{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:54:52Z","timestamp":1792169692888,"version":"4.4.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.placenta.2026.07.010","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T17:25:40Z","timestamp":1785086740000},"page":"1-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The role and mechanism of S1PR2 in endothelial dysfunction and aortic lesions during gestational diabetes mellitus"],"prefix":"10.1016","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5065-4166","authenticated-orcid":false,"given":"Lin","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.placenta.2026.07.010_bib1","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1038\/s41467-025-59442-6","article-title":"Genetic architecture and risk prediction of gestational diabetes mellitus in Chinese pregnancies","volume":"16","author":"Gu","year":"2025","journal-title":"Nat. Commun."},{"issue":"15","key":"10.1016\/j.placenta.2026.07.010_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/nu17152429","article-title":"Vitamin D deficiency and risk of gestational diabetes mellitus in Western countries: a scoping review","volume":"17","author":"Correa","year":"2025","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.placenta.2026.07.010_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4093\/dmj.2021.0335","article-title":"Gestational diabetes mellitus: diagnostic approaches and maternal-offspring complications","volume":"46","author":"Moon","year":"2022","journal-title":"Diabetes Metab. J"},{"issue":"5","key":"10.1016\/j.placenta.2026.07.010_bib4","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1210\/endrev\/bnac003","article-title":"A clinical update on gestational diabetes mellitus","volume":"43","author":"Sweeting","year":"2022","journal-title":"Endocr. Rev."},{"issue":"2","key":"10.1016\/j.placenta.2026.07.010_bib5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/aogs.15022","article-title":"Gestational diabetes mellitus and subsequent cardiovascular disease in a period of rising diagnoses: cohort study","volume":"104","author":"Mehrabadi","year":"2025","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"11","key":"10.1016\/j.placenta.2026.07.010_bib6","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/s41569-024-01045-7","article-title":"Autoimmune diseases and atherosclerotic cardiovascular disease","volume":"21","author":"Porsch","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.placenta.2026.07.010_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2019.109485","article-title":"Endothelial tight junctions and their regulatory signaling pathways in vascular homeostasis and disease","volume":"66","author":"Cong","year":"2020","journal-title":"Cell. Signal."},{"issue":"7586","key":"10.1016\/j.placenta.2026.07.010_bib8","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature17040","article-title":"Angiocrine functions of organ-specific endothelial cells","volume":"529","author":"Rafii","year":"2016","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.placenta.2026.07.010_bib9","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1002\/ptr.7854","article-title":"Icariin alleviates ferroptosis-related atherosclerosis by promoting autophagy in xo-LDL-induced vascular endothelial cell injury and atherosclerotic mice","volume":"37","author":"Wang","year":"2023","journal-title":"Phytother Res."},{"issue":"11","key":"10.1016\/j.placenta.2026.07.010_bib10","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.metabol.2007.06.020","article-title":"Changes in plasma lipids and increased low-density lipoprotein susceptibility to oxidation in pregnancies complicated by gestational diabetes: consequences of obesity","volume":"56","author":"Sanchez-Vera","year":"2007","journal-title":"Metabolism"},{"key":"10.1016\/j.placenta.2026.07.010_bib11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.freeradbiomed.2020.07.026","article-title":"Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell","volume":"160","author":"Bai","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.placenta.2026.07.010_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.575390","article-title":"Metformin ameliorates gestational diabetes mellitus-induced endothelial dysfunction via downregulation of p65 and upregulation of Nrf2","volume":"11","author":"Sun","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.placenta.2026.07.010_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110529","article-title":"PRMT5 knockdown enhances cell viability and suppresses cell apoptosis, oxidative stress, inflammation and endothelial dysfunction in ox-LDL-induced vascular endothelial cells via interacting with PDCD4","volume":"122","author":"Fei","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"1\u20132","key":"10.1016\/j.placenta.2026.07.010_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11010-019-03503-0","article-title":"Hyperglycaemia cause vascular inflammation through advanced glycation end products\/early growth response-1 axis in gestational diabetes mellitus","volume":"456","author":"Rajaraman","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.placenta.2026.07.010_bib15","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.freeradbiomed.2025.09.057","article-title":"MiRNA-27a-5p alleviates diabetic vascular injury via modulating autophagy by targeting NOX4","volume":"241","author":"Wang","year":"2025","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.placenta.2026.07.010_bib16","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1007\/s12035-023-03228-8","article-title":"Advanced glycation end-products (AGEs) promote endothelial cell pyroptosis under cerebral ischemia and hypoxia via HIF-1alpha-RAGE-NLRP3","volume":"60","author":"Han","year":"2023","journal-title":"Mol. Neurobiol."