{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:16:26Z","timestamp":1791296186315,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.plefa.2009.01.007","type":"journal-article","created":{"date-parts":[[2009,3,24]],"date-time":"2009-03-24T08:46:10Z","timestamp":1237884370000},"page":"221-227","source":"Crossref","is-referenced-by-count":88,"title":["Plasma fatty acid profiles in autism: A case-control study"],"prefix":"10.1016","volume":"80","author":[{"given":"M.M.","family":"Wiest","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.B.","family":"German","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.J.","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Hertz-Picciotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.plefa.2009.01.007_bib1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1023\/A:1005592401947","article-title":"The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism","volume":"30","author":"Lord","year":"2000","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.plefa.2009.01.007_bib2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.0021-9630.2003.00317.x","article-title":"Autism and pervasive developmental disorders","volume":"45","author":"Volkmar","year":"2004","journal-title":"J. Child Psychol. Psychiatry"},{"key":"10.1016\/j.plefa.2009.01.007_bib3","unstructured":"CDC Prevalence of autism spectrum disorders\u2014Autism and Developmental Disabilities Monitoring Network, six sites, United States, 2000, in: Surveillance Summaries, February 9, 2007, MMWR 56 (No. SS-1), pp. 1\u201311."},{"key":"10.1016\/j.plefa.2009.01.007_bib4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1365-2788.2005.00676.x","article-title":"Aetiology of autism: findings and questions","volume":"49","author":"Rutter","year":"2005","journal-title":"J. Intellect. Disabil. Res."},{"key":"10.1016\/j.plefa.2009.01.007_bib5","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1542\/peds.113.5.e472","article-title":"The genetics of autism","volume":"113","author":"Muhle","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.plefa.2009.01.007_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1054\/plef.2000.0184","article-title":"Fatty acid metabolism in neurodevelopmental disorder: a new perspective on associations between attention-deficit\/hyperactivity disorder, dyslexia, dyspraxia and the autistic spectrum","volume":"63","author":"Richardson","year":"2000","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"issue":"6","key":"10.1016\/j.plefa.2009.01.007_bib7","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1172\/JCI117293","article-title":"Incorporation of chylomicron fatty acids into the developing rat brain","volume":"93","author":"Anderson","year":"1994","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.plefa.2009.01.007_bib8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/jn\/134.1.183","article-title":"Is docosahexaenoic acid (DHA) essential? Lessons from DHA status regulation, our ancient diet, epidemiology and randomized controlled trials","volume":"134","author":"Muskiet","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.plefa.2009.01.007_bib9","doi-asserted-by":"crossref","first-page":"8755","DOI":"10.1074\/jbc.R100062200","article-title":"Minireview: the biochemistry of n-3 polyunsaturated fatty acids","volume":"277","author":"Jump","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.plefa.2009.01.007_bib10","doi-asserted-by":"crossref","first-page":"35215","DOI":"10.1074\/jbc.M004446200","article-title":"Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3)","volume":"275","author":"Kim","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.plefa.2009.01.007_bib11","doi-asserted-by":"crossref","first-page":"11056","DOI":"10.1074\/jbc.273.18.11056","article-title":"Functional modulation of human recombinant gamma-aminobutyric acid type a receptor by docosahexaenoic acid","volume":"273","author":"Nabekura","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.plefa.2009.01.007_bib12","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1073\/pnas.86.8.2903","article-title":"Membrane docosahexaenoate is supplied to the developing brain and retina by the liver","volume":"86","author":"Scott","year":"1989","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.plefa.2009.01.007_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1054\/plef.2001.0281","article-title":"Plasma fatty acid levels in autistic children","volume":"65","author":"Vancassel","year":"2001","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.plefa.2009.01.007_bib14","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.mehy.2004.01.011","article-title":"Is autism a disorder of fatty-acid metabolism? Possible dysfunction of mitochondrial beta-oxidation by long chain acyl-CoA dehydrogenase","volume":"62","author":"Clark-Taylor","year":"2004","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.plefa.2009.01.007_bib15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1054\/plef.2000.0186","article-title":"Red blood cell fatty acid compositions in a patient with autistic spectrum disorder: a characteristic abnormality in neurodevelopmental disorders?","volume":"63","author":"Bell","year":"2000","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.plefa.2009.01.007_bib16","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.plefa.2004.03.008","article-title":"Essential fatty acids and phospholipase A2 in autistic spectrum disorders","volume":"71","author":"Bell","year":"2004","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.plefa.2009.01.007_bib17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/ajmg.b.20104","article-title":"No association between the APOE gene and autism","volume":"125B","author":"Raiford","year":"2004","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.plefa.2009.01.007_bib18","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0278-5846(02)00303-2","article-title":"Normal phospholipid-related signal transduction in autism","volume":"26","author":"Puri","year":"2002","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.plefa.2009.01.007_bib19","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1016\/j.lfs.2004.04.038","article-title":"Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferring\u2014the antioxidant