{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:26:43Z","timestamp":1790796403922,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.plefa.2011.05.001","type":"journal-article","created":{"date-parts":[[2011,6,25]],"date-time":"2011-06-25T01:26:49Z","timestamp":1308965209000},"page":"53-60","source":"Crossref","is-referenced-by-count":12,"title":["Brain protection by rapeseed oil in magnesium-deficient mice"],"prefix":"10.1016","volume":"85","author":[{"given":"Nicole","family":"Pages","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Maurois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Delplanque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Bac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Charles","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley I.","family":"Rapoport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Vamecq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.plefa.2011.05.001_bib1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.plefa.2007.10.023","article-title":"Brain metabolism of nutritionally polyunsaturated fatty acids depends on both the diet and the liver","volume":"77","author":"Rapoport","year":"2007","journal-title":"Prostaglandins Leukotrienes Essent. Fatty Acids"},{"key":"10.1016\/j.plefa.2011.05.001_bib2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neuroscience.2005.08.083","article-title":"Alpha linolenic acid and riluzole treatment confer cerebral protection and improve survival after focal brain ischemia","volume":"137","author":"Heurteaux","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.plefa.2011.05.001_bib3","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1038\/npp.2009.84","article-title":"Subchronic alpha-linolenic acid treatment enhances brain plasticity and exerts an antidepressant effect: a versatile potential therapy for stroke","volume":"34","author":"Blondeau","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.plefa.2011.05.001_bib4","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.neures.2009.11.006","article-title":"Evaluation of chronic omega-3 fatty acids supplementation on behavioral and neurochemical alterations in 6-hydroxydopamine-lesion model of Parkinson's disease","volume":"66","author":"Delattre","year":"2010","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.plefa.2011.05.001_bib5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1385\/JMN:16:2-3:223","article-title":"Inhibition of neuronal apoptosis by polyunsaturated fatty acids","volume":"16","author":"Kim","year":"2001","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.plefa.2011.05.001_bib6","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1093\/emboj\/19.8.1784","article-title":"Polyunsaturated fatty acids are potent neuroprotectors","volume":"19","author":"Lauritzen","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.plefa.2011.05.001_bib7","doi-asserted-by":"crossref","first-page":"12559","DOI":"10.1073\/pnas.93.22.12559","article-title":"Polyunsaturated acids modulate sodium and calcium currents in CA1 neurons","volume":"93","author":"Vreugdenhil","year":"1996","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"10.1016\/j.plefa.2011.05.001_bib8","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0006-8993(99)01997-6","article-title":"Polyunsaturated fatty acids modify mouse hippocampal neuronal hyperexcitability during excitotoxic or convulsant stimulation","volume":"846","author":"Xiao","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.plefa.2011.05.001_bib9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1528-1167.2008.01731.x","article-title":"Dose-dependent anticonvulsant effects of linoleic and alpha-linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats","volume":"50","author":"Taha","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.plefa.2011.05.001_bib10","first-page":"735","article-title":"The emerging role of docosahexaenoic acid in neuroinflammation","volume":"9","author":"Orr","year":"2008","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.plefa.2011.05.001_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-277X.2006.00669.x","article-title":"Identification of nutritionally adequate mixtures of vegetable oils by linear programming","volume":"19","author":"Darmon","year":"2006","journal-title":"J. Hum. Nutr. Diet."