{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:03:06Z","timestamp":1791813786112,"version":"4.3.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004410","name":"The Scientific and Technological Research Council of T\u00fcrkiye","doi-asserted-by":"publisher","award":["121S821"],"award-info":[{"award-number":["121S821"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007613","name":"Ankara University","doi-asserted-by":"publisher","award":["TSA-2026-4503"],"award-info":[{"award-number":["TSA-2026-4503"]}],"id":[{"id":"10.13039\/100007613","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007613","name":"Ankara University","doi-asserted-by":"publisher","award":["TSG-2022-2545"],"award-info":[{"award-number":["TSG-2022-2545"]}],"id":[{"id":"10.13039\/100007613","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.placenta.2026.09.023","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:17:20Z","timestamp":1790608640000},"page":"99-109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Preeclampsia-associated changes in umbilical cord stromal VEGFR-2 and EV-mediated in vitro angiogenesis"],"prefix":"10.1016","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0622-6687","authenticated-orcid":false,"given":"Ibrahim","family":"Alptekin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5061-2775","authenticated-orcid":false,"given":"Bilge","family":"Alptekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2703-0138","authenticated-orcid":false,"given":"Ezel","family":"Erkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8254-0558","authenticated-orcid":false,"given":"Ferda Topal","family":"Celikkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1866-7295","authenticated-orcid":false,"given":"Derya Uyan","family":"Hendem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3882-0728","authenticated-orcid":false,"given":"Mohammadreza","family":"Dastouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1449-7874","authenticated-orcid":false,"given":"Mesut","family":"Akyol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-9048","authenticated-orcid":false,"given":"Dilek","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5393-6115","authenticated-orcid":false,"given":"Alp","family":"Can","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2026.09.023_bib1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.preghy.2021.09.008","article-title":"The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis & management recommendations for international practice","volume":"27","author":"Magee","year":"2022","journal-title":"Pregnancy Hypertens."},{"issue":"5","key":"10.1016\/j.placenta.2026.09.023_bib2","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1161\/HYPERTENSIONAHA.120.14781","article-title":"Subtypes of Preeclampsia: Recognition and determining clinical usefulness","volume":"77","author":"Roberts","year":"2021","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.placenta.2026.09.023_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jogoh.2020.101975","article-title":"Preeclampsia: pathophysiology and management","volume":"50","author":"Nirupama","year":"2021","journal-title":"J Gynecol Obstet Hum Reprod"},{"issue":"4","key":"10.1016\/j.placenta.2026.09.023_bib4","doi-asserted-by":"crossref","first-page":"e626","DOI":"10.1016\/S2214-109X(24)00560-6","article-title":"Global and regional causes of maternal deaths 2009-20: a WHO systematic analysis","volume":"13","author":"Cresswell","year":"2025","journal-title":"Lancet Global Health"},{"issue":"11","key":"10.1016\/j.placenta.2026.09.023_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/cells10113055","article-title":"Vascular dysfunction in Preeclampsia","volume":"10","author":"Opichka","year":"2021","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.placenta.2026.09.023_bib6","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1007\/s13577-023-00901-x","article-title":"Downregulation of argininosuccinate synthase 1 (ASS1) is associated with hypoxia in placental development","volume":"36","author":"Fantone","year":"2023","journal-title":"Hum. Cell"},{"issue":"1","key":"10.1016\/j.placenta.2026.09.023_bib7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s40001-023-01182-8","article-title":"Human umbilical cord mesenchymal stem cell derived exosomes (HUCMSC-exos) recovery soluble fms-like tyrosine kinase-1 (sFlt-1)-induced endothelial dysfunction in preeclampsia","volume":"28","author":"Chang","year":"2023","journal-title":"Eur. J. Med. Res."