{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:08:12Z","timestamp":1793282892187,"version":"4.5.0"},"reference-count":205,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Lipid Research"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.plipres.2010.07.002","type":"journal-article","created":{"date-parts":[[2010,7,14]],"date-time":"2010-07-14T08:56:10Z","timestamp":1279097770000},"page":"476-492","source":"Crossref","is-referenced-by-count":69,"title":["Defective lipid transport and biosynthesis in recessive and dominant Stargardt macular degeneration"],"prefix":"10.1016","volume":"49","author":[{"given":"Robert S.","family":"Molday","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.plipres.2010.07.002_bib1","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/S0140-6736(06)69740-7","article-title":"Retinitis pigmentosa","volume":"368","author":"Hartong","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.plipres.2010.07.002_bib2","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1146\/annurev.neuro.26.041002.131416","article-title":"Progress toward understanding the genetic and biochemical mechanisms of inherited photoreceptor degenerations","volume":"26","author":"Pacione","year":"2003","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.plipres.2010.07.002_bib3","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.preteyeres.2008.05.003","article-title":"Leber congenital amaurosis: genes, proteins and disease mechanisms","volume":"27","author":"den Hollander","year":"2008","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.plipres.2010.07.002_bib4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/ICU.0b013e3282fc27fc","article-title":"Hereditary retinal disease","volume":"19","author":"Goodwin","year":"2008","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.plipres.2010.07.002_bib5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/ICU.0b013e32832f8016","article-title":"Genetics of age-related macular degeneration","volume":"20","author":"Ting","year":"2009","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.plipres.2010.07.002_bib6","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/hmg\/11.10.1219","article-title":"Retinitis pigmentosa and allied diseases: numerous diseases, genes, and inheritance patterns","volume":"11","author":"Rivolta","year":"2002","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib7","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nrn2007","article-title":"Macular degeneration: recent advances and therapeutic opportunities","volume":"7","author":"Rattner","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.plipres.2010.07.002_bib8","doi-asserted-by":"crossref","first-page":"16725","DOI":"10.1073\/pnas.0708151104","article-title":"Bringing the genetics of macular degeneration into focus","volume":"104","author":"Haines","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.plipres.2010.07.002_bib9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000072045","article-title":"Genetics of macular dystrophies and implications for age-related macular degeneration","volume":"37","author":"Klaver","year":"2003","journal-title":"Dev Ophthalmol"},{"key":"10.1016\/j.plipres.2010.07.002_bib10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/ng1294-315","article-title":"New dimensions in macular dystrophies","volume":"8","author":"Humphries","year":"1994","journal-title":"Nat Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib11","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/08820530701745140","article-title":"Review of genetics in age related macular degeneration","volume":"22","author":"Montezuma","year":"2007","journal-title":"Semin Ophthalmol"},{"key":"10.1016\/j.plipres.2010.07.002_bib12","first-page":"196","article-title":"An update on the genetics of age-related macular degeneration","volume":"13","author":"Scholl","year":"2007","journal-title":"Mol Vis"},{"key":"10.1016\/j.plipres.2010.07.002_bib13","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1056\/NEJMra0801537","article-title":"Age-related macular degeneration","volume":"358","author":"Jager","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.plipres.2010.07.002_bib14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.genom.9.081307.164350","article-title":"Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration","volume":"10","author":"Swaroop","year":"2009","journal-title":"Annu Rev Genom Hum Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib15","doi-asserted-by":"crossref","first-page":"c981","DOI":"10.1136\/bmj.c981","article-title":"Age related macular degeneration","volume":"340","author":"Chakravarthy","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.plipres.2010.07.002_bib16","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1126\/science.1109557","article-title":"Complement factor H polymorphism in age-related macular degeneration","volume":"308","author":"Klein","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.plipres.2010.07.002_bib17","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.1073\/pnas.0501536102","article-title":"A common haplotype in the complement regulatory gene factor H (HF1\/CFH) predisposes individuals to age-related macular degeneration","volume":"102","author":"Hageman","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.plipres.2010.07.002_bib18","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1126\/science.1110359","article-title":"Complement factor H variant increases the risk of age-related macular degeneration","volume":"308","author":"Haines","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.plipres.2010.07.002_bib19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1126\/science.1110189","article-title":"Complement factor H polymorphism and age-related macular degeneration","volume":"308","author":"Edwards","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.plipres.2010.07.002_bib20","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/ng.170","article-title":"Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA","volume":"40","author":"Fritsche","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib21","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1126\/science.1133811","article-title":"A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration","volume":"314","author":"Yang","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.plipres.2010.07.002_bib22","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/ng0397-236","article-title":"A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy [see comments]","volume":"15","author":"Allikmets","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib23","doi-asserted-by":"crossref","first-page":"8269","DOI":"10.1074\/jbc.274.12.8269","article-title":"Retinal stimulates ATP hydrolysis by purified, reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease","volume":"274","author":"Sun","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0092-8674(00)80602-9","article-title":"Insights into the function of rim protein in photoreceptors and etiology of Stargardt\u2019s disease from the phenotype in abcr knockout mice","volume":"98","author":"Weng","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.plipres.2010.07.002_bib25","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s10863-007-9118-6","article-title":"ATP-binding cassette transporter ABCA4: molecular properties and role in vision and macular degeneration","volume":"39","author":"Molday","year":"2007","journal-title":"J Bioenerg