{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T12:16:39Z","timestamp":1768479399895,"version":"3.49.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"am","delay-in-days":276,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["5R21NS109856"],"award-info":[{"award-number":["5R21NS109856"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["5R01NS119279"],"award-info":[{"award-number":["5R01NS119279"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","plefa.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.plefa.2025.102679","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T06:19:32Z","timestamp":1743574772000},"page":"102679","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Fatty acid synthase global inducible knockout does not alter brain fatty acid concentrations but attenuates cholesterol synthesis in the adult mouse"],"prefix":"10.1016","volume":"205","author":[{"given":"Drew R.","family":"Seeger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peddanna","family":"Kotha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana A.","family":"Golovko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail Y.","family":"Golovko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.plefa.2025.102679_bib0001","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s11745-004-1329-9","article-title":"Structure and function of animal fatty acid synthase","volume":"39","author":"Chirala","year":"2004","journal-title":"Lipids"},{"key":"10.1016\/j.plefa.2025.102679_bib0002","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1021\/bi00437a001","article-title":"Fatty acid synthase, a proficient multifunctional enzyme","volume":"28","author":"Wakil","year":"1989","journal-title":"Biochemistry"},{"key":"10.1016\/j.plefa.2025.102679_bib0003","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1096\/fasebj.8.15.8001737","article-title":"The animal fatty acid synthase: one gene, one polypeptide, seven enzymes","volume":"8","author":"Smith","year":"1994","journal-title":"FASEB J."},{"key":"10.1016\/j.plefa.2025.102679_bib0004","doi-asserted-by":"crossref","first-page":"8695","DOI":"10.1073\/pnas.92.19.8695","article-title":"Human fatty acid synthase: properties and molecular cloning","volume":"92","author":"Jayakumar","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.plefa.2025.102679_bib0005","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1083\/jcb.201706010","article-title":"De novo fatty acid synthesis by schwann cells is essential for peripheral nervous system myelination","volume":"217","author":"Montani","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.plefa.2025.102679_bib0006","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/nbm.1327","article-title":"Sources of hepatic triglyceride accumulation during high-fat feeding in the healthy rat","volume":"22","author":"Delgado","year":"2009","journal-title":"NMR Biomed."},{"key":"10.1016\/j.plefa.2025.102679_bib0007","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/nature20117","article-title":"Fatty acid synthesis configures the plasma membrane for inflammation in diabetes","volume":"539","author":"Wei","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.plefa.2025.102679_bib0008","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2112040119","article-title":"Fasn-dependent de novo lipogenesis is required for brain development","volume":"119","author":"Gonzalez-Bohorquez","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.plefa.2025.102679_bib0009","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1177\/002215540004800505","article-title":"Fatty acid synthase is expressed mainly in adult hormone-sensitive cells or cells with high lipid metabolism and in proliferating fetal cells","volume":"48","author":"Kusakabe","year":"2000","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.plefa.2025.102679_bib0010","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1172\/JCI118645","article-title":"Human fatty acid synthesis is stimulated by a eucaloric low fat, high carbohydrate diet","volume":"97","author":"Hudgins","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.plefa.2025.102679_bib0011","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/ajcn\/87.4.817","article-title":"Parallel activation of de novo lipogenesis and stearoyl-coa desaturase activity after 3 d of high-carbohydrate feeding","volume":"87","author":"Chong","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.plefa.2025.102679_bib0012","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.cell.2009.05.036","article-title":"Identification of a physiologically relevant endogenous ligand for pparalpha in liver","volume":"138","author":"Chakravarthy","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.plefa.2025.102679_bib0013","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cmet.2005.04.002","article-title":"New\u201d hepatic fat activates ppar\u03b1 to maintain glucose, lipid, and cholesterol homeostasis","volume":"1","author":"Chakravarthy","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.plefa.2025.102679_bib0014","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.bbalip.2011.09.017","article-title":"Fatty