{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T08:42:22Z","timestamp":1760604142493,"version":"build-2065373602"},"reference-count":51,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","plefa.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.plefa.2012.06.002","type":"journal-article","created":{"date-parts":[[2012,6,30]],"date-time":"2012-06-30T17:32:05Z","timestamp":1341077525000},"page":"63-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Brain anticonvulsant protection of mice given chronic carbamazepine under various fatty acid and magnesium diet conditions"],"prefix":"10.1016","volume":"87","author":[{"given":"Nicole","family":"Pag\u00e8s","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Maurois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadette","family":"Delplanque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Bac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Vamecq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.plefa.2012.06.002_bib1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0140-6736(89)90828-3","article-title":"Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART)","volume":"2","author":"Burr","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.plefa.2012.06.002_bib2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.jacc.2009.02.084","article-title":"Omega-3 polyunsaturated fatty acids and cardiovascular diseases","volume":"54","author":"Lavie","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.plefa.2012.06.002_bib3","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4065\/83.3.324","article-title":"Omega-3 fatty acids for cardioprotection","volume":"83","author":"Lee","year":"2008","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.plefa.2012.06.002_bib4","first-page":"e320","volume":"116","author":"London","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.plefa.2012.06.002_bib5","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1038\/npp.2009.84","article-title":"Subchronic alpha-linolenic acid treatment enhances brain plasticity and exerts an antidepressant effect: a versatile potential therapy for stroke","volume":"34","author":"Blondeau","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.plefa.2012.06.002_bib6","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.neures.2009.11.006","article-title":"Evaluation of chronic omega-3 fatty acids supplementation on behavioral and neurochemical alterations in 6-hydroxydopamine-lesion model of Parkinson's disease","volume":"66","author":"Delattre","year":"2010","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.plefa.2012.06.002_bib7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neuroscience.2005.08.083","article-title":"Alpha linolenic acid and riluzole treatment confer cerebral protection and improve survival after focal brain ischemia","volume":"137","author":"Heurteaux","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.plefa.2012.06.002_bib8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1385\/JMN:16:2-3:223","article-title":"Inhibition of neuronal apoptosis by polyunsaturated fatty acids","volume":"16","author":"Kim","year":"2001","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.plefa.2012.06.002_bib9","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1093\/emboj\/19.8.1784","article-title":"Polyunsaturated fatty acids are potent neuroprotectors","volume":"19","author":"Lauritzen","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.plefa.2012.06.002_bib10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1528-1167.2008.01731.x","article-title":"Dose-dependent anticonvulsant effects of linoleic and alpha-linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats","volume":"50","author":"Taha","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.plefa.2012.06.002_bib11","doi-asserted-by":"crossref","first-page":"12559","DOI":"10.1073\/pnas.93.22.12559","article-title":"Polyunsaturated acids modulate sodium and calcium currents in CA1 neurons","volume":"93","author":"Vreugdenhil","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.plefa.2012.06.002_bib12","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0006-8993(99)01997-6","article-title":"Polyunsaturated fatty acids modify mouse hippocampal neuronal hyperexcitability during excitotoxic or convulsant stimulation","volume":"846","author":"Xiao","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.plefa.2012.06.002_bib13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.plefa.2011.05.001","article-title":"Brain protection by rapeseed oil in magnesium-deficient mice","volume":"85","author":"Pag\u00e8s","year":"2011","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.plefa.2012.06.002_bib14","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1523\/JNEUROSCI.18-11-04363.1998","article-title":"Magnesium-deficiency-dependent audiogenic seizures (MDDASs) in adult mice: a nutritional model for discriminatory screening of anticonvulsant drugs and original assessment of neuroprotection properties","volume":"18","author":"Bac","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.plefa.2012.06.002_bib15","series-title":"Nutrition and Health","first-page":"434","article-title":"The multiple facets of the MDDAS test: application to the detection of neurotoxic molecules or neuroprotective (anti-inflammatory and\/or antioxidant) molecules in central nervous hyperexcitability induced by severe magnesium deficiency","author":"Maurois","year":"2001"},{"key":"10.1016\/j.plefa.2012.06.002_bib16","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1017\/S0007114508006752","article-title":"Threshold to NMDA-induced seizures in mice undergoing chronic nutritional magnesium deprivation is lowered in a way partly responsive to acute magnesium and antioxidant administrations","volume":"101","author":"Maurois","year":"2009","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.plefa.2012.06.002_bib17","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.biopha.2007.10.014","article-title":"The PPAR gamma-agonist FMOC-L-leucine protects both mature and immature brain","volume":"62","author":"Maurois","year":"2008","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.plefa.2012.06.002_bib18","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.biomag.2011.09.005","article-title":"The \u03b1-asarone\/clofibrate hybrid compound, 2-methoxy-4-(2-propenyl)phenoxyacetic acid (MPPA) is endowed with neuroprotective and anticonvulsant potentialities","volume":"1","author":"Pag\u00e8s","year":"2011","journal-title":"Biomed. Aging Pathol."