{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T15:21:38Z","timestamp":1777216898936,"version":"3.51.4"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","plefa.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.plefa.2020.102099","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T11:28:31Z","timestamp":1590406111000},"page":"102099","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Plasma metabolomic profiles associated with infant food allergy with further consideration of other early life factors"],"prefix":"10.1016","volume":"159","author":[{"given":"Susan","family":"Ellul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Marx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Collier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Saffery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Burgner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Carlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Vuillermin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Louise","family":"Ponsonby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.plefa.2020.102099_bib0001","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jaci.2017.11.007","article-title":"Food allergy and omics","volume":"141","author":"Dhondalay","year":"2018","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.plefa.2020.102099_bib0002","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrm.2016.25","article-title":"Metabolomics: beyond biomarkers and towards mechanisms","volume":"17","author":"Johnson","year":"2016","journal-title":"Nature reviews. Molecular cell biology,"},{"key":"10.1016\/j.plefa.2020.102099_bib0003","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/all.12579","article-title":"Comprehensive metabolomics identifies the alarmin uric acid as a critical signal for the induction of peanut allergy","volume":"70","author":"Kong","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.plefa.2020.102099_bib0004","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000318654","article-title":"A Search for Biomarkers as Diagnostic Tools for Food Allergy: A Pilot Study in Peanut-Allergic Patients","volume":"155","author":"Peeters","year":"2011","journal-title":"International Archives of Allergy and Immunology"},{"key":"10.1016\/j.plefa.2020.102099_bib0005","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1080\/004982599238047","article-title":"Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data","volume":"29","author":"Nicholson","year":"1999","journal-title":"Xenobiotica; the fate of foreign compounds in biological systems"},{"key":"10.1016\/j.plefa.2020.102099_bib0006","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1093\/aje\/kwx016","article-title":"Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Large-Scale Epidemiology: A Primer on -Omic Technologies","volume":"186","author":"Wurtz","year":"2017","journal-title":"American journal of epidemiology"},{"key":"10.1016\/j.plefa.2020.102099_bib0007","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.011852","article-title":"A Cross-Cohort Study Examining the Associations of Metabolomic Profile and Subclinical Atherosclerosis in Children and Their Parents: The Child Health CheckPoint Study and Avon Longitudinal Study of Parents and Children","volume":"8","author":"Juonala","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.plefa.2020.102099_bib0008","series-title":"BMJ open","first-page":"106","article-title":"Metabolomics: population epidemiology and concordance in Australian children aged 11-12 years and their parents","author":"Ellul","year":"2019"},{"key":"10.1016\/j.plefa.2020.102099_bib0009","doi-asserted-by":"crossref","DOI":"10.1038\/s41390-020-0762-4","article-title":"Barwon Infant Study investigator team, Sex differences in infant blood metabolite profile in association with weight and adiposity measures","author":"Ellul","year":"2020","journal-title":"Pediatric Research"},{"key":"10.1016\/j.plefa.2020.102099_bib0010","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1111\/j.1365-2222.2012.04031.x","article-title":"Fish oil supplementation in early infancy modulates developing infant immune responses","volume":"42","author":"D'Vaz","year":"2012","journal-title":"Clinical & Experimental Allergy"},{"key":"10.1016\/j.plefa.2020.102099_bib0011","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3945\/ajcn.115.111104","article-title":"Omega-3 long-chain PUFA intake during pregnancy and allergic disease outcomes in the offspring: a systematic review and meta-analysis of observational studies