Biomembr"},{"key":"10.1016\/j.plipres.2010.07.002_bib26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/84765","article-title":"A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy","volume":"27","author":"Zhang","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib27","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1007\/BF01961301","article-title":"Uber familiare, progressive degeenration under makulagegend des augen","volume":"71","author":"Stargardt","year":"1909","journal-title":"Albrecht von Graefes Arch Ophthalmol"},{"key":"10.1016\/j.plipres.2010.07.002_bib28","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1001\/archopht.1979.01020020023005","article-title":"Stargardt\u2019s disease and fundus flavimaculatus","volume":"97","author":"Noble","year":"1979","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.plipres.2010.07.002_bib29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/13816810802695550","article-title":"Natural history of phenotypic changes in Stargardt macular dystrophy","volume":"30","author":"Walia","year":"2009","journal-title":"Ophthalmic Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib30","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1001\/archopht.1994.01090180050033","article-title":"Stargardt\u2019s macular dystrophy","volume":"112","author":"Weleber","year":"1994","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.plipres.2010.07.002_bib31","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0161-6420(87)33533-X","article-title":"Visual acuity loss in patients with Stargardt\u2019s macular dystrophy","volume":"94","author":"Fishman","year":"1987","journal-title":"Ophthalmology"},{"key":"10.1016\/j.plipres.2010.07.002_bib32","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0161-6420(03)00333-6","article-title":"Visual acuity loss and clinical observations in a large series of patients with Stargardt disease","volume":"110","author":"Rotenstreich","year":"2003","journal-title":"Ophthalmology"},{"key":"10.1016\/j.plipres.2010.07.002_bib33","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0161-6420(91)32196-1","article-title":"Delayed rod dark adaptation in patients with Stargardt\u2019s disease","volume":"98","author":"Fishman","year":"1991","journal-title":"Ophthalmology"},{"key":"10.1016\/j.plipres.2010.07.002_bib34","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0002-9394(83)90455-5","article-title":"Retinal function in Stargardt\u2019s disease and fundus flavimaculatus","volume":"96","author":"Moloney","year":"1983","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.plipres.2010.07.002_bib35","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/BF00918432","article-title":"Color vision in Stargardt\u2019s disease","volume":"16","author":"Mantyjarvi","year":"1992","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.plipres.2010.07.002_bib36","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0161-6420(13)31725-4","article-title":"Histopathology and immunocytochemistry of the neurosensory retina in fundus flavimaculatus","volume":"101","author":"Birnbach","year":"1994","journal-title":"Ophthalmology"},{"key":"10.1016\/j.plipres.2010.07.002_bib37","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0161-6420(91)32197-3","article-title":"Histopathology of incipient fundus flavimaculatus","volume":"98","author":"Steinmetz","year":"1991","journal-title":"Ophthalmology"},{"key":"10.1016\/j.plipres.2010.07.002_bib38","first-page":"2327","article-title":"In vivo measurement of lipofuscin in Stargardt\u2019s disease \u2013 fundus flavimaculatus","volume":"36","author":"Delori","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib39","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/361724a0","article-title":"Retinal age pigments generated by self-assembling lysosomotropic detergents","volume":"361","author":"Eldred","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.plipres.2010.07.002_bib40","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1136\/bjo.65.5.359","article-title":"The dark choroid in posterior retinal dystrophies","volume":"65","author":"Fish","year":"1981","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.plipres.2010.07.002_bib41","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1001\/archopht.119.3.359","article-title":"Phenotypic subtypes of Stargardt macular dystrophy \u2013 fundus flavimaculatus","volume":"119","author":"Lois","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.plipres.2010.07.002_bib42","first-page":"2668","article-title":"Intrafamilial variation of phenotype in Stargardt macular dystrophy \u2013 fundus flavimaculatus","volume":"40","author":"Lois","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib43","doi-asserted-by":"crossref","first-page":"5867","DOI":"10.1167\/iovs.09-3611","article-title":"The Natural history of Stargardt disease with specific sequence mutation in the ABCA4 gene","volume":"50","author":"Genead","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib44","first-page":"505","article-title":"Fundus flavimaculatus","volume":"25","author":"Franceschetti","year":"1965","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.plipres.2010.07.002_bib45","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/0002-9394(76)90539-0","article-title":"Fundus flavimaculatus and Stargardt\u2019s disease","volume":"82","author":"Hadden","year":"1976","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.plipres.2010.07.002_bib46","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/ng1193-308","article-title":"A gene for Stargardt\u2019s disease (fundus flavimaculatus) maps to the short arm of chromosome 1","volume":"5","author":"Kaplan","year":"1993","journal-title":"Nat Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/08820530701745249","article-title":"Stargardt\u2019s disease and the ABCR gene","volume":"23","author":"Westerfeld","year":"2008","journal-title":"Semin Ophthalmol"},{"key":"10.1016\/j.plipres.2010.07.002_bib48","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1083\/jcb.78.2.415","article-title":"Immunocytochemical localization of a large intrinsic membrane protein to the incisures and margins of frog rod outer segment disks","volume":"78","author":"Papermaster","year":"1978","journal-title":"J Cell Biol"},{"key":"10.1016\/j.plipres.2010.07.002_bib49","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1016\/S0021-9258(17)30060-1","article-title":"Identification and characterization of multiple forms of rhodopsin and minor proteins in frog and bovine rod outer segment disc membranes. Electrophoresis, lectin labeling, and proteolysis studies","volume":"254","author":"Molday","year":"1979","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib50","doi-asserted-by":"crossref","first-page":"10303","DOI":"10.1074\/jbc.272.15.10303","article-title":"The 220-kDa rim protein of retinal rod outer segments is a member of the ABC transporter superfamily","volume":"272","author":"Illing","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib51","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0014-5793(97)00517-6","article-title":"The photoreceptor rim protein is an ABC transporter encoded by the gene for recessive Stargardt\u2019s disease (ABCR)","volume":"409","author":"Azarian","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.plipres.2010.07.002_bib52","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s004390050649","article-title":"Mapping of the rod photoreceptor ABC transporter (ABCR) to 1p21\u2013p22.1 and identification