{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:05:54Z","timestamp":1791965154222,"version":"4.3.4"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","plefa.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.plefa.2021.102336","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T22:48:27Z","timestamp":1629758907000},"page":"102336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Omega 6 polyunsaturated fatty acids in red blood cell membrane are associated with xerostomia and taste loss in patients with breast cancer"],"prefix":"10.1016","volume":"173","author":[{"given":"J.","family":"Am\u00e9zaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ugartemendia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Larraioz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Breta\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Iruretagoyena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Camba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Urruticoechea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ferreri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Tueros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.plefa.2021.102336_bib0001","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1634\/theoncologist.2009-0333","article-title":"Taste alterations in cancer patients receiving chemotherapy: a neglected side effect?","volume":"15","author":"Zabernigg","year":"2010","journal-title":"Oncologist"},{"key":"10.1016\/j.plefa.2021.102336_bib0002","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1002\/jsfa.8789","article-title":"Innovative food products for cancer patients: future directions","volume":"98","author":"Tueros","year":"2018","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.plefa.2021.102336_bib0003","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2017.00134","article-title":"Alteration in taste perception in cancer: causes and strategies of treatment","volume":"8","author":"Murtaza","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.plefa.2021.102336_bib0004","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.jpainsymman.2011.11.011","article-title":"Coming to your senses: detecting taste and smell alterations in chemotherapy patients. A systematic review","volume":"44","author":"Gamper","year":"2012","journal-title":"J. Pain Symptom. Manage."},{"key":"10.1016\/j.plefa.2021.102336_bib0005","first-page":"018","article-title":"Assessing taste and smell alterations in cancer patients undergoing chemotherapy according to treatment","volume":"31","author":"Amezaga","year":"2018","journal-title":"Support. Care Cancer"},{"key":"10.1016\/j.plefa.2021.102336_bib0006","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.2174\/1381612822666160216150812","article-title":"Smell and taste disorders resulting from cancer and chemotherapy","volume":"22","author":"Cohen","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.plefa.2021.102336_bib0007","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejon.2008.10.002","article-title":"Olfactory changes among patients receiving chemotherapy","volume":"13","author":"Bernhardson","year":"2009","journal-title":"Eur. J. Oncol. Nurs."},{"key":"10.1016\/j.plefa.2021.102336_bib0008","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1056\/NEJMoa1113713","article-title":"Efficacy and safety of vismodegib in advanced basal-cell carcinoma","volume":"366","author":"Sekulic","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.plefa.2021.102336_bib0009","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1056\/NEJMoa0905360","article-title":"Inhibition of the hedgehog pathway in advanced basal-cell carcinoma","volume":"361","author":"Von Hoff","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.plefa.2021.102336_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185473","article-title":"Cellular mechanisms of cyclophosphamide-induced taste loss in mice","volume":"12","author":"Mukherjee","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.plefa.2021.102336_bib0011","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1177\/10454411000110020501","article-title":"Role of saliva in the maintenance of taste sensitivity","volume":"11","author":"Matsuo","year":"2000","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.plefa.2021.102336_bib0012","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1034\/j.1601-0825.2002.10815.x","article-title":"Understanding salivary fluid and protein secretion","volume":"8","author":"Turner","year":"2002","journal-title":"Oral Dis."},{"key":"10.1016\/j.plefa.2021.102336_bib0013","first-page":"1021","article-title":"Salivary lipids: a review, Advances in clinical and experimental medicine: official organ","volume":"26","author":"Matczuk","year":"2017","journal-title":"Wroclaw Med. Univ."},{"key":"10.1016\/j.plefa.2021.102336_bib0014","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2017.00043","article-title":"Actions and mechanisms of polyunsaturated fatty acids on voltage-gated ion channels","volume":"8","author":"Elinder","year":"2017","journal-title":"Front. Physiol"},{"key":"10.1016\/j.plefa.2021.102336_bib0015","first-page":"18","article-title":"Membrane Lipid Replacement for chronic illnesses, aging and cancer using oral glycerolphospholipid formulations with fructooligosaccharides to restore phospholipid function in cellular membranes, organelles, cells and tissues","volume":"9","author":"Nicolson","year":"2017","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.plefa.2021.102336_bib0016","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nrc2809","article-title":"Eicosanoids and cancer","volume":"10","author":"Wang","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.plefa.2021.102336_bib0017","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1016\/j.jmb.2016.08.013","article-title":"Homeoviscous adaptation and the regulation of membrane lipids","volume":"428","author":"Ernst","year":"2016","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.plefa.2021.102336_bib0018","series-title":"Lehninger Principles of Biochemistry, 7th e","author":"Nelson","year":"2017"},{"key":"10.1016\/j.plefa.2021.102336_bib0019","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1586\/erm.12.73","article-title":"Role of fatty acid-based functional lipidomics in the development of molecular diagnostic tools","volume":"12","author":"Ferreri","year":"2012","journal-title":"Expert Rev. Mol. Diagn."