{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:26:07Z","timestamp":1778840767603,"version":"3.51.4"},"reference-count":61,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physical Medicine and Rehabilitation Clinics of North America"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.pmr.2022.08.019","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T16:18:32Z","timestamp":1668788312000},"page":"71-81","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evidence-Based Approach to Orthobiologics for Osteoarthritis and Other Joint Disorders"],"prefix":"10.1016","volume":"34","author":[{"given":"Katarzyna","family":"Herman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Gobbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10264","key":"10.1016\/j.pmr.2022.08.019_bib1","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(20)32230-3","article-title":"Osteoarthritis in 2020 and beyond: a Lancet Commission","volume":"396","author":"Hunter","year":"2020","journal-title":"Lancet [Internet]"},{"key":"10.1016\/j.pmr.2022.08.019_bib3","series-title":"Bio-orthopaedics: A new approach","first-page":"1","author":"Gobbi","year":"2017"},{"issue":"10","key":"10.1016\/j.pmr.2022.08.019_bib4","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1016\/j.arthro.2019.08.021","article-title":"How to Manage Cartilage Injuries?","volume":"35","author":"Chahla","year":"2019","journal-title":"Arthroscopy-j Arthrosc Relat Surg"},{"issue":"9","key":"10.1016\/j.pmr.2022.08.019_bib5","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1007\/s00167-013-2676-8","article-title":"Long-term results after microfracture treatment for full-thickness knee chondral lesions in athletes","volume":"22","author":"Gobbi","year":"2014","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"3","key":"10.1016\/j.pmr.2022.08.019_bib6","first-page":"170","article-title":"Microfracture to treat full-thickness chondral defects: surgical technique, rehabilitation, and outcomes","volume":"15","author":"Steadman","year":"2002","journal-title":"J\u00a0Knee Surg"},{"issue":"6","key":"10.1016\/j.pmr.2022.08.019_bib7","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.arthro.2020.04.001","article-title":"Editorial Commentary: Cartilage Restoration\u2014What Is Currently Available?","volume":"36","author":"Gobbi","year":"2020","journal-title":"Arthrosc - J Arthrosc Relat Surg"},{"issue":"5","key":"10.1016\/j.pmr.2022.08.019_bib8","first-page":"347","article-title":"Characterization of initial microfracture defects in human condyles","volume":"26","author":"Hoemann","year":"2013","journal-title":"J\u00a0Knee Surg"},{"issue":"12","key":"10.1016\/j.pmr.2022.08.019_bib9","doi-asserted-by":"crossref","first-page":"e1561","DOI":"10.1016\/j.eats.2019.08.016","article-title":"Primary Anterior Cruciate Ligament Repair With Hyaluronic Scaffold and Autogenous Bone Marrow Aspirate Augmentation in Adolescents With Open Physes","volume":"8","author":"Gobbi","year":"2019","journal-title":"Arthrosc Tech"},{"issue":"10","key":"10.1016\/j.pmr.2022.08.019_bib10","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1177\/0363546508328414","article-title":"Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: An evidence-based systematic analysis","volume":"37","author":"Mithoefer","year":"2009","journal-title":"Am J Sports Med"},{"issue":"11","key":"10.1016\/j.pmr.2022.08.019_bib11","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1177\/0363546516656179","article-title":"One-Stage Cartilage Repair Using a Hyaluronic Acid-Based Scaffold with Activated Bone Marrow-Derived Mesenchymal Stem Cells Compared with Microfracture","volume":"44","author":"Gobbi","year":"2016","journal-title":"Am J Sports Med"},{"issue":"1","key":"10.1016\/j.pmr.2022.08.019_bib12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/JSA.0000000000000134","article-title":"Failure of Bone Marrow Stimulation Techniques","volume":"25","author":"Frank","year":"2017","journal-title":"Sports Med Arthrosc Rev"},{"key":"10.1016\/j.pmr.2022.08.019_bib13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/JSM.0000000000000004","article-title":"Treatment of cartilage defects of the knee: Expanding on the existing algorithm","volume":"24","author":"Behery","year":"2014","journal-title":"Clin J Sport