acid synthase and liver triglyceride metabolism: housekeeper or messenger?","volume":"1821","author":"Jensen-Urstad","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.plefa.2025.102679_bib0015","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/S0022-2275(20)39738-8","article-title":"Human fatty acid synthase mrna: tissue distribution, genetic mapping, and kinetics of decay after glucose deprivation","volume":"36","author":"Semenkovich","year":"1995","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.plefa.2025.102679_bib0016","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1016\/S0021-9258(19)44137-9","article-title":"Fatty acid synthetase of developing brain and liver: content, synthesis, and degradation during development","volume":"248","author":"Volpe","year":"1973","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.plefa.2025.102679_bib0017","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0169-328X(02)00161-4","article-title":"Fatty acid synthase expression during peripheral nervous system myelination","volume":"101","author":"Salles","year":"2002","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.plefa.2025.102679_bib0018","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120424","article-title":"Dietary triacylglycerols with palmitic acid in the sn-2 position modulate levels of n-acylethanolamides in rat tissues","volume":"10","author":"Carta","year":"2015","journal-title":"PLoS. One"},{"key":"10.1016\/j.plefa.2025.102679_bib0019","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.bbamem.2012.01.011","article-title":"Fatty acid composition of membrane bilayers: importance of diet polyunsaturated fat balance","volume":"1818","author":"Abbott","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.plefa.2025.102679_bib0020","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/jnc.15539","article-title":"The majority of brain palmitic acid is maintained by lipogenesis from dietary sugars and is augmented in mice fed low palmitic acid levels from birth","volume":"161","author":"Smith","year":"2022","journal-title":"J. Neurochem."},{"key":"10.1016\/j.plefa.2025.102679_bib0021","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF02668124","article-title":"Metabolism of brain glycolipid fatty acids","volume":"1","author":"Kishimoto","year":"1966","journal-title":"Lipids"},{"key":"10.1016\/j.plefa.2025.102679_bib0022","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1432-1033.1972.tb01974.x","article-title":"Fatty-acid biosynthesis","volume":"29","author":"Landriscina","year":"1972","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.plefa.2025.102679_bib0023","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.plefa.2008.09.003","article-title":"Regulation of brain polyunsaturated fatty acid uptake and turnover","volume":"79","author":"Chen","year":"2008","journal-title":"Prostaglandins. Leukot. Essent. Fatty. Acids."},{"key":"10.1016\/j.plefa.2025.102679_bib0024","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1471-4159.2005.03258.x","article-title":"\u0391-linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid","volume":"94","author":"DeMar","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.plefa.2025.102679_bib0025","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1194\/jlr.M600029-JLR200","article-title":"Uptake and metabolism of plasma-derived erucic acid by rat brain","volume":"47","author":"Golovko","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.plefa.2025.102679_bib0026","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1046\/j.1471-4159.1995.65052290.x","article-title":"Specific activity of brain palmitoyl-coa pool provides rates of incorporation of palmitate in brain phospholipids in awake rats","volume":"65","author":"Grange","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.plefa.2025.102679_bib0027","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1111\/j.1471-4159.1987.tb01021.x","article-title":"Utilization of plasma fatty acid in rat brain: distribution of [14c]palmitate between oxidative and synthetic pathways","volume":"49","author":"Miller","year":"1987","journal-title":"J. Neurochem."},{"key":"10.1016\/j.plefa.2025.102679_bib0028","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41467-023-44388-4","article-title":"Upregulated hepatic lipogenesis from dietary sugars in response to low palmitate feeding supplies brain palmitate","volume":"15","author":"Smith","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.plefa.2025.102679_bib0029","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1471-4159.2010.07116.x","article-title":"Rapid de-esterification and loss of eicosapentaenoic acid from rat brain phospholipids: an intracerebroventricular study","volume":"116","author":"Chen","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.plefa.2025.102679_bib0030","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0197-0186(84)90115-3","article-title":"Ketone-body utilization and lipid synthesis by developing rat brain-a comparison between in vivo and in vitro experiments","volume":"6","author":"Lopes-Cardozo","year":"1984","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.plefa.2025.102679_bib0031","doi-asserted-by":"crossref","first-page":"8251","DOI":"10.1021\/bi0502137","article-title":"\u0391-synuclein gene deletion decreases brain palmitate uptake and alters the palmitate metabolism in the absence of \u03b1-synuclein palmitate binding","volume":"44","author":"Golovko","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.plefa.2025.102679_bib0032","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/jnc.12617","article-title":"Fatty acid biosynthesis from glutamate and glutamine is specifically induced in neuronal cells under hypoxia","volume":"129","author":"Brose","year":"2014","journal-title":"J. Neurochem."