{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:27:54Z","timestamp":1793312874516,"version":"4.5.0"},"reference-count":163,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Lipid Research"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.plipres.2023.101264","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T02:17:56Z","timestamp":1699237076000},"page":"101264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"special_numbering":"C","title":["The heterogeneity and complexity of skin surface lipids in human skin health and disease"],"prefix":"10.1016","volume":"93","author":[{"given":"Dalibor","family":"Mijaljica","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua P.","family":"Townley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Spada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian P.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.plipres.2023.101264_bb0005","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2114380119","article-title":"Elucidating the molecular landscape of the stratum corneum","volume":"119","author":"Starr","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.plipres.2023.101264_bb0010","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/JDN.0b013e3182274a98","article-title":"Anatomy and physiology of the skin","volume":"3","author":"Kolarsick","year":"2011","journal-title":"J Dermatol Nurses Assoc"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0015","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.0022-202X.2005.23668.x","article-title":"Stratum corneum defensive functions: an integrated view","volume":"125","author":"Elias","year":"2005","journal-title":"J Invest Dermatol"},{"issue":"8","key":"10.1016\/j.plipres.2023.101264_bb0020","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.3390\/ijms20081811","article-title":"The dynamics of the skin\u2019s immune system","volume":"20","author":"Nguyen","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.plipres.2023.101264_bb0025","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3390\/cosmetics8030088","article-title":"Revealing the correlation between altered skin lipids composition and skin disorders","volume":"8","author":"Drakou","year":"2021","journal-title":"Cosmetics"},{"issue":"9","key":"10.1016\/j.plipres.2023.101264_bb0030","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1111\/exd.14396","article-title":"Wound healing applications of creams and \u201csmart\u201d hydrogels","volume":"30","author":"Stan","year":"2021","journal-title":"Exp Dermatol"},{"issue":"1 Suppl","key":"10.1016\/j.plipres.2023.101264_bb0035","doi-asserted-by":"crossref","first-page":"44s","DOI":"10.1038\/jid.1983.12","article-title":"Epidermal lipids, barrier function, and desquamation","volume":"80","author":"Elias","year":"1983","journal-title":"J Invest Dermatol"},{"issue":"12","key":"10.1016\/j.plipres.2023.101264_bb0040","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1194\/jlr.R700013-JLR200","article-title":"Thematic review series: skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis","volume":"48","author":"Feingold","year":"2007","journal-title":"J Lipid Res"},{"issue":"5","key":"10.1016\/j.plipres.2023.101264_bb0045","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1600-0536.2008.01320.x","article-title":"Lipids and skin barrier function \u2013 a clinical perspective","volume":"58","author":"Jungersted","year":"2008","journal-title":"Contact Dermatitis"},{"issue":"9","key":"10.1016\/j.plipres.2023.101264_bb0050","first-page":"22","article-title":"The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin","volume":"4","author":"Del Rosso","year":"2011","journal-title":"J Clin Aesthet Dermatol"},{"key":"10.1016\/j.plipres.2023.101264_bb0055","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/ics.12042","article-title":"Stratum corneum fatty acids: their critical role in preserving barrier integrity during cleansing","volume":"35","author":"Ananthapadmanabhan","year":"2013","journal-title":"Int J Cosmet Sci"},{"issue":"3","key":"10.1016\/j.plipres.2023.101264_bb0060","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.bbalip.2013.11.006","article-title":"The important role of stratum corneum lipids for the cutaneous barrier function","volume":"1841","author":"van Smeden","year":"2014","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"10.1016\/j.plipres.2023.101264_bb0065","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000360009","article-title":"Skin diseases associated with the depletion of stratum corneum lipids and stratum corneum lipid substitution therapy","volume":"28","author":"Sahle","year":"2015","journal-title":"Skin Pharmacol Physiol"},{"key":"10.1016\/j.plipres.2023.101264_bb0070","first-page":"59","article-title":"A botanically derived skin surface lipid mimetic based on the composition of healthy 22-year-old females","volume":"68","author":"Addy","year":"2017","journal-title":"J Cosmet Sci"},{"key":"10.1016\/j.plipres.2023.101264_bb0075","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.plefa.2018.05.001","article-title":"Effects of atopic dermatitis and gender on sebum lipid mediator and fatty acid profiles","volume":"134","author":"Agrawal","year":"2018","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"3","key":"10.1016\/j.plipres.2023.101264_bb0080","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/cosmetics6030052","article-title":"Recent advances on topical application of ceramides to restore barrier function of skin","volume":"6","author":"Kahraman","year":"2019","journal-title":"Cosmetics"},{"issue":"3","key":"10.1016\/j.plipres.2023.101264_bb0085","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1039\/C8CP05706K","article-title":"Mechanisms of lipid extraction from skin lipid bilayers by sebum triglycerides","volume":"21","author":"Tascini","year":"2019","journal-title":"Phys Chem Chem Phys"},{"key":"10.1016\/j.plipres.2023.101264_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemphyslip.2021.105055","article-title":"Skin lipids in health and disease: a review","volume":"236","author":"Knox","year":"2021","journal-title":"Chem Phys Lipids"},{"key":"10.1016\/j.plipres.2023.101264_bb0095","article-title":"Mammalian epidermis: a compendium of lipid functionality","volume":"12","author":"Rudan","year":"2022","journal-title":"Front Physiol"},{"key":"10.1016\/j.plipres.2023.101264_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.110928","article-title":"Stratum corneum lipid matrix with unusual packing: a