proteins","volume":"75","author":"Chauhan","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.plefa.2009.01.007_bib20","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.plefa.2005.06.002","article-title":"Increased excretion of a lipid peroxidation biomarker in autism","volume":"73","author":"Ming","year":"2003","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.plefa.2009.01.007_bib21","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1289\/ehp.8483","article-title":"The CHARGE study: an epidemiologic investigation of genetic and envioronmental factors contributing to autism","volume":"114","author":"Hertz-Picciotto","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.plefa.2009.01.007_bib22","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of lipids from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.plefa.2009.01.007_bib23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s11745-001-0714-8","article-title":"Unique phospholipid metabolism in mouse heart in response to dietary docosahexaenoic or \u03b1-linolenic acids","volume":"36","author":"Watkins","year":"2001","journal-title":"Lipids"},{"key":"10.1016\/j.plefa.2009.01.007_bib24","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/sj.mp.4001943","article-title":"A proteomic study of serum from children with autism showing differential expression of apolipoproteins and complement proteins","author":"Corbett","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.plefa.2009.01.007_bib25","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1093\/jn\/133.11.3643","article-title":"Plasma concentrations of (n-3) highly unsaturated fatty acids are good biomarkers of relative dietary fatty acid intakes: a cross-sectional study","volume":"133","author":"Kuriki","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.plefa.2009.01.007_bib26","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/ajcn\/54.2.334","article-title":"Comparison of three species of dietary fish: effects on serum concentrations of low-density-lipoprotein cholesterol and apolipoprotein in normotriglyceridemic subjects","volume":"54","author":"Gerhard","year":"1991","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.plefa.2009.01.007_bib27","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1177\/107385840100700308","article-title":"Plasmalogens: workhorse lipids of membranes in normal and injured neurons and glia","volume":"7","author":"Farooqui","year":"2001","journal-title":"Neuroscientist"},{"key":"10.1016\/j.plefa.2009.01.007_bib28","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0163-7827(95)00013-5","article-title":"Glycerolipid biosynthesis in peroxisomes (microbodies)","volume":"34","author":"Hajra","year":"1995","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.plefa.2009.01.007_bib29","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.bbamcr.2006.09.010","article-title":"Peroxisome biogenesis disorders","volume":"1763","author":"Steinberg","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.plefa.2009.01.007_bib30","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0387-7604(03)00033-0","article-title":"Gas chromatography\/mass spectrometry analysis of very long chain fatty acids, docosahexaenoic acid, phytanic acid and plasmalogen for the screening of peroxisomal disorders","volume":"27","author":"Takemoto","year":"2003","journal-title":"Brain Dev."},{"key":"10.1016\/j.plefa.2009.01.007_bib31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/1531-8249(199901)45:1<100::AID-ART16>3.0.CO;2-U","article-title":"Plasma very long chain fatty acids in 3,000 peroxisome disease patients and 29,000 controls","volume":"45","author":"Moser","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.plefa.2009.01.007_bib32","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0022-2275(20)32454-8","article-title":"Plasmalogen status influences docosahexaenoic acid levels in a macrophage cell line: insights using ether lipid-deficient variants","volume":"40","author":"Gaposchkin","year":"1999","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.plefa.2009.01.007_bib33","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/jnr.21097","article-title":"Nerocortical and cerebellar developmental abnormalities in conditions of selective elimination of peroxisomes from brain or from liver","volume":"85","author":"Krysko","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.plefa.2009.01.007_bib34","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1542\/peds.87.5.781","article-title":"Neuroanatomic imaging in autism","volume":"87","author":"Courchesne","year":"1991","journal-title":"Pediatrics"},{"key":"10.1016\/j.plefa.2009.01.007_bib35","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijdevneu.2004.09.006","article-title":"Neuroanatomic observations of the brain in autism: a review and future directions","volume":"23","author":"Bauman","year":"2005","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.plefa.2009.01.007_bib36","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0387-7604(03)00056-1","article-title":"Purkinje cell vulnerability and autism: a possible etiological connection (review)","volume":"25","author":"Kern","year":"2003","journal-title":"Brain Dev."},{"key":"10.1016\/j.plefa.2009.01.007_bib37","doi-asserted-by":"crossref","DOI":"10.1186\/1742-2094-4-3","article-title":"Effect of pioglitazone treatment on behavioral symptoms in autistic children","volume":"4","author":"Boris","year":"2007","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.plefa.2009.01.007_bib38","unstructured":"D. Rubin, M. Lapasata, Cellular interactions between n-6 and n-3 fatty acids: a mass analysis of fatty acid elongation\/desaturation, distribution among complex lipids, and conversion to eicosanoids, J. Lipid Res. 33 (1992) 1431\u20131438."}],"container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952327809000192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952327809000192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T15:47:32Z","timestamp":1684943252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952327809000192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0952327809000192"],"URL":"https:\/\/doi.org\/10.1016\/j.plefa.2009.01.007","relation":{},"ISSN":["0952-3278"],"issn-type":[{"value":"0952-3278","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}