},{"key":"10.1016\/j.plefa.2025.102679_bib0033","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.1073\/pnas.0931394100","article-title":"Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero","volume":"100","author":"Chirala","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.plefa.2025.102679_bib0034","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cmet.2014.12.002","article-title":"Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability","volume":"21","author":"Lodhi","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.plefa.2025.102679_bib0035","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/453120","article-title":"Microglia and astrocyte activation by toll-like receptor ligands: modulation by ppar-gamma agonists","author":"Gurley","year":"2008","journal-title":"PPAR. Res."},{"key":"10.1016\/j.plefa.2025.102679_bib0036","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neuroscience.2021.10.029","article-title":"Brain expression, physiological regulation and role in motivation and associative learning of peroxisome proliferator-activated receptor \u03b3","volume":"479","author":"Moosecker","year":"2021","journal-title":"Neuroscience"},{"key":"10.1016\/j.plefa.2025.102679_bib0037","article-title":"The arrive guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.plefa.2025.102679_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2023.100452","article-title":"Exogenous oxygen is required for prostanoid induction under brain ischemia as evidence for a novel regulatory mechanism","volume":"64","author":"Seeger","year":"2023","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.plefa.2025.102679_bib0039","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s11745-008-3168-3","article-title":"Erucic acid is differentially taken up and metabolized in rat liver and heart","volume":"43","author":"Murphy","year":"2008","journal-title":"Lipids"},{"key":"10.1016\/j.plefa.2025.102679_bib0040","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.plefa.2025.102679_bib0041","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/lipd.12073","article-title":"Plasma unesterified fatty-acid profile is dramatically and acutely changed under ischemic stroke in the mouse model","volume":"53","author":"Golovko","year":"2018","journal-title":"Lipids"},{"key":"10.1016\/j.plefa.2025.102679_bib0042","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3389\/fnins.2016.00546","article-title":"Fatty acid biosynthesis inhibition increases reduction potential in neuronal cells under hypoxia","volume":"10","author":"Brose","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.plefa.2025.102679_bib0043","first-page":"213","article-title":"Malonyl-coenzyme-a is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts","volume":"60","author":"Pizer","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.plefa.2025.102679_bib0044","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1172\/JCI31183","article-title":"Brain fatty acid synthase activates ppar\u03b1 to maintain energy homeostasis","volume":"117","author":"Chakravarthy","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.plefa.2025.102679_bib0045","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature13992","article-title":"A comparative encyclopedia of DNA elements in the mouse genome","volume":"515","author":"Yue","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.plefa.2025.102679_bib0046","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/lipd.12046","article-title":"Natural abundance carbon isotopic analysis indicates the equal contribution of local synthesis and plasma uptake to palmitate levels in the mouse brain","volume":"53","author":"Lacombe","year":"2018","journal-title":"Lipids"},{"key":"10.1016\/j.plefa.2025.102679_bib0047","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1432-1033.1975.tb04084.x","article-title":"On the mechanism of malonyl-coa-independent fatty-acid synthesis. Characterization of the mitochondrial chain-elongating system of rat liver and pig-kidney cortex","volume":"53","author":"Hinsch","year":"1975","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.plefa.2025.102679_bib0048","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0005-2760(72)90090-2","article-title":"On the mechanism of malonyl-coa independent fatty acid synthesis. Ii. Isolation, properties and subcellular location of trans-2,3-hexenoyl-coa and trans-2,3-decenoyl-coa