},{"key":"10.1016\/j.plefa.2021.102336_bib0020","doi-asserted-by":"crossref","unstructured":"C. Ferreri, C. Chatgilialoglu, Membrane lipidomics for personalized health, 2015.","DOI":"10.1002\/9781118683682"},{"key":"10.1016\/j.plefa.2021.102336_bib0021","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics7010001","article-title":"Fatty acids in membranes as homeostatic, metabolic and nutritional biomarkers: recent advancements in analytics and diagnostics","volume":"7","author":"Ferreri","year":"2016","journal-title":"Diagnostics"},{"key":"10.1016\/j.plefa.2021.102336_bib0022","first-page":"203","article-title":"Abnormalities in fatty acids in plasma, erythrocytes and adipose tissue in Japanese patients with colorectal cancer","volume":"27","author":"Okuno","year":"2013","journal-title":"In Vivo"},{"key":"10.1016\/j.plefa.2021.102336_bib0023","first-page":"4775","article-title":"Erythrocyte membrane fatty acids profile in colorectal cancer patients: a preliminary study","volume":"34","author":"Coviello","year":"2014","journal-title":"Anticancer Res."},{"key":"10.1016\/j.plefa.2021.102336_bib0024","first-page":"107","article-title":"Erythrocyte membrane fatty acid composition in cancer patients","volume":"23","author":"Mikirova","year":"2004","journal-title":"P R. Health Sci. J."},{"key":"10.1016\/j.plefa.2021.102336_bib0025","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1093\/jnci\/93.14.1088","article-title":"Erythrocyte membrane fatty acids and subsequent breast cancer: a prospective Italian study","volume":"93","author":"Pala","year":"2001","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.plefa.2021.102336_bib0026","doi-asserted-by":"crossref","DOI":"10.3390\/nu10121853","article-title":"Altered red blood cell membrane fatty acid profile in cancer patients","volume":"10","author":"Amezaga","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.plefa.2021.102336_bib0027","doi-asserted-by":"crossref","DOI":"10.3390\/metabo10090345","article-title":"Fatty acids and membrane lipidomics in oncology: a cross-road of nutritional, signaling and metabolic pathways","volume":"10","author":"Ferreri","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.plefa.2021.102336_bib0028","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1017\/S0007114514002815","article-title":"Lipidomic analysis of fatty acids in erythrocytes of coeliac patients before and after a gluten-free diet intervention: a comparison with healthy subjects","volume":"112","author":"Riezzo","year":"2014","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.plefa.2021.102336_bib0029","doi-asserted-by":"crossref","first-page":"e66418","DOI":"10.1371\/journal.pone.0066418","article-title":"Oxidative stress and erythrocyte membrane alterations in children with autism: correlation with clinical features","volume":"8","author":"Ghezzo","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.plefa.2021.102336_bib0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152378","article-title":"Hexadecenoic fatty acid isomers in human blood lipids and their relevance for the interpretation of lipidomic profiles","volume":"11","author":"Sansone","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.plefa.2021.102336_bib0031","doi-asserted-by":"crossref","first-page":"9854","DOI":"10.1038\/s41598-017-10361-7","article-title":"High predictive values of RBC membrane-based diagnostics by biophotonics in an integrated approach for Autism Spectrum Disorders","volume":"7","author":"Giacometti","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.plefa.2021.102336_bib0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40268-016-0153-9","article-title":"A guide to medications inducing Salivary Gland Dysfunction, Xerostomia, and Subjective Sialorrhea: a systematic review sponsored by the world workshop on Oral Medicine VI","volume":"17","author":"Wolff","year":"2017","journal-title":"Drugs R. D."},{"key":"10.1016\/j.plefa.2021.102336_bib0033","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1017\/S0007114509993837","article-title":"Relative validity of a semi-quantitative food-frequency questionnaire in an elderly Mediterranean population of Spain","volume":"103","author":"Fernandez-Ballart","year":"2010","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.plefa.2021.102336_bib0034","series-title":"DIAL Software For Assessing Diets and Food Calculations","author":"Ortega","year":"2017"},{"key":"10.1016\/j.plefa.2021.102336_bib0035","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-2141.1985.tb02843.x","article-title":"Counterflow centrifugation of red cell populations: a cell age related separation technique","volume":"61","author":"van der Vegt","year":"1985","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.plefa.2021.102336_bib0036","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18040708","article-title":"\u201cBligh and Dyer\u201d and folch methods for solid-liquid-liquid extraction of lipids from microorganisms. Comprehension of Solvatation Mechanisms and towards Substitution with Alternative Solvents","volume":"18","author":"Breil","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.plefa.2021.102336_bib0037","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ypmed.2004.02.030","article-title":"The Omega-3 Index: a new risk factor for death from coronary heart disease?","volume":"39","author":"Harris","year":"2004","journal-title":"Prev. Med."