{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:30:36Z","timestamp":1783427436644,"version":"3.54.6"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NHRI-EX105-10528NI"],"award-info":[{"award-number":["NHRI-EX105-10528NI"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["CMU103-S-03"],"award-info":[{"award-number":["CMU103-S-03"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["CMU104-S-1603"],"award-info":[{"award-number":["CMU104-S-1603"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["CMU104-S44"],"award-info":[{"award-number":["CMU104-S44"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["DMR-103-078"],"award-info":[{"award-number":["DMR-103-078"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","plefa.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.plefa.2017.01.006","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T05:46:41Z","timestamp":1485323201000},"page":"117-121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Genetic polymorphisms of FADS1, FADS2, and FADS3 and fatty acid profiles in subjects received methadone maintenance therapy"],"prefix":"10.1016","volume":"136","author":[{"given":"Hui-Ting","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruey-Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh-Liang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Pin","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.plefa.2017.01.006_bib1","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1001\/archinte.166.19.2087","article-title":"Association between mental health disorders, problem drug use, and regular prescription opioid use","volume":"166","author":"Sullivan","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.plefa.2017.01.006_bib2","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1526-4637.2011.01075.x","article-title":"Societal costs of prescription opioid abuse, dependence, and misuse in the United States","volume":"12","author":"Birnbaum","year":"2011","journal-title":"Pain Med."},{"key":"10.1016\/j.plefa.2017.01.006_bib3","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00228-011-1122-4","article-title":"Benzodiazepines and alcohol are associated with cases of fatal buprenorphine poisoning","volume":"68","author":"Hakkinen","year":"2012","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.plefa.2017.01.006_bib4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.alcohol.2009.07.003","article-title":"Positive relationship between dietary fat, ethanol intake, triglycerides, and hypothalamic peptides: counteraction by lipid-lowering drugs","volume":"43","author":"Barson","year":"2009","journal-title":"Alcohol"},{"key":"10.1016\/j.plefa.2017.01.006_bib5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0376-8716(91)90047-3","article-title":"Plasma cholesterol and triglycerides in heroin addicts","volume":"29","author":"Maccari","year":"1991","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.plefa.2017.01.006_bib6","first-page":"48","article-title":"Serum biochemical parameters following heroin withdrawal: an exploratory study","volume":"23","author":"Divsalar","year":"2014","journal-title":"Am. J. Addict. \/ Am. Acad. Psychiatr. Alcohol. Addict."},{"key":"10.1016\/j.plefa.2017.01.006_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1051\/rnd:2005001","article-title":"Omega-3 fatty acids and neuropsychiatric disorders","volume":"45","author":"Young","year":"2005","journal-title":"Reprod., Nutr., Dev."},{"key":"10.1016\/j.plefa.2017.01.006_bib8","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.4088\/JCP.11r07546","article-title":"A meta-analytic review of polyunsaturated fatty acid compositions in dementia","volume":"73","author":"Lin","year":"2012","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.plefa.2017.01.006_bib9","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/mp.2012.111","article-title":"Are omega-3 fatty acids antidepressants or just mood-improving agents? The effect depends upon diagnosis, supplement preparation, and severity of depression","volume":"17","author":"Lin","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.plefa.2017.01.006_bib10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S2215-0366(14)00051-0","article-title":"R. international society for nutritional psychiatry, nutritional medicine as mainstream in psychiatry","volume":"2","author":"Sarris","year":"2015","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.plefa.2017.01.006_bib11","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/wps.20223","article-title":"International society for nutritional psychiatry research consensus position statement: nutritional medicine in modern psychiatry","volume":"14","author":"Sarris","year":"2015","journal-title":"World Psychiatry.: Off. J. World Psychiatr. Assoc."