{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:54:50Z","timestamp":1792169690159,"version":"4.4.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.placenta.2026.08.339","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T15:15:04Z","timestamp":1788016504000},"page":"82-93","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Placental transcriptomics identifies a candidate HLA-DQA2-FGL2 immune signature in gestational diabetes mellitus"],"prefix":"10.1016","volume":"183","author":[{"given":"Shuyu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxiang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youde","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9534-7634","authenticated-orcid":false,"given":"Weizhang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2026.08.339_bib1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0140-6736(24)00825-0","article-title":"Epidemiology and management of gestational diabetes","volume":"404","author":"Sweeting","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.placenta.2026.08.339_bib2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s12884-024-06378-2","article-title":"Prevalence of gestational diabetes in the United States and Canada: a systematic review and meta-analysis","volume":"24","author":"Eades","year":"2024","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.placenta.2026.08.339_bib3","doi-asserted-by":"crossref","first-page":"e091258","DOI":"10.1136\/bmjopen-2024-091258","article-title":"Association between gestational diabetes mellitus diagnostic criteria and adverse pregnancy outcomes-a systematic review and meta-analysis of adjusted effect sizes from studies using current diagnostic criteria","volume":"14","author":"Mahmoud","year":"2024","journal-title":"BMJ Open"},{"key":"10.1016\/j.placenta.2026.08.339_bib4","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1056\/NEJMoa0707943","article-title":"Hyperglycemia and adverse pregnancy outcomes","volume":"358","author":"Metzger","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.placenta.2026.08.339_bib5","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1038\/s41591-024-02936-5","article-title":"Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes","volume":"30","author":"Hivert","year":"2024","journal-title":"Nat Med"},{"key":"10.1016\/j.placenta.2026.08.339_bib6","doi-asserted-by":"crossref","first-page":"11409","DOI":"10.3390\/ijms252111409","article-title":"Gestational diabetes mellitus-induced inflammation in the placenta via IL-1 beta and toll-like receptor pathways","volume":"25","author":"Zgutka","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2026.08.339_bib7","doi-asserted-by":"crossref","first-page":"10867","DOI":"10.3390\/ijms262210867","article-title":"Gestational diabetes mellitus alters cytokine profiles and macrophage polarization in human placenta","volume":"26","author":"Barbosa","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2026.08.339_bib8","doi-asserted-by":"crossref","first-page":"e2264","DOI":"10.1210\/clinem\/dgae754","article-title":"Heterogeneity of gestational diabetes and risk for adverse pregnancy outcome: a cohort study","volume":"110","author":"Gong","year":"2025","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.placenta.2026.08.339_bib9","doi-asserted-by":"crossref","first-page":"390","DOI":"10.2337\/dc24-1735","article-title":"Subtypes of gestational diabetes mellitus are differentially associated with newborn and childhood metabolic outcomes","volume":"48","author":"Osmulski","year":"2025","journal-title":"Diabetes Care"},{"key":"10.1016\/j.placenta.2026.08.339_bib10","first-page":"4068","article-title":"Placenta inflammation is closely associated with gestational diabetes mellitus","volume":"13","author":"Pan","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.placenta.2026.08.339_bib11","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00418-022-02163-4","article-title":"Lower HLA-g levels in extravillous trophoblasts of human term placenta in gestational diabetes mellitus than in normal controls","volume":"159","author":"Knabl","year":"2023","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.placenta.2026.08.339_bib12","doi-asserted-by":"crossref","first-page":"e24515","DOI":"10.1002\/jcla.24515","article-title":"Identification of potential gene markers in gestational diabetes mellitus","volume":"36","author":"Tang","year":"2022","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.placenta.2026.08.339_bib13","doi-asserted-by":"crossref","first-page":"15388","DOI":"10.3390\/ijms232315388","article-title":"Placental transcriptome profiling in subtypes of diabetic pregnancies is strongly confounded by fetal sex","volume":"23","author":"Kedziora","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2026.08.339_bib14","doi-asserted-by":"crossref","first-page":"971354","DOI":"10.3389\/fendo.2022.971354","article-title":"Systematic