molecular dynamics study","volume":"190","author":"Antunes","year":"2020","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0105","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3390\/nano12020275","article-title":"Nanodelivery strategies for skin diseases with barrier impairment: focusing on ceramides and glucocorticoids","volume":"12","author":"Almeida","year":"2022","journal-title":"Nanomaterials (Basel)"},{"issue":"4","key":"10.1016\/j.plipres.2023.101264_bb0110","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41385-022-00505-y","article-title":"Skin immunity: dissecting the complex biology of our body\u2019s outer barrier","volume":"15","author":"Zhang","year":"2022","journal-title":"Mucosal Immunol"},{"issue":"12","key":"10.1016\/j.plipres.2023.101264_bb0115","first-page":"30","article-title":"Skin 1: the structure and functions of the skin","volume":"115","author":"Lawton","year":"2019","journal-title":"Nurs Times"},{"issue":"8","key":"10.1016\/j.plipres.2023.101264_bb0120","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.3390\/ijms21082867","article-title":"Skin barrier abnormalities and immune dysfunction in atopic dermatitis","volume":"21","author":"Yang","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.plipres.2023.101264_bb0125","first-page":"1","article-title":"Lipid-based formulations in cosmeceuticals and biopharmaceuticals","volume":"4","author":"Ahmad","year":"2020","journal-title":"Biomed Dermatol"},{"issue":"6","key":"10.1016\/j.plipres.2023.101264_bb0130","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/intimm\/dxv013","article-title":"Dissecting the formation, structure and barrier function of the stratum corneum","volume":"27","author":"Matsui","year":"2015","journal-title":"Int Immunol"},{"key":"10.1016\/j.plipres.2023.101264_bb0135","doi-asserted-by":"crossref","first-page":"5954034","DOI":"10.1155\/2018\/5954034","article-title":"Lipids and the permeability and antimicrobial barriers of the skin","volume":"2018","author":"Wertz","year":"2018","journal-title":"J Lipids"},{"issue":"17","key":"10.1016\/j.plipres.2023.101264_bb0140","first-page":"1","article-title":"Ceramides metabolism and impaired epidermal barrier in cutaneous diseases and skin aging: focus on the role of the enzyme PNPLA1 in the synthesis of v-O-acylceramides and its pathophysiological involvement in some forms of congenital ichthyoses","volume":"26","author":"Jonca","year":"2019","journal-title":"OCL"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0145","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4161\/derm.3.2.14995","article-title":"The expression and regulation of enzymes mediating the biosynthesis of triglycerides and phospholipids in keratinocytes\/epidermis","volume":"3","author":"Jiang","year":"2011","journal-title":"Dermatoendocrinol"},{"key":"10.1016\/j.plipres.2023.101264_bb0150","first-page":"10","article-title":"The lipid organisation in human stratum corneum and model systems","volume":"4","author":"Bouwstra","year":"2010","journal-title":"Open Dermatol J"},{"key":"10.1016\/j.plipres.2023.101264_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.05.012","article-title":"Human skin equivalents: impaired barrier function in relation to the lipid and protein properties of the stratum corneum","volume":"175","author":"Bouwstra","year":"2021","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.plipres.2023.101264_bb0160","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jcis.2021.07.012","article-title":"Extraction of natural moisturizing factor from the stratum corneum and its implication on skin molecular mobility","volume":"604","author":"Gunnarsson","year":"2021","journal-title":"J Colloid Interface Sci"},{"key":"10.1016\/j.plipres.2023.101264_bb0165","first-page":"43","article-title":"Skin lipids: their origin and function","volume":"3","author":"Bont\u00e9","year":"1999","journal-title":"Recent Res Dev Lipid Res"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0170","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4161\/derm.1.2.7811","article-title":"Epidermal surface lipids","volume":"1","author":"Pappas","year":"2009","journal-title":"Dermatoendocrinol"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0175","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4161\/derm.1.2.8472","article-title":"Sebaceous gland lipids","volume":"1","author":"Picardo","year":"2009","journal-title":"Dermatoendocrinol"},{"issue":"11","key":"10.1016\/j.plipres.2023.101264_bb0180","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1194\/jlr.D008391","article-title":"Comprehensive analysis of the major lipid classes in sebum by rapid resolution high-performance liquid chromatography and electrospray mass spectrometry","volume":"51","author":"Camera","year":"2010","journal-title":"J Lipid Res"},{"issue":"12","key":"10.1016\/j.plipres.2023.101264_bb0185","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1600-0625.2008.00786.x","article-title":"The skin: an indispensable barrier","volume":"17","author":"Proksch","year":"2008","journal-title":"Exp Dermatol"},{"issue":"9","key":"10.1016\/j.plipres.2023.101264_bb0190","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.3390\/cells10092386","article-title":"The pathogenic and therapeutic implications of ceramide abnormalities in atopic dermatitis","volume":"10","author":"Fujii","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.plipres.2023.101264_bb0195","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bpj.2017.10.031","article-title":"Effect of ceramide tail length on the structure of model stratum corneum lipid bilayers","volume":"114","author":"Moore","year":"2018","journal-title":"Biophys J"},{"issue":"3","key":"10.1016\/j.plipres.2023.101264_bb0200","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000464337","article-title":"Potential applications of phyto-derived ceramides in improving epidermal barrier function","volume":"30","author":"Tessema","year":"2017","journal-title":"Skin Pharmacol Physiol"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0205","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4161\/derm.3.2.14662","article-title":"The role of fatty acid elongation in epidermal structure and function","volume":"3","author":"Uchida","year":"2011","journal-title":"Dermatoendocrinol"},{"issue":"7","key":"10.1016\/j.plipres.2023.101264_bb0210","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1194\/jlr.M800014-JLR200","article-title":"Characterization of overall ceramide