of novel mutations in Stargardt\u2019s disease","volume":"102","author":"Nasonkin","year":"1998","journal-title":"Hum Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib53","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1750-1172-2-7","article-title":"Cone rod dystrophies","volume":"2","author":"Hamel","year":"2007","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.plipres.2010.07.002_bib54","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1086\/303079","article-title":"Mutations in the ABCA4 (ABCR) gene are the major cause of autosomal recessive cone-Rod dystrophy","volume":"67","author":"Maugeri","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib55","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/archopht.121.6.851","article-title":"ABCA4 gene sequence variations in patients with autosomal recessive cone-rod dystrophy","volume":"121","author":"Fishman","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.plipres.2010.07.002_bib56","first-page":"2229","article-title":"Mutations in ABCR (ABCA4) in patients with Stargardt macular degeneration or cone-rod degeneration","volume":"42","author":"Briggs","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib57","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/hmg\/7.3.355","article-title":"Autosomal recessive retinitis pigmentosa and cone-rod dystrophy caused by splice site mutations in the Stargardt\u2019s disease gene ABCR","volume":"7","author":"Cremers","year":"1998","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib58","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/hmg\/ddn421","article-title":"ABCA4 disease progression and a proposed strategy for gene therapy","volume":"18","author":"Cideciyan","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib59","first-page":"1659","article-title":"Retinitis pigmentosa. The Friedenwald lecture","volume":"34","author":"Berson","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib60","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/ng0198-11","article-title":"Retinitis pigmentosa caused by a homozygous mutation in the Stargardt disease gene ABCR","volume":"18","author":"Martinez-Mir","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib61","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1126\/science.277.5333.1805","article-title":"Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration","volume":"277","author":"Allikmets","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.plipres.2010.07.002_bib62","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1086\/303018","article-title":"Further evidence for an association of ABCR alleles with age-related macular degeneration. The international ABCR screening consortium","volume":"67","author":"Allikmets","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib63","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/3798","article-title":"Allelic variation in ABCR associated with Stargardt disease but not age-related macular degeneration","volume":"20","author":"Stone","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib64","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1086\/303100","article-title":"Simple and complex ABCR: genetic predisposition to retinal disease","volume":"67","author":"Allikmets","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib65","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/hmg\/ddn421","article-title":"ABCA4 Disease progression and a proposed strategy for gene therapy","volume":"18","author":"Cideciyan","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib66","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1086\/302323","article-title":"The 2588G\u2013>C mutation in the ABCR gene is a mild frequent founder mutation in the Western European population and allows the classification of ABCR mutations in patients with Stargardt disease","volume":"64","author":"Maugeri","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib67","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1076\/opge.19.3.117.2187","article-title":"ABCR unites what ophthalmologists divide(s)","volume":"19","author":"van Driel","year":"1998","journal-title":"Ophthalmic Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib68","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/S0042-6989(99)00037-1","article-title":"The rod photoreceptor ATP-binding cassette transporter gene, ABCR, and retinal disease: from monogenic to multifactorial","volume":"39","author":"Shroyer","year":"1999","journal-title":"Vision Res"},{"key":"10.1016\/j.plipres.2010.07.002_bib69","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev.cb.08.110192.000435","article-title":"ABC transporters: from microorganisms to man","volume":"8","author":"Higgins","year":"1992","journal-title":"Annu Rev Cell Biol"},{"key":"10.1016\/j.plipres.2010.07.002_bib70","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.genom.6.080604.162122","article-title":"Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates","volume":"6","author":"Dean","year":"2005","journal-title":"Annu Rev Genom Hum Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib71","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1007\/s00018-009-0064-9","article-title":"The ATP-binding cassette family: a structural perspective","volume":"66","author":"Kos","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib72","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1152\/physiol.00046.2006","article-title":"Structure and function of ABC transporters","volume":"22","author":"Linton","year":"2007","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.plipres.2010.07.002_bib73","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1098\/rstb.2008.0125","article-title":"Review. Structure and mechanism of ATP-binding cassette transporters","volume":"364","author":"Locher","year":"2009","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib74","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1023\/A:1012823120935","article-title":"Complete characterization of the human ABC gene family","volume":"33","author":"Dean","year":"2001","journal-title":"J Bioenerg Biomembr"},{"key":"10.1016\/j.plipres.2010.07.002_bib75","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S1388-1981(00)00053-6","article-title":"ABC transporters in lipid transport","volume":"1486","author":"Borst","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.plipres.2010.07.002_bib76","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.bbadis.2006.01.011","article-title":"ABC A-subfamily transporters: structure, function and disease","volume":"1762","author":"Kaminski","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.plipres.2010.07.002_bib77","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1146\/annurev.biochem.71.102301.093055","article-title":"Mammalian ABC transporters in health and disease","volume":"71","author":"Borst","year":"2002","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.plipres.2010.07.002_bib78","doi-asserted-by":"crossref","first-page":"23539","DOI":"10.1074\/jbc.M101902200","article-title":"Membrane topology of the ATP binding cassette transporter ABCR and its relationship to ABC1 and related ABCA transporters: identification of N- linked glycosylation sites","volume":"276","author":"Bungert","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib79","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0022-2836(02)01105-1","article-title":"Characterization of the ABCA transporter subfamily: identification of prokaryotic and