review of transcriptome and microRNAome associations with gestational diabetes mellitus","volume":"13","author":"Lewis","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.placenta.2026.08.339_bib15","doi-asserted-by":"crossref","first-page":"326.e1","DOI":"10.1016\/j.ajog.2024.05.014","article-title":"Discrete placental gene expression signatures accompany diabetic disease classifications during pregnancy","volume":"232","author":"Barrozo","year":"2025","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2026.08.339_bib16","doi-asserted-by":"crossref","first-page":"679582","DOI":"10.3389\/fendo.2021.679582","article-title":"Transcriptomic profiling of human placenta in gestational diabetes mellitus at the single-cell level","volume":"12","author":"Yang","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.placenta.2026.08.339_bib17","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s10735-025-10707-w","article-title":"Single-cell sequencing reveals that neutrophils mediate the inflammatory response in the placenta of women with GDM","volume":"57","author":"Yin","year":"2026","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.placenta.2026.08.339_bib18","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nrg2825","article-title":"Tackling the widespread and critical impact of batch effects in high-throughput data","volume":"11","author":"Leek","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.placenta.2026.08.339_bib19","doi-asserted-by":"crossref","first-page":"e561","DOI":"10.7717\/peerj.561","article-title":"Removing batch effects for prediction problems with frozen surrogate variable analysis","volume":"2","author":"Parker","year":"2014","journal-title":"PeerJ"},{"key":"10.1016\/j.placenta.2026.08.339_bib20","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s42003-023-04588-6","article-title":"Cross-platform normalization enables machine learning model training on microarray and RNA-seq data simultaneously","volume":"6","author":"Foltz","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.placenta.2026.08.339_bib21","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s12916-019-1466-7","article-title":"Topic Group \u2018Evaluating diagnostic tests and prediction models\u2019 of the STRATOS initiative. Calibration: the achilles heel of predictive analytics","volume":"17","author":"Van Calster","year":"2019","journal-title":"BMC Med."},{"key":"10.1016\/j.placenta.2026.08.339_bib22","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/aogs.13811","article-title":"External validation and clinical utility of prognostic prediction models for gestational diabetes mellitus: a prospective cohort study","volume":"99","author":"Meertens","year":"2020","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.placenta.2026.08.339_bib23","doi-asserted-by":"crossref","first-page":"105533","DOI":"10.1016\/j.ijmedinf.2024.105533","article-title":"External validation of risk prediction model for gestational diabetes: individual participant data meta-analysis of randomized trials","volume":"190","author":"Ranasinha","year":"2024","journal-title":"Int. J. Med. Inf."},{"key":"10.1016\/j.placenta.2026.08.339_bib24","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12918-016-0349-1","article-title":"DGCA: a comprehensive r package for differential gene correlation analysis","volume":"10","author":"McKenzie","year":"2016","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.placenta.2026.08.339_bib25","doi-asserted-by":"crossref","first-page":"100434","DOI":"10.1016\/j.patter.2022.100434","article-title":"scTenifoldKnk: an efficient virtual knockout tool for gene function predictions via single-cell gene regulatory network perturbation","volume":"3","author":"Osorio","year":"2022","journal-title":"Patterns (N Y)"},{"key":"10.1016\/j.placenta.2026.08.339_bib26","article-title":"Artificial intelligence in gestational diabetes care: a systematic review","volume":"Epub ahead of print","author":"AlSaad","year":"2025","journal-title":"J. Diabetes Sci. Technol."