species in human stratum corneum","volume":"49","author":"Masukawa","year":"2008","journal-title":"J Lipid Res"},{"issue":"3_suppl","key":"10.1016\/j.plipres.2023.101264_bb0215","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1177\/1091581820958692","article-title":"Safety assessment of ceramides as used in cosmetics","volume":"39","author":"Burnett","year":"2020","journal-title":"Int J Toxicol"},{"issue":"1","key":"10.1016\/j.plipres.2023.101264_bb0220","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.chemphyslip.2009.10.007","article-title":"Impact of the long chain omega-acylceramides on the stratum corneum lipid nanostructure. Part 1: thermotropic phase behaviour of CER[EOS] and CER[EOP] studied using X-ray powder diffraction and FT-Raman spectroscopy","volume":"163","author":"Kessner","year":"2010","journal-title":"Chem Phys Lipids"},{"issue":"6","key":"10.1016\/j.plipres.2023.101264_bb0225","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/ics.12162","article-title":"The physical chemistry of the stratum corneum lipids","volume":"36","author":"Boncheva","year":"2014","journal-title":"Int J Cosmet Sci"},{"issue":"5","key":"10.1016\/j.plipres.2023.101264_bb0230","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/1523-1747.ep12265510","article-title":"The composition of the ceramides from human stratum corneum and from comedones","volume":"84","author":"Wertz","year":"1985","journal-title":"J Invest Dermatol"},{"issue":"1","key":"10.1016\/j.plipres.2023.101264_bb0235","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/00015559850135788","article-title":"Ceramide and cholesterol composition of the skin of patients with atopic dermatitis","volume":"78","author":"Di Nardo","year":"1998","journal-title":"Acta Derm Venereol"},{"issue":"6","key":"10.1016\/j.plipres.2023.101264_bb0240","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1194\/jlr.M014456","article-title":"LC\/MS analysis of stratum corneum lipids: ceramide profiling and discovery","volume":"52","author":"van Smeden","year":"2011","journal-title":"J Lipid Res"},{"issue":"1","key":"10.1016\/j.plipres.2023.101264_bb0245","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1021\/ac202646v","article-title":"Profiling and characterizing skin ceramides using reversed-phase liquid chromatography-quadrupole time-of-flight mass spectrometry","volume":"84","author":"t\u2019Kindt","year":"2012","journal-title":"Anal Chem"},{"issue":"6","key":"10.1016\/j.plipres.2023.101264_bb0250","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1194\/jlr.RA120000671","article-title":"Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC\/MS\/MS","volume":"61","author":"Kawana","year":"2020","journal-title":"J Lipid Res"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0255","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1515\/afpuc-2017-0004","article-title":"Ceramides in the skin barrier","volume":"64","author":"V\u00e1vrov\u00e1","year":"2017","journal-title":"Eur Pharm J"},{"issue":"9 Pt B","key":"10.1016\/j.plipres.2023.101264_bb0260","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/j.bbamem.2017.03.016","article-title":"Lipid functions in skin: differential effects of n-3 polyunsaturated fatty acids on cutaneous ceramides, in a human skin organ culture model","volume":"1859","author":"Kendall","year":"2017","journal-title":"Biochim Biophys Acta Biomembr"},{"issue":"1","key":"10.1016\/j.plipres.2023.101264_bb0265","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3892\/ijmm.2016.2600","article-title":"Intercellular and intracellular functions of ceramides and their metabolites in skin (review)","volume":"38","author":"Cha","year":"2016","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.plipres.2023.101264_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2022.101184","article-title":"Using molecular simulation to understand the skin barrier","volume":"88","author":"Shamaprasad","year":"2022","journal-title":"Prog Lipid Res"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0275","first-page":"63","article-title":"Developments in ceramide identification, synthesis, function and nomenclature","volume":"124","author":"Farwick","year":"2009","journal-title":"Cosmetics and Toiletries Magazine"},{"issue":"4","key":"10.1016\/j.plipres.2023.101264_bb0280","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/ics.12399","article-title":"The chemistry, function and (patho)physiology of stratum corneum barrier ceramides","volume":"39","author":"Moore","year":"2017","journal-title":"Int J Cosmet Sci"},{"issue":"6","key":"10.1016\/j.plipres.2023.101264_bb0285","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1007\/s13555-021-00622-9","article-title":"Letter to the editor regarding \u2018an investigation of the skin barrier restoring effects of a cream and lotion containing ceramides in a multi-vesicular emulsion in people with dry, eczema-prone skin: the RESTORE study phase 1\u2019","volume":"11","author":"Rawlings","year":"2021","journal-title":"Dermatol Ther (Heidelb)"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0290","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2165\/00128071-200304020-00004","article-title":"Ceramides and skin function","volume":"4","author":"Coderch","year":"2003","journal-title":"Am J Clin Dermatol"},{"issue":"4","key":"10.1016\/j.plipres.2023.101264_bb0295","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.3390\/ijms23042121","article-title":"Atopic dermatitis: the fate of the fat","volume":"23","author":"Pavel","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.plipres.2023.101264_bb0300","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/BF02505294","article-title":"Stratum corneum lipids: the effect of ageing and the seasons","volume":"288","author":"Rogers","year":"1996","journal-title":"Arch Dermatol Res"},{"issue":"1","key":"10.1016\/j.plipres.2023.101264_bb0305","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jid.2021.09.017","article-title":"Research techniques made simple: lipidomic analysis in skin research","volume":"142","author":"Sochorov\u00e1","year":"2022","journal-title":"J Invest Dermatol"},{"issue":"16","key":"10.1016\/j.plipres.2023.101264_bb0310","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.159762","article-title":"Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes","volume":"7","author":"Merleev","year":"2022","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.plipres.2023.101264_bb0315","doi-asserted-by":"crossref","first-page":"11500","DOI":"10.1038\/s41598-018-29742-7","article-title":"Influence