{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:51:48Z","timestamp":1793746308276,"version":"4.6.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31201261"],"award-info":[{"award-number":["31201261"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Plant Physiology and Biochemistry"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.plaphy.2025.110208","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T03:07:35Z","timestamp":1751425655000},"page":"110208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Characterization of camptothecin biosynthesis in endophytic fungus from Camptotheca acuminate"],"prefix":"10.1016","volume":"228","author":[{"given":"Tong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2990-5738","authenticated-orcid":false,"given":"Siyi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5652-2956","authenticated-orcid":false,"given":"Wentao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dasheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6947-8983","authenticated-orcid":false,"given":"Lijie","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.plaphy.2025.110208_bib1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s00253-024-13187-2","article-title":"Biotechnological approaches for the production of camptothecin","volume":"108","author":"Banadka","year":"2024","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.plaphy.2025.110208_bib2","first-page":"28","article-title":"A review on medicinal value of Xi\u2013Shu tree","volume":"1","author":"Balasubramanian","year":"2012","journal-title":"SPECIES"},{"issue":"6465","key":"10.1016\/j.plaphy.2025.110208_bib3","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1126\/science.aaw9285","article-title":"Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome","volume":"366","author":"Carri\u00f3n","year":"2019","journal-title":"Science"},{"issue":"6714","key":"10.1016\/j.plaphy.2025.110208_bib5","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1126\/science.adr0956","article-title":"Anticancer drugs imperil Asian tree species","volume":"38","author":"Chen","year":"2024","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.plaphy.2025.110208_bib6","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1111\/jipb.13649","article-title":"Identification and characterization of camptothecin tailoring enzymes in Nothapodytes tomentosa","volume":"66","author":"Chen","year":"2024","journal-title":"J. Integr. Plant Biol."},{"key":"10.1016\/j.plaphy.2025.110208_bib4","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.cell.2020.07.010","article-title":"Converting Escherichia coli to a synthetic methylotroph growing solely on methanol","volume":"182","author":"Chen","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.plaphy.2025.110208_bib7","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1126\/science.1246929","article-title":"Chemistry. Envisioning the bioconversion of methane to liquid fuels","volume":"343","author":"Conrado","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.plaphy.2025.110208_bib8","doi-asserted-by":"crossref","first-page":"8227","DOI":"10.1038\/srep08227","article-title":"Co-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila","volume":"5","author":"Cui","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.plaphy.2025.110208_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1475-2859-5-17","article-title":"Operational strategies, monitoring and control of heterologous protein production in the methylotrophic yeast Pichia pastoris under different promoters: a review","volume":"5","author":"Cos","year":"2006","journal-title":"Microb. Cell Fact."},{"issue":"6","key":"10.1016\/j.plaphy.2025.110208_bib10","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1751-7915.2010.00221.x","article-title":"Natural products for cancer chemotherapy","volume":"4","author":"Demain","year":"2011","journal-title":"Microb. Biotechnol."},{"issue":"2","key":"10.1016\/j.plaphy.2025.110208_bib11","doi-asserted-by":"crossref","DOI":"10.1177\/00368504241253675","article-title":"Isolation, anticancer potency, and camptothecin-producing ability of endophytic fungi isolated from Ixora chinensis","volume":"107","author":"Doan","year":"2024","journal-title":"Sci. Prog."},{"issue":"1","key":"10.1016\/j.plaphy.2025.110208_bib12","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s12934-024-02471-5","article-title":"Bioprocessing of camptothecin from Alternaria brassicicola, an endophyte of Catharanthus roseus, with a strong antiproliferative activity and inhibition to topoisomerases","volume":"23","author":"El-Hady","year":"2024","journal-title":"Microb. Cell Fact."},{"issue":"3","key":"10.1016\/j.plaphy.2025.110208_bib13","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/lam.12606","article-title":"Biotransformation of ginsenoside Rb1 to ginsenoside C\u2010K by endophytic fungus arthrinium sp. GE 17\u201018 isolated from Panax ginseng","volume":"63","author":"Fu","year":"2016","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.plaphy.2025.110208_bib14","doi-asserted-by":"crossref","DOI":"10.1007\/s12257-025-00187-w","article-title":"Enhancing camptothecin yields: innovative approaches for sustainable anticancer drug production","author":"Jadhav","year":"2025","journal-title":"Biotechnol Bioproc E"},{"key":"10.1016\/j.plaphy.2025.110208_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.5598\/imafungus.2012.03.01.07","article-title":"Aspergillus section versicolores: nine new species and multilocus DNA sequence based phylogeny","volume":"1","author":"Jurjevic","year":"2012","journal-title":"Ima. Fungus."