{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:55:51Z","timestamp":1792169751063,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.placenta.2026.09.003","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:07:06Z","timestamp":1789085226000},"page":"177-185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Placental endoglin protein expression across gestation in normal pregnancy and preeclampsia: Implications for anti-angiogenic therapeutic strategies"],"prefix":"10.1016","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2945-3970","authenticated-orcid":false,"given":"Jayasri","family":"Basu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liaisan","family":"Uzianbaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Mehdizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdy","family":"Mikhail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.placenta.2026.09.003_bib1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1053\/j.semperi.2009.02.010","article-title":"The global impact of pre-eclampsia and eclampsia","volume":"33","author":"Duley","year":"2009","journal-title":"Semin. Perinatol."},{"issue":"14","key":"10.1016\/j.placenta.2026.09.003_bib2","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.jacc.2020.08.014","article-title":"Preeclampsia: pathophysiology and clinical presentations. JACC state-of-the-art review","volume":"76","author":"Ives","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"issue":"6","key":"10.1016\/j.placenta.2026.09.003_bib3","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1097\/AOG.0000000000003891","article-title":"Gestational hypertension and preeclampsia: ACOG practice bulletin, number 222","volume":"135","year":"2020","journal-title":"Obstet. Gynecol."},{"issue":"Suppl A","key":"10.1016\/j.placenta.2026.09.003_bib4","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/j.placenta.2008.11.021","article-title":"Placental stress and pre-eclampsia: a revised view","volume":"30","author":"Redman","year":"2009","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.placenta.2026.09.003_bib5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ajog.2010.08.009","article-title":"The Great Obstetrical Syndromes are associated with disorders of deep placentation","volume":"204","author":"Brosens","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"5","key":"10.1016\/j.placenta.2026.09.003_bib6","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.placenta.2011.05.007","article-title":"Trophoblast invasion and spiral artery remodeling in the placental bed of the lowland gorilla","volume":"32","author":"Pijnenborg","year":"2011","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.placenta.2026.09.003_bib7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.bpobgyn.2010.10.012","article-title":"Defective deep placentation","volume":"25","author":"Khong","year":"2011","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"issue":"10","key":"10.1016\/j.placenta.2026.09.003_bib8","article-title":"Defective uteroplacental vascular remodeling in preeclampsia: key molecular factors leading to long-term cardiovascular disease","volume":"22","author":"Hong","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.placenta.2026.09.003_bib9","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.placenta.2026.09.003_bib10","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/AOG.0000000000005532","article-title":"Angiogenic biomarkers in preeclampsia","volume":"133","author":"Burwick","year":"2019","journal-title":"Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.placenta.2026.09.003_bib11","doi-asserted-by":"crossref","first-page":"H661","DOI":"10.1152\/ajpheart.00202.2020","article-title":"Vascular mechanisms and molecular targets in hypertensive pregnancy and preeclampsia","volume":"319","author":"Qu","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.placenta.2026.09.003_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.semnephrol.2010.10.004","article-title":"Angiogenic factors and preeclampsia","volume":"31","author":"Maynard","year":"2011","journal-title":"Semin. Nephrol."},{"issue":"5","key":"10.1016\/j.placenta.2026.09.003_bib13","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase-1 (sFlt-1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.placenta.2026.09.003_bib14","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nm1429","article-title":"Soluble endoglin contributes to the pathogenesis of preeclampsia","volume":"12","author":"Venkatesha","year":"2006","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.placenta.2026.09.003_bib15","doi-asserted-by":"crossref","first-page":"174.e1","DOI":"10.1016\/j.ajog.2007.03.058","article-title":"Soluble endoglin as a second-trimester marker for preeclampsia","volume":"197","author":"Robinson","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.placenta.2026.09.003_bib16","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s11010-021-04294-z","article-title":"The role of endoglin and its soluble form in pathogenesis of preeclampsia","volume":"477","author":"Margioula-Siarkou","year":"2022","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.placenta.2026.09.003_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1271756","article-title":"Editorial: role of membrane-bound and circulating endoglin in disease","volume":"10","author":"Bernabeu","year":"2023","journal-title":"Front. Med."},{"issue":"5419","key":"10.1016\/j.placenta.2026.09.003_bib18","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1126\/science.284.5419.1534","article-title":"Defective angiogenesis in mice lacking endoglin","volume":"284","author":"Li","year":"1999","journal-title":"Science"},{"issue":"2S","key":"10.1016\/j.placenta.2026.09.003_bib19","doi-asserted-by":"crossref","first-page":"S1019","DOI":"10.1016\/j.ajog.2020.10.022","article-title":"Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders","volume":"226","author":"Rana","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"8","key":"10.1016\/j.placenta.2026.09.003_bib20","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s00380-017-0976-5","article-title":"High soluble endoglin levels do not induce changes in structural parameters of mouse heart","volume":"32","author":"Rathousk\u00e1","year":"2017","journal-title":"Heart Vessels."