{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:46:33Z","timestamp":1793421993045,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T00:00:00Z","timestamp":1586736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004271","name":"Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","award":["AR118163F8C319B7"],"award-info":[{"award-number":["AR118163F8C319B7"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","award":["RM11916B558D1F93"],"award-info":[{"award-number":["RM11916B558D1F93"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Plant Physiology and Biochemistry"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.plaphy.2020.04.004","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T02:07:13Z","timestamp":1586484433000},"page":"729-742","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["Nitric oxide alleviates cadmium- but not arsenic-induced damages in rice roots"],"prefix":"10.1016","volume":"151","author":[{"given":"D.","family":"Piacentini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ronzan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Fattorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Della Rovere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Massimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.M.","family":"Altamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Falasca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.plaphy.2020.04.004_bib1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3390\/ijerph15010059","article-title":"Arsenic uptake, toxicity, detoxification, and speciation in plants: physiological, biochemical, and molecular aspects","volume":"15","author":"Abbas","year":"2018","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.plaphy.2020.04.004_bib2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.phytochem.2011.02.025","article-title":"Understanding the fate of peroxynitrite in plant cells\u2013from physiology to pathophysiology","volume":"72","author":"Arasimowicz-Jelonek","year":"2011","journal-title":"Phytochemistry"},{"key":"10.1016\/j.plaphy.2020.04.004_bib3","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.plantsci.2011.03.019","article-title":"The message of nitric oxide in cadmium challenged plants","volume":"181","author":"Arasimowicz-Jelonek","year":"2011","journal-title":"Plant Sci."},{"key":"10.1016\/j.plaphy.2020.04.004_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.aca.2018.07.037","article-title":"Optimization and validation of a fast digestion method for the determination of major and trace elements in breast milk by ICP-MS","volume":"1040","author":"Astolfi","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.plaphy.2020.04.004_bib5","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1104\/pp.108.133348","article-title":"Nitric oxide contributes to cadmium toxicity in Arabidopsis by promoting cadmium accumulation in roots and by up-regulating genes related to iron uptake","volume":"149","author":"Besson-Bard","year":"2009","journal-title":"Plant Physiol."},{"key":"10.1016\/j.plaphy.2020.04.004_bib6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1741-7007-6-26","article-title":"A subgroup of plant aquaporins facilitate the bi-directional diffusion of As(OH)3 and Sb(OH)3 across membranes","volume":"6","author":"Bienert","year":"2008","journal-title":"BMC Biol."},{"key":"10.1016\/j.plaphy.2020.04.004_bib7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jhazmat.2015.04.077","article-title":"Nitric oxide ameliorates zinc oxide nanoparticles-induced phytotoxicity in rice seedlings","volume":"297","author":"Chen","year":"2015","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.plaphy.2020.04.004_bib8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S1360-1385(02)02295-1","article-title":"A long way ahead: understanding and engineering plant metal accumulation","volume":"7","author":"Clemens","year":"2002","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.plaphy.2020.04.004_bib9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/aob\/mct260","article-title":"Peroxynitrite (ONOO\u2212) is endogenously produced in Arabidopsis peroxisomes and is overproduced under cadmium stress","volume":"113","author":"Corpas","year":"2014","journal-title":"Ann. Bot."},{"key":"10.1016\/j.plaphy.2020.04.004_bib10","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3390\/plants4020240","article-title":"Functions of nitric oxide (NO) in roots during development and under adverse stress conditions","volume":"4","author":"Corpas","year":"2015","journal-title":"Plants"},{"key":"10.1016\/j.plaphy.2020.04.004_bib11","doi-asserted-by":"crossref","first-page":"274","DOI":"10.17221\/98\/2009-PSE","article-title":"The investigation of the alleviated effect of copper toxicity by exogenous nitric oxide in tomato plants","volume":"56","author":"Cui","year":"2010","journal-title":"Plant Soil Environ."},{"key":"10.1016\/j.plaphy.2020.04.004_bib12","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/pce.12707","article-title":"Nitric oxide function in plant abiotic stress","volume":"40","author":"Fancy","year":"2017","journal-title":"Plant Cell Environ."