of the sebaceous gland density on the stratum corneum lipidome","volume":"8","author":"Ludovici","year":"2018","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.plipres.2023.101264_bb0320","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1080\/10408347.2017.1310613","article-title":"Analytical techniques in lipidomics: state of the art","volume":"47","author":"Jurowski","year":"2017","journal-title":"Crit Rev Anal Chem"},{"issue":"7","key":"10.1016\/j.plipres.2023.101264_bb0325","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.3390\/ijms22073679","article-title":"The importance of free fatty chain length on the lipid organization in the long periodicity phase","volume":"22","author":"Beddoes","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0330","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0022-2275(20)38005-6","article-title":"Human stratum corneum lipids: characterization and regional variations","volume":"24","author":"Lampe","year":"1983","journal-title":"J Lipid Res"},{"issue":"1","key":"10.1016\/j.plipres.2023.101264_bb0335","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/1523-1747.ep12523574","article-title":"Free fatty acids and fatty acids of triacylglycerols in normal and hyperkeratotic human stratum corneum","volume":"87","author":"Nicollier","year":"1986","journal-title":"J Invest Dermatol"},{"issue":"9","key":"10.1016\/j.plipres.2023.101264_bb0340","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1007\/s004030050344","article-title":"A new HPLC-based method for the quantitative analysis of inner stratum corneum lipids with special reference to the free fatty acid fraction","volume":"290","author":"Norl\u00e9n","year":"1998","journal-title":"Arch Dermatol Res"},{"issue":"4","key":"10.1016\/j.plipres.2023.101264_bb0345","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1046\/j.1523-1747.2003.12103.x","article-title":"New acylceramide in native and reconstructed epidermis","volume":"120","author":"Ponec","year":"2003","journal-title":"J Invest Dermatol"},{"issue":"1","key":"10.1016\/j.plipres.2023.101264_bb0350","doi-asserted-by":"crossref","first-page":"16683","DOI":"10.1038\/s41598-018-34286-x","article-title":"Imaging the distribution of skin lipids and topically applied compounds in human skin using mass spectrometry","volume":"8","author":"Sj\u00f6vall","year":"2018","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.plipres.2023.101264_bb0355","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/jocd.12245","article-title":"Advancements in the maintenance of skin barrier\/skin lipid composition and the involvement of metabolic enzymes","volume":"15","author":"Cui","year":"2016","journal-title":"J Cosmet Dermatol"},{"key":"10.1016\/j.plipres.2023.101264_bb0360","series-title":"Dry skin and moisturizers: chemistry and function","first-page":"23","article-title":"Epidermal lipids and formation of the barrier of the skin","author":"Wertz","year":"2006"},{"key":"10.1016\/j.plipres.2023.101264_bb0365","doi-asserted-by":"crossref","first-page":"43761","DOI":"10.1038\/srep43761","article-title":"Large-scale human skin lipidomics by quantitative, high-throughput shotgun mass spectrometry","volume":"7","author":"Sadowski","year":"2017","journal-title":"Sci Rep"},{"issue":"7","key":"10.1016\/j.plipres.2023.101264_bb0370","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1194\/jlr.R300005-JLR200","article-title":"Cholesterol sulfate in human physiology: what\u2019s it all about?","volume":"44","author":"Strott","year":"2003","journal-title":"J Lipid Res"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0375","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/jidsymp.1998.17","article-title":"pH, cholesterol sulfate, and fatty acids affect the stratum corneum lipid organization","volume":"3","author":"Bouwstra","year":"1998","journal-title":"J Investig Dermatol Symp Proc"},{"issue":"4","key":"10.1016\/j.plipres.2023.101264_bb0380","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000509019","article-title":"State of the art in stratum corneum research. Part II: hypothetical stratum corneum lipid matrix models","volume":"33","author":"Schmitt","year":"2020","journal-title":"Skin Pharmacol Physiol"},{"issue":"4","key":"10.1016\/j.plipres.2023.101264_bb0385","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2340\/00015555-2865","article-title":"Degree of skin barrier disruption affects lipid organization in regenerated stratum corneum","volume":"98","author":"Berkers","year":"2018","journal-title":"Acta Derm Venereol"},{"issue":"6","key":"10.1016\/j.plipres.2023.101264_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2022.183886","article-title":"The importance of ceramide headgroup for lipid localisation in skin lipid models","volume":"1864","author":"Beddoes","year":"2022","journal-title":"Biochim Biophys Acta Biomembr"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0395","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0005-2736(99)00057-7","article-title":"The role of ceramide composition in the lipid organisation of the skin barrier","volume":"1419","author":"Bouwstra","year":"1999","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"10.1016\/j.plipres.2023.101264_bb0400","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1529\/biophysj.106.094292","article-title":"Infrared spectroscopic study of stratum corneum model membranes prepared from human ceramides, cholesterol, and fatty acids","volume":"92","author":"Gooris","year":"2007","journal-title":"Biophys J"},{"issue":"5","key":"10.1016\/j.plipres.2023.101264_bb0405","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.bbamem.2008.01.022","article-title":"Molecular organization of the lipid matrix in intact stratum corneum using ATR-FTIR spectroscopy","volume":"1778","author":"Boncheva","year":"2008","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"10.1016\/j.plipres.2023.101264_bb0410","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1046\/j.1523-1747.2002.01706.x","article-title":"Phase behavior of stratum corneum lipid mixtures based on human ceramides: the role of natural and synthetic ceramide 1","volume":"118","author":"Bouwstra","year":"2002","journal-title":"J Invest Dermatol"},{"issue":"3","key":"10.1016\/j.plipres.2023.101264_bb0415","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s11095-017-2288-y","article-title":"Topically applied ceramides interact with the stratum corneum