{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:34:04Z","timestamp":1774614844864,"version":"3.50.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology"},{"name":"T. Nanba Memorial Health Care Foundation"},{"DOI":"10.13039\/501100007655","name":"Aichi Cancer Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007655","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006062","name":"Sagawa Foundation for Promotion of Cancer Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004398","name":"Mitsubishi Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004398","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","plefa.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.plefa.2014.09.001","type":"journal-article","created":{"date-parts":[[2014,9,28]],"date-time":"2014-09-28T16:17:25Z","timestamp":1411921045000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Dietary n-3\/long-chain n-3 polyunsaturated fatty acids for prevention of sporadic colorectal tumors: A randomized controlled trial in polypectomized participants"],"prefix":"10.1016","volume":"94","author":[{"given":"Shinkan","family":"Tokudome","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyonori","family":"Kuriki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Joh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinglei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Shirai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahomi","family":"Imaeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiho","family":"Goto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Tokudome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1616-2154","authenticated-orcid":false,"given":"Hiromitsu","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harumi","family":"Okuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.plefa.2014.09.001_bib1","series-title":"GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]","author":"Ferlay","year":"2013"},{"key":"10.1016\/j.plefa.2014.09.001_bib2","series-title":"Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective","author":"World Cancer Research Fund\/American Institute for Cancer Research","year":"2007"},{"key":"10.1016\/j.plefa.2014.09.001_bib3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00008469-199906000-00009","article-title":"Possible beneficial effect of fish and fish n-3 polyunsaturated fatty acids in breast and colorectal cancer","volume":"8","author":"de Deckere","year":"1999","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.plefa.2014.09.001_bib4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0361-090X(02)00179-4","article-title":"Specific fatty acids and human colorectal cancer: an overview","volume":"27","author":"Nkondjock","year":"2003","journal-title":"Cancer Detect. Prev."},{"key":"10.1016\/j.plefa.2014.09.001_bib5","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1136\/bmj.38755.366331.2F","article-title":"Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review","volume":"332","author":"Hooper","year":"2006","journal-title":"Br. Med. J."},{"key":"10.1016\/j.plefa.2014.09.001_bib6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1001\/jama.295.4.403","article-title":"Effects of omega-3 fatty acids on cancer risk: a systematic review","volume":"295","author":"MacLean","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.plefa.2014.09.001_bib7","first-page":"735","article-title":"Fish, n-3 polyunsaturated fatty acid and colorectal cancer prevention: a review of experimental and epidemiological studies","volume":"53","author":"Kimura","year":"2006","journal-title":"Jpn. J. Public Health"},{"key":"10.1016\/j.plefa.2014.09.001_bib8","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1093\/aje\/kwm197","article-title":"Fish consumption, n-3 fatty acids, and colorectal cancer: a meta-analysis of prospective cohort studies","volume":"166","author":"Geelen","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.plefa.2014.09.001_bib9","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1358\/dnp.2008.21.9.1290819","article-title":"Fatty acid facts, part II: role in the prevention of carcinogenesis, or, more fish on the dish?","volume":"21","author":"Pauwels","year":"2008","journal-title":"Drug News Perspect."},{"key":"10.1016\/j.plefa.2014.09.001_bib10","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1080\/10408398.2010.483527","article-title":"Update on the relationship of fish intake with prostate, breast, and colorectal cancers","volume":"51","author":"Sala-Vila","year":"2011","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.plefa.2014.09.001_bib11","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.amjmed.2012.01.022","article-title":"Fish consumption and colorectal cancer risk in humans: a systematic review and metaanalysis","volume":"125","author":"Wu","year":"2012","journal-title":"Am. J. Med."},{"issue":"Suppl 2","key":"10.1016\/j.plefa.2014.09.001_bib12","doi-asserted-by":"crossref","first-page":"S228","DOI":"10.1017\/S0007114512001614","article-title":"Omega-3 fatty acids and cancers: a systematic update review of epidemiological studies","volume":"107","author":"Gerber","year":"2012","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.plefa.2014.09.001_bib13","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/jjco\/hyt094","article-title":"Fish consumption and colorectal cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population","volume":"43","author":"Pham","year":"2013","journal-title":"Jpn. J. Clin. Oncol."