{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T11:24:51Z","timestamp":1784978691620,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"am","delay-in-days":330,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["550KR171714"],"award-info":[{"award-number":["550KR171714"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R21DE029746"],"award-info":[{"award-number":["R21DE029746"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007810","name":"University of North Carolina Wilmington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007810","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","plefa.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.plefa.2022.102476","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T10:20:32Z","timestamp":1658571632000},"page":"102476","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Circulating polyunsaturated fatty acids, pressure pain thresholds, and nociplastic pain conditions"],"prefix":"10.1016","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2607-9514","authenticated-orcid":false,"given":"Anne E.","family":"Sanders","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Diane","family":"Weatherspoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandie M.","family":"Ehrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Soma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saame R.","family":"Shaikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Preisser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Ohrbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger B.","family":"Fillingim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary D.","family":"Slade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.plefa.2022.102476_bib0001","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.3389\/fphar.2019.01147","article-title":"Oxidized Lipids in Persistent Pain States","volume":"10","author":"Osthues","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.plefa.2022.102476_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.114953","article-title":"Oxidized linoleic acid metabolites maintain mechanical and thermal hypersensitivity during sub-chronic inflammatory pain","volume":"198","author":"Wedel","year":"2022","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.plefa.2022.102476_bib0003","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/s42255-021-00410-x","article-title":"Elevated dietary omega-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions","volume":"3","author":"Boyd","year":"2021","journal-title":"Nat Metab"},{"key":"10.1016\/j.plefa.2022.102476_bib0004","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nm.2123","article-title":"Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions","volume":"16","author":"Xu","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.plefa.2022.102476_bib0005","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2147\/JIR.S142424","article-title":"Comparative effects of the omega3 polyunsaturated fatty acid derivatives resolvins E1 and D1 and protectin DX in models of inflammation and pain","volume":"10","author":"Fonseca","year":"2017","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.plefa.2022.102476_bib0006","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1097\/j.pain.0000000000000507","article-title":"Do we need a third mechanistic descriptor for chronic pain states?","volume":"157","author":"Kosek","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.plefa.2022.102476_bib0007","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/S0140-6736(21)00392-5","article-title":"Nociplastic pain: towards an understanding of prevalent pain conditions","volume":"397","author":"Fitzcharles","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.plefa.2022.102476_bib0008","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jpain.2019.05.007","article-title":"ICD-10 Codes for the Study of Chronic Overlapping Pain Conditions in Administrative Databases","volume":"21","author":"Schrepf","year":"2020","journal-title":"J Pain"},{"key":"10.1016\/j.plefa.2022.102476_bib0009","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/jnr.23768","article-title":"Animal models of chronic pain: Advances and challenges for clinical translation","volume":"95","author":"Burma","year":"2017","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.plefa.2022.102476_bib0010","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.288.5472.1765","article-title":"Neuronal plasticity: increasing the gain in pain","volume":"288","author":"Woolf","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.plefa.2022.102476_bib0011","article-title":"Chronic Pain: Structural and Functional Changes in Brain Structures and Associated Negative Affective States","volume":"20","author":"Yang","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.plefa.2022.102476_bib0012","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/PHM.0000000000001603","article-title":"Pressure Pain Threshold in Patients With Chronic Pain: A Systematic Review and Meta-Analysis","volume":"100","author":"Amiri","year":"2021","journal-title":"Am J Phys Med Rehabil"},{"key":"10.1016\/j.plefa.2022.102476_bib0013","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/360825","article-title":"The Pharmacokinetic Profile of a New Gastroresistant Capsule Preparation of Eicosapentaenoic Acid as the Free Fatty