lipid matrix in compromised ex vivo skin","volume":"35","author":"Berkers","year":"2018","journal-title":"Pharm Res"},{"issue":"3","key":"10.1016\/j.plipres.2023.101264_bb0420","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1046\/j.1523-1747.1999.00706.x","article-title":"Electron diffraction provides new information on human stratum corneum lipid organization studied in relation to depth and temperature","volume":"113","author":"Pilgram","year":"1999","journal-title":"J Invest Dermatol"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0425","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/jid.2009.272","article-title":"The extent of orthorhombic lipid phases in the stratum corneum determines the barrier efficiency of human skin in vivo","volume":"130","author":"Damien","year":"2010","journal-title":"J Invest Dermatol"},{"issue":"12","key":"10.1016\/j.plipres.2023.101264_bb0430","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1194\/jlr.P030338","article-title":"Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients","volume":"53","author":"Janssens","year":"2012","journal-title":"J Lipid Res"},{"issue":"5","key":"10.1016\/j.plipres.2023.101264_bb0435","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202100021","article-title":"The fine-tuning of cell membrane lipid bilayers accentuates their compositional complexity","volume":"43","author":"Dingjan","year":"2021","journal-title":"Bioessays"},{"issue":"Pt 1","key":"10.1016\/j.plipres.2023.101264_bb0440","first-page":"65","article-title":"Freeze-fracture replication of cells of stratum corneum of human epidermis","volume":"114","author":"Breathnach","year":"1973","journal-title":"J Anat"},{"issue":"6","key":"10.1016\/j.plipres.2023.101264_bb0445","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/1523-1747.ep12470386","article-title":"Presence of intact intercellular lipid lamellae in the upper layers of the stratum corneum","volume":"88","author":"Madison","year":"1987","journal-title":"J Invest Dermatol"},{"issue":"3","key":"10.1016\/j.plipres.2023.101264_bb0450","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/dermato2030009","article-title":"Stratum corneum structure and function studied by X-ray diffraction","volume":"2","author":"Hatta","year":"2022","journal-title":"Dermato"},{"issue":"12","key":"10.1016\/j.plipres.2023.101264_bb0455","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1016\/j.bbamem.2006.06.021","article-title":"The skin barrier in healthy and diseased state","volume":"1758","author":"Bouwstra","year":"2006","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"10.1016\/j.plipres.2023.101264_bb0460","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1016\/j.bbamem.2016.05.006","article-title":"Stratum corneum lipid matrix: location of acyl ceramide and cholesterol in the unit cell of the long periodicity phase","volume":"1858","author":"Mojumdar","year":"2016","journal-title":"Biochim Biophys Acta"},{"issue":"9","key":"10.1016\/j.plipres.2023.101264_bb0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2022.100258","article-title":"Phytosphingosine ceramide mainly localizes in the central layer of the unique lamellar phase of skin lipid model systems","volume":"63","author":"N\u0103d\u0103ban","year":"2022","journal-title":"J Lipid Res"},{"issue":"4","key":"10.1016\/j.plipres.2023.101264_bb0470","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/jid.2001.1","article-title":"Skin barrier structure and function: the single gel phase model","volume":"117","author":"Norl\u00e9n","year":"2001","journal-title":"J Invest Dermatol"},{"issue":"7","key":"10.1016\/j.plipres.2023.101264_bb0475","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/j.bpj.2009.06.054","article-title":"Simulation studies of stratum corneum lipid mixtures","volume":"97","author":"Das","year":"2009","journal-title":"Biophys J"},{"issue":"9","key":"10.1016\/j.plipres.2023.101264_bb0480","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1038\/jid.2012.43","article-title":"The human skin barrier is organized as stacked bilayers of fully extended ceramides with cholesterol molecules associated with the ceramide sphingoid moiety","volume":"132","author":"Iwai","year":"2012","journal-title":"J Invest Dermatol"},{"issue":"40","key":"10.1016\/j.plipres.2023.101264_bb0485","doi-asserted-by":"crossref","first-page":"17383","DOI":"10.1002\/anie.202003375","article-title":"The sphingosine and acyl chains of ceramide [NS] show very different structure and dynamics that challenge our understanding of the skin barrier","volume":"59","author":"Engberg","year":"2020","journal-title":"Angew Chem Int Ed Engl"},{"issue":"11","key":"10.1016\/j.plipres.2023.101264_bb0490","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1039\/C9MD00364A","article-title":"Lipidomic analysis as a tool for identifying susceptibility to various skin diseases","volume":"10","author":"Smirnov","year":"2019","journal-title":"Medchemcomm"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0495","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1194\/jlr.R700015-JLR200","article-title":"Thematic review series: skin lipids. Sebaceous gland lipids: friend or foe?","volume":"49","author":"Smith","year":"2008","journal-title":"J Lipid Res"},{"issue":"1","key":"10.1016\/j.plipres.2023.101264_bb0500","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3390\/molecules14010540","article-title":"Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology","volume":"14","author":"Huang","year":"2009","journal-title":"Molecules"},{"key":"10.1016\/j.plipres.2023.101264_bb0505","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/321494","article-title":"Surface lipids as multifunctional mediators of skin responses to environmental stimuli","volume":"2010","author":"De Luca","year":"2010","journal-title":"Mediators Inflamm"},{"issue":"1","key":"10.1016\/j.plipres.2023.101264_bb0510","doi-asserted-by":"crossref","DOI":"10.1080\/19381980.2017.1375636","article-title":"Sebaceous-immunobiology is orchestrated by sebum lipids","volume":"9","author":"Lov\u00e1szi","year":"2017","journal-title":"Dermatoendocrinol"},{"issue":"3","key":"10.1016\/j.plipres.2023.101264_bb0515","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4161\/derm.1.3.8473","article-title":"Sebum analysis of individuals with and without acne","volume":"1","author":"Pappas","year":"2009","journal-title":"Dermatoendocrinol"},{"key":"10.1016\/j.plipres.2023.101264_bb0520","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.acc.2016.11.001","article-title":"Triglycerides