{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:09:09Z","timestamp":1789042149514,"version":"build-2803163510"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004581","name":"Brandenburg State Ministry of Science Research and Culture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004581","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","plefa.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.plefa.2026.102760","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T14:59:05Z","timestamp":1783781945000},"page":"102760","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Intermittent fasting increases plasma arachidonic acid"],"prefix":"10.1016","volume":"210","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0192-1756","authenticated-orcid":false,"given":"Nina","family":"Kahle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Kunkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina","family":"B\u00f6ttcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1514-2729","authenticated-orcid":false,"given":"Anne","family":"Pietzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5361-4327","authenticated-orcid":false,"given":"Karsten-H.","family":"Weylandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.plefa.2026.102760_bib0001","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1365-2125.2012.04374.x","article-title":"Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?","volume":"75","author":"Calder","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"5","key":"10.1016\/j.plefa.2026.102760_bib0002","first-page":"453","article-title":"The importance of maintaining a low Omega-6\/Omega-3 ratio for reducing the risk of autoimmune diseases, asthma, and allergies","volume":"118","author":"DiNicolantonio","year":"2021","journal-title":"Mo Med."},{"issue":"16","key":"10.1016\/j.plefa.2026.102760_bib0003","article-title":"A balanced dietary ratio of n-6:n-3 polyunsaturated fatty acids exerts an effect on total fatty acid profile in RBCs and inflammatory markers in subjects with Obesity","volume":"11","author":"Gonzalez-Becerra","year":"2023","journal-title":"Healthc. (Basel)"},{"issue":"6","key":"10.1016\/j.plefa.2026.102760_bib0004","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3181\/0711-MR-311","article-title":"The importance of the omega-6\/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases","volume":"233","author":"Simopoulos","year":"2008","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"2","key":"10.1016\/j.plefa.2026.102760_bib0005","doi-asserted-by":"crossref","first-page":"427S","DOI":"10.1093\/jn\/128.2.427S","article-title":"The slow discovery of the importance of \u03c93 essential fatty acids in human health1","volume":"128","author":"Holman","year":"1998","journal-title":"J. Nutr."},{"key":"10.1016\/j.plefa.2026.102760_bib0006","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.nutr.24.121803.063211","article-title":"Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases","volume":"24","author":"Nakamura","year":"2004","journal-title":"Annu. Rev. Nutr."},{"issue":"3","key":"10.1016\/j.plefa.2026.102760_bib0007","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.plipres.2006.01.004","article-title":"Fatty acid elongases in mammals: Their regulation and roles in metabolism","volume":"45","author":"Jakobsson","year":"2006","journal-title":"Prog. Lipid Res."},{"issue":"8","key":"10.1016\/j.plefa.2026.102760_bib0008","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1096\/fasebj.6.8.1592205","article-title":"Biochemistry and physiology of n-3 fatty acids","volume":"6","author":"Lands","year":"1992","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.plefa.2026.102760_bib0009","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1051\/rnd:2005047","article-title":"Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults","volume":"45","author":"Burdge","year":"2005","journal-title":"Reprod. Nutr. Dev."},{"issue":"2-3","key":"10.1016\/j.plefa.2026.102760_bib0010","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.plefa.2009.01.004","article-title":"alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans","volume":"80","author":"Brenna","year":"2009","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"issue":"19","key":"10.1016\/j.plefa.2026.102760_bib0011","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1056\/NEJM198505093121902","article-title":"Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia","volume":"312","author":"Phillipson","year":"1985","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.plefa.2026.102760_bib0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11883-022-01075-x","article-title":"Role of Omega-3 Fatty Acids in Cardiovascular Disease: the Debate Continues","volume":"25","author":"Sherratt","year":"2023","journal-title":"Curr. Atheroscler. Rep."