},{"key":"10.1016\/j.plefa.2012.06.002_bib19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neures.2010.08.011","article-title":"Activities of \u03b1-asarone in various animal seizure models and in biochemical assays might be essentially accounted for by antioxidant properties","volume":"68","author":"Pag\u00e8s","year":"2010","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.plefa.2012.06.002_bib20","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1046\/j.1460-9568.2003.02846.x","article-title":"Potent mammalian cerebroprotection and neuronal cell death inhibition are afforded by a synthetic antioxidant analogue of marine invertebrate cell protectant ovothiols","volume":"18","author":"Vamecq","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.plefa.2012.06.002_bib21","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1016\/j.ejmech.2010.03.044","article-title":"1,2-ethane bis-1-amino-4-benzamidine is active against several brain insult and seizure challenges through anti-NMDA mechanisms targeting the 3H-TCP binding site and antioxidant action","volume":"45","author":"Vamecq","year":"2010","journal-title":"Eur. J. Med. Chem."},{"issue":"Suppl. 2","key":"10.1016\/j.plefa.2012.06.002_bib22","first-page":"S2","article-title":"Antiepileptic drug mechanisms of action","volume":"36","author":"Macdonald","year":"1995","journal-title":"Epilepsia"},{"key":"10.1016\/j.plefa.2012.06.002_bib23","article-title":"Oxcarbazepine versus carbamazepine monotherapy for partial onset seizures","volume":"4","author":"Koch","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.plefa.2012.06.002_bib24","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJMra035354","article-title":"Bipolar disorder","volume":"351","author":"Belmaker","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.plefa.2012.06.002_bib25","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1007\/s11064-008-9817-3","article-title":"Chronic administration of mood stabilizers upregulates BDNF and bcl-2 expression levels in rat frontal cortex","volume":"34","author":"Chang","year":"2009","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.plefa.2012.06.002_bib26","first-page":"130","article-title":"Brain arachidonic acid uptake and turnover: implications for signaling and bipolar disorder","volume":"13","author":"Duncan","year":"2010","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.plefa.2012.06.002_bib27","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.biopsych.2004.05.012","article-title":"Chronic carbamazepine selectively downregulates cytosolic phospholipase A2 expression and cyclooxygenase activity in rat brain","volume":"56","author":"Ghelardoni","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.plefa.2012.06.002_bib28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2174\/1874467210902020207","article-title":"Mood-stabilizers target the brain arachidonic acid cascade","volume":"2","author":"Rao","year":"2009","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.plefa.2012.06.002_bib29","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.biopsych.2006.03.029","article-title":"Chronic administration of carbamazepine down-regulates AP-2 DNA-binding activity and AP-2alpha protein expression in rat frontal cortex","volume":"61","author":"Rao","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.plefa.2012.06.002_bib30","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.biopsych.2005.07.024","article-title":"Chronic carbamazepine decreases the incorporation rate and turnover of arachidonic acid but not docosahexaenoic acid in brain phospholipids of the unanesthetized rat: relevance to bipolar disorder","volume":"59","author":"Bazinet","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.plefa.2012.06.002_bib31","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1046\/j.1471-4159.1996.67031145.x","article-title":"Receptor-mediated activation of G proteins is increased in postmortem brains of bipolar affective disorder subjects","volume":"67","author":"Friedman","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.plefa.2012.06.002_bib32","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1111\/j.1471-4159.1993.tb03600.x","article-title":"Cerebral cortex Gs alpha protein levels and forskolin-stimulated cyclic AMP formation are increased in bipolar affective disorder","volume":"61","author":"Young","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/j.plefa.2012.06.002_bib33","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1111\/j.1471-4159.2007.04648.x","article-title":"Chronic NMDA administration to rats up-regulates frontal cortex cytosolic phospholipase A2 and its transcription factor, activator protein-2","volume":"102","author":"Rao","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.plefa.2012.06.002_bib34","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.biopsych.2006.03.022","article-title":"Chronic treatment with mood stabilizers increases membrane GRK3 in rat frontal cortex","volume":"61","author":"Ertley","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.plefa.2012.06.002_bib35","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.yebeh.2011.05.025","article-title":"Antiepileptic drug therapy: does mechanism of action matter?","volume":"21","author":"Brodie","year":"2011","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.plefa.2012.06.002_bib36","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1734-1140(11)70497-2","article-title":"Basic mechanisms of antiepileptic drugs and their pharmacokinetic\/pharmacodynamic interactions: an update","volume":"63","author":"Laso\u0144","year":"2011","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.plefa.2012.06.002_bib37","first-page":"183","article-title":"Protective effect of severe magnesium deficiency on Plasmodium chabaudi infection","volume":"2","author":"Maurois","year":"1989","journal-title":"Magnes. Res."