{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T22:27:14Z","timestamp":1767824834726,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physical Medicine and Rehabilitation Clinics of North America"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.pmr.2011.11.011","type":"journal-article","created":{"date-parts":[[2011,12,12]],"date-time":"2011-12-12T12:17:40Z","timestamp":1323692260000},"page":"173-186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Exercise Testing in Metabolic Myopathies"],"prefix":"10.1016","volume":"23","author":[{"given":"Mark","family":"Tarnopolsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Pt 3","key":"10.1016\/j.pmr.2011.11.011_bib1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/j.1469-7793.2001.t01-1-00881.x","article-title":"Myoadenylate deaminase deficiency does not affect muscle anaplerosis during exhaustive exercise in humans","volume":"533","author":"Tarnopolsky","year":"2001","journal-title":"J\u00a0Physiol"},{"issue":"3","key":"10.1016\/j.pmr.2011.11.011_bib2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/CND.0b013e3181903126","article-title":"Metabolic myopathies: update 2009","volume":"10","author":"van Adel","year":"2009","journal-title":"J\u00a0Clin Neuromuscul Dis"},{"issue":"2","key":"10.1016\/j.pmr.2011.11.011_bib3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/mus.20567","article-title":"Genetic risk factors associated with lipid-lowering drug-induced myopathies","volume":"34","author":"Vladutiu","year":"2006","journal-title":"Muscle Nerve"},{"issue":"4","key":"10.1016\/j.pmr.2011.11.011_bib4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1358\/dot.2005.41.4.908565","article-title":"Statin-associated neuromyotoxicity","volume":"41","author":"Baker","year":"2005","journal-title":"Drugs Today (Barc)"},{"issue":"4","key":"10.1016\/j.pmr.2011.11.011_bib5","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/mus.21817","article-title":"Statin-associated myopathy and its exacerbation with exercise","volume":"42","author":"Meador","year":"2010","journal-title":"Muscle Nerve"},{"issue":"7-8","key":"10.1016\/j.pmr.2011.11.011_bib6","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.nut.2004.04.008","article-title":"Protein requirements for endurance athletes","volume":"20","author":"Tarnopolsky","year":"2004","journal-title":"Nutrition"},{"issue":"9","key":"10.1016\/j.pmr.2011.11.011_bib7","first-page":"1009","article-title":"Carbohydrate dependence during marathon running","volume":"25","author":"O\u2019Brien","year":"1993","journal-title":"Med Sci Sports Exerc"},{"issue":"26","key":"10.1016\/j.pmr.2011.11.011_bib8","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1056\/NEJMoa031836","article-title":"The effect of oral sucrose on exercise tolerance in patients with McArdle\u2019s disease","volume":"349","author":"Vissing","year":"2003","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.pmr.2011.11.011_bib9","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1001\/archneur.65.6.786","article-title":"Effect of oral sucrose shortly before exercise on work capacity in McArdle disease","volume":"65","author":"Andersen","year":"2008","journal-title":"Arch Neurol"},{"issue":"1","key":"10.1016\/j.pmr.2011.11.011_bib10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1212\/WNL.62.1.82","article-title":"No spontaneous second wind in muscle phosphofructokinase deficiency","volume":"62","author":"Haller","year":"2004","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.pmr.2011.11.011_bib11","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/ana.20881","article-title":"Aerobic conditioning: an effective therapy in McArdle\u2019s disease","volume":"59","author":"Haller","year":"2006","journal-title":"Ann Neurol"},{"issue":"7","key":"10.1016\/j.pmr.2011.11.011_bib12","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1001\/archneur.57.7.956","article-title":"Creatine therapy in myophosphorylase deficiency (McArdle disease): a placebo-controlled crossover trial","volume":"57","author":"Vorgerd","year":"2000","journal-title":"Arch Neurol"},{"issue":"4","key":"10.1016\/j.pmr.2011.11.011_bib13","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1212\/01.WNL.0000078195.05396.20","article-title":"Effect of diet on exercise tolerance in carnitine palmitoyltransferase II deficiency","volume":"61","author":"Orngreen","year":"2003","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.pmr.2011.11.011_bib14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1071-9091(96)80038-6","article-title":"Metabolic myopathies","volume":"3","author":"Tein","year":"1996","journal-title":"Semin Pediatr Neurol"},{"issue":"5\u20136","key":"10.1016\/j.pmr.2011.11.011_bib15","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.mito.2004.07.011","article-title":"Exercise