},{"key":"10.1016\/j.plefa.2014.09.001_bib14","first-page":"219","article-title":"Dietary determinants of colorectal proliferation in the normal mucosa of subjects with previous colon adenomas","volume":"8","author":"Caderni","year":"1999","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.plefa.2014.09.001_bib15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0163-7258(99)00026-1","article-title":"Omega-3 fatty acids as cancer chemopreventive agents","volume":"83","author":"Rose","year":"1999","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.plefa.2014.09.001_bib16","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1093\/carcin\/20.12.2209","article-title":"Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers","volume":"20","author":"Bartsch","year":"1999","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.plefa.2014.09.001_bib17","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1054\/plef.1999.0085","article-title":"Essential fatty acids, lipid peroxidation and apoptosis","volume":"61","author":"Das","year":"1999","journal-title":"Prostaglandins Leukotr. Essent. Fatty Acids"},{"key":"10.1016\/j.plefa.2014.09.001_bib18","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1054\/plef.2000.0218","article-title":"Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells","volume":"63","author":"Chen","year":"2000","journal-title":"Prostaglandins Leukotr. Essent. Fatty Acids"},{"key":"10.1016\/j.plefa.2014.09.001_bib19","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s004280050034","article-title":"Protein expression of p53, p21 (WAF1\/CIP1), bcl-2, Bax cyclin D1 and pRb in human colon carcinomas","volume":"436","author":"Buckholm","year":"2000","journal-title":"Virchows Arch."},{"key":"10.1016\/j.plefa.2014.09.001_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ijc.20320","article-title":"Omega-3 fatty acids in colorectal cancer prevention","volume":"112","author":"Reddy","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.plefa.2014.09.001_bib21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.clnu.2003.07.005","article-title":"n-3 polyunsaturated fatty acids and colon cancer prevention","volume":"23","author":"Roynette","year":"2004","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.plefa.2014.09.001_bib22","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/ajcn\/79.6.935","article-title":"Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms","volume":"79","author":"Larsson","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.plefa.2014.09.001_bib23","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.2174\/092986707782793934","article-title":"n-3 polyunsaturated fatty acids and the prevention of colorectal cancer: molecular mechanisms involved","volume":"14","author":"Calviello","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.plefa.2014.09.001_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304383502007176","article-title":"Increased intake of n-3 polyunsaturated fatty acids elevates the level of apoptosis in the normal sigmoid colon of patients polypectomized for adenomas\/tumors","volume":"193","author":"Cheng","year":"2003","journal-title":"Cancer Lett."},{"key":"10.1016\/j.plefa.2014.09.001_bib25","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3945\/ajcn.2009.27630","article-title":"Fish consumption and markers of colorectal cancer risk: a multicenter randomized controlled trial","volume":"90","author":"Pot","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.plefa.2014.09.001_bib26","doi-asserted-by":"crossref","unstructured":"T. Higurashi, K. Hosono, H. Endo, et al., Eicosapentaenoic acid (EPA) efficacy for colorectal aberrant crypt foci (ACF): a double-blind randomized controlled trial, BMC Cancer 2012 Sep 19;12:413. 10.1186\/1471-2407-12-413","DOI":"10.1186\/1471-2407-12-413"},{"key":"10.1016\/j.plefa.2014.09.001_bib27","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s10555-011-9324-x","article-title":"Eicosanoid signaling pathways in the development and progression of colorectal cancer: novel approaches for prevention\/intervention","volume":"30","author":"Cathcart","year":"2011","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.plefa.2014.09.001_bib28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/978-3-642-30331-9_8","article-title":"Nutritional agents with anti-inflammatory properties in chemoprevention of colorectal neoplasia","volume":"191","author":"Hull","year":"2013","journal-title":"Recent Results Cancer Res."},{"key":"10.1016\/j.plefa.2014.09.001_bib29","first-page":"5575","article-title":"Aspirin and the potential role of prostaglandins in colon cancer","volume":"52","author":"Marnett","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/j.plefa.2014.09.001_bib30","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1093\/jnci\/91.11.916","article-title":"Colorectal cancer: molecules and populations","volume":"91","author":"Potter","year":"1999","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.plefa.2014.09.001_bib31","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1040-8428(99)00075-X","article-title":"Chemoprevention for colorectal cancer","volume":"33","author":"Krishnan","year":"2000","journal-title":"Crit. Rev. Oncol.\/Hematol."