},{"issue":"4","key":"10.1016\/j.placenta.2026.09.003_bib21","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1177\/1933719117725819","article-title":"Correlation between placental matrix metalloproteinase-9 and tumor necrosis factor-\u03b1 protein expression throughout gestation in normal human pregnancy","volume":"25","author":"Basu","year":"2018","journal-title":"Reprod. Sci."},{"issue":"1","key":"10.1016\/j.placenta.2026.09.003_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0210655","article-title":"Cesarean section on the rise\u2014Does advanced maternal age explain the increase? A population register-based study","volume":"14","author":"Rydahl","year":"2019","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.placenta.2026.09.003_bib23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bpobgyn.2010.10.016","article-title":"Oxidative stress","volume":"25","author":"Burton","year":"2011","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.placenta.2026.09.003_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/276095","article-title":"Placental oxidative status throughout normal gestation in women with uncomplicated pregnancies","volume":"2015","author":"Basu","year":"2015","journal-title":"Obstet Gynecol Int"},{"issue":"7","key":"10.1016\/j.placenta.2026.09.003_bib25","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.freeradbiomed.2010.07.011","article-title":"Oxidative stress in development: nature or nurture?","volume":"49","author":"Dennery","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.placenta.2026.09.003_bib26","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.2174\/15665240113139990058","article-title":"Membrane and soluble forms of endoglin in preeclampsia","volume":"13","author":"Oujo","year":"2013","journal-title":"Curr. Mol. Med."},{"issue":"3","key":"10.1016\/j.placenta.2026.09.003_bib27","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1095\/biolreprod51.3.405","article-title":"Localization of endoglin, a transforming growth factor-\u03b2 binding protein, and of CD44 and integrins in placenta during the first trimester of pregnancy","volume":"51","author":"St-Jacques","year":"1994","journal-title":"Biol. Reprod."},{"issue":"6","key":"10.1016\/j.placenta.2026.09.003_bib28","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1530\/REP-09-0092","article-title":"Regulation of vascular growth and function in the human placenta","volume":"138","author":"Burton","year":"2009","journal-title":"Reproduction"},{"issue":"6","key":"10.1016\/j.placenta.2026.09.003_bib29","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00418-016-1474-z","article-title":"The trophoblast plug during early pregnancy: a deeper insight","volume":"146","author":"Weiss","year":"2016","journal-title":"Histochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.placenta.2026.09.003_bib30","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.atherosclerosis.2015.10.003","article-title":"Soluble endoglin, hypercholesterolemia, and endothelial dysfunction","volume":"243","author":"Rathousk\u00e1","year":"2015","journal-title":"Atherosclerosis"},{"issue":"20","key":"10.1016\/j.placenta.2026.09.003_bib31","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1038\/sj.emboj.7600386","article-title":"Endoglin promotes endothelial cell proliferation and TGF-\u03b2\/ALK1 signal transduction","volume":"23","author":"Lebrin","year":"2004","journal-title":"EMBO J."},{"issue":"10","key":"10.1016\/j.placenta.2026.09.003_bib32","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1056\/NEJMoa055352","article-title":"Soluble endoglin and other circulating anti-angiogenic factors in preeclampsia","volume":"355","author":"Levine","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.placenta.2026.09.003_bib33","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3109\/10641950902968684","article-title":"Soluble endoglin for the prediction of preeclampsia in a high-risk cohort","volume":"29","author":"Maynard","year":"2010","journal-title":"Hypertens. Pregnancy"},{"issue":"5","key":"10.1016\/j.placenta.2026.09.003_bib34","doi-asserted-by":"crossref","first-page":"312","DOI":"10.18869\/acadpub.ibj.21.5.312","article-title":"Accuracy of soluble endoglin for diagnosis of preeclampsia and its severity","volume":"21","author":"Nikuei","year":"2017","journal-title":"Iran. Biomed. J."},{"issue":"1","key":"10.1016\/j.placenta.2026.09.003_bib35","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/jalm\/jfaa149","article-title":"A critical review on the use of race in understanding racial disparities in preeclampsia","volume":"6","author":"Fasanya","year":"2021","journal-title":"J. Appl. Lab. Med."},{"issue":"3","key":"10.1016\/j.placenta.2026.09.003_bib36","doi-asserted-by":"crossref","first-page":"359.e1","DOI":"10.1016\/j.ajog.2016.04.002","article-title":"Racial-ethnic differences in midtrimester maternal serum levels of angiogenic and antiangiogenic factors","volume":"215","author":"Yang","year":"2016","journal-title":"Am. J. Obstet. Gynecol."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426006776?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426006776?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:40:18Z","timestamp":1792168818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400426006776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":36,"alternative-id":["S0143400426006776"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2026.09.003","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Placental endoglin protein expression across gestation in normal pregnancy and preeclampsia: Implications for anti-angiogenic therapeutic strategies","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2026.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}