Acid","author":"Scaioli","year":"2015","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.plefa.2022.102476_bib0014","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.3390\/nu6051993","article-title":"Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases","volume":"6","author":"Chilton","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.plefa.2022.102476_bib0015","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12937-020-00582-4","article-title":"Roles for circulating polyunsaturated fatty acids in ischemic stroke and modifiable factors: a Mendelian randomization study","volume":"19","author":"Yuan","year":"2020","journal-title":"Nutr J"},{"key":"10.1016\/j.plefa.2022.102476_bib0016","doi-asserted-by":"crossref","unstructured":"Y. Sun, R. Chatterjee, A. Ronanki, K. Ye, Circulating polyunsaturated fatty acids and COVID-19: a prospective cohort study and Mendelian randomization analysis, medRxiv, (2022).","DOI":"10.1101\/2022.02.06.22270562"},{"key":"10.1016\/j.plefa.2022.102476_bib0017","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000486244","article-title":"Circulating Polyunsaturated Fatty Acids as Biomarkers for Dietary Intake across Subgroups: The CODAM and Hoorn Studies","volume":"72","author":"Wanders","year":"2018","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.plefa.2022.102476_bib0018","doi-asserted-by":"crossref","first-page":"s15","DOI":"10.11607\/ofph.2581","article-title":"Overlap of Five Chronic Pain Conditions: Temporomandibular Disorders, Headache, Back Pain, Irritable Bowel Syndrome, and Fibromyalgia","volume":"34","author":"Slade","year":"2020","journal-title":"J Oral Facial Pain Headache"},{"key":"10.1016\/j.plefa.2022.102476_bib0019","doi-asserted-by":"crossref","first-page":"T2","DOI":"10.1016\/j.jpain.2013.06.006","article-title":"Study protocol, sample characteristics, and loss to follow-up: the OPPERA prospective cohort study","volume":"14","author":"Bair","year":"2013","journal-title":"J Pain"},{"key":"10.1016\/j.plefa.2022.102476_bib0020","doi-asserted-by":"crossref","first-page":"T116","DOI":"10.1016\/j.jpain.2013.09.010","article-title":"Summary of findings from the OPPERA prospective cohort study of incidence of first-onset temporomandibular disorder: implications and future directions","volume":"14","author":"Slade","year":"2013","journal-title":"J Pain"},{"key":"10.1016\/j.plefa.2022.102476_bib0021","doi-asserted-by":"crossref","first-page":"s43","DOI":"10.11607\/ofph.2583","article-title":"Experimental Pain Sensitivity in Subjects with Temporomandibular Disorders and Multiple Other Chronic Pain Conditions: The OPPERA Prospective Cohort Study","volume":"34","author":"Greenspan","year":"2020","journal-title":"J Oral Facial Pain Headache"},{"key":"10.1016\/j.plefa.2022.102476_bib0022","doi-asserted-by":"crossref","first-page":"6","DOI":"10.11607\/jop.1151","volume":"28","author":"Schiffman","year":"2014","journal-title":"J. Oral Facial Pain Headache"},{"key":"10.1016\/j.plefa.2022.102476_bib0023","first-page":"1","article-title":"The International Classification of Headache Disorders","volume":"38","year":"2018","journal-title":"Cephalalgia"},{"key":"10.1016\/j.plefa.2022.102476_bib0024","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1212\/01.WNL.0000078940.53438.83","article-title":"A self-administered screener for migraine in primary care: The ID Migraine validation study","volume":"61","author":"Lipton","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.plefa.2022.102476_bib0025","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/BRS.0b013e31815e7f94","article-title":"A consensus approach toward the standardization of back pain definitions for use in prevalence studies","volume":"33","author":"Dionne","year":"2008","journal-title":"Spine (Phila Pa 1976)"},{"issue":"Suppl 2","key":"10.1016\/j.plefa.2022.102476_bib0026","first-page":"II43","article-title":"Functional bowel disorders and functional abdominal pain","volume":"45","author":"Thompson","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.plefa.2022.102476_bib0027","first-page":"160","article-title":"The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia","volume":"33","author":"Wolfe","year":"1990","journal-title":"Report of the Multicenter Criteria Committee, Arthritis Rheum"},{"key":"10.1016\/j.plefa.2022.102476_bib0028","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1017\/S0007114513002985","article-title":"Age and sex differences in the incorporation of EPA and DHA into plasma fractions, cells and adipose tissue in humans","volume":"111","author":"Walker","year":"2014","journal-title":"Br J Nutr"},{"key":"10.1016\/j.plefa.2022.102476_bib0029","first-page":"161","article-title":"Quantitative sensory testing in the trigeminal region: site and gender differences","volume":"25","author":"Matos","year":"2011","journal-title":"J Orofac Pain"},{"key":"10.1016\/j.plefa.2022.102476_bib0030","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.pain.2005.03.025","article-title":"Age effects on pain thresholds, temporal summation and spatial summation of heat and pressure pain","volume":"115","author":"Lautenbacher","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.plefa.2022.102476_bib0031","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1194\/jlr.P000695","article-title":"Marked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome","volume":"51","author":"Clarke","year":"2010","journal-title":"J Lipid Res"},{"key":"10.1016\/j.plefa.2022.102476_bib0032","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3109\/09513599509160464","article-title":"Concentrations of various arachidonic acid metabolites in menstrual fluid are associated