},{"issue":"10","key":"10.1016\/j.placenta.2026.07.010_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0240382","article-title":"The relationship between advanced glycation end products and gestational diabetes: a systematic review and meta-analysis","volume":"15","author":"Sisay","year":"2020","journal-title":"PLoS One"},{"issue":"17","key":"10.1016\/j.placenta.2026.07.010_bib18","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1080\/14767058.2018.1449201","article-title":"Relationship between advanced glycation end products and gestational diabetes mellitus","volume":"32","author":"Li","year":"2019","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"6","key":"10.1016\/j.placenta.2026.07.010_bib19","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s11427-017-9046-6","article-title":"Targeting sphingosine-1-phosphate signaling for cancer therapy","volume":"60","author":"Xie","year":"2017","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.placenta.2026.07.010_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104793","article-title":"Significance of sphingosine-1-phosphate in cardiovascular physiology and pathology","volume":"156","author":"Jozefczuk","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.placenta.2026.07.010_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/biom13050818","article-title":"Sphingosine-1-Phosphate signaling in cardiovascular diseases","volume":"13","author":"Wang","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.placenta.2026.07.010_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115077","article-title":"S1PR2\/RhoA\/ROCK1 pathway promotes inflammatory bowel disease by inducing intestinal vascular endothelial barrier damage and M1 macrophage polarization","volume":"201","author":"Wang","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.placenta.2026.07.010_bib23","article-title":"Role of Moesin in advanced glycation end products-induced angiogenesis of human umbilical vein endothelial cells","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.placenta.2026.07.010_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/antiox8090344","article-title":"How does pyridoxamine inhibit the formation of advanced glycation end products? The role of its primary antioxidant activity","volume":"8","author":"Ramis","year":"2019","journal-title":"Antioxidants"},{"issue":"9","key":"10.1016\/j.placenta.2026.07.010_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23094970","article-title":"Extracellular vesicles as an index for endothelial injury and cardiac dysfunction in a rodent model of GDM","volume":"23","author":"Kereliuk","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.placenta.2026.07.010_bib26","doi-asserted-by":"crossref","DOI":"10.4239\/wjd.v16.i6.104177","article-title":"Correlation between serum advanced glycation end-products and their receptor-mediated oxidative stress and perinatal outcomes in gestational diabetes mellitus","volume":"16","author":"Zhang","year":"2025","journal-title":"World J. Diabetes"},{"issue":"3","key":"10.1016\/j.placenta.2026.07.010_bib27","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1182\/blood-2012-11-467191","article-title":"Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation","volume":"122","author":"Zhang","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.placenta.2026.07.010_bib28","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.mvr.2018.03.002","article-title":"High glucose induces dysfunction of human umbilical vein endothelial cells by upregulating miR-137 in gestational diabetes mellitus","volume":"118","author":"Peng","year":"2018","journal-title":"Microvasc. Res."},{"issue":"12","key":"10.1016\/j.placenta.2026.07.010_bib29","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.numecd.2014.06.005","article-title":"Features of endothelial dysfunction in umbilical cord vessels of women with gestational diabetes","volume":"24","author":"Di Fulvio","year":"2014","journal-title":"Nutr. Metabol. Cardiovasc. Dis."},{"issue":"8","key":"10.1016\/j.placenta.2026.07.010_bib30","doi-asserted-by":"crossref","DOI":"10.1161\/ATVBAHA.126.324964","article-title":"Endothelial Nucleoporin93 (Nup93) maintains vascular homeostasis via Sun1-Dependent regulation of RhoA\/ROCK activity","volume":"46","author":"Nguyen","year":"2026","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.placenta.2026.07.010_bib31","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1186\/s13098-025-01915-1","article-title":"THBS1 regulates the function and insulin sensitivity of HTR8\/SVneo cells treated with high glucose through the RhoA\/ROCK1 signaling pathway","volume":"17","author":"Chai","year":"2025","journal-title":"Diabetol. Metab. Syndr."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426003231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426003231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:39:37Z","timestamp":1792168777000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400426003231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":31,"alternative-id":["S0143400426003231"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2026.07.010","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role and mechanism of S1PR2 in endothelial dysfunction and aortic lesions during gestational diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2026.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}