},{"key":"10.1016\/j.plaphy.2025.110208_bib16","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1021\/np1008398","article-title":"Effect of artificial reconstitution of the interaction between the plant Camptotheca acuminata and the fungal endophyte Fusarium solani on camptothecin biosynthesis","volume":"74","author":"Kusari","year":"2011","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.plaphy.2025.110208_bib17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.tibtech.2014.03.009","article-title":"Biotechnological potential of plant-associated endophytic fungi: hope versus hype","volume":"32","author":"Kusari","year":"2014","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.plaphy.2025.110208_bib18","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1080\/14786410802270779","article-title":"Anti-HSV activity of camptothecin analogues","volume":"24","author":"Liu","year":"2010","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.plaphy.2025.110208_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.plaphy.2024.109367","article-title":"Effects of dark septate endophyte on root growth, physiology and transcriptome of Ammopiptanthus mongolicus seedlings under drought stress","volume":"219","author":"Lu","year":"2025","journal-title":"Plant Physiol Biochem."},{"key":"10.1016\/j.plaphy.2025.110208_bib20","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1093\/jxb\/ert342","article-title":"Elicitors from the endophytic fungus Trichoderma atroviride promote Salvia miltiorrhiza hairy root growth and tanshinone biosynthesis","volume":"64","author":"Ming","year":"2013","journal-title":"J. Exp. Bot."},{"issue":"1","key":"10.1016\/j.plaphy.2025.110208_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-41738-6","article-title":"Genomic and transcriptomic analysis of camptothecin producing novel fungal Endophyte: Alternaria burnsii NCIM 1409","volume":"13","author":"Natarajan","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.plaphy.2025.110208_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/srep26583","article-title":"Fungal endophytes of Catharanthus roseus enhance vindoline content by modulating structural and regulatory genes related to terpenoid indole alkaloid biosynthesis","volume":"6","author":"Pandey","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.plaphy.2025.110208_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.plaphy.2025.109716","article-title":"Muti-omics insights the enhancement of drought tolerance in sweet cherry with dark septate endophyte S16","volume":"222","author":"Pang","year":"2025","journal-title":"Plant Physiol Biochem"},{"issue":"8","key":"10.1016\/j.plaphy.2025.110208_bib24","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s10295-015-1643-4","article-title":"Isolation and characterization of Paenibacillus polymyxa LY214, a camptothecin-producing endophytic bacterium from Camptotheca acuminata","volume":"42","author":"Pu","year":"2015","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"10.1016\/j.plaphy.2025.110208_bib25","doi-asserted-by":"crossref","first-page":"9365","DOI":"10.1007\/s00253-013-5163-8","article-title":"Camptothecin-producing endophytic fungus Trichoderma atroviride LY357: isolation,identification, and fermentation conditions optimization for camptothecin production","volume":"97","author":"Pu","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.plaphy.2025.110208_bib26","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1469-8137.2009.02773.x","article-title":"Fungal endophytes: diversity and functional roles","volume":"182","author":"Rodriguez","year":"2009","journal-title":"New Phytol."},{"key":"10.1016\/j.plaphy.2025.110208_bib27","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1105\/tpc.16.00193","article-title":"Metabolite diversity in alkaloid biosynthesis: a multilane (diastereomer) highway for camptothecin synthesis in Camptotheca acuminata","volume":"28","author":"Sadre","year":"2016","journal-title":"Plant Cell"},{"key":"10.1016\/j.plaphy.2025.110208_bib28","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev.arplant.54.031902.134840","article-title":"Functional genomics of P450s","volume":"54","author":"Schuler","year":"2003","journal-title":"Annu. Rev. Plant Biol."},{"key":"10.1016\/j.plaphy.2025.110208_bib29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0169-5347(97)01230-5","article-title":"The land flora: a phototroph\u2013fungus partnership?","volume":"13","author":"Selosse","year":"1998","journal-title":"Trends Ecol. Evol."