},{"key":"10.1016\/j.plefa.2011.05.001_bib12","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.biochi.2009.01.008","article-title":"Polyunsaturated fatty acids and inflammatory processes: new twists in an old tale","volume":"91","author":"Calder","year":"2009","journal-title":"Biochimie"},{"key":"10.1016\/j.plefa.2011.05.001_bib13","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1017\/S0007114508923692","article-title":"Effect of dietary supplementation with increasing doses of docosahexaenoic acid on neutrophil lipid composition and leukotriene production in human healthy volunteers","volume":"100","author":"Stanke-Labesque","year":"2008","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.plefa.2011.05.001_bib14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0753-3322(02)00253-6","article-title":"The importance of the ratio of omega-6\/omega-3 essential fatty acids","volume":"56","author":"Simopoulos","year":"2002","journal-title":"Biomed. Pharmacother"},{"key":"10.1016\/j.plefa.2011.05.001_bib15","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.prostaglandins.2004.03.005","article-title":"Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis","volume":"73","author":"Serhan","year":"2004","journal-title":"Prostaglandins Other Lipid Mediator"},{"key":"10.1016\/j.plefa.2011.05.001_bib16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1196\/annals.1344.011","article-title":"Brain response to injury and neurodegeneration: endogenous neuroprotective signaling","volume":"1053","author":"Bazan","year":"2005","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.plefa.2011.05.001_bib17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.abb.2006.03.031","article-title":"Magnesium and the inflammatory response: potential physiopathological implications","volume":"458","author":"Mazur","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.plefa.2011.05.001_bib18","series-title":"Advances in Magnesium research: Nutrition and Health","first-page":"285","article-title":"Pro-oxidant and pro-inflammatory neuropeptides in magnesium deficiency","author":"Weglicki","year":"2001"},{"key":"10.1016\/j.plefa.2011.05.001_bib19","doi-asserted-by":"crossref","first-page":"R734","DOI":"10.1152\/ajpregu.1992.263.3.R734","article-title":"Pathobiology of magnesium deficiency: a cytokine\/neurogenic inflammation hypothesis","volume":"263","author":"Weglicki","year":"1992","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.plefa.2011.05.001_bib20","first-page":"293","article-title":"Physiopathology of symptomatic and latent forms of central nervous system hyperexcitability due to magnesium deficiency: a current general scheme","volume":"13","author":"Durlach","year":"2000","journal-title":"Magnesium Res."},{"key":"10.1016\/j.plefa.2011.05.001_bib21","first-page":"49","article-title":"Biorhythms and possible central regulation of magnesium status, phototherapy, darkness therapy and chronopathological forms of magnesium depletion","volume":"15","author":"Durlach","year":"2002","journal-title":"Magnesium Res."},{"key":"10.1016\/j.plefa.2011.05.001_bib22","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1017\/S0007114508006752","article-title":"Threshold to NMDA-induced seizures in mice undergoing chronic nutritional magnesium deprivation is lowered in a way partly responsive to acute magnesium and antioxidant administrations","volume":"101","author":"Maurois","year":"2009","journal-title":"Brit. J. Nutr."},{"key":"10.1016\/j.plefa.2011.05.001_bib23","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1523\/JNEUROSCI.18-11-04363.1998","article-title":"Magnesium-deficiency-dependent audiogenic seizures (MDDASs) in adult mice: a nutritional model for discriminatory screening of anticonvulsant drugs and original assessment of neuroprotection properties","volume":"18","author":"Bac","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.plefa.2011.05.001_bib24","series-title":"Nutrition and Health","first-page":"434","article-title":"The multiple facets of the MDDAS test: application to the detection of neurotoxic molecules or neuroprotective (anti-inflammatory and\/or antioxidant) molecules in central nervous hyperexcitability induced by severe magnesium deficiency","author":"Maurois","year":"2001"},{"key":"10.1016\/j.plefa.2011.05.001_bib25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.biopha.2007.10.014","article-title":"The PPAR gamma-agonist FMOC-l-Leucine protects both mature and immature brain","volume":"62","author":"Maurois","year":"2008","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.plefa.2011.05.001_bib26","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neures.2010.08.011","article-title":"Activities of \u03b1-asarone in various animal seizure models and in biochemical assays might be essentially accounted for by antioxidant properties","volume":"68","author":"Pages","year":"2010","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.plefa.2011.05.001_bib27","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1046\/j.1460-9568.2003.02846.x","article-title":"Potent