eukaryotic members, phylogeny and topology","volume":"325","author":"Peelman","year":"2003","journal-title":"J Mol Biol"},{"key":"10.1016\/j.plipres.2010.07.002_bib80","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/11905","article-title":"Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency","volume":"22","author":"Brooks-Wilson","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib81","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/11921","article-title":"Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1","volume":"22","author":"Rust","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib82","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/11914","article-title":"The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease","volume":"22","author":"Bodzioch","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib83","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1194\/jlr.M600449-JLR200","article-title":"ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol","volume":"48","author":"Fitzgerald","year":"2007","journal-title":"J Lipid Res"},{"key":"10.1016\/j.plipres.2010.07.002_bib84","doi-asserted-by":"crossref","first-page":"9628","DOI":"10.1074\/jbc.M611767200","article-title":"ABCA3 as a lipid transporter in pulmonary surfactant biogenesis","volume":"282","author":"Ban","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib85","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa032178","article-title":"ABCA3 gene mutations in newborns with fatal surfactant deficiency","volume":"350","author":"Shulenin","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.plipres.2010.07.002_bib86","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0014-5793(01)03056-3","article-title":"ABCA3 is a lamellar body membrane protein in human lung alveolar type II cells","volume":"508","author":"Yamano","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1016\/j.plipres.2010.07.002_bib87","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1093\/hmg\/ddg235","article-title":"Mutations in the transporter ABCA12 are associated with lamellar ichthyosis type 2","volume":"12","author":"Lefevre","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib88","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1172\/JCI24834","article-title":"Mutations in lipid transporter ABCA12 in harlequin ichthyosis and functional recovery by corrective gene transfer","volume":"115","author":"Akiyama","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.plipres.2010.07.002_bib89","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1373\/49.2.230","article-title":"Real-time reverse transcription-PCR expression profiling of the complete human ATP-binding cassette transporter superfamily in various tissues","volume":"49","author":"Langmann","year":"2003","journal-title":"Clin Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib90","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1111\/j.1471-4159.2004.02941.x","article-title":"Retinal-specific ATP-binding cassette transporter (ABCR\/ABCA4) is expressed at the choroid plexus in rat brain","volume":"92","author":"Bhongsatiern","year":"2005","journal-title":"J Neurochem"},{"key":"10.1016\/j.plipres.2010.07.002_bib91","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1471-4159.2005.03369.x","article-title":"Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain","volume":"95","author":"Tachikawa","year":"2005","journal-title":"J Neurochem"},{"key":"10.1016\/j.plipres.2010.07.002_bib92","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/ng0997-15","article-title":"Stargardt\u2019s ABCR is localized to the disc membrane of retinal rod outer segments [letter]","volume":"17","author":"Sun","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib93","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/77004","article-title":"ABCR expression in foveal cone photoreceptors and its role in Stargardt macular dystrophy","volume":"25","author":"Molday","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib94","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/0042-6989(82)90204-8","article-title":"Cone lamellae and red and green rod outer segment disks contain a large intrinsic membrane protein on their margins: an ultrastructural immunocytochemical study of frog retinas","volume":"22","author":"Papermaster","year":"1982","journal-title":"Vision Res"},{"key":"10.1016\/j.plipres.2010.07.002_bib95","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1083\/jcb.105.6.2589","article-title":"Differences in the protein composition of bovine retinal rod outer segment disk and plasma membranes isolated by a ricin-gold-dextran density perturbation method","volume":"105","author":"Molday","year":"1987","journal-title":"J Cell Biol"},{"key":"10.1016\/j.plipres.2010.07.002_bib96","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/cne.902570104","article-title":"Structural features of the terminal loop region of frog retinal rod outer segment disk membranes: III Implications of the terminal loop complex for disk morphogenesis, membrane fusion, and cell surface interactions","volume":"257","author":"Corless","year":"1987","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.plipres.2010.07.002_bib97","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00239-004-0118-4","article-title":"Evolution of ABCA4 proteins in vertebrates","volume":"60","author":"Yatsenko","year":"2005","journal-title":"J Mol Evol"},{"key":"10.1016\/j.plipres.2010.07.002_bib98","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1074\/mcp.M700571-MCP200","article-title":"Proteomics of photoreceptor outer segments identifies a subset of SNARE and Rab proteins implicated in membrane vesicle trafficking and fusion","volume":"7","author":"Kwok","year":"2008","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.plipres.2010.07.002_bib99","doi-asserted-by":"crossref","first-page":"33178","DOI":"10.1074\/jbc.M204996200","article-title":"Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I","volume":"277","author":"Fitzgerald","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib100","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1432-1033.1988.tb14150.x","article-title":"Topogenic signals in integral membrane proteins","volume":"174","author":"von Heijne","year":"1988","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.plipres.2010.07.002_bib101","doi-asserted-by":"crossref","first-page":"11293","DOI":"10.1074\/jbc.M900580200","article-title":"Formation of two intramolecular disulfide bonds is necessary for ApoA-I-dependent cholesterol efflux mediated by ABCA1","volume":"284","author":"Hozoji","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0033583599003480","article-title":"Nucleoside triphosphate-binding proteins: different scaffolds to achieve phosphoryl transfer","volume":"32","author":"Vetter","year":"1999","journal-title":"Q Rev Biophys"},{"key":"10.1016\/j.plipres.2010.07.002_bib103","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1097-2765(02)00576-2","article-title":"ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer","volume":"10","author":"Smith","year":"2002","journal-title":"Mol Cell"},{"key":"10.1016\/j.plipres.2010.07.002_bib104","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.bbalip.2009.02.004","article-title":"The role of the photoreceptor ABC transporter ABCA4 in lipid transport and Stargardt macular