and mortality from preeclampsia: US Preventive services task force recommendation statement","volume":"161","author":"LeFevre","year":"2014","journal-title":"Ann. Intern. Med."},{"issue":"1","key":"10.1016\/j.placenta.2026.03.010_bib47","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1096\/fba.2020-00057","article-title":"Modelling preeclampsia: a comparative analysis of the common human trophoblast cell lines","volume":"3","author":"Zhao","year":"2021","journal-title":"FASEB BioAdvances"},{"key":"10.1016\/j.placenta.2026.03.010_bib49","article-title":"Single-cell RNA-seq reveals developmental deficiencies in both the placentation and the decidualization in women with late-onset preeclampsia","volume":"14","author":"Yang","year":"2023","journal-title":"Front. Immunol."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426000883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426000883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:32:52Z","timestamp":1774578772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400426000883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":50,"alternative-id":["S0143400426000883"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2026.03.010","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disrupted placental circadian clock networks drive preeclampsia pathogenesis: An integrative bioinformatic analysis of key hub genes and regulatory pathways","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2026.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}