mammalian cerebroprotection and neuronal cell death inhibition are afforded by a synthetic antioxidant analogue of marine invertebrate cell protectant ovothiols","volume":"18","author":"Vamecq","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.plefa.2011.05.001_bib28","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1016\/j.ejmech.2010.03.044","article-title":"1,2-ethane bis-1-amino-4-benzamidine is active against several brain insult and seizure challenges through anti-NMDA mechanisms targeting the 3H-TCP binding site and antioxidant action","volume":"45","author":"Vamecq","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.plefa.2011.05.001_bib29","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/jn\/112.3.488","article-title":"Role of magnesium in glutathione metabolism of rat erythrocytes","volume":"112","author":"Hsu","year":"1982","journal-title":"J. Nutr."},{"key":"10.1016\/j.plefa.2011.05.001_bib30","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3181\/00379727-181-42260","article-title":"Magnesium deficiency inhibits biosynthesis of blood glutathione and tumor growth in the rat","volume":"181","author":"Mills","year":"1986","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.plefa.2011.05.001_bib31","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1432-1033.1972.tb02124.x","article-title":"Studies on the reconstitution of apotransketolase with thiamin pyrophosphate and analogs of the coenzyme","volume":"30","author":"Heinrich","year":"1972","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.plefa.2011.05.001_bib32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0005-2744(74)90148-X","article-title":"Isolation and some properties of 6-phosphogluconate dehydrogenase from Bacillus stearothermophilus","volume":"334","author":"Veronese","year":"1974","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.plefa.2011.05.001_bib33","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0006-8993(00)03156-5","article-title":"Magnesium deprivation decreases cellular reduced glutathione and causes oxidative neuronal death in murine cortical cultures","volume":"890","author":"Regan","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.plefa.2011.05.001_bib34","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1051\/ocl.2007.0125","article-title":"Is chronic rapeseed oil more neuroprotective than chronic corn\/sunflower diet? Evaluation by audiogenic seizure test in magnesium-deficient mice (MDDAS)","volume":"14","author":"Pages","year":"2007","journal-title":"OCL (Ol\u00e9agineux, Corps gras, Lipides)"},{"key":"10.1016\/j.plefa.2011.05.001_bib35","first-page":"183","article-title":"Protective effect of severe magnesium deficiency on Plasmodium chabaudi infection","volume":"2","author":"Maurois","year":"1989","journal-title":"Magnesium Res."},{"key":"10.1016\/j.plefa.2011.05.001_bib36","unstructured":"F. Rousselet, J. Durlach, Techniques analytiques et explorations pratiques du m\u00e9tabolisme magn\u00e9sique en clinique humaine, in: J. Duralch (Ed.), 1er Symposium International sur le D\u00e9ficit Magn\u00e9sique en Pathologie Humaine. I. Vol. des rapports, SGEMV ed., Vittel (1971) pp. 65\u201390."},{"key":"10.1016\/j.plefa.2011.05.001_bib37","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s11745-004-1236-0","article-title":"Dose effect of alpha-linolenic acid on PUFA conversion, bioavailability, and storage in the hamster","volume":"39","author":"Morise","year":"2004","journal-title":"Lipids"},{"key":"10.1016\/j.plefa.2011.05.001_bib38","first-page":"456","article-title":"Serum magnesium levels in idiopathic epilepsy","volume":"42","author":"Gupta","year":"1994","journal-title":"J. Assoc. Physicians India"},{"key":"10.1016\/j.plefa.2011.05.001_bib39","first-page":"37","article-title":"Inhibition of mouse-killing behaviour in magnesium-deficient rats: effect of pharmacological doses of magnesium pidolate, magnesium aspartate, magnesium lactate, magnesium gluconate and magnesium chloride","volume":"8","author":"Bac","year":"1995","journal-title":"Magnesium Res."},{"key":"10.1016\/j.plefa.2011.05.001_bib40","first-page":"303","article-title":"magnesium concentrations during magnesium deficit in animals and humans: neurological symptoms","volume":"5","author":"Morris","year":"1992","journal-title":"Magnesium Res."