revisited to the serial","volume":"80","author":"Viecili","year":"2017","journal-title":"Adv Clin Chem"},{"issue":"20","key":"10.1016\/j.plipres.2023.101264_bb0525","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1007\/s00018-015-1982-3","article-title":"DAG tales: the multiple faces of diacylglycerol\u2013stereochemistry, metabolism, and signaling","volume":"72","author":"Eichmann","year":"2015","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"10.1016\/j.plipres.2023.101264_bb0530","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1194\/jlr.R700016-JLR200","article-title":"Thematic review series: skin lipids. Antimicrobial lipids at the skin surface","volume":"49","author":"Drake","year":"2008","journal-title":"J Lipid Res"},{"issue":"1","key":"10.1016\/j.plipres.2023.101264_bb0535","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s12944-018-0844-z","article-title":"Sebomic identification of sex- and ethnicity-specific variations in residual skin surface components (RSSC) for bio-monitoring or forensic applications","volume":"17","author":"Shetage","year":"2018","journal-title":"Lipids Health Dis"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0540","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4161\/derm.25366","article-title":"Age and ethnic variations in sebaceous lipids","volume":"5","author":"Pappas","year":"2013","journal-title":"Dermatoendocrinol"},{"issue":"1","key":"10.1016\/j.plipres.2023.101264_bb0545","doi-asserted-by":"crossref","first-page":"E19","DOI":"10.1152\/ajpendo.90898.2008","article-title":"The genetics of neutral lipid biosynthesis: an evolutionary perspective","volume":"297","author":"Turkish","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.plipres.2023.101264_bb0550","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1021\/op5002337","article-title":"Catalytic hydrogenation of squalene to squalane","volume":"18","author":"Ciriminna","year":"2014","journal-title":"Org Process Res Dev"},{"issue":"4","key":"10.1016\/j.plipres.2023.101264_bb0555","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/ics.12208","article-title":"Oxidization of squalene, a human skin lipid: a new and reliable marker of environmental pollution studies","volume":"37","author":"Pham","year":"2015","journal-title":"Int J Cosmet Sci"},{"issue":"8","key":"10.1016\/j.plipres.2023.101264_bb0560","doi-asserted-by":"crossref","first-page":"688","DOI":"10.3390\/antiox9080688","article-title":"Squalene: more than a step toward sterols","volume":"9","author":"Micera","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.plipres.2023.101264_bb0565","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/858176","article-title":"Lipid mediators in acne","volume":"2010","author":"Ottaviani","year":"2010","journal-title":"Mediators Inflamm"},{"issue":"8","key":"10.1016\/j.plipres.2023.101264_bb0570","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1038\/jid.2009.133","article-title":"Epidermal barrier dysfunction in atopic dermatitis","volume":"129","author":"Cork","year":"2009","journal-title":"J Invest Dermatol"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0575","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/srt.12424","article-title":"The relationship between skin function, barrier properties, and body-dependent factors","volume":"24","author":"D\u0105browska","year":"2018","journal-title":"Skin Res Technol"},{"issue":"6","key":"10.1016\/j.plipres.2023.101264_bb0580","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/j.1523-1747.2005.23726.x","article-title":"Stratum corneum moisturization at the molecular level: an update in relation to the dry skin cycle","volume":"124","author":"Rawlings","year":"2005","journal-title":"J Invest Dermatol"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0585","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00403-012-1286-5","article-title":"Variations in the ceramide profile in different seasons and regions of the body contribute to stratum corneum functions","volume":"305","author":"Ishikawa","year":"2013","journal-title":"Arch Dermatol Res"},{"issue":"8","key":"10.1016\/j.plipres.2023.101264_bb0590","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/exd.13499","article-title":"Seasonal changes in epidermal ceramides are linked to impaired barrier function in acne patients","volume":"27","author":"Pappas","year":"2018","journal-title":"Exp Dermatol"},{"issue":"6","key":"10.1016\/j.plipres.2023.101264_bb0595","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.18632\/aging.102946","article-title":"Aging-associated alterations in epidermal function and their clinical significance","volume":"12","author":"Wang","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"6","key":"10.1016\/j.plipres.2023.101264_bb0600","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.3390\/molecules27062010","article-title":"Skin cleansing without or with compromise: soaps and syndets","volume":"27","author":"Mijaljica","year":"2022","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.plipres.2023.101264_bb0605","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1529\/biophysj.106.096164","article-title":"Direct visualization of lipid domains in human skin stratum corneum\u2019s lipid membranes: effect of pH and temperature","volume":"93","author":"Plasencia","year":"2007","journal-title":"Biophys J"},{"issue":"6","key":"10.1016\/j.plipres.2023.101264_bb0610","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1159\/000094670","article-title":"The pH of the skin surface and its impact on the barrier function","volume":"19","author":"Schmid-Wendtner","year":"2006","journal-title":"Skin Pharmacol Physiol"},{"issue":"9","key":"10.1016\/j.plipres.2023.101264_bb0615","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/1346-8138.14489","article-title":"pH in nature, humans and skin","volume":"45","author":"Proksch","year":"2018","journal-title":"J Dermatol"},{"issue":"4","key":"10.1016\/j.plipres.2023.101264_bb0620","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1021\/la026601g","article-title":"Modulation of the polymorphism of the palmitic acid\/cholesterol system by the pH","volume":"19","author":"Ouimet","year":"2003","journal-title":"Langmuir"},{"key":"10.1016\/j.plipres.2023.101264_bb0625","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/535612","article-title":"Lipid disturbances in psoriasis: an