testing as a diagnostic entity in mitochondrial myopathies","volume":"4","author":"Tarnopolsky","year":"2004","journal-title":"Mitochondrion"},{"issue":"12","key":"10.1016\/j.pmr.2011.11.011_bib16","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1249\/01.mss.0000177341.89478.06","article-title":"Mitochondrial myopathies: diagnosis, exercise intolerance, and treatment options","volume":"37","author":"Tarnopolsky","year":"2005","journal-title":"Med Sci Sports Exerc"},{"issue":"8","key":"10.1016\/j.pmr.2011.11.011_bib17","doi-asserted-by":"crossref","first-page":"e6518","DOI":"10.1371\/journal.pone.0006518","article-title":"Limb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women","volume":"4","author":"Abadi","year":"2009","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.pmr.2011.11.011_bib18","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1212\/WNL.58.10.1533","article-title":"A\u00a0forearm exercise screening test for mitochondrial myopathy","volume":"58","author":"Jensen","year":"2002","journal-title":"Neurology"},{"issue":"Pt 2","key":"10.1016\/j.pmr.2011.11.011_bib19","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/brain\/awg028","article-title":"The spectrum of exercise tolerance in mitochondrial myopathies: a study of 40 patients","volume":"126","author":"Taivassalo","year":"2003","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.pmr.2011.11.011_bib20","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/ana.10027","article-title":"Venous oxygen levels during aerobic forearm exercise: an index of impaired oxidative metabolism in mitochondrial myopathy","volume":"51","author":"Taivassalo","year":"2002","journal-title":"Ann Neurol"},{"issue":"4","key":"10.1016\/j.pmr.2011.11.011_bib21","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/ana.10725","article-title":"A\u00a0diagnostic cycle test for McArdle\u2019s disease","volume":"54","author":"Vissing","year":"2003","journal-title":"Ann Neurol"},{"issue":"3","key":"10.1016\/j.pmr.2011.11.011_bib22","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/mus.10330","article-title":"Diagnostic utility of a modified forearm ischemic exercise test and technical issues relevant to exercise testing","volume":"27","author":"Tarnopolsky","year":"2003","journal-title":"Muscle Nerve"},{"issue":"6","key":"10.1016\/j.pmr.2011.11.011_bib23","first-page":"735","article-title":"Lactate production upon short-term non-ischemic forearm exercise in mitochondrial disorders and other myopathies","volume":"253","author":"Hanisch","year":"2006","journal-title":"J\u00a0Neurol"},{"issue":"4","key":"10.1016\/j.pmr.2011.11.011_bib24","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/(SICI)1099-1492(199606)9:4<165::AID-NBM408>3.0.CO;2-X","article-title":"ADP recovery after a brief ischemic exercise in normal and diseased human muscle\u2013a 31P MRS study","volume":"9","author":"Argov","year":"1996","journal-title":"NMR Biomed"},{"issue":"2","key":"10.1016\/j.pmr.2011.11.011_bib25","first-page":"305","article-title":"Responses to ischaemic work in the human forearm","volume":"15","author":"McArdle","year":"1956","journal-title":"Clin Sci (Lond)"},{"issue":"4","key":"10.1016\/j.pmr.2011.11.011_bib26","first-page":"535","article-title":"Myogenic hyperuricemia: what can we learn from metabolic myopathies?","volume":"19","author":"Knochel","year":"1996","journal-title":"Muscle Nerve"},{"issue":"12","key":"10.1016\/j.pmr.2011.11.011_bib27","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1136\/jnnp.45.12.1144","article-title":"The forearm ischaemic work test\u2013hazardous to McArdle patients?","volume":"45","author":"Meinck","year":"1982","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"issue":"2","key":"10.1016\/j.pmr.2011.11.011_bib28","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ana.10263","article-title":"A\u00a0nonischemic forearm exercise test for McArdle disease","volume":"52","author":"Kazemi-Esfarjani","year":"2002","journal-title":"Ann Neurol"},{"issue":"12","key":"10.1016\/j.pmr.2011.11.011_bib29","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1212\/WNL.56.12.1733","article-title":"A\u00a0non-ischemic forearm exercise test for the screening of patients with exercise intolerance","volume":"56","author":"Hogrel","year":"2001","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.pmr.2011.11.011_bib30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ymgme.2005.03.002","article-title":"A\u00a0novel mutation in the PYGM gene in a family with pseudo-dominant transmission of McArdle disease","volume":"85","author":"Isackson","year":"2005","journal-title":"Mol Genet