},{"issue":"1","key":"10.1016\/j.plefa.2026.102760_bib0013","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/0006-291X(83)91572-3","article-title":"Human neutrophil chemotactic and degranulating activities of leukotriene B5 (LTB5) derived from eicosapentaenoic acid","volume":"117","author":"Goldman","year":"1983","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.plefa.2026.102760_bib0014","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.pharmthera.2017.10.016","article-title":"Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases","volume":"183","author":"Schunck","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.plefa.2026.102760_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.tifs.2024.104799","article-title":"Omega-3 supplementation: Impact on low chronic inflammation associated with obesity","volume":"155","author":"L\u00f3pez-Mill\u00e1n","year":"2025","journal-title":"Trends Food Sci. Technol."},{"issue":"6","key":"10.1016\/j.plefa.2026.102760_bib0016","first-page":"444","article-title":"Fasting therapy for treating and preventing disease - current state of evidence","volume":"20","author":"Michalsen","year":"2013","journal-title":"Forsch. Komplementmed."},{"issue":"2","key":"10.1016\/j.plefa.2026.102760_bib0017","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cmet.2013.12.008","article-title":"Fasting: molecular mechanisms and clinical applications","volume":"19","author":"Longo","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.plefa.2026.102760_bib0018","article-title":"Intermittent fasting, fatty acid metabolism reprogramming, and neuroimmuno microenvironment: mechanisms and application prospects","volume":"11","author":"Zhang","year":"2024","journal-title":"Front. Nutr."},{"issue":"5","key":"10.1016\/j.plefa.2026.102760_bib0019","doi-asserted-by":"crossref","DOI":"10.1111\/eci.14382","article-title":"Long-term fasting induces a remodelling of fatty acid composition in erythrocyte membranes","volume":"55","author":"Gewecke","year":"2025","journal-title":"Eur. J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.plefa.2026.102760_bib0020","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0021-9258(18)84888-8","article-title":"On a possible relationship of arachidonic acid to the saturated fatty acids in fatty acid metabolism","volume":"65","author":"Wesson","year":"1925","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.plefa.2026.102760_bib0021","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0304-4165(64)90145-X","article-title":"The enzymatic formation of prostaglandin E2 from arachidonic acid prostaglandins and related factors 32","volume":"90","author":"Bergstr\u00f6m","year":"1964","journal-title":"Biochim. Biophys. Acta (BBA) - Gen. Subj."},{"issue":"2","key":"10.1016\/j.plefa.2026.102760_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113700","article-title":"Arachidonic acid inhibition of the NLRP3 inflammasome is a mechanism to explain the anti-inflammatory effects of fasting","volume":"43","author":"Pereira","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.plefa.2026.102760_bib0023","series-title":"Eat and Drink Well \u2013 Recommendations of the German Nutrition Society","author":"German Nutrition","year":"2024"},{"key":"10.1016\/j.plefa.2026.102760_bib0024","unstructured":"Echosens, FibroScan\u00ae Interpretation Guide: Quantifying fibrosis and steatosis with FibroScan\u00ae. Echosens."},{"issue":"6","key":"10.1016\/j.plefa.2026.102760_bib0025","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1053\/j.gastro.2019.01.042","article-title":"Accuracy of FibroScan controlled attenuation parameter and liver stiffness measurement in assessing steatosis and fibrosis in patients with nonalcoholic fatty liver disease","volume":"156","author":"Eddowes","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.plefa.2026.102760_bib0026","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1356986","article-title":"Effect of FADS1 SNPs rs174546, rs174547 and rs174550 on blood fatty acid profiles and plasma free oxylipins","volume":"11","author":"Rabehl","year":"2024","journal-title":"Front. Nutr."},{"key":"10.1016\/j.plefa.2026.102760_bib0027","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2091-6-5","article-title":"A simplified method for analysis of polyunsaturated fatty acids","volume":"6","author":"Kang","year":"2005","journal-title":"BMC. Biochem."