},{"key":"10.1016\/j.plefa.2014.09.001_bib32","first-page":"97","article-title":"NSAIDs as cancer preventive agents","volume":"1","author":"Wakabayashi","year":"2000","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.plefa.2014.09.001_bib33","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/jnci\/94.4.252","article-title":"Non-steroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues","volume":"94","author":"Thun","year":"2002","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.plefa.2014.09.001_bib34","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0140-6736(07)60747-8","article-title":"Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomized and observational studies","volume":"369","author":"Flossmann","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.plefa.2014.09.001_bib35","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1158\/1940-6207.CAPR-11-0391","article-title":"Aspirin in the chemoprevention of colorectal neoplasia: an overview","volume":"5","author":"Chan","year":"2012","journal-title":"Cancer Prev. Res. (Phila.)"},{"key":"10.1016\/j.plefa.2014.09.001_bib36","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S1470-2045(12)70112-2","article-title":"Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomized trials","volume":"13","author":"Algra","year":"2012","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.plefa.2014.09.001_bib37","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1158\/1078-0432.CCR-10-2395","article-title":"Randomized double-blind trial of sulindac and etodolac to eradicate aberrant crypt foci and to prevent sporadic colorectal polyps","volume":"17","author":"Takayama","year":"2011","journal-title":"Clin. Cancer Res."},{"issue":"11","key":"10.1016\/j.plefa.2014.09.001_bib38","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1136\/gutjnl-2013-305827","article-title":"The preventive effects of low-dose enteric-coated aspirin tablets on the development of colorectal tumours in Asian patients: a randomized trial","volume":"63","author":"Ishikawa","year":"2014","journal-title":"Gut"},{"issue":"Suppl","key":"10.1016\/j.plefa.2014.09.001_bib39","doi-asserted-by":"crossref","first-page":"S721","DOI":"10.1093\/ajcn\/61.3.721S","article-title":"Long-term fat intake and biomarkers","volume":"61","author":"Lands","year":"1995","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.plefa.2014.09.001_bib40","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1093\/ajcn\/68.1.142","article-title":"Linoleic acid intake and cancer risk: a review and meta-analysis","volume":"68","author":"Zock","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.plefa.2014.09.001_bib41","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/1438-9312(200106)103:6<418::AID-EJLT418>3.0.CO;2-#","article-title":"High n-6 to n-3 ratio of dietary fatty acids rather than serum cholesterol as a major risk factor for coronary heart disease","volume":"103","author":"Okuyama","year":"2001","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"10.1016\/j.plefa.2014.09.001_bib42","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3181\/0711-MR-311","article-title":"The importance of the omega-6\/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases","volume":"233","author":"Simopoulos","year":"2008","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.plefa.2014.09.001_bib43","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1002\/ijc.23729","article-title":"Opposing associations of serum n-3 and n-6 polyunsaturated fatty acids with colorectal adenoma risk: an endoscopy-based case-control study","volume":"123","author":"Pot","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.plefa.2014.09.001_bib44","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-I","article-title":"A genetic model for colorectal tumorigenesis","volume":"61","author":"Fearon","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.plefa.2014.09.001_bib45","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1615\/CritRevOncog.v7.i5-6.10","article-title":"The adenoma-carcinoma sequence and prospects for the prevention of colorectal neoplasia","volume":"7","author":"Cotton","year":"1996","journal-title":"Crit. Rev. Oncol."},{"key":"10.1016\/j.plefa.2014.09.001_bib46","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1093\/jjco\/hyf108","article-title":"Rationale and study design of dietary intervention in participants polypectomized for tumors of the colorectum","volume":"32","author":"Tokudome","year":"2002","journal-title":"Jpn. J. Clin. Oncol."},{"key":"10.1016\/j.plefa.2014.09.001_bib47","series-title":"General Rules for Clinical and Pathological Studies on Cancer of the Colon, Rectum and Anus","year":"1998"},{"key":"10.1016\/j.plefa.2014.09.001_bib48","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1056\/NEJM197905313002203","article-title":"A new design for randomized clinical trials","volume":"300","author":"Zelen","year":"1979","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.plefa.2014.09.001_bib49","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/sj.ejcn.1601215","article-title":"Relative validity of a semi-quantitative food frequency questionnaire versus 28 day weighed diet records in Japanese female dietitians","volume":"55","author":"Tokudome","year":"2001","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.plefa.2014.09.001_bib50","first-page":"61","article-title":"Japanese versus Mediterranean diets and cancer","volume":"1","author":"Tokudome","year":"2000","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.plefa.2014.09.001_bib51","doi-asserted-by":"crossref","first-page":"78","DOI":"10.2188\/jea.9.78","article-title":"Food contributing to absolute intake and variance in intake of fat, fatty acids and cholesterol in middle-aged Japanese","volume":"9","author":"Tokudome","year":"1999","journal-title":"J. Epidemiol."