Med"},{"issue":"1","key":"10.1016\/j.pmr.2022.08.019_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00402-012-1621-5","article-title":"Outcome of Autologous Matrix Induced Chondrogenesis (AMIC) in cartilage knee surgery: Data of the AMIC Registry","volume":"133","author":"Gille","year":"2013","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.pmr.2022.08.019_bib15","first-page":"1","article-title":"Spontaneous Minced Cartilage Procedure for Unexpectedly Large Femoral Condyle Surface Defect","volume":"2016","author":"Salzmann","year":"2016","journal-title":"Case Rep Orthop"},{"issue":"11","key":"10.1016\/j.pmr.2022.08.019_bib16","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.5312\/wjo.v6.i11.1006","article-title":"Use of chondral fragments for one stage cartilage repair: A systematic review","volume":"6","author":"Bonasia","year":"2015","journal-title":"World J Orthop"},{"issue":"12","key":"10.1016\/j.pmr.2022.08.019_bib17","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1007\/s00167-012-1920-y","article-title":"One-step osteochondral repair with cartilage fragments in a composite scaffold","volume":"20","author":"Marmotti","year":"2012","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"12","key":"10.1016\/j.pmr.2022.08.019_bib18","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1007\/s00167-016-4323-7","article-title":"Articular cartilage paste graft for severe osteochondral lesions of the knee: a 10- to 23-year follow-up study","volume":"25","author":"Stone","year":"2017","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"6","key":"10.1016\/j.pmr.2022.08.019_bib19","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1177\/0363546509360405","article-title":"Clinical experiences with autologous osteochondral mosaicplasty in an athletic population: a 17-year prospective multicenter study","volume":"38","author":"Hangody","year":"2010","journal-title":"Am J Sports Med"},{"issue":"2","key":"10.1016\/j.pmr.2022.08.019_bib20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1350-4533(01)00122-9","article-title":"Inadequate placement of osteochondral plugs may induce abnormal stress-strain distributions in articular cartilage --finite element simulations","volume":"24","author":"Wu","year":"2002","journal-title":"Med Eng Phys"},{"issue":"6","key":"10.1016\/j.pmr.2022.08.019_bib21","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.arthro.2020.04.001","article-title":"Editorial Commentary: Cartilage Restoration\u2014What Is Currently Available? Arthrosc","volume":"36","author":"Gobbi","year":"2020","journal-title":"J\u00a0Arthrosc Relat Surg"},{"issue":"14","key":"10.1016\/j.pmr.2022.08.019_bib22","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1056\/NEJM199410063311401","article-title":"Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation","volume":"331","author":"Brittberg","year":"1994","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.pmr.2022.08.019_bib23","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1177\/0363546509357915","article-title":"Autologous chondrocyte implantation: A long-term follow-up","volume":"38","author":"Peterson","year":"2010","journal-title":"Am J Sports Med"},{"issue":"12","key":"10.1016\/j.pmr.2022.08.019_bib24","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1016\/j.joca.2013.10.004","article-title":"A\u00a0histological comparison of the repair tissue formed when using either Chondrogide(\u00ae) or periosteum during autologous chondrocyte implantation","volume":"21","author":"McCarthy","year":"2013","journal-title":"Osteoarthr Cartil"},{"issue":"10","key":"10.1016\/j.pmr.2022.08.019_bib25","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1007\/s00264-014-2368-0","article-title":"First-generation versus second-generation autologous chondrocyte implantation for treatment of cartilage defects of the knee: a matched-pair analysis on long-term clinical outcome","volume":"38","author":"Niemeyer","year":"2014","journal-title":"Int Orthop"},{"issue":"11","key":"10.1016\/j.pmr.2022.08.019_bib26","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1016\/j.arthro.2013.07.271","article-title":"Evidence-based status of second- and third-generation autologous chondrocyte implantation over first generation: a systematic review of level I and II