},{"key":"10.1016\/j.plefa.2012.06.002_bib38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0014-2999(89)90687-0","article-title":"GABAB receptors are up-regulated by chronic treatment with lithium or carbamazepine\u2014GABA hypothesis of affective disorders?","volume":"166","author":"Motohashi","year":"1989","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.plefa.2012.06.002_bib39","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.conb.2011.02.004","article-title":"GABAB receptor modulation of synaptic function","volume":"21","author":"Chalifoux","year":"2011","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.plefa.2012.06.002_bib40","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/ana.410250610","article-title":"Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons","volume":"25","author":"Coulter","year":"1989","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.plefa.2012.06.002_bib41","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1124\/mol.60.5.1121","article-title":"Block of cloned human T-type calcium channels by succinimide antiepileptic drugs","volume":"60","author":"Gomora","year":"2001","journal-title":"Mol. Pharmacol."},{"issue":"Suppl. 9","key":"10.1016\/j.plefa.2012.06.002_bib42","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1528-1167.2005.00326.x","article-title":"Properties of antiepileptic drugs in the treatment of idiopathic generalized epilepsies","volume":"46","author":"Patsalos","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.plefa.2012.06.002_bib43","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S1054-3589(10)58006-2","article-title":"GABAB receptor coupling to G-proteins and ion channels","volume":"58","author":"Padgett","year":"2010","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.plefa.2012.06.002_bib44","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/S0026-895X(25)08760-7","article-title":"Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamazepine and phenytoin","volume":"47","author":"Granger","year":"1995","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.plefa.2012.06.002_bib45","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0006-8993(92)91246-B","article-title":"Inhibition of GABA-gated chloride channel function by arachidonic acid","volume":"585","author":"Schwartz","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.plefa.2012.06.002_bib46","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1046\/j.1460-9568.1999.00661.x","article-title":"Facilitation of GABA release by arachidonic acid in rat hippocampal synaptosomes","volume":"11","author":"Cunha","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.plefa.2012.06.002_bib47","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1194\/jlr.M700406-JLR200","article-title":"Chronic N-methyl-D-aspartate administration increases the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat","volume":"49","author":"Lee","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.plefa.2012.06.002_bib48","first-page":"713","article-title":"Anticonvulsant drugs: mechanisms of action","volume":"44","author":"Macdonald","year":"1986","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.plefa.2012.06.002_bib49","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.conb.2011.02.004","article-title":"GABAB receptor modulation of synaptic function","volume":"21","author":"Chalifoux","year":"2011","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.plefa.2012.06.002_bib50","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.pbb.2011.03.021","article-title":"Does conventional anti-bipolar and antidepressant drug therapy reduce NMDA-mediated neuronal excitation by downregulating astrocytic GluK2 function?","volume":"100","author":"Peng","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.plefa.2012.06.002_bib51","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/sj.mp.4001887","article-title":"Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex","volume":"12","author":"Rao","year":"2007","journal-title":"Mol. Psychiatry"}],"container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952327812000920?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952327812000920?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T08:03:46Z","timestamp":1760601826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952327812000920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":51,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0952327812000920"],"URL":"https:\/\/doi.org\/10.1016\/j.plefa.2012.06.002","relation":{},"ISSN":["0952-3278"],"issn-type":[{"type":"print","value":"0952-3278"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain anticonvulsant protection of mice given chronic carbamazepine under various fatty acid and magnesium diet conditions","name":"articletitle","label":"Article Title"},{"value":"Prostaglandins, Leukotrienes and Essential Fatty Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.plefa.2012.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}