},{"issue":"2","key":"10.1016\/j.plefa.2026.102760_bib0028","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23020766","article-title":"Essential polyunsaturated fatty acids in blood from patients with and without catheter-proven coronary artery disease","volume":"23","author":"Wang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.plefa.2026.102760_bib0029","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.plefa.2014.10.002","article-title":"Determining the fatty acid composition in plasma and tissues as fatty acid methyl esters using gas chromatography \u2013 a comparison of different derivatization and extraction procedures","volume":"91","author":"Ostermann","year":"2014","journal-title":"Prostaglandins Leukot Essent Fat. Acids"},{"issue":"1","key":"10.1016\/j.plefa.2026.102760_bib0030","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1186\/s12885-025-13806-9","article-title":"The effects of intermittent fasting on anthropometric indices, glycemic profile, chemotherapy-related toxicity, and subjective perception in gynecological and breast cancer patients: a systematic review and meta-analysis","volume":"25","author":"Liu","year":"2025","journal-title":"BMC. Cancer"},{"key":"10.1016\/j.plefa.2026.102760_bib0031","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.arr.2016.10.005","article-title":"Impact of intermittent fasting on health and disease processes","volume":"39","author":"Mattson","year":"2017","journal-title":"Ageing Res. Rev."},{"issue":"13","key":"10.1016\/j.plefa.2026.102760_bib0032","doi-asserted-by":"crossref","DOI":"10.3390\/nu16132101","article-title":"Intermittent fasting attenuates obesity-induced triple-negative breast cancer progression by disrupting cell cycle, epithelial-mesenchymal transition, immune contexture, and proinflammatory signature","volume":"16","author":"Son","year":"2024","journal-title":"Nutrients."},{"issue":"1","key":"10.1016\/j.plefa.2026.102760_bib0033","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12937-025-01178-6","article-title":"The impact of intermittent fasting on body composition and cardiometabolic outcomes in overweight and obese adults: a systematic review and meta-analysis of randomized controlled trials","volume":"24","author":"Wang","year":"2025","journal-title":"Nutr. J."},{"key":"10.1016\/j.plefa.2026.102760_bib0034","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.plefa.2016.09.007","article-title":"Gas chromatography determination of fatty acids in the human erythrocyte membranes \u2013 A review","volume":"115","author":"Bystrick\u00e1","year":"2016","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"issue":"1","key":"10.1016\/j.plefa.2026.102760_bib0035","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/ajcn\/86.1.74","article-title":"Comparison between plasma and erythrocyte fatty acid content as biomarkers of fatty acid intake in US women23","volume":"86","author":"Sun","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.plefa.2026.102760_bib0036","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11745-007-3132-7","article-title":"Comparison of low fat and low carbohydrate diets on circulating fatty acid composition and markers of inflammation","volume":"43","author":"Forsythe","year":"2008","journal-title":"Lipids"},{"issue":"1","key":"10.1016\/j.plefa.2026.102760_bib0037","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0304-4165(90)90214-H","article-title":"Differential utilization of long chain fatty acids during fasting-induced triacylglycerol depletion. III. Comparison of n\u22123 and n\u22126 fatty acids in rat plasma and liver","volume":"1036","author":"Cunnane","year":"1990","journal-title":"Biochim. Biophys. Acta (BBA) - Gen. Subj."},{"issue":"6","key":"10.1016\/j.plefa.2026.102760_bib0038","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0049-3848(82)90096-2","article-title":"Effect of fasting on production from exogenous arachidonic acid of thromboxane and 12-hydroxy 5, 8, 10, 14-Eicosatetraenoic acid (12-HETE) by washed platelets of normal and streptozotocin diabetic mice","volume":"28","author":"Rosenblum","year":"1982","journal-title":"Thromb. Res."},{"issue":"4","key":"10.1016\/j.plefa.2026.102760_bib0039","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3109\/10715762.2014.883071","article-title":"High serum n6 fatty acid proportion is associated with lowered LDL oxidation and inflammation: the cardiovascular risk in young Finns study","volume":"48","author":"Kaikkonen","year":"2014","journal-title":"Free Radic. Res."},{"issue":"5","key":"10.1016\/j.plefa.2026.102760_bib0040","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.ajhg.2012.03.014","article-title":"Genetic adaptation of fatty-acid metabolism: a human-specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids","volume":"90","author":"Ameur","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.plefa.2026.102760_bib0041","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev-nutr-082018-124250","article-title":"FADS1 and FADS2 polymorphisms modulate fatty acid metabolism and dietary impact on health","volume":"39","author":"Koletzko","year":"2019","journal-title":"Annu. Rev. Nutr."