update","volume":"2010","author":"Pietrzak","year":"2010","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.plipres.2023.101264_bb0630","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12944-016-0178-7","article-title":"The role of epidermal sphingolipids in dermatologic diseases","volume":"15","author":"Borodzicz","year":"2016","journal-title":"Lipids Health Dis"},{"issue":"5","key":"10.1016\/j.plipres.2023.101264_bb0635","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/14789450.2016.1177462","article-title":"Lipidomic analysis of epidermal lipids: a tool to predict progression of inflammatory skin disease in humans","volume":"13","author":"Li","year":"2016","journal-title":"Expert Rev Proteomics"},{"issue":"12","key":"10.1016\/j.plipres.2023.101264_bb0640","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0261253","article-title":"Molecular characterization of xerosis cutis: a systematic review","volume":"16","author":"Amin","year":"2021","journal-title":"PloS One"},{"issue":"10","key":"10.1016\/j.plipres.2023.101264_bb0645","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1111\/exd.14185","article-title":"Stratum corneum lipidomics analysis reveals altered ceramide profile in atopic dermatitis patients across body sites with correlated changes in skin microbiome","volume":"30","author":"Emmert","year":"2021","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.plipres.2023.101264_bb0650","doi-asserted-by":"crossref","first-page":"44","DOI":"10.25259\/CSDM_33_2021","article-title":"Ceramides: where do we stand?","volume":"1","author":"Yadav","year":"2021","journal-title":"CosmoDerma"},{"issue":"4","key":"10.1016\/j.plipres.2023.101264_bb0655","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3390\/cosmetics9040075","article-title":"A review of moisturizing additives for atopic dermatitis","volume":"9","author":"Vanessa","year":"2022","journal-title":"Cosmetics"},{"issue":"4","key":"10.1016\/j.plipres.2023.101264_bb0660","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/1523-1747.ep12470233","article-title":"Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin?","volume":"96","author":"Imokawa","year":"1991","journal-title":"J Invest Dermatol"},{"issue":"4","key":"10.1016\/j.plipres.2023.101264_bb0665","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.3390\/ijms22041613","article-title":"Cutting edge of the pathogenesis of atopic dermatitis: sphingomyelin deacylase, the enzyme involved in its ceramide deficiency, plays a pivotal role","volume":"22","author":"Imokawa","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0670","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1194\/jlr.RA119000420","article-title":"Effects of omega-O-acylceramide structures and concentrations in healthy and diseased skin barrier lipid membrane models","volume":"61","author":"Op\u00e1lka","year":"2020","journal-title":"J Lipid Res"},{"issue":"3","key":"10.1016\/j.plipres.2023.101264_bb0675","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.jid.2016.10.034","article-title":"As in atopic dermatitis, nonlesional skin in allergic contact dermatitis displays abnormalities in barrier function and ceramide content","volume":"137","author":"Kim","year":"2017","journal-title":"J Invest Dermatol"},{"issue":"8","key":"10.1016\/j.plipres.2023.101264_bb0680","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2023.100400","article-title":"Effect of sphingosine and phytosphingosine ceramide ratio on lipid arrangement and barrier function in skin lipid models","volume":"64","author":"N\u0103d\u0103ban","year":"2023","journal-title":"J Lipid Res"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0685","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1365-2222.2006.02433.x","article-title":"Abnormal fatty acid profiles occur in atopic dermatitis but what do they mean?","volume":"36","author":"Calder","year":"2006","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.plipres.2023.101264_bb0690","series-title":"Psoriasis \u2013 new research","first-page":"139","article-title":"Topical moisturisers for the management of psoriasis vulgaris","author":"Mijaljica","year":"2022"},{"issue":"3","key":"10.1016\/j.plipres.2023.101264_bb0695","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/jid.2013.364","article-title":"Interferon-\u03b3 decreases ceramides with long-chain fatty acids: possible involvement in atopic dermatitis and psoriasis","volume":"134","author":"Tawada","year":"2014","journal-title":"J Invest Dermatol"},{"issue":"1","key":"10.1016\/j.plipres.2023.101264_bb0700","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12895-020-00102-1","article-title":"The ceramide [NP]\/[NS] ratio in the stratum corneum is a potential marker for skin properties and epidermal differentiation","volume":"20","author":"Yokose","year":"2020","journal-title":"BMC Dermatol"},{"issue":"9","key":"10.1016\/j.plipres.2023.101264_bb0705","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0001-7310(08)76171-4","article-title":"Xerosis: una disfunci\u00f3n de la barrera epid\u00e9rmica [Xerosis: a dysfunction of the epidermal barrier]","volume":"99","author":"Barco","year":"2008","journal-title":"Actas Dermosifiliogr"},{"issue":"1","key":"10.1016\/j.plipres.2023.101264_bb0710","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s13023-022-02430-6","article-title":"New developments in the molecular treatment of ichthyosis: review of the literature","volume":"17","author":"Joosten","year":"2022","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.plipres.2023.101264_bb0715","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.yadr.2007.07.011","article-title":"Ichthyosis update: towards a function-driven model of pathogenesis of the disorders of cornification and the role of corneocyte proteins in these disorders","volume":"23","author":"Schmuth","year":"2007","journal-title":"Adv Dermatol"},{"issue":"8","key":"10.1016\/j.plipres.2023.101264_bb0720","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.3390\/molecules21081063","article-title":"Treatment modalities for acne","volume":"21","author":"Fox","year":"2016","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.plipres.2023.101264_bb0725","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2165\/00128071-200304110-00005","article-title":"Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders","volume":"4","author":"Lod\u00e9n","year":"2003","journal-title":"Am J Clin Dermatol"},{"issue":"4","key":"10.1016\/j.plipres.2023.101264_bb0730","doi-asserted-by":"crossref","DOI":"10.1111\/dth.14970","article-title":"A