degeneration","volume":"1791","author":"Molday","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.plipres.2010.07.002_bib105","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/j.1460-2075.1982.tb01276.x","article-title":"Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold","volume":"1","author":"Walker","year":"1982","journal-title":"EMBO J"},{"key":"10.1016\/j.plipres.2010.07.002_bib106","doi-asserted-by":"crossref","first-page":"7605","DOI":"10.1021\/bi060308o","article-title":"The conserved tyrosine residues 401 and 1044 in ATP sites of human P-glycoprotein are critical for ATP binding and hydrolysis: evidence for a conserved subdomain, the A-loop in the ATP-binding cassette","volume":"45","author":"Kim","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.plipres.2010.07.002_bib107","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.febslet.2005.12.051","article-title":"The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding","volume":"580","author":"Ambudkar","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1016\/j.plipres.2010.07.002_bib108","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0959-440X(03)00037-X","article-title":"Rad50\/SMC proteins and ABC transporters: unifying concepts from high-resolution structures","volume":"13","author":"Hopfner","year":"2003","journal-title":"Curr Opin Struct Biol"},{"key":"10.1016\/j.plipres.2010.07.002_bib109","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1038\/sj.emboj.7600657","article-title":"H662 is the linchpin of ATP hydrolysis in the nucleotide-binding domain of the ABC transporter HlyB","volume":"24","author":"Zaitseva","year":"2005","journal-title":"EMBO J"},{"key":"10.1016\/j.plipres.2010.07.002_bib110","doi-asserted-by":"crossref","first-page":"8181","DOI":"10.1021\/bi0106686","article-title":"Nucleotide binding domain 1 of the human retinal ABC transporter functions as a general ribonucleotidase","volume":"40","author":"Biswas","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.plipres.2010.07.002_bib111","doi-asserted-by":"crossref","first-page":"15879","DOI":"10.1021\/bi0015966","article-title":"The C-terminal nucleotide binding domain of the human retinal ABCR protein is an adenosine triphosphatase","volume":"39","author":"Biswas","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.plipres.2010.07.002_bib112","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1021\/bi052059u","article-title":"Interaction of the nucleotide binding domains and regulation of the ATPase activity of the human retina specific ABC transporter, ABCR","volume":"45","author":"Biswas-Fiss","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.plipres.2010.07.002_bib113","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1074\/jbc.M806580200","article-title":"Role of the C-terminus of the photoreceptor ABCA4 transporter in protein folding, function and retinal degenerative diseases","volume":"284","author":"Zhong","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib114","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/79994","article-title":"Biochemical defects in ABCR protein variants associated with human retinopathies","volume":"26","author":"Sun","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib115","doi-asserted-by":"crossref","first-page":"39600","DOI":"10.1074\/jbc.M304236200","article-title":"Functional interaction between the two halves of the photoreceptor-specific ATP binding cassette protein ABCR (ABCA4). Evidence for a non-exchangeable ADP in the first nucleotide binding domain","volume":"278","author":"Ahn","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib116","doi-asserted-by":"crossref","first-page":"32670","DOI":"10.1074\/jbc.M109.047415","article-title":"Localization, purification, and functional reconstitution of the P4-ATPase Atp8a2, a phosphatidylserine flippase in photoreceptor disc membranes","volume":"284","author":"Coleman","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib117","doi-asserted-by":"crossref","first-page":"20399","DOI":"10.1074\/jbc.M000555200","article-title":"The effect of lipid environment, retinoids on the ATPase activity of ABCR, the photoreceptor ABC transporter responsible for Stargardt macular dystrophy","volume":"275","author":"Ahn","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib118","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1016\/S0021-9258(19)39690-5","article-title":"Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells","volume":"265","author":"Raviv","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib119","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/0092-8674(94)90446-4","article-title":"Phosphatidylcholine translocase: a physiological role for the mdr2 gene","volume":"77","author":"Ruetz","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.plipres.2010.07.002_bib120","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0092-8674(00)81370-7","article-title":"MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine","volume":"87","author":"van Helvoort","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.plipres.2010.07.002_bib121","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s10863-005-9496-6","article-title":"New insights into the drug binding, transport and lipid flippase activities of the p-glycoprotein multidrug transporter","volume":"37","author":"Sharom","year":"2005","journal-title":"J Bioenerg Biomembr"},{"key":"10.1016\/j.plipres.2010.07.002_bib122","doi-asserted-by":"crossref","first-page":"53972","DOI":"10.1074\/jbc.M405216200","article-title":"N-retinylidene-phosphatidylethanolamine is the preferred retinoid substrate for the photoreceptor-specific ABC transporter ABCA4 (ABCR)","volume":"279","author":"Beharry","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib123","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nsmb836","article-title":"The ATP switch model for ABC transporters","volume":"11","author":"Higgins","year":"2004","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.plipres.2010.07.002_bib124","doi-asserted-by":"crossref","first-page":"7154","DOI":"10.1073\/pnas.130110497","article-title":"Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration","volume":"97","author":"Mata","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.plipres.2010.07.002_bib125","first-page":"1685","article-title":"Delayed dark-adaptation and lipofuscin accumulation in abcr+\/\u2212 mice. implications for involvement of ABCR in age-related macular degeneration","volume":"42","author":"Mata","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib126","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.exer.2005.01.007","article-title":"RPE lipofuscin and its role in retinal pathobiology","volume":"80","author":"Sparrow","year":"2005","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.plipres.2010.07.002_bib127","doi-asserted-by":"crossref","first-page":"20155","DOI":"10.1074\/jbc.M109.021345","article-title":"Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease","volume":"284","author":"Wu","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib128","doi-asserted-by":"crossref","first-page":"19273","DOI":"10.1073\/pnas.0708714104","article-title":"The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model","volume":"104","author":"Kim","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.plipres.2010.07.002_bib129","doi-asserted-by":"crossref","first-page":"7183","DOI":"10.1074\/jbc.M108981200","article-title":"Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin","volume":"277","author":"Ben-Shabat","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib130","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1167\/iovs.07-1499","article-title":"Recovery