},{"key":"10.1016\/j.plefa.2017.01.006_bib12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.9758\/cpn.2015.13.2.129","article-title":"Omega-3 Polyunsaturated fatty acids in prevention of mood and anxiety disorders","volume":"13","author":"Su","year":"2015","journal-title":"Clin. Psychopharmacol. Neurosci.: Off. Sci. J. Korean Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.plefa.2017.01.006_bib13","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1517\/13543784.2013.836487","article-title":"Omega-3 polyunsaturated fatty acids for major depressive disorder","volume":"22","author":"Su","year":"2013","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.plefa.2017.01.006_bib14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbi.2014.11.005","article-title":"Polyunsaturated fatty acids (PUFAs) levels in patients with cardiovascular diseases (CVDs) with and without depression","volume":"44","author":"Chang","year":"2015","journal-title":"Brain, Behav., Immun."},{"key":"10.1016\/j.plefa.2017.01.006_bib15","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000198167","article-title":"Biological mechanism of antidepressant effect of omega-3 fatty acids: how does fish oil act as a 'mind-body interface'?","volume":"17","author":"Su","year":"2009","journal-title":"Neuro-Signals"},{"key":"10.1016\/j.plefa.2017.01.006_bib16","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.biopsych.2014.01.008","article-title":"Omega-3 fatty acids in the prevention of interferon-alpha-induced depression: results from a randomized, controlled trial","volume":"76","author":"Su","year":"2014","journal-title":"Biol. Psychiatry"},{"issue":"Suppl 1","key":"10.1016\/j.plefa.2017.01.006_bib17","first-page":"151","article-title":"Mind-body interface: the role of n-3 fatty acids in psychoneuroimmunology, somatic presentation, and medical illness comorbidity of depression","volume":"17","author":"Su","year":"2008","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"10.1016\/j.plefa.2017.01.006_bib18","doi-asserted-by":"crossref","unstructured":"V.C. Chen, M.H. Wu, T.Y. Lin, Y.F. Ho, H.Y. Wang, M. Gossop, Comparison of socio-demographic characteristics, substance, and depression among male heroin users attending therapeutic community and methadone maintenance treatment program in Nantou, Taiwan, Substance abuse treatment, prevention, and policy, 10 ,41, 2015.","DOI":"10.1186\/s13011-015-0037-y"},{"key":"10.1016\/j.plefa.2017.01.006_bib19","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/clpt.1980.86","article-title":"Effect of acute methadone withdrawal on prostaglandin E-stimulated 3H-cyclic adenosine monophosphate accumulation in human platelets","volume":"27","author":"Pandey","year":"1980","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.plefa.2017.01.006_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/nu8010023","article-title":"Fatty acid desaturases, polyunsaturated fatty acid regulation, and biotechnological advances","volume":"8","author":"Lee","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.plefa.2017.01.006_bib21","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1086\/422474","article-title":"Genomewide linkage scan for bipolar-disorder susceptibility loci among ashkenazi jewish families","volume":"75","author":"Fallin","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.plefa.2017.01.006_bib22","doi-asserted-by":"crossref","first-page":"e1000338","DOI":"10.1371\/journal.pgen.1000338","article-title":"Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study","volume":"5","author":"Tanaka","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.plefa.2017.01.006_bib23","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1017\/S0007114508992564","article-title":"Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 ( FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes","volume":"101","author":"Rzehak","year":"2009","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.plefa.2017.01.006_bib24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s11745-008-3158-5","article-title":"SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease","volume":"43","author":"Malerba","year":"2008","journal-title":"Lipids"},{"key":"10.1016\/j.plefa.2017.01.006_bib25","doi-asserted-by":"crossref","first-page":"e1000282","DOI":"10.1371\/journal.pgen.1000282","article-title":"Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum","volume":"4","author":"Gieger","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.plefa.2017.01.006_bib26","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.3945\/jn.108.096156","article-title":"Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation","volume":"138","author":"Xie","year":"2008","journal-title":"J. Nutr."