},{"key":"10.1016\/j.plaphy.2020.04.004_bib13","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3389\/fpls.2016.00471","article-title":"When bad guys become good ones: the key role of reactive oxygen species and nitric oxide in the plant responses to abiotic stress","volume":"7","author":"Farnese","year":"2016","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.plaphy.2020.04.004_bib14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.envexpbot.2017.10.005","article-title":"Cadmium and arsenic affect quiescent centre formation and maintenance in Arabidopsis thaliana post-embryonic roots disrupting auxin biosynthesis and transport","volume":"144","author":"Fattorini","year":"2017","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.plaphy.2020.04.004_bib15","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.plaphy.2010.08.016","article-title":"Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants","volume":"48","author":"Gill","year":"2010","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.plaphy.2020.04.004_bib16","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s11738-012-0927-9","article-title":"Protective role of nitric oxide against arsenic-induced damages in germinating mung bean seeds","volume":"34","author":"Ismail","year":"2012","journal-title":"Acta Physiol. Plant."},{"key":"10.1016\/j.plaphy.2020.04.004_bib17","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1093\/jxb\/erl279","article-title":"NADPH oxidase-dependent reactive oxygen species formation required for root hair growth depends on ROP GTPase","volume":"58","author":"Jones","year":"2007","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.plaphy.2020.04.004_bib18","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/ppl.13012","article-title":"Responses of nitric oxide and hydrogen sulfide in regulating oxidative defence system in wheat plants grown under cadmium stress","volume":"168","author":"Kaya","year":"2020","journal-title":"Physiol. Plantarum"},{"key":"10.1016\/j.plaphy.2020.04.004_bib19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jplph.2017.09.010","article-title":"Alleviation of Cr(VI)-induced oxidative stress in maize (Zea mays L.) seedlings by NO and H2S donors through differential organ-dependent regulation of ROS and NADPH-recycling metabolisms","volume":"219","author":"Kharbech","year":"2017","journal-title":"J. Plant Physiol."},{"key":"10.1016\/j.plaphy.2020.04.004_bib20","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s11738-006-0048-4","article-title":"Effects of exogenous nitric oxide on the antioxidant capacity of cadmium-treated soybean cell suspension","volume":"28","author":"Kopyra","year":"2006","journal-title":"Acta Physiol. Plant."},{"key":"10.1016\/j.plaphy.2020.04.004_bib21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1469-8137.2002.00363.x","article-title":"Arsenic uptake and metabolism in arsenic resistant and nonresistant plant species","volume":"154","author":"Meharg","year":"2002","journal-title":"New Phytol."},{"key":"10.1016\/j.plaphy.2020.04.004_bib22","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/hdy.1992.133","article-title":"Genetic correlation between arsenate tolerance and the rate of influx of arsenate and phosphate in Holcus lanatus L","volume":"69","author":"Meharg","year":"1992","journal-title":"Heredity"},{"key":"10.1016\/j.plaphy.2020.04.004_bib23","first-page":"210","article-title":"Oxidative and nitrosative signaling in plants: two branches in the same tree? Plant Signal","volume":"6","author":"Molassiotis","year":"2011","journal-title":"Beyond Behav."},{"key":"10.1016\/j.plaphy.2020.04.004_bib24","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1399-3054.1962.tb08052.x","article-title":"A Revised Medium for Rapid Growth and Bio Assays with Tobacco tissue cultures","volume":"15","author":"Murashige","year":"1962","journal-title":"Physiol. Plantarum"},{"key":"10.1016\/j.plaphy.2020.04.004_bib25","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s00425-007-0561-8","article-title":"The effect of nitric oxide on heme oxygenase gene expression in soybean leaves","volume":"226","author":"Noriega","year":"2007","journal-title":"Planta"},{"key":"10.1016\/j.plaphy.2020.04.004_bib26","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.envpol.2018.04.096","article-title":"Nitric oxide confronts arsenic stimulated oxidative stress and root architecture through distinct gene expression of auxin transporters, nutrient related genes and modulates biochemical responses in Oryza sativa L","volume":"240","author":"Praveen","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.plaphy.2020.04.004_bib27","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00709-010-0222-9","article-title":"Gating of aquaporins by heavy metals in Allium cepa L","volume":"248","author":"Przedpelska-Wasowicz","year":"2011","journal-title":"Protoplasma"},{"key":"10.1016\/j.plaphy.2020.04.004_bib28","first-page":"114","article-title":"Bioaccumulation and translocation factors of cadmium and lead in Aeluropus littoralis","volume":"2","author":"Rezvani","year":"2011","journal-title":"Aust. J. Agric. Eng."},{"key":"10.1016\/j.plaphy.2020.04.004_bib29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.envexpbot.2018.06.028","article-title":"Arsenate disrupts ion balance, sulfur and nitric oxide metabolisms in roots and leaves of pea (Pisum sativum L.) plants","volume":"161","author":"Rodr\u00edguez-Ruiz","year":"2019","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.plaphy.2020.04.004_bib30","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1111\/j.1365-3040.2006.01531.x","article-title":"Cadmium effect on oxidative metabolism of pea (Pisum sativum L.) roots. Imaging of reactive oxygen species and nitric oxide accumulation in vivo","volume":"29","author":"Rodr\u00edguez-Serrano","year":"2006","journal-title":"Plant Cell Environ."