},{"key":"10.1016\/j.plefa.2011.05.001_bib41","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4103\/0253-7613.59926","article-title":"Effect of magnesium oxide on the activity of standard anti-epileptic drugs against experimental seizures in rats","volume":"41","author":"Dhande","year":"2009","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.plefa.2011.05.001_bib42","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/S0002-9378(12)90855-8","article-title":"Central anticonvulsant effects of magnesium sulfate on N-methyl-d-aspartate_induced seizures","volume":"168","author":"Cotton","year":"1993","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.plefa.2011.05.001_bib43","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/309261a0","article-title":"Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurons","volume":"309","author":"Mayer","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.plefa.2011.05.001_bib44","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/307462a0","article-title":"Magnesium gates glutamate-activated channels in mouse central neurons","volume":"307","author":"Nowak","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.plefa.2011.05.001_bib45","series-title":"The treatment of epilepsy: principles and practice","first-page":"53","article-title":"Mechanisms of epileptogenesis and the expression of epileptiform activity","author":"Clark","year":"1996"},{"key":"10.1016\/j.plefa.2011.05.001_bib46","first-page":"229","article-title":"Magnesium: nature's physiologic calcium blocker","volume":"4","author":"Iseri","year":"1989","journal-title":"Am. Heart J."},{"key":"10.1016\/j.plefa.2011.05.001_bib47","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.plefa.2010.04.001","article-title":"Omega-3 long chain fatty acid synthesis is regulated more by substrate levels than gene expression","volume":"83","author":"Tu","year":"2010","journal-title":"Prostaglandins Leukotrienes Essent. Fatty Acids"},{"key":"10.1016\/j.plefa.2011.05.001_bib48","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.bbalip.2006.06.006","article-title":"Brain elongation of linoleic acid is a negligible source of the arachidonate in brain phospholipids of adult rats","volume":"1761","author":"Demar","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.plefa.2011.05.001_bib49","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1042\/bst0180503","article-title":"Receptor-mediated activation of phospholipase A2 and arachidonic acid release in signal transduction","volume":"18","author":"Axelrod","year":"1990","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.plefa.2011.05.001_bib50","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1042\/BST0371104","article-title":"Is the brain arachidonic acid cascade a common target of drugs used to manage bipolar disorder?","volume":"37","author":"Bazinet","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.plefa.2011.05.001_bib51","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1471-4159.2006.04371.x","article-title":"Modulation of inflammation in brain: a matter of fat","volume":"101","author":"Farooqui","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.plefa.2011.05.001_bib52","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/342918a0","article-title":"Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells","volume":"342","author":"Barbour","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.plefa.2011.05.001_bib53","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/ana.410250610","article-title":"Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons","volume":"25","author":"Coulter","year":"1989","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.plefa.2011.05.001_bib54","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1124\/mol.60.5.1121","article-title":"Block of cloned human T-type calcium channels by succinimide antiepileptic drugs","volume":"60","author":"Gomora","year":"2001","journal-title":"Mol. Pharmacol."},{"issue":"Suppl 9","key":"10.1016\/j.plefa.2011.05.001_bib55","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1528-1167.2005.00326.x","article-title":"Properties of antiepileptic drugs in the treatment of idiopathic generalized epilepsies","volume":"46","author":"Patsalos","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.plefa.2011.05.001_bib56","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.bbrc.2004.12.033","article-title":"Modulation of native T-type calcium channels by omega-3 fatty acids","volume":"327","author":"Danthi","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952327811000731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952327811000731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T07:48:07Z","timestamp":1560325687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952327811000731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0952327811000731"],"URL":"https:\/\/doi.org\/10.1016\/j.plefa.2011.05.001","relation":{},"ISSN":["0952-3278"],"issn-type":[{"value":"0952-3278","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}