and randomized controlled trials","volume":"103","author":"Best","year":"2016","journal-title":"The American Journal of Clinical Nutrition"},{"key":"10.1016\/j.plefa.2020.102099_bib0012","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1139\/apnm-2015-0660","article-title":"Evidence for the essentiality of arachidonic and docosahexaenoic acid in the postnatal maternal and infant diet for the development of the infant's immune system early in life","volume":"41","author":"Richard","year":"2016","journal-title":"Applied Physiology, Nutrition, and Metabolism"},{"key":"10.1016\/j.plefa.2020.102099_bib0013","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-009377","article-title":"VITALITY trial: protocol for a randomised controlled trial to establish the role of postnatal vitamin D supplementation in infant immune health","volume":"5","author":"Allen","year":"2015","journal-title":"BMJ open"},{"key":"10.1016\/j.plefa.2020.102099_bib0014","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1017\/S0007114517001167","article-title":"High-quality fish oil has a more favourable effect than oxidised fish oil on intermediate-density lipoprotein and LDL subclasses: a randomised controlled trial","volume":"117","author":"Rundblad","year":"2017","journal-title":"British Journal of Nutrition"},{"key":"10.1016\/j.plefa.2020.102099_bib0015","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/ije\/dyw222","article-title":"Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: a cross-sectional analysis in population-based data","volume":"45","author":"Vogt","year":"2016","journal-title":"International Journal of Epidemiology"},{"key":"10.1016\/j.plefa.2020.102099_bib0016","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4103\/1947-2714.187137","article-title":"Associations between Serum 25-hydroxyvitamin D and Lipids, Lipoprotein Cholesterols, and Homocysteine","volume":"8","author":"Glueck","year":"2016","journal-title":"North American Journal of Medical Sciences"},{"issue":"suppl 1","key":"10.1016\/j.plefa.2020.102099_bib0017","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000448262","article-title":"Docosahexaenoic Acid","volume":"69","author":"Calder","year":"2016","journal-title":"Annals of Nutrition and Metabolism"},{"key":"10.1016\/j.plefa.2020.102099_bib0018","doi-asserted-by":"crossref","DOI":"10.1111\/apa.13395","article-title":"High levels of omega-3 fatty acids in milk from omega-3 fatty acid-supplemented mothers are related to less immunoglobulin E-associated disease in infancy","volume":"105","author":"Warstedt","year":"2016","journal-title":"Acta Paediatrica"},{"key":"10.1016\/j.plefa.2020.102099_bib0019","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002507","article-title":"Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis","volume":"15","author":"Garcia-Larsen","year":"2018","journal-title":"PLoS medicine"},{"key":"10.1016\/j.plefa.2020.102099_bib0020","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/all.13385","article-title":"Fish oil in infancy protects against food allergy in Iceland-Results from a birth cohort study","volume":"73","author":"Clausen","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.plefa.2020.102099_bib0021","article-title":"Dietary and Plasma Polyunsaturated Fatty Acids Are Inversely Associated with Asthma and Atopy in Early Childhood","volume":"7","author":"Lee-Sarwar","year":"2019","journal-title":"The Journal of Allergy and Clinical Immunology: In Practice"},{"key":"10.1016\/j.plefa.2020.102099_bib0022","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.numecd.2012.11.007","article-title":"Association between habitual dietary intake and lipoprotein subclass profile in healthy young adults, Nutrition","volume":"23","author":"Bogl","year":"2013","journal-title":"Metabolism and Cardiovascular Diseases"},{"key":"10.1016\/j.plefa.2020.102099_bib0023","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1002\/jcb.26084","article-title":"High Dose Supplementation of Vitamin D Affects Measures of Systemic Inflammation: Reductions in High Sensitivity C-Reactive Protein Level and Neutrophil to Lymphocyte Ratio (NLR) Distribution","volume":"118","author":"Tabatabaeizadeh","year":"2017","journal-title":"Journal of Cellular Biochemistry"},{"key":"10.1016\/j.plefa.2020.102099_bib0024","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.3945\/ajcn.117.158220","article-title":"Vitamin D prenatal programming of childhood metabolomics profiles at age 3 y","volume":"106","author":"Blighe","year":"2017","journal-title":"The American Journal of Clinical Nutrition"},{"key":"10.1016\/j.plefa.2020.102099_bib0025","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/ije\/dyv026","article-title":"Cohort Profile: The Barwon Infant Study","volume":"44","author":"Vuillermin","year":"2015","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.plefa.2020.102099_bib0026","unstructured":"B. Pink, Technical Paper: Socio-economic Indexes for Areas (SEIFA), Australian Bureau of Statistics, (2011)."