},{"key":"10.1016\/j.plaphy.2020.04.004_bib31","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.envexpbot.2016.10.011","article-title":"The morphogenic responses and phytochelatin complexes induced by arsenic in Pteris vittata change in the presence of cadmium","volume":"133","author":"Ronzan","year":"2017","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.plaphy.2020.04.004_bib32","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.envexpbot.2018.04.008","article-title":"Cadmium and arsenic affect root development in Oryza sativa L. negatively interacting with auxin","volume":"151","author":"Ronzan","year":"2018","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.plaphy.2020.04.004_bib33","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.envexpbot.2019.05.013","article-title":"Auxin-jasmonate crosstalk in Oryza sativa L. root system formation after cadmium and\/or arsenic exposure","volume":"165","author":"Ronzan","year":"2019","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.plaphy.2020.04.004_bib34","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s11270-015-2630-0","article-title":"Nitric oxide attenuates oxidative stress induced by arsenic in lettuce (Lactuca sativa) leaves","volume":"226","author":"Silveira","year":"2015","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.plaphy.2020.04.004_bib35","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.envexpbot.2007.12.005","article-title":"Nitric oxide (as sodium nitroprusside) supplementation ameliorates Cd toxicity in hydroponically grown wheat roots","volume":"63","author":"Singh","year":"2008","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.plaphy.2020.04.004_bib36","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.plaphy.2017.02.019","article-title":"A protective role for nitric oxide and salicylic acid for arsenite phytotoxicity in rice (Oryza sativa L.)","volume":"115","author":"Singh","year":"2017","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.plaphy.2020.04.004_bib37","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1093\/jxb\/erz184","article-title":"Role of nitric oxide in plant responses to heavy metal stress: exogenous application versus endogenous production","volume":"70","author":"Terr\u00f3n-Camero","year":"2019","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.plaphy.2020.04.004_bib38","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11032-010-9412-6","article-title":"Recent advances in arsenic accumulation and metabolism in rice","volume":"26","author":"Tuli","year":"2010","journal-title":"Mol. Breed."},{"key":"10.1016\/j.plaphy.2020.04.004_bib39","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.plantsci.2011.05.002","article-title":"Peroxynitrite formation and function in plants","volume":"181","author":"Vandelle","year":"2011","journal-title":"Plant Sci."},{"key":"10.1016\/j.plaphy.2020.04.004_bib40","series-title":"Arabidopsis: a Laboratory Manual","author":"Weigel","year":"2002"},{"key":"10.1016\/j.plaphy.2020.04.004_bib41","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.niox.2009.06.003","article-title":"Nitrite reduction and superoxide-dependent nitric oxide degradation by Arabidopsis mitochondria: influence of external NAD(P)H dehydrogenases and alternative oxidase in the control of nitric oxide levels","volume":"21","author":"Wulff","year":"2009","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.plaphy.2020.04.004_bib42","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00425-009-0984-5","article-title":"Exogenous nitric oxide enhances cadmium tolerance of rice by increasing pectin and hemicellulose contents in root cell wall","volume":"230","author":"Xiong","year":"2009","journal-title":"Planta"},{"key":"10.1016\/j.plaphy.2020.04.004_bib43","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s11104-009-0011-4","article-title":"Exogenous nitric oxide improves antioxidative capacity and reduces auxin degradation in roots of Medicago truncatula seedlings under cadmium stress","volume":"326","author":"Xu","year":"2010","journal-title":"Plant Soil"},{"key":"10.1016\/j.plaphy.2020.04.004_bib44","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1104\/pp.125.1.199","article-title":"Lipid peroxidation is an early symptom triggered by aluminum, but not the primary cause of elongation inhibition in pea roots","volume":"12","author":"Yamamoto","year":"2001","journal-title":"Plant Physiol."},{"key":"10.1016\/j.plaphy.2020.04.004_bib45","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/pce.12597","article-title":"Inhibition of root meristem growth by cadmium involves nitric oxide\u2010mediated repression of auxin accumulation and signalling in Arabidopsis","volume":"39","author":"Yuan","year":"2016","journal-title":"Plant Cell Environ."},{"key":"10.1016\/j.plaphy.2020.04.004_bib46","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1469-8137.2008.02716.x","article-title":"Arsenic uptake and metabolism in plants","volume":"181","author":"Zhao","year":"2009","journal-title":"New Phytol."}],"container-title":["Plant Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S098194282030173X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S098194282030173X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:39:08Z","timestamp":1777603148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S098194282030173X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":46,"alternative-id":["S098194282030173X"],"URL":"https:\/\/doi.org\/10.1016\/j.plaphy.2020.04.004","relation":{},"ISSN":["0981-9428"],"issn-type":[{"value":"0981-9428","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitric oxide alleviates cadmium- but not arsenic-induced damages in rice roots","name":"articletitle","label":"Article Title"},{"value":"Plant Physiology and Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.plaphy.2020.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}