},{"key":"10.1016\/j.plaphy.2025.110208_bib30","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.phymed.2012.11.015","article-title":"Endophytic fungus from Miquelia dentata bedd. Produce the anti-cancer alkaloid","volume":"20","author":"Shweta","year":"2013","journal-title":"Camptothecin. Phytomedicine"},{"issue":"10","key":"10.1016\/j.plaphy.2025.110208_bib31","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.phymed.2013.04.004","article-title":"Isolation of endophytic bacteria producing the anti-cancer alkaloid camptothecin from Miquelia dentata bedd (icacinaceae)","volume":"20","author":"Shweta","year":"2013","journal-title":"Phytomedicine"},{"key":"10.1016\/j.plaphy.2025.110208_bib32","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.phymed.2017.09.019","article-title":"Camptothecin-producing endophytic bacteria from Pyrenacantha volubilis hook. (icacinaceae): a possible role of a plasmid in the production of camptothecin","volume":"36","author":"Soujanya","year":"2017","journal-title":"Phytomedicine"},{"key":"10.1016\/j.plaphy.2025.110208_bib33","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.biortech.2016.01.079","article-title":"Effect of fermentation parameters, elicitors and precursors on camptothecin production from the endophyte Fusarium solani","volume":"206","author":"Venugopalan","year":"2016","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.plaphy.2025.110208_bib34","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.biortech.2014.12.106","article-title":"Enhanced methanol production by ethanol addition in the suspension culture of the endophyte, Fusarium solani","volume":"188","author":"Venugopalan","year":"2015","journal-title":"Bioresour. Technol."},{"issue":"6","key":"10.1016\/j.plaphy.2025.110208_bib44","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.1111\/pce.15422","article-title":"Correlation analysis of secondary metabolism and endophytic fungal assembles provide insights into screening efficient taxol-related fungal elicitors","volume":"48","author":"Wang","year":"2025","journal-title":"Plant Cell Environ."},{"issue":"16","key":"10.1016\/j.plaphy.2025.110208_bib35","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.3390\/ijms20163996","article-title":"Transcription factor OpWRKY3 is involved in the development and biosynthesis of camptothecin and its precursors in Ophiorrhiza pumila hairy roots","volume":"20","author":"Wang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"32","key":"10.1016\/j.plaphy.2025.110208_bib36","first-page":"5854","article-title":"Antioxidant and antibacterial activities of Camptotheca acuminate D. seed oil","volume":"5","author":"Wang","year":"2011","journal-title":"Afr. J. Microbiol. Res."},{"key":"10.1016\/j.plaphy.2025.110208_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.plaphy.2024.109412","article-title":"Photoinduced electron transfer enables cytochrome P450 enzyme-catalyzed reaction cycling","volume":"219","author":"Wei","year":"2025","journal-title":"Plant Physiol Biochem"},{"key":"10.1016\/j.plaphy.2025.110208_bib38","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.2147\/IJN.S134005","article-title":"10-Hydroxycamptothecin (HCPT) nanosuspensions stabilized by mPEG1000-HCPT conjugate: high stabilizing efficiency and improved antitumor efficacy","volume":"12","author":"Yang","year":"2017","journal-title":"Int. J. Nanomed."},{"issue":"20","key":"10.1016\/j.plaphy.2025.110208_bib39","doi-asserted-by":"crossref","first-page":"7872","DOI":"10.1016\/j.biortech.2010.04.102","article-title":"Biotransformation of ginsenoside Rb1 to ginsenoside Rd by highly substrate-tolerant paecilomyces bainier 229-7","volume":"101","author":"Ye","year":"2010","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.plaphy.2025.110208_bib40","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/jof3010012","article-title":"Characterization of blue mold penicillium species isolated from stored fruits using multiple highly conserved loci","volume":"3","author":"Yin","year":"2017","journal-title":"J. Fungi"},{"issue":"6","key":"10.1016\/j.plaphy.2025.110208_bib41","first-page":"681","article-title":"Antifungal activity of camptothecin on Rhizoctonia solani, Sphaerotheca fuliginea and Pseudoperonospora cubensis","volume":"25","author":"Zhang","year":"2008","journal-title":"J. Zhejiang For. Coll."},{"key":"10.1016\/j.plaphy.2025.110208_bib42","doi-asserted-by":"crossref","first-page":"12185","DOI":"10.1039\/C7RA00588A","article-title":"Accumulation of camptothecin and 10-hydroxycamptothecin and the transcriptional expression of camptothecin biosynthetic genes in Camptotheca acuminata cambial meristematic and dedifferentiated cells","volume":"7","author":"Zhang","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.plaphy.2025.110208_bib43","first-page":"567","article-title":"Endophytic fungus for producing bioactive compounds originally from their host plants","volume":"1","author":"Zhao","year":"2010","journal-title":"Curr. Res. Technol. Educ. Trop. Appl. Microbiol. Microb. Biotechnol."}],"container-title":["Plant Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0981942825007363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0981942825007363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:26:48Z","timestamp":1761492408000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0981942825007363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":44,"alternative-id":["S0981942825007363"],"URL":"https:\/\/doi.org\/10.1016\/j.plaphy.2025.110208","relation":{},"ISSN":["0981-9428"],"issn-type":[{"value":"0981-9428","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of camptothecin biosynthesis in endophytic fungus from Camptotheca acuminate","name":"articletitle","label":"Article Title"},{"value":"Plant Physiology and Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.plaphy.2025.110208","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110208"}}