},{"issue":"8","key":"10.1016\/j.plefa.2026.102760_bib0042","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.tem.2024.03.003","article-title":"Effects of APOE4 on Omega-3 brain metabolism across the lifespan","volume":"35","author":"Ebright","year":"2024","journal-title":"Trends. Endocrinol. Metab."},{"issue":"16","key":"10.1016\/j.plefa.2026.102760_bib0043","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.127902","article-title":"Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids","volume":"4","author":"Luukkonen","year":"2019","journal-title":"JCI. Insight."},{"issue":"10","key":"10.1016\/j.plefa.2026.102760_bib0044","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.metabol.2014.06.016","article-title":"Shifts in dietary carbohydrate-lipid exposure regulate expression of the non-alcoholic fatty liver disease-associated gene PNPLA3\/adiponutrin in mouse liver and HepG2 human liver cells","volume":"63","author":"Hao","year":"2014","journal-title":"Metabolism."},{"issue":"9","key":"10.1016\/j.plefa.2026.102760_bib0045","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1111\/liv.14507","article-title":"The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue","volume":"40","author":"Qadri","year":"2020","journal-title":"Liver. Int."},{"issue":"1","key":"10.1016\/j.plefa.2026.102760_bib0046","doi-asserted-by":"crossref","first-page":"4847","DOI":"10.1038\/s41467-024-49224-x","article-title":"PNPLA3 is a triglyceride lipase that mobilizes polyunsaturated fatty acids to facilitate hepatic secretion of large-sized very low-density lipoprotein","volume":"15","author":"Johnson","year":"2024","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.plefa.2026.102760_bib0047","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1039\/D5FO04964D","article-title":"Genetic modulation of omega-3 and omega-6 polyunsaturated fatty acid metabolism and health outcomes: a systematic review","volume":"17","author":"Visioli","year":"2026","journal-title":"Food Funct."},{"issue":"11","key":"10.1016\/j.plefa.2026.102760_bib0048","doi-asserted-by":"crossref","DOI":"10.3390\/nu9111165","article-title":"Precision nutrition and Omega-3 polyunsaturated fatty acids: a case for personalized supplementation approaches for the prevention and management of human diseases","volume":"9","author":"Chilton","year":"2017","journal-title":"Nutrients."},{"issue":"1","key":"10.1016\/j.plefa.2026.102760_bib0049","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2337\/dc09-1235","article-title":"Marine \u03c9-3 fatty acid intake: associations with cardiometabolic risk and response to weight loss intervention in the look AHEAD (action for health in diabetes) study","volume":"33","author":"Belalcazar","year":"2009","journal-title":"Diabetes Care"},{"issue":"12","key":"10.1016\/j.plefa.2026.102760_bib0050","doi-asserted-by":"crossref","DOI":"10.3390\/nu17121996","article-title":"Dietary n-6:n-3 PUFA ratio modulates inflammation-related gene expression and influences improvements in biochemical parameters in a murine model of diet-induced obesity","volume":"17","author":"Gutierrez-Guerra","year":"2025","journal-title":"Nutrients."},{"issue":"4","key":"10.1016\/j.plefa.2026.102760_bib0051","first-page":"406","article-title":"Blood Eicosapentaenoic and docosahexaenoic acids predict all-cause mortality in patients with stable coronary heart disease","volume":"3","author":"Pottala","year":"2010","journal-title":"Circ.: Cardiovasc. Qual. Outcomes"},{"issue":"5","key":"10.1016\/j.plefa.2026.102760_bib0052","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1592\/phco.27.5.633","article-title":"Effect of Omega-3 fatty acid supplementation on the arachidonic acid: eicosapentaenoic acid ratio","volume":"27","author":"Burns","year":"2007","journal-title":"Pharmacother.: J. Hum. Pharmacol. Drug Ther."},{"key":"10.1016\/j.plefa.2026.102760_bib0053","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1017\/jns.2021.46","article-title":"Effect of n-3 long-chain polyunsaturated fatty acid intake on the eicosanoid profile in individuals with obesity and overweight: a systematic review and meta-analysis of clinical trials","volume":"10","author":"Schweitzer","year":"2021","journal-title":"J. Nutr. Sci."