Metab"},{"issue":"20","key":"10.1016\/j.pmr.2011.11.011_bib31","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1212\/01.wnl.0000289190.66955.67","article-title":"Is muscle glycogenolysis impaired in X-linked phosphorylase b kinase deficiency?","volume":"70","author":"Orngreen","year":"2008","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.pmr.2011.11.011_bib32","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1152\/jappl.2000.89.6.2325","article-title":"Gender differences in muscle inflammation after eccentric exercise","volume":"89","author":"Stupka","year":"2000","journal-title":"J\u00a0Appl Physiol"},{"issue":"4","key":"10.1016\/j.pmr.2011.11.011_bib33","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1152\/jappl.2001.91.4.1669","article-title":"Cellular adaptation to repeated eccentric exercise-induced muscle damage","volume":"91","author":"Stupka","year":"2001","journal-title":"J\u00a0Appl Physiol"},{"issue":"3","key":"10.1016\/j.pmr.2011.11.011_bib34","first-page":"293","article-title":"Cycle ergometry is not a sensitive diagnostic test for mitochondrial myopathy","volume":"250","author":"Jeppesen","year":"2003","journal-title":"J\u00a0Neurol"},{"issue":"7","key":"10.1016\/j.pmr.2011.11.011_bib35","first-page":"857","article-title":"The usefulness of lactate stress testing in the diagnosis of mitochondrial myopathy. Concerning the paper \"Cycle ergometry is not a sensitive diagnostic test for mitochondrial myopathy\" by Jeppesen et\u00a0al","volume":"252","author":"Finsterer","year":"2005","journal-title":"J\u00a0Neurol"},{"issue":"12","key":"10.1016\/j.pmr.2011.11.011_bib36","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1468-1331.2004.00859.x","article-title":"Stress lactate in mitochondrial myopathy under constant, unadjusted workload","volume":"11","author":"Finsterer","year":"2004","journal-title":"Eur J Neurol"},{"issue":"5","key":"10.1016\/j.pmr.2011.11.011_bib37","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/mus.10096","article-title":"Near infrared spectroscopy in the evaluation of skeletal muscle disease","volume":"25","author":"McCully","year":"2002","journal-title":"Muscle Nerve"},{"issue":"4","key":"10.1016\/j.pmr.2011.11.011_bib38","first-page":"417","article-title":"Lactate increase and oxygen desaturation in mitochondrial disorders\u2013evaluation of two diagnostic screening protocols","volume":"253","author":"Hanisch","year":"2006","journal-title":"J\u00a0Neurol"},{"issue":"1","key":"10.1016\/j.pmr.2011.11.011_bib39","first-page":"29","article-title":"31P-MRS of skeletal muscle is not a sensitive diagnostic test for mitochondrial myopathy","volume":"254","author":"Jeppesen","year":"2007","journal-title":"J\u00a0Neurol"},{"issue":"1","key":"10.1016\/j.pmr.2011.11.011_bib40","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0733-8619(05)70178-X","article-title":"MR spectroscopy and imaging in metabolic myopathies","volume":"18","author":"Argov","year":"2000","journal-title":"Neurol Clin"},{"issue":"9","key":"10.1016\/j.pmr.2011.11.011_bib41","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1002\/1097-4598(200009)23:9<1316::AID-MUS2>3.0.CO;2-I","article-title":"Insights into muscle diseases gained by phosphorus magnetic resonance spectroscopy","volume":"23","author":"Argov","year":"2000","journal-title":"Muscle Nerve"},{"issue":"2","key":"10.1016\/j.pmr.2011.11.011_bib42","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/(SICI)1097-4598(200002)23:2<175::AID-MUS5>3.0.CO;2-R","article-title":"Muscle phosphorus magnetic resonance spectroscopy oxidative indices correlate with physical activity","volume":"23","author":"Tartaglia","year":"2000","journal-title":"Muscle Nerve"},{"issue":"10","key":"10.1016\/j.pmr.2011.11.011_bib43","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1212\/WNL.33.10.1283","article-title":"Hyperkinetic circulation during exercise in neuromuscular disease","volume":"33","author":"Haller","year":"1983","journal-title":"Neurology"}],"container-title":["Physical Medicine and Rehabilitation Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047965111001100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047965111001100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T03:34:10Z","timestamp":1760931250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1047965111001100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S1047965111001100"],"URL":"https:\/\/doi.org\/10.1016\/j.pmr.2011.11.011","relation":{},"ISSN":["1047-9651"],"issn-type":[{"value":"1047-9651","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exercise Testing in Metabolic Myopathies","name":"articletitle","label":"Article Title"},{"value":"Physical Medicine and Rehabilitation Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pmr.2011.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}