},{"issue":"12","key":"10.1016\/j.placenta.2026.09.023_bib8","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1177\/1947601911423031","article-title":"Vascular Endothelial Growth Factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: a crucial target for Anti- and pro-angiogenic therapies","volume":"2","author":"Shibuya","year":"2011","journal-title":"Genes Cancer"},{"key":"10.1016\/j.placenta.2026.09.023_bib9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.earlhumdev.2016.02.001","article-title":"Morphometric characteristics of the umbilical cord and vessels in fetal growth restriction and pre-eclampsia (vol 92, pg 57, 2016)","volume":"95","author":"Sharony","year":"2016","journal-title":"Early Hum. Dev."},{"issue":"2 Suppl","key":"10.1016\/j.placenta.2026.09.023_bib10","first-page":"681","article-title":"Ultrastructure and histomorphometric analysis of human umbilical cord vessels in preeclampsia: a potential role of VEGF, VEGFR-1 and VEGFR-2","volume":"57","author":"Almasry","year":"2016","journal-title":"Rom. J. Morphol. Embryol."},{"issue":"2","key":"10.1016\/j.placenta.2026.09.023_bib11","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.placenta.2014.11.024","article-title":"The assessment of the in vivo to in vitro cellular transition of human umbilical cord multipotent stromal cells","volume":"36","author":"Coskun","year":"2015","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2026.09.023_bib12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jcyt.2018.10.010","article-title":"Optimizing the transport and storage conditions of current Good Manufacturing Practice -grade human umbilical cord mesenchymal stromal cells for transplantation (HUC-HEART Trial)","volume":"21","author":"Celikkan","year":"2019","journal-title":"Cytotherapy"},{"issue":"3","key":"10.1016\/j.placenta.2026.09.023_bib13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00441-024-03920-8","article-title":"Revisiting the human umbilical cord epithelium. An atypical epithelial sheath with distinctive features","volume":"398","author":"Erkan","year":"2024","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.placenta.2026.09.023_bib14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/978-1-60761-999-4_5","article-title":"Isolation, culture, and characterization of human umbilical cord stroma-derived mesenchymal stem cells","volume":"698","author":"Can","year":"2011","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.placenta.2026.09.023_bib15","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Thery","year":"2018","journal-title":"J. Extracell. Vesicles"},{"issue":"1","key":"10.1016\/j.placenta.2026.09.023_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67289-8","article-title":"Angiogenesis Analyzer for ImageJ - a comparative morphometric analysis of \"Endothelial Tube Formation Assay\" and \"Fibrin Bead Assay\"","volume":"10","author":"Carpentier","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.placenta.2026.09.023_bib17","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1751-7176.2010.00384.x","article-title":"Histomorphometry of umbilical cord blood vessels in preeclampsia","volume":"13","author":"Blanco","year":"2011","journal-title":"J. Clin. Hypertens."},{"issue":"1","key":"10.1016\/j.placenta.2026.09.023_bib18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.5115\/acb.19.158","article-title":"Human umbilical cord and its vessels: a histomorphometric study in difference severity of hypertensive disorders of pregnancy","volume":"53","author":"Chillakuru","year":"2020","journal-title":"Anat Cell Biol"},{"key":"10.1016\/j.placenta.2026.09.023_bib19","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.placenta.2016.11.014","article-title":"Impact of early- and late-onset preeclampsia on features of placental and newborn vascular health","volume":"49","author":"Herzog","year":"2017","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.placenta.2026.09.023_bib20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/01478885.2020.1734741","article-title":"The histology and histomorphometry of umbilical cord cross section in preeclampsia and normal pregnancies: a comparative study","volume":"43","author":"Thomas","year":"2020","journal-title":"J. Histotechnol."},{"issue":"2","key":"10.1016\/j.placenta.2026.09.023_bib21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0301-2115(96)02390-1","article-title":"Collagen and glycosaminoglycans of Wharton's jelly and their alterations in EPH-gestosis","volume":"66","author":"Bankowski","year":"1996","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"4","key":"10.1016\/j.placenta.2026.09.023_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/jpm12040648","article-title":"Histological profiling of the human umbilical cord: a potential alternative cell source in tissue engineering","volume":"12","author":"Blanco-Elices","year":"2022","journal-title":"J Pers Med"},{"issue":"11","key":"10.1016\/j.placenta.2026.09.023_bib23","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1634\/stemcells.2007-0417","article-title":"Concise review: human umbilical cord stroma with regard to the source of fetus-derived stem cells","volume":"25","author":"Can","year":"2007","journal-title":"Stem Cell."