},{"key":"10.1016\/j.plefa.2014.09.001_bib52","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00008469-199908000-00049","article-title":"Chemoprevention versus behavioural modification in primary prevention of cancer","volume":"8","author":"Tokudome","year":"1999","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.plefa.2014.09.001_bib53","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3177\/jnsv.45.519","article-title":"Foods contributing to absolute intake and variance in intake of selected vitamins, minerals and dietary fiber in middle-aged Japanese","volume":"45","author":"Imaeda","year":"1999","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.plefa.2014.09.001_bib54","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1753-4887.2012.00512.x","article-title":"Tocotrienol research: past into future","volume":"70","author":"Wong","year":"2012","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.plefa.2014.09.001_bib55","first-page":"1029","volume":"330","year":"1994","journal-title":"The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers, N. Engl. J. Med."},{"key":"10.1016\/j.plefa.2014.09.001_bib56","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3390\/nu2090929","article-title":"Reexamination of a meta-analysis of the effect of antioxidant supplementation on mortality and health in randomized trials","volume":"2","author":"Biesalski","year":"2010","journal-title":"Nutrients"},{"key":"10.1016\/j.plefa.2014.09.001_bib57","doi-asserted-by":"crossref","first-page":"558","DOI":"10.7326\/M14-0198","article-title":"Vitamin, mineral, and multivitamin supplements for the primary prevention of cardiovascular disease and cancer: U.S. preventive task force recommendation statement","volume":"160","author":"Moyer","year":"2014","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.plefa.2014.09.001_bib58","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1158\/1055-9965.EPI-10-1141","article-title":"Meta-analysis of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal risk, Cancer Epidemiol","volume":"20","author":"Touvier","year":"2011","journal-title":"Biomark. Prev."},{"key":"10.1016\/j.plefa.2014.09.001_bib59","unstructured":"Ministry of Health, Labour, and Welfare, Dietary Reference Intakes for Japanese, 2010, Daiichi-shuppan, Tokyo, 2009"},{"key":"10.1016\/j.plefa.2014.09.001_bib60","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/ijc.24356","article-title":"Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention","volume":"125","author":"Kearney","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.plefa.2014.09.001_bib61","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.metabol.2009.10.022","article-title":"Role of FADS1 and FADS2 polymorphisms in polyunsaturated fatty acid metabolism","volume":"59","author":"Glaser","year":"2010","journal-title":"Metabolism"},{"key":"10.1016\/j.plefa.2014.09.001_bib62","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1053\/gast.2001.26265","article-title":"Polymorphisms and colorectal tumor risk","volume":"121","author":"Houlston","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.plefa.2014.09.001_bib63","first-page":"383","article-title":"Meat consumption, cigarette smoking, and genetic susceptibility in the etiology of colorectal cancer: results from a Dutch prospective study","volume":"13","author":"Tiemersma","year":"2002","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.plefa.2014.09.001_bib64","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.3748\/wjg.v18.i14.1672","article-title":"Vitamin D receptor gene polymorphisms and colorectal cancer risk: a systematic meta-analysis","volume":"18","author":"Bai","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.plefa.2014.09.001_bib65","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1056\/NEJM200011303432203","article-title":"The effect of fecal occult-blood screening on the incidence of colorectal cancer","volume":"343","author":"Mandel","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.plefa.2014.09.001_bib67","first-page":"1118","article-title":"Biomarkers for early detection of colon cancer","volume":"7","author":"Srivastava","year":"2001","journal-title":"Clin. Cancer Res."}],"container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952327814001458?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952327814001458?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T08:05:07Z","timestamp":1760601907000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952327814001458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":66,"alternative-id":["S0952327814001458"],"URL":"https:\/\/doi.org\/10.1016\/j.plefa.2014.09.001","relation":{},"ISSN":["0952-3278"],"issn-type":[{"value":"0952-3278","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary n-3\/long-chain n-3 polyunsaturated fatty acids for prevention of sporadic colorectal tumors: A randomized controlled trial in polypectomized participants","name":"articletitle","label":"Article Title"},{"value":"Prostaglandins, Leukotrienes and Essential Fatty Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.plefa.2014.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}