of rod photoresponses in ABCR-deficient mice","volume":"49","author":"Pawar","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib131","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.1073\/pnas.0308302101","article-title":"Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt\u2019s macular degeneration","volume":"101","author":"Radu","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.plipres.2010.07.002_bib132","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1167\/iovs.07-1470","article-title":"Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation","volume":"49","author":"Radu","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib133","doi-asserted-by":"crossref","first-page":"26684","DOI":"10.1074\/jbc.M804505200","article-title":"Retinopathy in mice induced by disrupted all-trans-retinal clearance","volume":"283","author":"Maeda","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib134","doi-asserted-by":"crossref","first-page":"9855","DOI":"10.1073\/pnas.0708405105","article-title":"How vision begins: an odyssey","volume":"105","author":"Luo","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.plipres.2010.07.002_bib135","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev.physiol.64.082701.102229","article-title":"G proteins and phototransduction","volume":"64","author":"Arshavsky","year":"2002","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.plipres.2010.07.002_bib136","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.preteyeres.2004.03.001","article-title":"Dark adaptation and the retinoid cycle of vision","volume":"23","author":"Lamb","year":"2004","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.plipres.2010.07.002_bib137","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S1350-9462(01)00002-7","article-title":"Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina","volume":"20","author":"McBee","year":"2001","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.plipres.2010.07.002_bib138","first-page":"337","article-title":"Biochemistry of visual pigment regeneration: the Friedenwald lecture","volume":"41","author":"Saari","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib139","doi-asserted-by":"crossref","first-page":"e4382","DOI":"10.1371\/journal.pone.0004382","article-title":"A ligand channel through the G protein coupled receptor opsin","volume":"4","author":"Hildebrand","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.plipres.2010.07.002_bib140","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nature07063","article-title":"Crystal structure of the ligand-free G-protein-coupled receptor opsin","volume":"454","author":"Park","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.plipres.2010.07.002_bib141","doi-asserted-by":"crossref","first-page":"11034","DOI":"10.1074\/jbc.275.15.11034","article-title":"Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol","volume":"275","author":"Rattner","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib142","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/221256a0","article-title":"Lipid to protein chromophore transfer in the photolysis of visual pigments","volume":"221","author":"Poincelot","year":"1969","journal-title":"Nature"},{"key":"10.1016\/j.plipres.2010.07.002_bib143","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1021\/bi00820a019","article-title":"Phospholipids of bovine outer segments","volume":"9","author":"Anderson","year":"1970","journal-title":"Biochemistry"},{"key":"10.1016\/j.plipres.2010.07.002_bib144","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/978-0-387-74904-4_46","article-title":"A2E, a pigment of RPE lipofuscin, is generated from the precursor, A2PE by a lysosomal enzyme activity","volume":"613","author":"Sparrow","year":"2008","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.plipres.2010.07.002_bib145","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-1-4615-0067-4_26","article-title":"A2E, a fluorophore of RPE lipofuscin: can it cause RPE degeneration?","volume":"533","author":"Sparrow","year":"2003","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.plipres.2010.07.002_bib146","first-page":"1981","article-title":"The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells","volume":"41","author":"Sparrow","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib147","first-page":"737","article-title":"Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin","volume":"40","author":"Holz","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib148","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1073\/pnas.052025899","article-title":"The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium","volume":"99","author":"Finnemann","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.plipres.2010.07.002_bib149","doi-asserted-by":"crossref","first-page":"11026","DOI":"10.1073\/pnas.0702504104","article-title":"The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells","volume":"104","author":"Lakkaraju","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.plipres.2010.07.002_bib150","doi-asserted-by":"crossref","first-page":"24770","DOI":"10.1074\/jbc.M800706200","article-title":"The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells","volume":"283","author":"Vives-Bauza","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib151","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1167\/iovs.08-2868","article-title":"Complement activation by bisretinoid constituents of RPE lipofuscin","volume":"50","author":"Zhou","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib152","doi-asserted-by":"crossref","first-page":"20621","DOI":"10.1074\/jbc.271.34.20621","article-title":"Mechanisms of opsin activation","volume":"271","author":"Buczylko","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib153","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1006\/exer.1997.0453","article-title":"Enhancement of opsin activity by all-trans-retinal","volume":"66","author":"Surya","year":"1998","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.plipres.2010.07.002_bib154","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1515\/CCLM.2006.116","article-title":"De novo deletion removes a conserved motif in the C-terminus of ABCA4 and results in cone-rod dystrophy","volume":"44","author":"Stenirri","year":"2006","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.plipres.2010.07.002_bib155","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s004390100583","article-title":"Mutational scanning of the ABCR gene with double-gradient denaturing-gradient gel electrophoresis (DG-DGGE) in Italian Stargardt disease patients","volume":"109","author":"Fumagalli","year":"2001","journal-title":"Hum Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib156","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1093\/hmg\/ddi310","article-title":"ABCA4 mutations causing mislocalization are found frequently in patients with severe retinal dystrophies","volume":"14","author":"Wiszniewski","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib157","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1001\/archopht.1994.01090180063036","article-title":"Clinical features of a Stargardt-like dominant progressive macular dystrophy with genetic linkage to chromosome 6q","volume":"112","author":"Stone","year":"1994","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.plipres.2010.07.002_bib158","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0039-6257(01)00251-X","article-title":"Autosomal