studies","volume":"29","author":"Goyal","year":"2013","journal-title":"Arthrosc"},{"issue":"6","key":"10.1016\/j.pmr.2022.08.019_bib27","doi-asserted-by":"crossref","first-page":"V-160","DOI":"10.3310\/hta21060","article-title":"Autologous chondrocyte implantation in the knee: systematic review and economic evaluation","volume":"21","author":"Mistry","year":"2017","journal-title":"Health Technol Assess"},{"issue":"2","key":"10.1016\/j.pmr.2022.08.019_bib28","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/1947603514563597","article-title":"Matrix-Induced Autologous Chondrocyte Implantation versus Multipotent Stem Cells for the Treatment of Large Patellofemoral Chondral Lesions: A Nonrandomized Prospective Trial","volume":"6","author":"Gobbi","year":"2015","journal-title":"Cartilage"},{"issue":"12","key":"10.1016\/j.pmr.2022.08.019_bib29","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1177\/0363546518814236","article-title":"Osteochondral Allograft Transplantation in the Patellofemoral Joint: A Systematic Review","volume":"47","author":"Chahla","year":"2019","journal-title":"Am J Sports Med"},{"issue":"11","key":"10.1016\/j.pmr.2022.08.019_bib30","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1177\/0363546511417172","article-title":"Cocultures of adult and juvenile chondrocytes compared with adult and juvenile chondral fragments: in\u00a0vitro matrix production","volume":"39","author":"Bonasia","year":"2011","journal-title":"Am J Sports Med"},{"issue":"6","key":"10.1016\/j.pmr.2022.08.019_bib31","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1177\/0363546514528671","article-title":"Clinical, Radiographic, and Histological Outcomes After Cartilage Repair With Particulated Juvenile Articular Cartilage: A 2-Year Prospective Study","volume":"42","author":"Farr","year":"2014","journal-title":"Am J Sports Med"},{"issue":"9","key":"10.1016\/j.pmr.2022.08.019_bib32","article-title":"Intramedullary nails for extracapsular hip fractures in adults","volume":"2014","author":"Queally","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"10.1016\/j.pmr.2022.08.019_bib33","doi-asserted-by":"crossref","first-page":"e1613","DOI":"10.1016\/j.eats.2017.06.018","article-title":"Arthroscopic Management of Isolated Tibial Plateau Defect With Microfracture and Micronized Allogeneic Cartilage-Platelet-Rich Plasma Adjunct","volume":"6","author":"Wang","year":"2017","journal-title":"Arthrosc Tech"},{"issue":"3","key":"10.1016\/j.pmr.2022.08.019_bib34","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1177\/0363546520981750","article-title":"Aragonite-Based Scaffold for the Treatment of Joint Surface Lesions in Mild to Moderate Osteoarthritic Knees: Results of a 2-Year Multicenter Prospective Study","volume":"49","author":"Kon","year":"2021","journal-title":"Am J Sports Med"},{"issue":"8","key":"10.1016\/j.pmr.2022.08.019_bib35","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1007\/s00167-016-3984-6","article-title":"One-step surgery with multipotent stem cells and Hyaluronan-based scaffold for the treatment of full-thickness chondral defects of the knee in patients older than 45 years","volume":"25","author":"Gobbi","year":"2017","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"1","key":"10.1016\/j.pmr.2022.08.019_bib36","doi-asserted-by":"crossref","DOI":"10.1186\/s13018-015-0211-y","article-title":"Osteochondral regeneration with a novel aragonite-hyaluronate biphasic scaffold: Up to 12-month follow-up study in a goat model","volume":"10","author":"Kon","year":"2015","journal-title":"J\u00a0Orthop Surg Res"},{"issue":"3","key":"10.1016\/j.pmr.2022.08.019_bib37","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1177\/1947603510392023","article-title":"One-step cartilage repair with bone marrow aspirate concentrated cells and collagen matrix in full-thickness knee cartilage lesions: results at 2-year follow-up","volume":"2","author":"Gobbi","year":"2011","journal-title":"Cartilage"},{"issue":"3","key":"10.1016\/j.pmr.2022.08.019_bib38","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1177\/0363546513518007","article-title":"One-step surgery with multipotent stem cells for the treatment of large full-thickness chondral defects of the knee","volume":"42","author":"Gobbi","year":"2014","journal-title":"Am J Sports Med"},{"issue":"7","key":"10.1016\/j.pmr.2022.08.019_bib39","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1177\/0363546519845362","article-title":"Long-term