},{"issue":"7","key":"10.1016\/j.placenta.2026.09.023_bib24","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1002\/sctm.16-0492","article-title":"Concise review: wharton's jelly: the rich, but enigmatic, source of mesenchymal stromal cells","volume":"6","author":"Davies","year":"2017","journal-title":"Stem Cells Transl. Med."},{"issue":"5","key":"10.1016\/j.placenta.2026.09.023_bib25","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1007\/s12015-021-10157-3","article-title":"Mesenchymal stromal cells from different parts of umbilical cord: approach to Comparison & Characteristics","volume":"17","author":"Semenova","year":"2021","journal-title":"Stem Cell Rev. Rep."},{"issue":"6","key":"10.1016\/j.placenta.2026.09.023_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127992","article-title":"Comparative characterization of cells from the various compartments of the human umbilical cord shows that the Wharton's jelly compartment provides the best source of clinically utilizable mesenchymal stem cells","volume":"10","author":"Subramanian","year":"2015","journal-title":"PLoS One"},{"issue":"7070","key":"10.1016\/j.placenta.2026.09.023_bib27","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nature04478","article-title":"Angiogenesis in life, disease and medicine","volume":"438","author":"Carmeliet","year":"2005","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.placenta.2026.09.023_bib28","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.semcdb.2011.10.006","article-title":"Regulation of blood vessel sprouting","volume":"22","author":"Chappell","year":"2011","journal-title":"Semin. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.placenta.2026.09.023_bib29","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J. Clin. Investig."},{"issue":"5","key":"10.1016\/j.placenta.2026.09.023_bib30","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrm1911","article-title":"VEGF receptor signalling - in control of vascular function","volume":"7","author":"Olsson","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"Suppl A","key":"10.1016\/j.placenta.2026.09.023_bib31","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.placenta.2008.11.009","article-title":"The two stage model of preeclampsia: variations on the theme","volume":"30","author":"Roberts","year":"2009","journal-title":"Placenta"},{"issue":"12","key":"10.1016\/j.placenta.2026.09.023_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115316","article-title":"Proangiogenic compositions of microvesicles derived from human umbilical cord mesenchymal stem cells","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.placenta.2026.09.023_bib33","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s13287-017-0660-9","article-title":"Exosomes of human placenta-derived mesenchymal stem cells stimulate angiogenesis","volume":"8","author":"Komaki","year":"2017","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.placenta.2026.09.023_bib34","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3892\/mmr.2015.3409","article-title":"Conditioned medium from umbilical cord mesenchymal stem cells induces migration and angiogenesis","volume":"12","author":"Shen","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.placenta.2026.09.023_bib35","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.biopha.2018.06.032","article-title":"Protective effect of human umbilical cord mesenchymal stem cell exosomes on preserving the morphology and angiogenesis of placenta in rats with preeclampsia","volume":"105","author":"Xiong","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.placenta.2026.09.023_bib36","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.placenta.2020.10.022","article-title":"Umbilical cord plasma-derived exosomes from preeclamptic women induce vascular dysfunction by targeting HMGCS1 in endothelial cells","volume":"103","author":"Ying","year":"2021","journal-title":"Placenta"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426007034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400426007034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:44:17Z","timestamp":1791812657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400426007034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":36,"alternative-id":["S0143400426007034"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2026.09.023","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preeclampsia-associated changes in umbilical cord stromal VEGFR-2 and EV-mediated in vitro angiogenesis","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2026.09.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}