dominant Stargardt-like macular dystrophy","volume":"46","author":"Donoso","year":"2001","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.plipres.2010.07.002_bib159","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S0002-9394(98)00331-6","article-title":"Autosomal dominant Stargardt-like macular dystrophy: I. Clinical characterization, longitudinal follow-up, and evidence for a common ancestry in families linked to chromosome 6q14","volume":"127","author":"Edwards","year":"1999","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.plipres.2010.07.002_bib160","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/S0161-6420(90)32508-3","article-title":"Autosomal-dominant fundus flavimaculatus. Clinicopathologic correlation","volume":"97","author":"Lopez","year":"1990","journal-title":"Ophthalmology"},{"key":"10.1016\/j.plipres.2010.07.002_bib161","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1086\/302377","article-title":"A new locus for autosomal dominant Stargardt-like disease maps to chromosome 4","volume":"64","author":"Kniazeva","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.plipres.2010.07.002_bib162","first-page":"3331","article-title":"Diverse macular dystrophy phenotype caused by a novel complex mutation in the ELOVL4 gene","volume":"42","author":"Bernstein","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib163","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1167\/iovs.04-0078","article-title":"A novel mutation in the ELOVL4 gene causes autosomal dominant Stargardt-like macular dystrophy","volume":"45","author":"Maugeri","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib164","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1096\/fasebj.8.15.8001737","article-title":"The animal fatty acid synthase: one gene, one polypeptide, seven enzymes","volume":"8","author":"Smith","year":"1994","journal-title":"FASEB J"},{"key":"10.1016\/j.plipres.2010.07.002_bib165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0163-7827(92)90014-A","article-title":"The fatty acid chain elongation system of mammalian endoplasmic reticulum","volume":"31","author":"Cinti","year":"1992","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.plipres.2010.07.002_bib166","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.plipres.2006.01.004","article-title":"Fatty acid elongases in mammals: their regulation and roles in metabolism","volume":"45","author":"Jakobsson","year":"2006","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.plipres.2010.07.002_bib167","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1388-1981(00)00077-9","article-title":"Metabolism of highly unsaturated n-3 and n-6 fatty acids","volume":"1486","author":"Sprecher","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.plipres.2010.07.002_bib168","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1002\/j.1460-2075.1990.tb07513.x","article-title":"Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum","volume":"9","author":"Jackson","year":"1990","journal-title":"EMBO J"},{"key":"10.1016\/j.plipres.2010.07.002_bib169","doi-asserted-by":"crossref","first-page":"12787","DOI":"10.1021\/bi00209a009","article-title":"Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stearoyl-CoA desaturase, and are conserved in alkane hydroxylase and xylene monooxygenase","volume":"33","author":"Shanklin","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.plipres.2010.07.002_bib170","doi-asserted-by":"crossref","first-page":"12776","DOI":"10.1021\/bi00209a008","article-title":"Resonance Raman evidence for an Fe\u2013O\u2013Fe center in stearoyl-ACP desaturase. Primary sequence identity with other diiron-oxo proteins","volume":"33","author":"Fox","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.plipres.2010.07.002_bib171","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1083\/jcb.149.3.707","article-title":"Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids","volume":"149","author":"Tvrdik","year":"2000","journal-title":"J Cell Biol"},{"issue":"Pt 3","key":"10.1016\/j.plipres.2010.07.002_bib172","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1042\/0264-6021:3500765","article-title":"Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids","volume":"350","author":"Leonard","year":"2000","journal-title":"Biochem J"},{"key":"10.1016\/j.plipres.2010.07.002_bib173","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/978-1-60761-322-0_19","article-title":"Mammalian fatty acid elongases","volume":"579","author":"Jump","year":"2009","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.plipres.2010.07.002_bib174","doi-asserted-by":"crossref","first-page":"8133","DOI":"10.1158\/0008-5472.CAN-09-0775","article-title":"Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism","volume":"69","author":"Tamura","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.plipres.2010.07.002_bib175","doi-asserted-by":"crossref","first-page":"12843","DOI":"10.1073\/pnas.0802607105","article-title":"Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids","volume":"105","author":"Agbaga","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.plipres.2010.07.002_bib176","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1167\/iovs.02-0991","article-title":"Evolutionarily conserved ELOVL4 gene expression in the vertebrate retina","volume":"44","author":"Lagali","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib177","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ygeno.2003.10.004","article-title":"Atrophic macular degeneration mutations in ELOVL4 result in the intracellular misrouting of the protein","volume":"83","author":"Ambasudhan","year":"2004","journal-title":"Genomics"},{"key":"10.1016\/j.plipres.2010.07.002_bib178","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.ygeno.2003.09.020","article-title":"Characterization of mouse orthologue of ELOVL4: genomic organization and spatial and temporal expression","volume":"83","author":"Mandal","year":"2004","journal-title":"Genomics"},{"key":"10.1016\/j.plipres.2010.07.002_bib179","doi-asserted-by":"crossref","first-page":"32521","DOI":"10.1074\/jbc.M503411200","article-title":"Dominant negative mechanism underlies autosomal dominant Stargardt-like macular dystrophy linked to mutations in ELOVL4","volume":"280","author":"Grayson","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib180","doi-asserted-by":"crossref","first-page":"111","DOI":"10.7150\/ijbs.3.111","article-title":"Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival","volume":"3","author":"Cameron","year":"2007","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib181","doi-asserted-by":"crossref","first-page":"120","DOI":"10.7150\/ijbs.3.120","article-title":"Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice","volume":"3","author":"Li","year":"2007","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib182","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1167\/iovs.05-1527","article-title":"Haploinsufficiency is not the key mechanism of pathogenesis in a heterozygous Elovl4 knockout mouse model of STGD3 disease","volume":"47","author":"Raz-Prag","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.plipres.2010.07.002_bib183","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.visres.2006.10.023","article-title":"Elovl4 haploinsufficiency does not induce early onset retinal degeneration in mice","volume":"47","author":"Li","year":"2007","journal-title":"Vision