},{"key":"10.1016\/j.plefa.2020.102099_bib0027","unstructured":"J.M. Fujisaki, G. van Belle, P.D. Sampson, \"Size\" and \"shape\" variables in the presence of covariates: an application to the sudden infant death syndrome., Journal of Clinical Epidemiology, 43173-180."},{"key":"10.1016\/j.plefa.2020.102099_bib0028","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1042\/CS20150685","article-title":", Infant adiposity at birth and early postnatal weight gain predict increased aortic intima-media thickness at 6 weeks of age: a population-derived cohort study","volume":"130","author":"McCloskey","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.plefa.2020.102099_bib0029","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s11306-013-0518-9","article-title":"Optimized 25-hydroxyvitamin D analysis using liquid\u2013liquid extraction with 2D separation with LC\/MS\/MS detection, provides superior precision compared to conventional assays","volume":"9","author":"Clarke","year":"2013","journal-title":"Metabolomics"},{"key":"10.1016\/j.plefa.2020.102099_bib0030","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1039\/b910205a","article-title":"High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism","volume":"134","author":"Soininen","year":"2009","journal-title":"Analyst"},{"key":"10.1016\/j.plefa.2020.102099_bib0031","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/ng.1073","article-title":"Genome-wide association study identifies multiple loci influencing human serum metabolite levels","volume":"44","author":"Kettunen","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.plefa.2020.102099_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2011.01.039","article-title":"Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants","volume":"127","author":"Osborne","year":"2011","journal-title":"The Journal of allergy and clinical immunology"},{"key":"10.1016\/j.plefa.2020.102099_bib0034","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1111\/all.13122","article-title":"Vitamin D insufficiency in the first 6 months of infancy and challenge-proven IgE-mediated food allergy at 1 year of age: a case-cohort study","volume":"72","author":"Molloy","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.plefa.2020.102099_bib0035","unstructured":"StataCorp, Stata Statistical Software: Release 15., College Station, TX: StatCorpLLC, (2017)."},{"key":"10.1016\/j.plefa.2020.102099_bib0036","series-title":"R: A language and environment for statistical computing","year":"2018"},{"key":"10.1016\/j.plefa.2020.102099_bib0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00031305.2019.1583913","article-title":"Moving to a World Beyond \u201cp\u2009<\u20090.05\u201d","volume":"73","author":"Wasserstein","year":"2019","journal-title":"The American Statistician"},{"key":"10.1016\/j.plefa.2020.102099_bib0038","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/00031305.2016.1154108","article-title":"The ASA's Statement on p-Values: Context, Process, and Purpose","volume":"70","author":"Wasserstein","year":"2016","journal-title":"The American Statistician"},{"key":"10.1016\/j.plefa.2020.102099_bib0039","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1136\/bmj.316.7139.1236","article-title":"What's wrong with Bonferroni adjustments","volume":"316","author":"Perneger","year":"1998","journal-title":"BMJ"},{"key":"10.1016\/j.plefa.2020.102099_bib0040","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00001648-199001000-00010","article-title":"No adjustments are needed for multiple comparisons","volume":"1","author":"Rothman","year":"1990","journal-title":"Epidemiology (Cambridge, Mass.)"