Clinical Outcomes of One-Stage Cartilage Repair in the Knee With Hyaluronic Acid\u2013Based Scaffold Embedded With Mesenchymal Stem Cells Sourced From Bone Marrow Aspirate Concentrate","volume":"47","author":"Gobbi","year":"2019","journal-title":"Am J Sports Med"},{"issue":"2","key":"10.1016\/j.pmr.2022.08.019_bib40","first-page":"e383","article-title":"Biologic Inlay Osteochondral Reconstruction: Arthroscopic One-Step Osteochondral Lesion Repair in the Knee Using Morselized Bone Grafting and Hyaluronic Acid-Based Scaffold Embedded With","volume":"6","author":"Sadlik","year":"2017","journal-title":"Bone Marrow Aspirate Concentrate"},{"key":"10.1016\/j.pmr.2022.08.019_bib41","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/978-3-030-82958-2_15","article-title":"Current Concepts in Subchondral Bone Pathology","author":"Gobbi","year":"2022","journal-title":"Jt Funct Preserv"},{"issue":"1","key":"10.1016\/j.pmr.2022.08.019_bib42","first-page":"1","article-title":"Isolation of clinically relevant concentrations of bone marrow mesenchymal stem cells without centrifugation 11 Medical and Health Sciences 1103 Clinical Sciences","volume":"17","author":"Scarpone","year":"2019","journal-title":"J\u00a0Transl Med"},{"key":"10.1016\/j.pmr.2022.08.019_bib43","author":"Gobbi"},{"issue":"12","key":"10.1016\/j.pmr.2022.08.019_bib44","doi-asserted-by":"crossref","DOI":"10.1177\/23259671211058459","article-title":"High Variability of Mesenchymal Stem Cells Obtained via Bone Marrow Aspirate Concentrate Compared With Traditional Bone Marrow Aspiration Technique","volume":"9","author":"Brozovich","year":"2021","journal-title":"Orthop J Sports Med"},{"issue":"11","key":"10.1016\/j.pmr.2022.08.019_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.eats.2020.07.023","article-title":"Osteo-core Plasty: A Minimally Invasive Approach for Subchondral Bone Marrow Lesions of the Knee","volume":"9","author":"Szwedowski","year":"2020","journal-title":"Arthrosc Tech"},{"issue":"1","key":"10.1016\/j.pmr.2022.08.019_bib46","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1186\/s13018-020-01919-9","article-title":"Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis","volume":"15","author":"Tang","year":"2020","journal-title":"J\u00a0Orthop Surg Res"},{"key":"10.1016\/j.pmr.2022.08.019_bib47","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/sj.bjp.0706975","article-title":"Protease-activated receptor-4: a novel mechanism of inflamma-tory pain modulation","volume":"150","author":"Asfaha","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pmr.2022.08.019_bib48","doi-asserted-by":"crossref","first-page":"421","DOI":"10.5435\/00124635-200311000-00006","article-title":"Articular cartilage biology","volume":"11","author":"Ulrich-Vinther","year":"2003","journal-title":"J\u00a0Am Acad Ort-hop Surg"},{"issue":"5","key":"10.1016\/j.pmr.2022.08.019_bib49","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1517\/14712598.2016.1157162","article-title":"A\u00a0new strategy to tackle severe knee osteoarthritis: Combination of intra-articular and intraosseous injections of Platelet Rich Plasma","volume":"16","author":"S\u00e1nchez","year":"2016","journal-title":"Expert Opin Biol Ther"},{"issue":"10","key":"10.1016\/j.pmr.2022.08.019_bib50","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1007\/s11999-011-1857-3","article-title":"The role of growth factors in cartilage repair","volume":"469","author":"Fortier","year":"2011","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"10.1016\/j.pmr.2022.08.019_bib51","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/0363546516665809","article-title":"Hyaluronic Acid Versus Platelet-Rich Plasma: A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis","volume":"45","author":"Cole","year":"2017","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.pmr.2022.08.019_bib52","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1007\/s00167-014-2987-4","article-title":"The effects of repeated intra-articular PRP injections on clinical outcomes of early osteoarthritis of the knee","volume":"23","author":"Gobbi","year":"2014","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"1_suppl","key":"10.1016\/j.pmr.2022.08.019_bib53","doi-asserted-by":"crossref","first-page":"364S","DOI":"10.1177\/1947603520931170","article-title":"PRP