},{"key":"10.1016\/j.plefa.2017.01.006_bib27","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1093\/hmg\/ddl117","article-title":"Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids","volume":"15","author":"Schaeffer","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.plefa.2017.01.006_bib28","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1093\/oxfordjournals.aje.a009878","article-title":"Biased tests of association: comparisons of allele frequencies when departing from Hardy-Weinberg proportions","volume":"149","author":"Schaid","year":"1999","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.plefa.2017.01.006_bib29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.kjms.2010.09.003","article-title":"Quality of life and its correlates among heroin users in Taiwan","volume":"27","author":"Yen","year":"2011","journal-title":"Kaohsiung J. Med. Sci."},{"key":"10.1016\/j.plefa.2017.01.006_bib30","first-page":"368","article-title":"Assessment of daily nutrition ratios of opiate-dependent persons before and after 4 years of methadone maintenance treatment","volume":"62","author":"Kolarzyk","year":"2005","journal-title":"Prz. Lek."},{"key":"10.1016\/j.plefa.2017.01.006_bib31","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3109\/10826084.2011.635324","article-title":"A pilot study of the nutritional status of opiate-using pregnant women on methadone maintenance therapy","volume":"47","author":"Tomedi","year":"2012","journal-title":"Subst. Use Misuse"},{"key":"10.1016\/j.plefa.2017.01.006_bib32","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0306-4603(98)00076-8","article-title":"Comorbidity of substance use disorders with mood and anxiety disorders: results of the international consortium in psychiatric epidemiology","volume":"23","author":"Merikangas","year":"1998","journal-title":"Addict. Behav."},{"key":"10.1016\/j.plefa.2017.01.006_bib33","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/01.jcp.0000246214.49271.f1","article-title":"n-3 polyunsaturated fatty acids decrease anxiety feelings in a population of substance abusers","volume":"26","author":"Buydens-Branchey","year":"2006","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.plefa.2017.01.006_bib34","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/ADM.0b013e318262a9a1","article-title":"Association between cholesterol plasma levels and craving among heroin users","volume":"6","author":"Lin","year":"2012","journal-title":"J. Addict. Med."},{"key":"10.1016\/j.plefa.2017.01.006_bib35","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/oxfordjournals.aje.a010210","article-title":"Re: \"biased tests of association: comparisons of allele frequencies when departing from Hardy-Weinberg proportions\"","volume":"151","author":"Deng","year":"2000","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.plefa.2017.01.006_bib36","doi-asserted-by":"crossref","first-page":"732","DOI":"10.4088\/JCP.12m07970","article-title":"Omega-3 polyunsaturated fatty acid (PUFA) status in major depressive disorder with comorbid anxiety disorders","volume":"74","author":"Liu","year":"2013","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.plefa.2017.01.006_bib37","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.psychres.2015.06.025","article-title":"Erythrocyte fatty acid profiles and plasma homocysteine, folate and vitamin B6 and B12 in recurrent depression: implications for co-morbidity with cardiovascular disease","volume":"229","author":"Assies","year":"2015","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.plefa.2017.01.006_bib38","first-page":"e222","article-title":"Effectiveness of acceptance-commitment therapy on anxiety and depression among patients on methadone treatment: a pilot study","volume":"9","author":"Saedy","year":"2015","journal-title":"Iran. J. Psychiatry Behav. Sci."},{"key":"10.1016\/j.plefa.2017.01.006_bib39","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1440-1819.2007.01618.x","article-title":"Psychiatric comorbidity and gender difference among treatment-seeking heroin abusers in Taiwan","volume":"61","author":"Chiang","year":"2007","journal-title":"Psychiatry Clin. Neurosci."}],"container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095232781630182X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095232781630182X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T08:05:57Z","timestamp":1760601957000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095232781630182X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":39,"alternative-id":["S095232781630182X"],"URL":"https:\/\/doi.org\/10.1016\/j.plefa.2017.01.006","relation":{},"ISSN":["0952-3278"],"issn-type":[{"value":"0952-3278","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic polymorphisms of FADS1, FADS2, and FADS3 and fatty acid profiles in subjects received methadone maintenance therapy","name":"articletitle","label":"Article Title"},{"value":"Prostaglandins, Leukotrienes and Essential Fatty Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.plefa.2017.01.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}