},{"key":"10.1016\/j.placenta.2026.08.339_bib27","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.3390\/ijms19113342","article-title":"The pathophysiology of gestational diabetes mellitus","volume":"19","author":"Plows","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2026.08.339_bib28","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4049\/jimmunol.180.1.249","article-title":"Targeted deletion of fgl2 leads to impaired regulatory t cell activity and development of autoimmune glomerulonephritis","volume":"180","author":"Shalev","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.placenta.2026.08.339_bib29","doi-asserted-by":"crossref","first-page":"e0024","DOI":"10.5041\/RMMJ.10209","article-title":"Role of regulatory t cells (treg) and the treg effector molecule fibrinogen-like protein 2 in alloimmunity and autoimmunity","volume":"6","author":"Chruscinski","year":"2015","journal-title":"Rambam Maimonides Med J"},{"key":"10.1016\/j.placenta.2026.08.339_bib30","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.4049\/jimmunol.158.5.2116","article-title":"The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of b lymphoblastoid cells","volume":"158","author":"Rudy","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.placenta.2026.08.339_bib31","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1046\/j.1365-2249.2003.02092.x","article-title":"Phenotypic characterization of human decidual macrophages","volume":"131","author":"Heikkinen","year":"2003","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.placenta.2026.08.339_bib32","first-page":"105","article-title":"Decidual macrophages and their roles at the maternal-fetal interface","volume":"85","author":"Houser","year":"2012","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.placenta.2026.08.339_bib33","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1126\/science.1132939","article-title":"The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease","volume":"313","author":"Lamb","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.placenta.2026.08.339_bib34","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","article-title":"A next generation connectivity map: L1000 platform and the first 1,000,000 profiles","volume":"171","author":"Subramanian","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.placenta.2026.08.339_bib35","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.1038\/s41467-022-32205-3","article-title":"Connecting omics signatures and revealing biological mechanisms with iLINCS","volume":"13","author":"Pilarczyk","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.placenta.2026.08.339_bib36","doi-asserted-by":"crossref","first-page":"D972","DOI":"10.1093\/nar\/gkad832","article-title":"PharmGWAS: a GWAS-based knowledgebase for drug repurposing","volume":"52","author":"Kang","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.placenta.2026.08.339_bib37","doi-asserted-by":"crossref","first-page":"W338","DOI":"10.1093\/nar\/gkaf373","article-title":"L2S2: chemical perturbation and CRISPR KO LINCS L1000 signature search engine","volume":"53","author":"Marino","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.placenta.2026.08.339_bib38","doi-asserted-by":"crossref","first-page":"D1477","DOI":"10.1093\/nar\/gkaf1312","article-title":"Medicines, diseases, indications, and contraindications (MeDIC): a foundational resource to support drug repurposing","volume":"54","author":"DeLuca","year":"2026","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.placenta.2026.08.339_bib39","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/s41467-021-27751-1","article-title":"Integrating gene expression and clinical data to identify drug repurposing candidates for hyperlipidemia and hypertension","volume":"13","author":"Wu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.placenta.2026.08.339_bib40","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.placenta.2007.12.010","article-title":"Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta","volume":"29","author":"Challier","year":"2008","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2026.08.339_bib41","doi-asserted-by":"crossref","first-page":"eadh8335","DOI":"10.1126\/scitranslmed.adh8335","article-title":"Deciphering maternal-fetal cross-talk in the human placenta during parturition using single-cell RNA sequencing","volume":"16","author":"Garcia-Flores","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.placenta.2026.08.339_bib42","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1186\/s12884-017-1589-9","article-title":"Placenta response of inflammation and oxidative stress in low-risk term childbirth: the implication of delivery mode","volume":"17","author":"Hu","year":"2017","journal-title":"BMC Pregnancy Childbirth"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426006727?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426006727?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:38:56Z","timestamp":1792168736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400426006727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":42,"alternative-id":["S0143400426006727"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2026.08.339","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Placental transcriptomics identifies a candidate HLA-DQA2-FGL2 immune signature in gestational diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2026.08.339","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}