Res"},{"key":"10.1016\/j.plipres.2010.07.002_bib184","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1073\/pnas.0407698102","article-title":"Lipofuscin accumulation, abnormal electrophysiology, and photoreceptor degeneration in mutant ELOVL4 transgenic mice: a model for macular degeneration","volume":"102","author":"Karan","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.plipres.2010.07.002_bib185","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.exer.2009.07.021","article-title":"Elovl4 5-bp deletion knock-in mouse model for Stargardt-like macular degeneration demonstrates accumulation of ELOVL4 and lipofuscin","volume":"89","author":"Vasireddy","year":"2009","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.plipres.2010.07.002_bib186","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.1016\/j.febslet.2007.10.050","article-title":"A Stargardt disease-3 mutation in the mouse Elovl4 gene causes retinal deficiency of C32\u2013C36 acyl phosphatidylcholines","volume":"581","author":"McMahon","year":"2007","journal-title":"FEBS Lett"},{"key":"10.1016\/j.plipres.2010.07.002_bib187","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1095\/biolreprod.106.056556","article-title":"Changes in lipids containing long- and very long-chain polyunsaturated fatty acids in cryptorchid rat testes","volume":"77","author":"Furland","year":"2007","journal-title":"Biol Reprod"},{"key":"10.1016\/j.plipres.2010.07.002_bib188","doi-asserted-by":"crossref","first-page":"18141","DOI":"10.1074\/jbc.M700708200","article-title":"Ceramides and sphingomyelins with high proportions of very long-chain polyunsaturated fatty acids in mammalian germ cells","volume":"282","author":"Furland","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib189","doi-asserted-by":"crossref","first-page":"18151","DOI":"10.1074\/jbc.M700709200","article-title":"Very long-chain polyunsaturated fatty acids are the major acyl groups of sphingomyelins and ceramides in the head of mammalian spermatozoa","volume":"282","author":"Furland","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib190","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/BF02536023","article-title":"Occurrence of long and very long polyenoic fatty acids of the n-9 series in rat spermatozoa","volume":"27","author":"Aveldano","year":"1992","journal-title":"Lipids"},{"key":"10.1016\/j.plipres.2010.07.002_bib191","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/978-1-4615-3426-6_19","article-title":"Long and very long polyunsaturated fatty acids of retina and spermatozoa: the whole complement of polyenoic fatty acid series","volume":"318","author":"Aveldano","year":"1992","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.plipres.2010.07.002_bib192","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1042\/bj2490191","article-title":"Synthesis of very long chain (up to 36 carbon) tetra, penta and hexaenoic fatty acids in retina","volume":"249","author":"Rotstein","year":"1988","journal-title":"Biochem J"},{"key":"10.1016\/j.plipres.2010.07.002_bib193","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/S0021-9258(19)75768-8","article-title":"Very long chain (C24 to C36) polyenoic fatty acids of the n-3 and n-6 series in dipolyunsaturated phosphatidylcholines from bovine retina","volume":"262","author":"Aveldano","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib194","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1042\/bj2350607","article-title":"Detection of a homologous series of C26\u2013C38 polyenoic fatty acids in the brain of patients without peroxisomes (Zellweger\u2019s syndrome)","volume":"235","author":"Poulos","year":"1986","journal-title":"Biochem J"},{"key":"10.1016\/j.plipres.2010.07.002_bib195","doi-asserted-by":"crossref","first-page":"5456","DOI":"10.1016\/j.febslet.2006.08.039","article-title":"Epidermal sphingolipids: metabolism, function, and roles in skin disorders","volume":"580","author":"Holleran","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1016\/j.plipres.2010.07.002_bib196","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1042\/bj2650763","article-title":"Unique molecular species of phosphatidylcholine containing very-long-chain (C24\u2013C38) polyenoic fatty acids in rat brain","volume":"265","author":"Robinson","year":"1990","journal-title":"Biochem J"},{"key":"10.1016\/j.plipres.2010.07.002_bib197","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0163-7827(83)90004-8","article-title":"Chemistry and metabolism of lipids in the vertebrate retina","volume":"22","author":"Fliesler","year":"1983","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.plipres.2010.07.002_bib198","first-page":"1185","article-title":"DHA does not protect ELOVL4 transgenic mice from retinal degeneration","volume":"15","author":"Li","year":"2009","journal-title":"Mol Vis"},{"key":"10.1016\/j.plipres.2010.07.002_bib199","doi-asserted-by":"crossref","unstructured":"McMahon A, Kedzierski W. Polyunsaturated extremely long chain C28\u2013C36 fatty acids and retinal physiology. Br J Ophthalmol 2010 [Epub ahead of print].","DOI":"10.1136\/bjo.2008.149286"},{"key":"10.1016\/j.plipres.2010.07.002_bib200","first-page":"258","article-title":"Retinal pathology and skin barrier defect in mice carrying a Stargardt disease-3 mutation in elongase of very long chain fatty acids-4","volume":"13","author":"McMahon","year":"2007","journal-title":"Mol Vis"},{"key":"10.1016\/j.plipres.2010.07.002_bib201","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/S0021-9258(19)75767-6","article-title":"A novel group of very long chain polyenoic fatty acids in dipolyunsaturated phosphatidylcholines from vertebrate retina","volume":"262","author":"Aveldano","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1016\/j.plipres.2010.07.002_bib202","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1021\/bi00404a024","article-title":"Phospholipid species containing long and very long polyenoic fatty acids remain with rhodopsin after hexane extraction of photoreceptor membranes","volume":"27","author":"Aveldano","year":"1988","journal-title":"Biochemistry"},{"key":"10.1016\/j.plipres.2010.07.002_bib203","first-page":"657","article-title":"Loss of ER retention and sequestration of the wild-type ELOVL4 by Stargardt disease dominant negative mutants","volume":"11","author":"Karan","year":"2005","journal-title":"Mol Vis"},{"key":"10.1016\/j.plipres.2010.07.002_bib204","first-page":"665","article-title":"Stargardt-like macular dystrophy protein ELOVL4 exerts a dominant negative effect by recruiting wild-type protein into aggresomes","volume":"11","author":"Vasireddy","year":"2005","journal-title":"Mol Vis"},{"key":"10.1016\/j.plipres.2010.07.002_bib205","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/gt.2008.78","article-title":"Correction of the disease phenotype in the mouse model of Stargardt disease by lentiviral gene therapy","volume":"15","author":"Kong","year":"2008","journal-title":"Gene Ther"}],"container-title":["Progress in Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163782710000330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163782710000330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T10:55:57Z","timestamp":1635677757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163782710000330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":205,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0163782710000330"],"URL":"https:\/\/doi.org\/10.1016\/j.plipres.2010.07.002","relation":{},"ISSN":["0163-7827"],"issn-type":[{"value":"0163-7827","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}