reductase","volume":"280","author":"Podack","year":"1972","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.plefa.2025.102679_bib0049","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1126\/science.1067081","article-title":"Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors","volume":"295","author":"Lois","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.plefa.2025.102679_bib0050","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.neuint.2011.07.008","article-title":"The human ubiquitin c promoter drives selective expression in principal neurons in the brain of a transgenic mouse line","volume":"59","author":"Wilhelm","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.plefa.2025.102679_bib0051","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.chom.2011.12.006","article-title":"Fatty acid synthase modulates intestinal barrier function through palmitoylation of mucin 2","volume":"11","author":"Wei","year":"2012","journal-title":"Cell Host. Microbe"},{"key":"10.1016\/j.plefa.2025.102679_bib0052","first-page":"735","article-title":"Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells","volume":"117","author":"Mitchell","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.plefa.2025.102679_bib0053","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/S0022-2275(20)39738-8","article-title":"Human fatty acid synthase mrna: tissue distribution, genetic mapping, and kinetics of decay after glucose deprivation","volume":"36","author":"Semenkovich","year":"1995","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.plefa.2025.102679_bib0054","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1042\/bj1960645","article-title":"Important sites of lipogenesis in the mouse other than liver and white adipose tissue","volume":"196","author":"Hollands","year":"1981","journal-title":"Biochem. J."},{"key":"10.1016\/j.plefa.2025.102679_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2024.101300","article-title":"Unraveling brain palmitic acid: origin, levels and metabolic fate","volume":"96","author":"Smith","year":"2024","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.plefa.2025.102679_bib0056","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrn3820","article-title":"Polyunsaturated fatty acids and their metabolites in brain function and disease","volume":"15","author":"Bazinet","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.plefa.2025.102679_bib0057","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1194\/jlr.M008334","article-title":"Imaging decreased brain docosahexaenoic acid metabolism and signaling in ipla(2)\u03b2 (via)-deficient mice","volume":"51","author":"Basselin","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.plefa.2025.102679_bib0058","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2015.00120","article-title":"Ppar\u03b3 mrna in the adult mouse hypothalamus: distribution and regulation in response to dietary challenges","volume":"9","author":"Liu","year":"2015","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.plefa.2025.102679_bib0059","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1074\/jbc.M110.193037","article-title":"De novo lipogenesis maintains vascular homeostasis through endothelial nitric-oxide synthase (enos) palmitoylation","volume":"286","author":"Wei","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.plefa.2025.102679_bib0060","doi-asserted-by":"crossref","first-page":"4333","DOI":"10.1073\/pnas.95.8.4333","article-title":"Add1\/srebp1 activates ppargamma through the production of endogenous ligand","volume":"95","author":"Kim","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.plefa.2025.102679_bib0061","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0022-2275(20)30187-5","article-title":"Rapid synthesis and turnover of brain microsomal ether phospholipids in the adult rat","volume":"43","author":"Rosenberger","year":"2002","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.plefa.2025.102679_bib0062","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1074\/jbc.RA118.001921","article-title":"An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation","volume":"293","author":"Carroll","year":"2018","journal-title":"J. Biol. Chem."}],"container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095232782500016X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095232782500016X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T03:56:12Z","timestamp":1749182172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095232782500016X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":62,"alternative-id":["S095232782500016X"],"URL":"https:\/\/doi.org\/10.1016\/j.plefa.2025.102679","relation":{},"ISSN":["0952-3278"],"issn-type":[{"value":"0952-3278","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fatty acid synthase global inducible knockout does not alter brain fatty acid concentrations but attenuates cholesterol synthesis in the adult mouse","name":"articletitle","label":"Article Title"},{"value":"Prostaglandins, Leukotrienes and Essential Fatty Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.plefa.2025.102679","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102679"}}