},{"issue":"12","key":"10.1016\/j.plefa.2026.102760_bib0054","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144996","article-title":"Changes in PTGS1 and ALOX12 gene expression in peripheral blood mononuclear cells are associated with changes in arachidonic acid, Oxylipins, and Oxylipin\/fatty acid ratios in response to Omega-3 fatty acid supplementation","volume":"10","author":"Berthelot","year":"2015","journal-title":"PLoS. One"},{"issue":"19","key":"10.1016\/j.plefa.2026.102760_bib0055","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1056\/NEJMoa1205409","article-title":"n-3 fatty acids in patients with multiple cardiovascular risk factors","volume":"368","author":"Roncaglioni","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.plefa.2026.102760_bib0056","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/ijo.2010.171","article-title":"The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women","volume":"35","author":"Harvie","year":"2011","journal-title":"Int. J. Obes. (L.)"},{"issue":"2","key":"10.1016\/j.plefa.2026.102760_bib0057","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3945\/ajcn.110.002741","article-title":"Effects of omega-3 supplementation in combination with diet and exercise on weight loss and body composition","volume":"93","author":"DeFina","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"issue":"6","key":"10.1016\/j.plefa.2026.102760_bib0058","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1093\/ajcn\/86.5.1670","article-title":"Treatment for 2 mo with n\u22123 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study2, 3","volume":"86","author":"Kabir","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.plefa.2026.102760_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2022.111847","article-title":"Effects of time-restricted feeding (16\/8) combined with a low-sugar diet on the management of non-alcoholic fatty liver disease: A randomized controlled trial","volume":"105","author":"Kord-Varkaneh","year":"2023","journal-title":"Nutrition"},{"key":"10.1016\/j.plefa.2026.102760_bib0060","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.clnu.2025.04.022","article-title":"Six weeks of time-restricted eating improves basal fat oxidation and body composition but not fat oxidation during exercise in young males","volume":"50","author":"Akta\u015f","year":"2025","journal-title":"Clin. Nutr."},{"issue":"5","key":"10.1016\/j.plefa.2026.102760_bib0061","doi-asserted-by":"crossref","first-page":"696","DOI":"10.3390\/life15050696","article-title":"Effects of intermittent fasting on liver steatosis and fibrosis, serum FGF-21 and autophagy markers in metabolic dysfunction-associated fatty liver disease: a randomized controlled trial","volume":"15","author":"Ozlu Karahan","year":"2025","journal-title":"Life"},{"key":"10.1016\/j.plefa.2026.102760_bib0062","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.709683","article-title":"Effect of Intermittent Fasting on Non-Alcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis","volume":"8","author":"Yin","year":"2021","journal-title":"Front. Nutr."},{"issue":"11","key":"10.1016\/j.plefa.2026.102760_bib0063","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00535-007-2107-z","article-title":"The impact of visceral fat in nonalcoholic fatty liver disease: cross-sectional and longitudinal studies","volume":"42","author":"Koda","year":"2007","journal-title":"J. Gastroenterol."},{"issue":"9","key":"10.1016\/j.plefa.2026.102760_bib0064","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1194\/jlr.M600177-JLR200","article-title":"Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity","volume":"47","author":"Wang","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.plefa.2026.102760_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.plefa.2022.102441","article-title":"Influence of the nutritional status and oxidative stress in the desaturation and elongation of n-3 and n-6 polyunsaturated fatty acids: Impact on non-alcoholic fatty liver disease","volume":"181","author":"Videla","year":"2022","journal-title":"Prostaglandins Leukot Essent Fat. Acids"}],"container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952327826000384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952327826000384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:19:08Z","timestamp":1789039148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952327826000384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":65,"alternative-id":["S0952327826000384"],"URL":"https:\/\/doi.org\/10.1016\/j.plefa.2026.102760","relation":{},"ISSN":["0952-3278"],"issn-type":[{"value":"0952-3278","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intermittent fasting increases plasma arachidonic acid","name":"articletitle","label":"Article Title"},{"value":"Prostaglandins, Leukotrienes and Essential Fatty Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.plefa.2026.102760","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102760"}}