},{"key":"10.1016\/j.plefa.2020.102099_bib0041","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2288-2-8","article-title":"Do multiple outcome measures require p-value adjustment?","volume":"2","author":"Feise","year":"2002","journal-title":"BMC Medical Research Methodology"},{"key":"10.1016\/j.plefa.2020.102099_bib0042","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society. Series B (Methodological)"},{"key":"10.1016\/j.plefa.2020.102099_bib0043","doi-asserted-by":"crossref","DOI":"10.1038\/srep09750","article-title":"Dietary \u03c93 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut","volume":"5","author":"Kunisawa","year":"2015","journal-title":"Scientific reports"},{"key":"10.1016\/j.plefa.2020.102099_bib0044","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1017\/S0029665110001552","article-title":"Is there a role for fatty acids in early life programming of the immune system?","volume":"69","author":"Calder","year":"2010","journal-title":"Proceedings of the Nutrition Society"},{"key":"10.1016\/j.plefa.2020.102099_bib0045","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1136\/adc.82.5.366","article-title":"Fish oil supplementation improves docosahexaenoic acid status of malnourished infants","volume":"82","author":"Smit","year":"2000","journal-title":"Archives of Disease in Childhood"},{"key":"10.1016\/j.plefa.2020.102099_bib0046","doi-asserted-by":"crossref","first-page":"29522","DOI":"10.1038\/srep29522","article-title":"Serum metabolomics profiles in response to n-3 fatty acids in Chinese patients with type 2 diabetes: a double-blind randomised controlled trial","volume":"6","author":"Zheng","year":"2016","journal-title":"Scientific Reports"},{"key":"10.1016\/j.plefa.2020.102099_bib0047","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jacl.2013.05.001","article-title":"Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: Implications for clinical utility","volume":"7","author":"Harris","year":"2013","journal-title":"Journal of Clinical Lipidology"},{"key":"10.1016\/j.plefa.2020.102099_bib0048","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jacl.2013.09.007","article-title":"Effect of fatty and lean fish intake on lipoprotein subclasses in subjects with coronary heart disease: A controlled trial","volume":"8","author":"Erkkil\u00e4","year":"2014","journal-title":"Journal of Clinical Lipidology"},{"key":"10.1016\/j.plefa.2020.102099_bib0049","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3109\/09637486.2014.886186","article-title":"Association between vitamin D status and lipid profile in children and adolescents: a systematic review and meta-analysis","volume":"65","author":"Kelishadi","year":"2014","journal-title":"International Journal of Food Sciences and Nutrition"},{"key":"10.1016\/j.plefa.2020.102099_bib0050","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1093\/ije\/dyw148","article-title":"Metabolomics analysis of serum 25-hydroxy-vitamin D in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study","volume":"45","author":"Nelson","year":"2016","journal-title":"International Journal of Epidemiology"},{"key":"10.1016\/j.plefa.2020.102099_bib0051","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042550","article-title":"Fish oil supplementation alters the plasma lipidomic profile and increases long-chain PUFAs of phospholipids and triglycerides in healthy subjects","volume":"7","author":"Ottestad","year":"2012","journal-title":"PloS one"},{"key":"10.1016\/j.plefa.2020.102099_bib0052","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1194\/jlr.M900193-JLR200","article-title":"Detection of omega-3 oxylipins in human plasma and response to treatment with omega-3 acid ethyl esters","volume":"51","author":"Shearer","year":"2010","journal-title":"Journal of lipid research"},{"key":"10.1016\/j.plefa.2020.102099_bib0053","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/mnfr.201200827","article-title":"Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids","volume":"57","author":"Lundstr\u00f6m","year":"2013","journal-title":"Molecular nutrition & food research"}],"container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952327820300570?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952327820300570?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T08:08:29Z","timestamp":1760602109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952327820300570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":52,"alternative-id":["S0952327820300570"],"URL":"https:\/\/doi.org\/10.1016\/j.plefa.2020.102099","relation":{},"ISSN":["0952-3278"],"issn-type":[{"value":"0952-3278","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma metabolomic profiles associated with infant food allergy with further consideration of other early life factors","name":"articletitle","label":"Article Title"},{"value":"Prostaglandins, Leukotrienes and Essential Fatty Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.plefa.2020.102099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102099"}}