with menstrual pain and are influenced by hormonal contraceptives","volume":"9","author":"Bieglmayer","year":"1995","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.plefa.2022.102476_bib0033","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1177\/0333102412451360","article-title":"Prostaglandin E(2) induces immediate migraine-like attack in migraine patients without aura","volume":"32","author":"Antonova","year":"2012","journal-title":"Cephalalgia"},{"key":"10.1016\/j.plefa.2022.102476_bib0034","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1097\/j.pain.0000000000001983","article-title":"Identifying oxidized lipid mediators as prognostic biomarkers of chronic posttraumatic headache","volume":"161","author":"Domenichiello","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.plefa.2022.102476_bib0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123114","article-title":"Serum levels of oxylipins in achilles tendinopathy: an exploratory study","volume":"10","author":"Gouveia-Figueira","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.plefa.2022.102476_bib0036","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.pain.2007.01.020","article-title":"A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain","volume":"129","author":"Goldberg","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.plefa.2022.102476_bib0037","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.2174\/138161209789909746","article-title":"Omega-3 polyunsaturated fatty acids and immune-mediated diseases: inflammatory bowel disease and rheumatoid arthritis","volume":"15","author":"Ruggiero","year":"2009","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.plefa.2022.102476_bib0038","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/annrheumdis-2014-207169","article-title":"Fish oil in knee osteoarthritis: a randomised clinical trial of low dose versus high dose","volume":"75","author":"Hill","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.plefa.2022.102476_bib0039","doi-asserted-by":"crossref","first-page":"n1448","DOI":"10.1136\/bmj.n1448","article-title":"Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial","volume":"374","author":"Ramsden","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.plefa.2022.102476_bib0040","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.plefa.2016.05.004","article-title":"Regulation of rat plasma and cerebral cortex oxylipin concentrations with increasing levels of dietary linoleic acid","volume":"138","author":"Taha","year":"2018","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.plefa.2022.102476_bib0041","doi-asserted-by":"crossref","first-page":"10748","DOI":"10.1038\/s41598-017-09516-3","article-title":"Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans","volume":"7","author":"Valdes","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.plefa.2022.102476_bib0042","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1186\/s12967-020-02569-5","article-title":"Early evidence of efficacy for orally administered SPM-enriched marine lipid fraction on quality of life and pain in a sample of adults with chronic pain","volume":"18","author":"Callan","year":"2020","journal-title":"J Transl Med"},{"key":"10.1016\/j.plefa.2022.102476_bib0043","doi-asserted-by":"crossref","first-page":"T61","DOI":"10.1016\/j.jpain.2011.08.006","article-title":"Pain sensitivity risk factors for chronic TMD: descriptive data and empirically identified domains from the OPPERA case control study","volume":"12","author":"Greenspan","year":"2011","journal-title":"J Pain"},{"key":"10.1016\/j.plefa.2022.102476_bib0044","doi-asserted-by":"crossref","first-page":"s85","DOI":"10.11607\/ofph.2584","article-title":"Associations of Psychologic Factors with Multiple Chronic Overlapping Pain Conditions","volume":"34","author":"Fillingim","year":"2020","journal-title":"J Oral Facial Pain Headache"},{"key":"10.1016\/j.plefa.2022.102476_bib0045","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/57.5.801S","article-title":"Omega-3 fatty acids: essential fatty acids with important biological effects, and serum phospholipid fatty acids as markers of dietary omega 3-fatty acid intake","volume":"57","author":"Bjerve","year":"1993","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.plefa.2022.102476_bib0046","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/ajcn\/54.4.668","article-title":"Persistent changes in the fatty acid composition of erythrocyte membranes after moderate intake of n-3 polyunsaturated fatty acids: study design implications","volume":"54","author":"Brown","year":"1991","journal-title":"Am J Clin Nutr"}],"container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952327822000886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952327822000886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T08:11:34Z","timestamp":1760602294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952327822000886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":46,"alternative-id":["S0952327822000886"],"URL":"https:\/\/doi.org\/10.1016\/j.plefa.2022.102476","relation":{},"ISSN":["0952-3278"],"issn-type":[{"value":"0952-3278","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating polyunsaturated fatty acids, pressure pain thresholds, and nociplastic pain conditions","name":"articletitle","label":"Article Title"},{"value":"Prostaglandins, Leukotrienes and Essential Fatty Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.plefa.2022.102476","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102476"}}