Injections for the Treatment of Knee Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials","volume":"13","author":"Filardo","year":"2021","journal-title":"Cartilage"},{"issue":"6","key":"10.1016\/j.pmr.2022.08.019_bib54","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/j.arthro.2021.11.005","article-title":"Platelet-Rich Plasma Versus Hyaluronic Acid for Hip Osteoarthritis Yields Similarly Beneficial Short-Term Clinical Outcomes: A Systematic Review and Meta-analysis of Level I and II Randomized Controlled Trials","volume":"38","author":"Belk","year":"2022","journal-title":"Arthroscopy"},{"issue":"3","key":"10.1016\/j.pmr.2022.08.019_bib55","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1177\/0363546515620383","article-title":"Ultrasound-Guided Injection of Platelet-Rich Plasma and Hyaluronic Acid, Separately and in Combination, for Hip Osteoarthritis: A Randomized Controlled Study","volume":"44","author":"Dallari","year":"2016","journal-title":"Am J Sports Med"},{"issue":"3","key":"10.1016\/j.pmr.2022.08.019_bib56","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1177\/03635465211064303","article-title":"Leukocyte-Rich versus Leukocyte-Poor Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis: A Double-Blind Randomized Trial","volume":"50","author":"Di Martino","year":"2022","journal-title":"Am J Sports Med"},{"issue":"6","key":"10.1016\/j.pmr.2022.08.019_bib57","doi-asserted-by":"crossref","first-page":"447","DOI":"10.5604\/01.3001.0014.6055","article-title":"A\u00a0Comparative Study for Different Types of Thumb Base Osteoarthritis Injections: A Randomized Controlled Interventional Study","volume":"22","author":"Abdelsabor Sabaah","year":"2020","journal-title":"Ortop Traumatol Rehabil"},{"issue":"16","key":"10.1016\/j.pmr.2022.08.019_bib58","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1001\/jama.2021.16602","article-title":"Effect of Platelet-Rich Plasma Injections vs Placebo on Ankle Symptoms and Function in Patients With Ankle Osteoarthritis: A Randomized Clinical Trial","volume":"326","author":"Paget","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.pmr.2022.08.019_bib59","first-page":"33","article-title":"Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis","volume":"4","author":"Russo","year":"2017","journal-title":"J\u00a0Exp Orthop"},{"issue":"9","key":"10.1016\/j.pmr.2022.08.019_bib60","doi-asserted-by":"crossref","DOI":"10.1177\/23259671221120678","article-title":"Platelet-Rich Plasma Versus Microfragmented Adipose Tissue for Knee Osteoarthritis: A Randomized Controlled Trial","volume":"10","author":"Baria","year":"2022","journal-title":"Orthop J Sports Med"},{"issue":"5","key":"10.1016\/j.pmr.2022.08.019_bib61","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00264-021-04947-0","article-title":"Two-year clinical outcomes of autologous microfragmented adipose tissue in elderly patients with knee osteoarthritis: a multi-centric, international study","volume":"45","author":"Gobbi","year":"2021","journal-title":"Int Orthop"},{"key":"10.1016\/j.pmr.2022.08.019_bib62","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1089\/scd.2021.0053","article-title":"A\u00a0Prospective Study Comparing Leukocyte-Poor Platelet-Rich Plasma Combined with Hyaluronic Acid and Autologous Microfragmented Adipose Tissue in Patients with Early Knee Osteoarthritis","volume":"30","author":"Dallo","year":"2021","journal-title":"Stem Cell Dev"}],"container-title":["Physical Medicine and Rehabilitation Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047965122000882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047965122000882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T03:45:29Z","timestamp":1760931929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1047965122000882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S1047965122000882"],"URL":"https:\/\/doi.org\/10.1016\/j.pmr.2022.08.019","relation":{},"ISSN":["1047-9651"],"issn-type":[{"value":"1047-9651","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence-Based Approach to Orthobiologics for Osteoarthritis and Other Joint Disorders","name":"articletitle","label":"Article Title"},{"value":"Physical Medicine and Rehabilitation Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pmr.2022.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}