},{"key":"10.1016\/j.plefa.2021.102336_bib0038","first-page":"18","article-title":"Fatty acid composition of membrane bilayers: importance of diet polyunsaturated fat balance","volume":"5","author":"Abbott","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.plefa.2021.102336_bib0039","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics7010001","article-title":"Fatty acids in membranes as homeostatic, metabolic and nutritional biomarkers: recent advancements in analytics and diagnostics","volume":"7","author":"Ferreri","year":"2016","journal-title":"Diagnostics"},{"key":"10.1016\/j.plefa.2021.102336_bib0040","first-page":"1081","article-title":"A systematic review of dysgeusia induced by cancer therapies","volume":"18","author":"Hovan","year":"2010","journal-title":"Support. Care Cancer"},{"key":"10.1016\/j.plefa.2021.102336_bib0041","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1188\/12.CJON.171-178","article-title":"Understanding taste dysfunction in patients with cancer","volume":"16","author":"McLaughlin","year":"2012","journal-title":"Clin. J. Oncol. Nurs."},{"key":"10.1016\/j.plefa.2021.102336_bib0042","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10100342","article-title":"Mechanisms underlying the action and synergism of trastuzumab and pertuzumab in targeting HER2-positive breast cancer","volume":"10","author":"Nami","year":"2018","journal-title":"Cancers"},{"key":"10.1016\/j.plefa.2021.102336_bib0043","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0006-2952(98)00307-4","article-title":"A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin","volume":"57","author":"Gewirtz","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.plefa.2021.102336_bib0044","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.lfs.2018.12.018","article-title":"Molecular mechanism involved in cyclophosphamide-induced cardiotoxicity: old drug with a new vision","volume":"218","author":"Iqubal","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.plefa.2021.102336_bib0045","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/cmdc.200600308","article-title":"Paclitaxel and docetaxel resistance: molecular mechanisms and development of new generation taxanes","volume":"2","author":"Galletti","year":"2007","journal-title":"ChemMedChem"},{"key":"10.1016\/j.plefa.2021.102336_bib0046","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1177\/0022034515599770","article-title":"Salivary glands: stem cells, self-duplication, or both?","volume":"94","author":"Aure","year":"2015","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.plefa.2021.102336_bib0047","doi-asserted-by":"crossref","DOI":"10.5402\/2012\/137289","article-title":"Oxidative stress and lipid peroxidation products in cancer progression and therapy","author":"Barrera","year":"2012","journal-title":"ISRN Oncol"},{"key":"10.1016\/j.plefa.2021.102336_bib0048","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.rmed.2005.04.002","article-title":"Effect of chemotherapy on serum end-products of lipid peroxidation in patients with small cell lung cancer: association with treatment results","volume":"100","author":"Nowak","year":"2006","journal-title":"Respir. Med."},{"key":"10.1016\/j.plefa.2021.102336_bib0049","first-page":"8","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"360438","author":"Ayala","year":"2014","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.plefa.2021.102336_bib0050","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/BOR.0b013e32832eba21","article-title":"Pathogenesis of Sj\u00f6gren\u2019s syndrome","volume":"21","author":"Nikolov","year":"2009","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.plefa.2021.102336_bib0051","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/ard.55.3.202","article-title":"Salivary eicosanoid concentration in patients with Sjogren\u2019s syndrome","volume":"55","author":"Tishler","year":"1996","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.plefa.2021.102336_bib0052","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1017\/S0029665113001031","article-title":"n-3 fatty acids, inflammation and immunity: new mechanisms to explain old actions","volume":"72","author":"Calder","year":"2013","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.plefa.2021.102336_bib0053","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1083\/jcb.201003144","article-title":"The cell biology of taste","volume":"190","author":"Chaudhari","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.plefa.2021.102336_bib0054","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF01871396","article-title":"Effects of arachidonic acid and the other long-chain fatty acids on the membrane currents in the squid giant axon","volume":"106","author":"Takenaka","year":"1988","journal-title":"J. Membr. Biol."}],"container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952327821000983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952327821000983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T08:11:30Z","timestamp":1760602290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952327821000983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":54,"alternative-id":["S0952327821000983"],"URL":"https:\/\/doi.org\/10.1016\/j.plefa.2021.102336","relation":{},"ISSN":["0952-3278"],"issn-type":[{"value":"0952-3278","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Omega 6 polyunsaturated fatty acids in red blood cell membrane are associated with xerostomia and taste loss in patients with breast cancer","name":"articletitle","label":"Article Title"},{"value":"Prostaglandins, Leukotrienes and Essential Fatty Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.plefa.2021.102336","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102336"}}