daily regimen of a ceramide-dominant moisturizing cream and cleanser restores the skin permeability barrier in adults with moderate eczema: a randomized trial","volume":"34","author":"Spada","year":"2021","journal-title":"Dermatol Ther"},{"issue":"3","key":"10.1016\/j.plipres.2023.101264_bb0735","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3390\/cosmetics8030069","article-title":"Towards optimal pH of the skin and topical formulations: from the current state of the art to tailored products","volume":"8","author":"Luki\u0107","year":"2021","journal-title":"Cosmetics"},{"issue":"3","key":"10.1016\/j.plipres.2023.101264_bb0740","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.bbalip.2013.10.001","article-title":"Lipid abnormalities and lipid-based repair strategies in atopic dermatitis","volume":"1841","author":"Elias","year":"2014","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"10.1016\/j.plipres.2023.101264_bb0745","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/bjd.21294","article-title":"Topical application of lipids to correct abnormalities in the epidermal lipid barrier","volume":"186","author":"Kendall","year":"2022","journal-title":"Br J Dermatol"},{"issue":"4","key":"10.1016\/j.plipres.2023.101264_bb0750","doi-asserted-by":"crossref","first-page":"175","DOI":"10.12788\/cutis.0622","article-title":"Petrolatum is effective as a moisturizer, but there are more uses for it","volume":"110","author":"Malave","year":"2022","journal-title":"Cutis"},{"key":"10.1016\/j.plipres.2023.101264_bb0755","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.toxlet.2017.07.899","article-title":"Review of data on the dermal penetration of mineral oils and waxes used in cosmetic applications","volume":"280","author":"Petry","year":"2017","journal-title":"Toxicol Lett"},{"issue":"3 Pt 2","key":"10.1016\/j.plipres.2023.101264_bb0760","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0190-9622(92)70060-S","article-title":"Effects of petrolatum on stratum corneum structure and function","volume":"26","author":"Ghadially","year":"1992","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"10.1016\/j.plipres.2023.101264_bb0765","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/1523-1747.ep12340135","article-title":"Optimization of physiological lipid mixtures for barrier repair","volume":"106","author":"Man","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.plipres.2023.101264_bb0770","doi-asserted-by":"crossref","first-page":"03019","DOI":"10.7189\/jogh.12.03019","article-title":"Optimised emollient mixture for skin barrier repair: applications to global child health","volume":"12","author":"Elias","year":"2022","journal-title":"J Glob Health"},{"issue":"3","key":"10.1016\/j.plipres.2023.101264_bb0775","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s40521-021-00289-9","article-title":"The role of the environment and exposome in atopic dermatitis","volume":"8","author":"Stefanovic","year":"2021","journal-title":"Curr Treat Options Allergy"},{"issue":"2","key":"10.1016\/j.plipres.2023.101264_bb0780","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1067\/mjd.2002.124617","article-title":"Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity","volume":"47","author":"Chamlin","year":"2002","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.plipres.2023.101264_bb0785","first-page":"34","article-title":"Evaluating clinical use of a ceramide-dominant, physiologic lipid-based topical emulsion for atopic dermatitis","volume":"4","author":"Kircik","year":"2011","journal-title":"J Clin Aesthet Dermatol"},{"issue":"12","key":"10.1016\/j.plipres.2023.101264_bb0790","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1111\/1346-8138.16175","article-title":"Clinical significance of the water retention and barrier function-improving capabilities of ceramide-containing formulations: a qualitative review","volume":"48","author":"Kono","year":"2021","journal-title":"J Dermatol"},{"issue":"6","key":"10.1016\/j.plipres.2023.101264_bb0795","doi-asserted-by":"crossref","DOI":"10.1111\/dth.14263","article-title":"Efficacy and safety of a topical moisturizer containing linoleic acid and ceramide for mild-to-moderate psoriasis vulgaris: a multicenter randomized controlled trial","volume":"33","author":"Li","year":"2020","journal-title":"Dermatol Ther"},{"issue":"6","key":"10.1016\/j.plipres.2023.101264_bb0800","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1080\/000155500300012774","article-title":"Skin-identical lipids versus petrolatum in the treatment of tape-stripped and detergent-perturbed human skin","volume":"80","author":"Lod\u00e9n","year":"2000","journal-title":"Acta Derm Venereol"},{"issue":"11","key":"10.1016\/j.plipres.2023.101264_bb0805","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.3390\/md11114544","article-title":"Antibacterial activity of long-chain polyunsaturated fatty acids against Propionibacterium acnes and Staphylococcus aureus","volume":"11","author":"Desbois","year":"2013","journal-title":"Mar Drugs"},{"issue":"4","key":"10.1016\/j.plipres.2023.101264_bb0810","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/jid.2009.384","article-title":"Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression","volume":"130","author":"Nakatsuji","year":"2010","journal-title":"J Invest Dermatol"},{"issue":"3","key":"10.1016\/j.plipres.2023.101264_bb0815","first-page":"18","article-title":"Moisturizers and ceramide-containing moisturizers may offer concomitant therapy with benefits","volume":"7","author":"Lynde","year":"2014","journal-title":"J Clin Aesthet Dermatol"}],"container-title":["Progress in Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163782723000541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163782723000541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:47:47Z","timestamp":1759013267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163782723000541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":163,"alternative-id":["S0163782723000541"],"URL":"https:\/\/doi.org\/10.1016\/j.plipres.2023.101264","relation":{},"ISSN":["0163-7827"],"issn-type":[{"value":"0163-7827","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The heterogeneity and complexity of skin surface lipids in human skin health and disease","name":"articletitle","label":"Article Title"},{"value":"Progress in Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.plipres.2023.101264","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101264"}}